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2 no.511 vol.49 no CODE CN(1)511
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5 CLINICIAN 02 NO
6 Bone and Joint Decade Bone and Joint Decade 3 CLINICIAN 02 NO. 511
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8 Bone and Joint Decade 5 CLINICIAN 02 NO. 511
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11 cooling CLINICIAN 02 NO
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15 thrust CLINICIAN 02 NO
16 drilling abrasion arthroplasty 13 CLINICIAN 02 NO. 511
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25 over use CLINICIAN 02 NO
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29 dermatome cervical angina CLINICIAN 02 NO
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31 spinal instrumentation cage CLINICIAN 02 NO
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37 Hagino, H., Yamamoto, K., Ohshiro, H., et al. : Changing incidence of hip, distal radius, and proximal humerus fractures in Tottori Prefecture, Japan. Bone, 24, (1999) Suzuki, T., Yoshida, H., Hashimoto, T., et al. : Casecontrol study of risk factors for hip fractures in the Japanese elderly by a Mediterranean Osteoporosis Study (MEDOS)questionnaire. Bone, 21, (1997) Gullberg, B., Johnell, O., Kanis, JA., : World-wide projection for hip fracture. Osteoporos. Int., 7, (1997) 35 CLINICIAN 02 NO. 511
38 CLINICIAN 02 NO
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41 39 CLINICIAN 02 NO. 511
42 post fall syndrome CLINICIAN 02 NO
43 Overstall, P W., et al 41 CLINICIAN 02 NO. 511
44 CLINICIAN 02 NO
45 43 CLINICIAN 02 NO. 511
46 Osteoporosis Japan vol. 6,601(1998) Overstall, PW., et al : Falls in the elderly related to postural imbalance. Brit. Med. J 1., (1997) CURRENT THERAPY 16, (1998) Gerontology Vol.11(4), (1999) CLINICIAN 02 NO
47 45 CLINICIAN 02 NO. 511
48 transcatheter arterial embolization TAE CLINICIAN 02 NO
49 rigid fixation primary fracture healing minimum invasive surgery closed reduction fitting dinamization 47 CLINICIAN 02 NO. 511
50 bone transport Methylpredonisolon sodium succinate Bracken CLINICIAN 02 NO
51 pedicle screw Harrington rod Luque rod hook rod wire pedicle screw and rod system Kaneda device plate and screw system screw bone quality 49 CLINICIAN 02 NO. 511
52 implant CLINICIAN 02 NO
53 51 CLINICIAN 02 NO. 511
54 fatigue microdamage microdamage microdamage Locomotion system CLINICIAN 02 NO
55 locomotion system microdamage 53 CLINICIAN 02 NO. 511
56 microdamage bulk stain microdamage microdamage osteocyte lacunae microdamage CLINICIAN 02 NO
57 microdamage stress fracture insufficiency fracture microdamage microdamage microdamage microdamage microdamage mechanosensor microdamage microdamage microdamage microdamage microdamage 55 CLINICIAN 02 NO. 511
58 microdamage Locomotion system microdamage Reifsnider, KL., Shulta, K., Dyke, JC., : Lon-term fatigue charasteristics of composite materials. In Long term behavior of composite materials STP813, American Society for testing and materials, Philadelphia (1983) Burr, DB., Stafford, T., : Validity of the bulk staining technique to separate artififactual from in vivo microdamage. Clin. Orthop., 260, 305(1990) Mori, S., Harruff, R., Ambrousius, W., Burr, DB., : Trabecular bone volume and microdamage accumulation in the femoral heads with and without femoral neck fractures, Bone, 12, 521(1997) Mori, S., Li, J., Kawaguchi, Y., : The histological appearance of stress fractures. In musculoskeltal fatigue and stress fractures(ed. Burr DB, Milgrom C.), CRCpress(2001) Mori, S., Burr, DB., : Increased intracortical remodeling following fatigue damage. Bone, 14, (1993) CLINICIAN 02 NO
59 57 CLINICIAN 02 NO. 511 Rosai gastro-intestinal stromal tumor Miettinen stem
60 CLINICIAN 02 NO cell factor Wv Wv Huizinga
61 59 CLINICIAN 02 NO. 511
62 CLINICIAN 02 NO
63 61 CLINICIAN 02 NO. 511 germline mutation desmin Hirota, S., et al. : Gain-of-function mutation of c-kit in human gastrointestinal stromal tumors. Science, 279, (1998) 2) Nishida, T., et al. : Familial gastrointestinal stromal tumors with germline mutation of the KIT gene. Nature Genetics, 19, (1998) 3) Taniguchi, M., et al. : Effect of c-kit Mutation on Prognosis of Gastrointestinal Stromal Tumors. Cancer Res., 59, (1999) 4) Rosai, J., : Stromal tumors. Ackerman s Surgical Pathology. 8th ed. Mosby-Year Book, Inc, St Louis, Chicago, (1996) 5) Miettinen, M., et al. : Gastrointestinal stromal tumors value of CD34antigen in their identification and
64 CLINICIAN 02 NO separation from true leiomyomas and shcwannomas. Am. J. Pathol., 19, (1995) 6) Maeda, H., et al. : Requirement of c-kit for development of intestinal pacemaker system. Development 116, (1992) 7) Kitamura, Y., et al. : Coincidental development of forestomach papilloma and prepyloric ulcer in nontreated mutant mice of W/Wv and Sl/Sld genotypes. Cancer Res., 40, (1980) 8) Huizinga, JD., et al. : W/kit gene required for interstitial cells of Cajar and for intestinal pacemaker activity. Nature373, (1995)
65 µ MRI 63 CLINICIAN 02 NO. 511
66 Hgmin µ µ µ CLINICIAN 02 NO
67 65 CLINICIAN 02 NO. 511
68 peak bone mass CLINICIAN 02 NO
69 D K 67 CLINICIAN 02 NO. 511
70 polymorphism single nucleotide polymorphisms, SNPs regulatory SNPs rsnps coding SNPs csnps silent SNPs CLINICIAN 02 NO
71 ssnps 69 CLINICIAN 02 NO. 511
72 CLINICIAN 02 NO
73 71 CLINICIAN 02 NO. 511
74 CLINICIAN 02 NO
75 empty vertebra 73 CLINICIAN 02 NO. 511
76 CLINICIAN 02 NO
77 K PSL menatetrenone etidronate YAM 75 CLINICIAN 02 NO. 511
78 Etid. Alend. Rised. Rised. Alend. Etid. Adachi Saag Cohen Reid Adachi yr yr yr yr yr yr CEREERRRRARR NNT Adachi Saag Cohen Reid Adachi CLINICIAN 02 NO
79 Intermittent etidronate therapy to prevent corticosteroidinduced osteoporosis. New Engl. J. Med., 337, Adachi, J. D., Bensen, W. G., Brown, J.,, et al. : Rheum., 44(7), (2001) on Glucocorticoid-Induced Osteoporosis. Arthritis American College of Rheumatology Ad Hoc Committee glucocorticoid-induced osteoporosis Update Recommendations for the prevention and treatment of Buckley, L., Greenwald, M., Hochberg, M., et al. : (1998) Consensus Group on management of glucocorticoidinduced osteoporosis : an update. J, Int. Med., 244(4), Eastell, R., Reid, D.M., Compston, J., et al. : A UK Japan. Osteoporosis BONE. Semin. Arthritis Rheum., 29, 228 THE 251(2000) Management of corticosteroid-induced osteoporosis. Adachi, J. D., Olszynski W. P., Hanley D. A., et al. : Arthritis Rheum., 44(1), (2001) vertebral fracture in patients receiving glucocorticoids. Adachi, J. D., Saag, K. G., Delmas, P. D., et al. : Twoyear effects of alendronate on bone mineral density and & Mineral Research. 15(6), (2000) Induced Osteoporosis Treatment Study. Journal of Bone women : a randomized trial. European Corticosteroid- corticosteroid-induced osteoporosis in men and safety of daily risedronate in the treatment of Reid, DM., Hughes, RA., Laan, RF., et al. : Efficacy and Arthritis Rheum., 42(11), (1999) Cohen, S., Levy, R. M., Keller, M., et al. : Risedronate (1998) therapy prevents corticosteroid-induced bone loss. (1997) Saag, K., Emkey, R., Schnitzer, T., et al. : Alendronate for the prevention and treatment of glucocorticoidinduced osteoporosis. New Engl. J. Med., 339, CLINICIAN 02 NO. 511
80 quality of life patient-based outcome CLINICIAN 02 NO
81 T T L 79 CLINICIAN 02 NO. 511
82 senile kyphosis gibbus.. CLINICIAN 02 NO
83 . 81 CLINICIAN 02 NO. 511
84 Silverman, SL., : The osteoporosis assessment questionnaire(opaq) : A reliable and valid diseasetargeted measure of health-related quality of life (HRQOL)in osteoporosis. Quality of Life Research 9, (2000) CLINICIAN 02 NO
85 Leidig-Bruckner, G., Minne, HW., Schlaich, C., Wagner, G., Scheidt-Nave, C., Bruckner, T., Gebest, HJ., Ziegler, R., : Clinical grading of spinal osteoporosis : quality of life components and spinal deformity in women with chronic low back pain and women with vertebral osteoporosis. J. Bone. Miner. Res., 12, (1997) Ensrud, KE., Thompson, DE., Cauley, JA., Nevitt, MC., Kado,DM.,Hochberg,MC.,Santora,AC.,Black,DN.,: Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. J. Am. Geriatr. Soc., 48, (2000) Suppl. 3, (2002) QOL. Osteoporosis Japan., 9, (2001) Osteoporosis. Japan., 9, (2001) Osteoporosis Japan., 9, (2001) QOL. Osteoporosis Japan. 9, (2001) Nevitt, MC., Thompson, DE., Black, DE., Rubin, SR., Ensrud, K., Yates, AJ., Cummings, SR., : Effect of Alendronate on limited-activity days and bed-disability days caused by back pain in postmenopousal women with existing vertebral fractures. Arch. Intern. Med., 160,77 85(2000) Liberman,UA.,Weiss,SR.,Broell,J.,Minne,HW.,Quan, H., Bell, NH., Rodriguez-Portales, J., Downs, RW., Dequeker, J., Favus, M., Seeman, E., Recker, RR., Capizzi, T., Santora, AC., Lombardi, A., Shah, RV., Hirsch, Lj., Karpf, DB., Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. New Engl. J. Med., 333, (1995) 83 CLINICIAN 02 NO. 511
86 Embryonic stem cell CLINICIAN 02 NO
87 85 CLINICIAN 02 NO. 511
88 ml ml CLINICIAN 02 NO
89 87 CLINICIAN 02 NO. 511
90 CLINICIAN 02 NO
91 Takakura Y., et al : Ankle arthroplasty. A comparative study of cemented metal and uncemented ceramic prostheses. Clin. Orthop., 252, (1990) Ohgushi, H., et al : Stem cell technology and bioceramics : from cell to gene engineering. J. Biomed Mater Res.,48, (1999) 89 CLINICIAN 02 NO. 511
92 91 CLINICIAN 02 NO. 511
93 evidence based medicine CLINICIAN 02 NO
94 93 CLINICIAN 02 NO. 511
95 CLINICIAN 02 NO
96 95 CLINICIAN 02 NO. 511
97 CLINICIAN 02 NO
98 97 CLINICIAN 02 NO. 511
99 CLINICIAN 02 NO
100 99 CLINICIAN 02 NO. 511
101 CLINICIAN 02 NO
102 101 CLINICIAN 02 NO. 511
103 CLINICIAN 02 NO
104 103 CLINICIAN 02 NO. 511
105 CLINICIAN 02 NO
106 Lennard poor metabolizerpm extensive metabolizerem 105 CLINICIAN 02 NO. 511
107 CLINICIAN 02 NO
108 107 CLINICIAN 02 NO. 511
109 encainide Beckmann CLINICIAN 02 NO
110 Na Na 109 CLINICIAN 02 NO. 511
111 Circulation, 105, (2002) phenotypes : a simulation study of mechanism. that causes both Brugada and long-qt syndrome Clancy, CE., and Rudy, Y., : Na(+)channel mutation (1989) metaboliser phenotype. Br. J. Clin. Pharmacol., 28, Br. Med. J., 297, 1316(1988) flecainidetoxicity. Gross, AS., et al. : Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine 156(1991) Beckmann, J., et al. : Is there a genetic factor in Chinese subjects. Clin. Pharmacol. Ther., 50, 150 (1999) Zhou, HH., and Woods, AJ., : Increased suppression of exercise-induced increase in renin by propranolol in genotypes. Clin. Pharmacol. Ther., 65, enantiomers in Chinese subjects of major CYP2D6 Huang, J-D., et al. : Pharmacokinetics of metoprolol Engl. J. Med., 307, (1982) determinant of metoprolol metabolism and response. N. Lennard, MS., et al. : Oxidation phenotype-a major Clin. Pharmacol. Ther., (1998) having different CYP2C9 and CYP2C19genotypes. (2002) Takahashi, H., et al. : Metabolism of warfarin enantiomers in Japanese patients with heart disease during warfarin therapy. JAMA, 287, genetic variants and anticoagulation-related outcomes Higashi, MK., et al. : Association between CYP2C9 CLINICIAN 02 NO
112 111 CLINICIAN 02 NO. 511
113 CLINICIAN 02 NO
114 113 CLINICIAN 02 NO. 511
115 CLINICIAN 02 NO
116 115 CLINICIAN 02 NO. 511
117 CLINICIAN 02 NO
118 empty sella MRI PRL PRL Bromocriptine Dopamine Levothyroxine sodiumµgday MRI PRL 117 CLINICIAN 02 NO. 511
119 germ cell tumor astrocytoma Niepce TSH negative feedback TSH TRH TSH PRL PRL PRL PRL PRL TRH PRL dopamine PRL dopamine CLINICIAN 02 NO
120 119 CLINICIAN 02 NO. 511
121 Sports injury
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