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1 SGPLOT 1, 2 * Drawing the useful graphs for the tumor shrinkage assessment in cancer clinical trials Innovative uses of new features in PROC SGPLOT Ryuji Uozumi 1, 2 * and Chikuma Hamada 1 1 Department of Management Science, Tokyo University of Science 2 Clinical Data Management and Biostatistics, Nippon Kayaku Co., Ltd * ryuji.uozumi@nipponkayaku.co.jp
2 V9.3SG (Statistical Graphics) Procedures Statistical Graphics; SGPLOT; Response Rate; Waterfall; SGANNO; Time-to-event; Cancer; Clinical Trials SASWeb
3 SG (Statistical Graphics) Procedures SGPLOT SGPANEL SGSCATTER SGRENDER 21 1 Graph Template Language (GTL), (2011) LIFETESTODS Kaplan-Meier 3
4 SGRENDERKaplan-Meier 9. SGRENDER LIFETEST 4
5 ! SGPLOT 5
6 1. 2. Waterfall
7 (1/4) Waterfall
8 2. 1. (95%)!? RECIST CR PR SD PD (95%) [33.70 to 58.96] FREQ 8
9 VBARPARM ResponseRate SAS (%) [95%CI] proc sgplot data=responserate; vbarparm category=group response=responserate / limitlower=lower limitupper=upper; xaxis display=(nolabel noticks); yaxis label= Response Rate (%) values=(0 to 100 by 10); run; [33.70 to 58.96] 1. V9.3 ResponseRate : 9
10 Waterfall 1. Waterfall???! Waterfall? 10
11 (2/4) 2. Waterfall Waterfall
12 Waterfall Waterfall Waterfall! 100 Maximum Tumor Change From Baseline (%) Nosov DA, et al. J Clin Oncol 2012; 30(14):
13 Waterfall (%) TumorChange Waterfall proc sgplot; vbar order / response=tumorchange; run; -100 order :: 4. 0% 13
14 Waterfall 2. Waterfall proc sgplot data=waterfall noautolegend; vbar order / response=tumorchange barwidth=0.95 transparency=0.5 name='recist' group=recist grouporder=ascending ; xaxis display=(novalues nolabel noticks); Waterfall yaxis label='change from Baseline (%)' values=(-100 to 100 by 20); keylegend 'RECIST' / position=topright location=inside down=4 noborder ; run; WATERFALL : 14
15 SGPLOTWaterfall 2. Waterfall 15
16 SGPLOTWaterfall 2. Waterfall Waterfall V9.3 proc sgplot data=waterfall; waterfall category=order response=tumorchange / colorgroup=recist ; run; 16
17 Waterfall 10. WATERFALL 2. Waterfall V
18 Waterfall (1/2) Waterfall < 0 () 100 Maximum Tumor Change From Baseline (%) n = XXX/XXX (XX%) Nosov DA, et al. J Clin Oncol 2012; 30(14):
19 Waterfall (2/2) Waterfall Stacchiotti S, et al. J Clin Oncol 2012; 30(9):
20 SGPLOTWaterfall 2. Waterfall < 0 () () () 20
21 SGPLOT 2. Waterfall HIGHLOW y V9.3 y x x x or y proc sgplot; highlow high= low= y= <or x= > / type=line highcap= lowcap= ; run; VECTOR y x y x proc sgplot; vector x= y= / arrowdirection= xorigin= yorigin= ; run; 21
22 VECTOR 2. Waterfall proc sgplot data=waterfall00; vector x=xmax y=ymax / arrowdirection=both xorigin=xmin yorigin=ymin lineattrs=(thickness=3px pattern=solid color=black) ; run; (xorigin, yorigin) (x, y) 22
23 HIGHLOW 2. Waterfall proc sgplot data=waterfall00; highlow high=xmax low=xmin y=ymax / type=line lineattrs=(color=black thickness=3px) highcap=barbedarrow lowcap=barbedarrow ; run; V9.3 (low, y) (high, y) x or y 23
24 SGPLOT 2. Waterfall proc sgplot data=waterfall00; vbar order / response=tumorchange group=recist ; vector x=xmax y=ymax / arrowdirection=both xorigin=xmin yorigin=ymin lineattrs=(thickness=3px pattern=solid color=black) ; run; HIGHLOW ERROR: 24
25 SGPLOTANNOTATE SGPLOT 2. Waterfall V9.3SGANNO! SGPLOTSGANNO proc sgplot data=waterfall sganno=anno; : : V9.3 run; anno: ANNOTATE 25
26 SGANNO DRAWING SPACE 2. Waterfall Graph Space Layout Space Wall Space Data Space 26
27 ANNOTATE 2. Waterfall (x1=33%, y1=51%) Wall Space (x2=100%, y2=51%) data annotate1; function= ARROW"; direction="both"; scale=0.5; x1space="wallpercent"; x2space="wallpercent"; y1space="wallpercent"; y2space="wallpercent"; x1=33; y1=51; x2=100; y2=51; output; ARROW function run; 27
28 ANNOTATE 2. Waterfall (x1=65%, y1=52%) data annotate2; function= TEXT"; width=100; anchor="bottom"; x1space="wallpercent"; y1space="wallpercent"; x1=65; y1=52; label="n = 46 / 65 (70.8%)"; output; TEXT function run; 28
29 ANNOTATE 2. Waterfall data annotate3;set waterfall; where ast=1; function= TEXT"; justify="center"; x1space="datavalue"; x1=order; y1space="datavalue"; y1=tumorchange; label="*"; output; TEXT function run; If 0<=TumorChange then do; anchor="bottom"; end; If TumorChange<0 then do; anchor= top"; end; 29
30 SGANNOSGPLOT 2. Waterfall SGANNO data anno; set annotate1 annotate2 annotate3; run; REFLINE : proc sgplot data=waterfall noautolegend sganno=anno; vbar <vbar statement>; V9.3 : refline / axis=y lineattrs=(pattern=dash); : run; 30
31 2. Waterfall SGANNOWaterfall 31
32 SGPLOT SGANNO 2. Waterfall < 0 () () () 32
33 2. Waterfall!?? 33
34 (3/4) Waterfall
35 Waterfall Kaplan-Meier 35
36 / / 7. 3.! Sosman JA, et al. N Engl J Med 2012; 366(8):
37 3. VECTOR / SCATTER proc sgplot data=timetoevent00 noautolegend; vector x=ttp y=order / noarrowheads yorigin=order lineattrs=(pattern=solid color=yellow) ; scatter x=os0 y=order / markerattrs=(symbol=circlefilled color=red) ; scatter x=ttr y=order / markerattrs=(symbol=diamondfilled color=green) ; scatter x=ttp0 y=order / markerattrs=(symbol=trianglerightfilled color=blue) ; run; TimeToEvent00 : 37
38 3. SGPLOT HBAR / SCATTER 38
39 (4/4) Waterfall
40 4. SGPLOT SG Procedures V9.3SGPLOT SGPLOT V9.3SGANNO : 40
41 1. Delwiche LD, Slaughter SJ. Using PROC SGPLOT for Quick High-Quality Graphs. Proceedings of the SAS Global Forum. Cary, NC: SAS Institute Inc., Available at 2. Eisenhauer EA, Therasse P, Bogaerts J, et al. New Response Evaluation Criteria in Solid Tumours: Revised RECIST Guideline (Version 1.1). Eur J Cancer 2009; 45: Heath D. Secrets of the SG Procedures. Proceedings of the SAS Global Forum. Cary, NC: SAS Institute Inc., Available at 4. Heath D. Now You Can Annotate Your Statistical Graphics Procedure Graphs. Proceedings of the SAS Global Forum. Cary, NC: SAS Institute Inc., Available at 5. Nosov DA, Esteves B, Lipatov ON, et al. Antitumor Activity and Safety of Tivozanib (AV-951) in a Phase II Randomized Discontinuation Trial in Patients With Renal Cell Carcinoma. J Clin Oncol 2012; 30(10): SAS Institute Inc. SAS/GRAPH(R) 9.2: Graph Template Language Reference, Second Edition. Cary, NC, USA: SAS Institute Inc., Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600 Mutant Advanced Melanoma Treated with Vemurafenib. N Engl J Med 2012; 366(8): Stacchiotti S, Longhi A, Ferraresi V, et al. Phase II Study of Imatinib in Advanced Chordoma. J Clin Oncol 2012; 30(9): ,. SG (Statistical Graphics) Procedures Kaplan-Meier. SAS 2011, ,
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