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2 14 2, , , ,300 3, ,500 Narita N, Kato M, Tazoe M, Miyazaki K, Narita M, and Okado N. Increased monoamine concentration in the brain and the blood of fetal thalidomide and valproic acid exposed rat ; putative animal models for autism. Pediatric Research, (4): Miyazaki K, Narita N, Sakuta R, Miyahara T, Naruse H, Okado N, Narita M. Serum neurotrophin concentrations in autism and mental retardation ; a pilot study. Brain and Development, 2004, in press Aika Yajima, Mariko Ikeda, Kaoru Miyazaki, Toru Maeshima, Naoko Narita, Masaaki Narita Manserin, a novel peptide from secretogranin II in the neuroendocrine system. NeuroReport, 2004, in press Kaoru Miyazaki, Naoko Narita, and Masaaki Narita. Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring : implication for pathogenesis of autism. International Journal of Developmental Neuroscience, in press 5. Clinical Neuroscience, , 2003
3 6. 7. State-Trait anxiety Inventory SSRI (5): Lasting Change in the Monoaminergic System in the Fetal Thalidomide and Valproic Acid Exposed Rat ; putative animal models for autism Miyazaki K, Kato M, Narita N, Narita M, Okado N The 32nd Society for Neuroscience Annual Meeting, 2002, November 1-7, Orlando, Florida, USA 2. Autism model rat : Part2 Marked behavioral changes in the embryonal thalidomide/valproic acid exposed rats. Miyahara T, Miyazaki K, Mugishima G, Narita M, Narita N. The 33rd Society for Neuroscience Annual Meeting, 2003, November 8-12, New Orleans, Georgia, USA 3. Autism model rat : Part1 Expression and functional analysis of serotonin transporter in teh embryonal thalidomide/valproic acid exposed rats. Nishigami N, Miyazaki K, Narita N, Narita M. The 33rd Society for Neuroscience Annual Meeting, 2003, November 8-12, New Orleans, Georgia, USA
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26 tumor necrosis factor-alpha (Calabrese et al, 2000; Ichiyama et al, 2000)
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30 Anderson GM, Horne WC, Chatterjee D, Cohen DJ. The hyperserotonemia of autism. Ann NY Acad Sci. 1990;600: ; discussion Calabrese L, Fleischer AB. Thalidomide: current and potential clinical applications. Am J Med. 2000;108(6): Carper RA, Courchesne E. Inverse correlation between frontal lobe and cerebellum sizes in children with autism. Brain. 2000;123 ( Pt 4): Caston J, Chianale C, Delhaye-Bouchaud N, Mariani J. Role of the cerebellum in exploration behavior. Brain Res. 1998;808(2): Chakrabarti S, Fombonne E. Pervasive developmental disorders in preschool children. JAMA. 2001;285(24): Cook E H, Leventhal B. The serotonin system in autism. Curr Opin Pediatr. 1996;8: Dalton R, Forman A M. Chapter 27. Pervasive developmental disorders and childhood psychosis. In Behrman R E, Kliegman R M, Jenson H B. Nelson Textbook of Pediatrics. 2000;ed 16;87-89 WB Saunders. Philadelphia Filipek PA, Accardo PJ, Baranek GT, Cook EH, Dawson G, Gordon B, Gravel JS, Johonson CP, Kallen RJ,Levy SE, Minshew NJ, Ozonoff S, Prizant BM, Rapin I, Rogers SJ, Stone WL, Teplin S, Tuchman RF,
31 Volkmar FR. The screening and diagnosis of autistic spectrum disorders. J Autism Dev Disord. 1999;29(6): Gordon CT, State RC, Nelson JE, Hamburger SD, Rapoport JL. A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry. 1993;50(6): Grailhe R, Waeber C, Dulawa SC, Hornung JP, Zhuang X, Brunner D, Geyer MA, Hen R. Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999;22(3): Hodges H, Maze procedures: the radial-arm and water maze compared. Brain Res Cogn Brain Res. 1996:(3) Ichiyama T, Okada K, Lipton JM, Matsubara T, Hayashi T, Furukawa S. Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB. Brain Res. 2000;857(1-2): Illig AM, Melia K, Snyder PJ, Badura LL. Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice. Brain Res. 2000;885(2): Ingram JL, Peckham SM, Tisdale B, Rodier PM. Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism. Neurotoxicol Teratol May-Jun;22(3): Kakimoto T, Hattori Y, Okamoto S, Sato N, Kamata T, Yamaguchi M, Morita K, Yamada T, Takayama N, Uchida H, Shimada N, Tanigawara Y,
32 Ikeda Y. Thalidomide for the treatment of refractory multiple myeloma: association of plasma concentrations of thalidomide and angiogenic growth factors with clinical outcome. Jpn J Cancer Res. 2002;93(9): Kinsey AM, Wainwright A, Heavens R, Sirinathsinghji DJ, Oliver KR. Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mrnas in the rat brain. Brain Res Mol Brain Res. 2001;88(1-2): Kroeze WK, Kristiansen K, Roth BL. Molecular biology of serotonin receptors structure and function at the molecular level. Curr Top Med Chem. 2002;2: Lauder JM. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann NY Acad Sci. 1990;600: McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry. 1996;53(11): Mishima K, Egashira N, Hirosawa N, Fujii M, Matsumoto Y, Iwasaki K, Fujiwara M. Characteristics of learning and memory impairment induced by delta9-tetrahydrocannabinol in rats. Jpn J Pharmacol. 2001;87(4): Miyazaki K, Narita N, Ryoichi S, Miyahara T, Naruse H, Okado N, Narita M. Serum neurotrophin concentrations in autism and mental retardation: apilot study. Brain Dev: in press Narita N, Kato M, Tazoe M, Miyazaki K, Narita M, Okado N. Increased
33 monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. Pediatr Res. 2002;52(4): Nelson KB, Grether JK, Croen LA, Dambrosia JM, Dickens BF, Jelliffe LL, Hansen RL, Phillips TM. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol. 2001;49(5): Pasqualetti M, Ori M, Nardi I, Castagna M, Cassano GB, Marazziti D. Distribution of the 5-HT5A serotonin receptor mrna in the human brain. Brain Res Mol Brain Res. 1998;56(1-2):1-8 Pierce K, Courchesne E. Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism. Biol Psychiatry.2001;49(8): Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. European J Pharmacology. 2003;463:3-33 Rice D, Barone SJ. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108: Rodier PM. The Early Origins of Autism. Sci Am. 2000;58-63 Rodier PM, Ingram JL, Tisdale B, Croog VJ. Linking etiologies in humans and animal models:studies of autism. Reprod Toxicol. 1997;11(2-3):
34 Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J. Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Com Neurol. 1996;370: Shastry BS. Molecular genetics of autism spectrum disorders. J Hum Genet. 2003;48(10): Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci. 2003;23(1): Stromland K, Nordin V, Miller M, Akerstrom B, Gillberg C. Autism in thalidomide embryopathy: a population study. Dev Med Child Neurol. 1994;36(4): Volkmar F, Pauls D. Autism. Lancet. 2003;362: Williams G, King J, Cunningham M, Stephan M, Kerr B, Hersh JH. Fetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol. 2001;43(3): Xu T, Pandey SC. Cellular localization of serotonin(2a) (5HT(2A)) receptors in the rat brain. Brain Res Bull. 2000;51(6): Ye W, Shimamura K, Rubenstein JL, Hynes MA, Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 1998;93(5): Zhou FC, Sari Y, Zhang JK, Goodlett CR, Li T. Prenatal alcohol
35 exposure retards the migration and development of serotonin neurons in fetal C57BL mice. Brain Res Dev Brain Res. 2001;126(2): (2002) ;(33) ,. 2003; ;45(5): JW-NIBS. Exp.Anim.1985;34(3):
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43 1: control (±SEM) THAL (±SEM) VPA (±SEM) (by t-test) sniffing ± ± ± 7.96 ND grooming 1.00 ± ± ± 0.97 ND genital investigation ± ± ± 1.67 ND following ± ± ± 2.02 ND climbing 9.86 ± ± ± 1.77 ND crawling under 2.57 ± ± ± 0.65 ND boxing 0.29 ± ± ± 0.30 ND sniffing each ± ± 1.65 * 5.86 ± ± ± ± p <0.05 (C vs VPA) p <0.05 (C vs VPA)
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