化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]

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1 (1) CAS N 2 H CAS ) 2.0 2,3) ,4) (15 ) 2,3) (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / ( ) 3) 5) K b K b (25) 4) 5) 3 6) 5) (OH ) cm 3 / sec 7) OH /cm ) ( ) cm 3 / sec (25 ) 7) /cm ) 100 7) ( ) ppm 20 ph %60 %47 %39 % 7) BOD

2 06 %( mg/l 30 mg/l) 6) BCF 316 7) ,312 t 1) 15,312 t 8) 1)

3 95 (1) EUSES 2.1 2,400km ),2) () (2) µg/g µg/l < 2 µg/l ( ) µg/g ( ) µg/g < < 2 < 0.2 < 0.2 < 2 < 2 < 0.2 < 0.2 < /45 0/3 0/7 0/3 0/ µg/m 3 (1979) 5) (3) 2.3

4 15m 3 2L 2,000g 50kg µg/l (1986) 0.08 µg/kg/day µg/g (1999) µg/kg/day 2 µg/l (1986) µg/g (1999) 0.08 µg/kg/day µg/kg/day µg/kg/day 0.08 µg/kg/day µg/kg/day

5 2.4 (µg/kg/day) (µg/kg/day) (4) PEC 2.5 PEC 0.1 µg/l 0.1 µg/l µg/l (1986) 2 µg/l (1986) 2 µg/l (1986) 2 µg/l (1986)

6 1 3.1 LD mg/kg LC ppm750 mg/m 3 4 LD mg/kg LD mg/kg LC ppm330 mg/m 3 4 LD mg/kg LD mg/kg mg/kg/day mg/kg/day 131 I ICR mg/m ppm mg/m ppm / 5 / 0.26 mg/m 3 LOAEL Sprague-Dawley mg/m 3 F mg/kg/day mg/kg/day

7 % ppm ppm( 0.2 ppm) 2.8 ppm-year ( 90 ) ppm NOEL ppm NOAEL ppm0.014mg/m ppm0.003 mg/m mg/m ppm IARC 2B 3 NOAEL NOAEL mg/m mg/m 3

8 4 3.1 MOE µg/kg/day µg/kg/day mg/kg/day mg/m mg/kg/day µg/kg/day µg/kg/day mg/kg/day MOEMargin of Exposure µg/kg/day MOE 9

9 (1) Ref. [ µg/l] / [] No. Dunaliella tertiolecta NOECGRO Dunaliella tertiolecta EC 50 GRO Selenastrum capricornutum EC 50 GRO Hyalella azteca LC 50 MOR Daphnia pulex EC 50 IMM Daphnia pulex EC 50 IMM Pimephales promelas NOECGRO Lepomis macrochirus NR EQU Poecilia reticulata LC 50 MOR Pimephales promelas LOECGRO Lepomis macrochirus LC 50 MOR ,400 Gasterosteus aculeatus LC 50 MOR ,500 Gasterosteus aculeatus LC 50 MOR Ambystoma sp. LC 50 MOR ,300 Ambystoma sp. LC 50 MOR ,110 Ambystoma sp. LC 50 MOR <20,000 Dreissena polymorpha LC 50 MOR <20,000 Dreissena polymorpha LC 50 MOR ,000 Dreissena polymorpha NR-LETH MOR ,000 Dreissena polymorpha NR-LETH MOR PNEC PNEC EC 50 Median Effective Concentration): LC 50 Median Lethal Concentration): LOECLowest Observed Effect Concentration): NOECNo Observed Effect Concentration): NRNot Reported): NR-LETH EQUEquilibrium): GROGrowth): IMMImmobilization): MOR Mortality):

10 (2) PNEC Dunaliella tertiolecta 68 EC µg/l Daphnia pulex 48 EC µg/l Lepomis machrochirus 96 LC 50 1,080 µg/l Ambystoma sp. 4 LC 50 2,120 µg/l µg/l PNEC µg/l Dunaliella tertiolecta 611 NOEC 0.5 µg/l Pimephales promelas 2224 LOEC 1,000 µg/l µg/l PNEC µg/l PNEC PNEC µg/l (3) 4.2 PNEC PEC 2 µg/l (1986) 2 µg/l (1986) <400 2 µg/l (1986) 2 µg/l (1986) µg/l < µg/g dry (1986) 0.2 µg/g dry (1986) 2 µg/l PEC 2 µg/l PEC PNEC 400

11 1 1) (2001) ) The Merck Index, 12th. Ed. (1996) Merck & Co., Inc. 3) Richardson, M. L. et al. (1992) The Dictionary of Substances and their Effects, Royal Society of Chemistry 4) (1994) 5) () (1997) 6) () (1998) 7) Hazardous Substances Data Bank (HSDS) (1998) U.S.National Library of Medicine 8) (1997;1998;1999;2000;2001) 13197, 13398, 13599, 13700, (2) 1 ) 11 2 ) 12 3 ) WHO:Environmental Health Criteria , 2Yaksctat, B. Y.1969Experimental assessment of hydrazine hydrate maximum allowable concentration in water bodies. In: Industrial pollution of water bodies, Moscow, Medicine, pp Haun, C.C. et al.1973proceedings of the 4th Annual Conference on Environmental Toxicology, Paper 25, pp , Aerospace Medical Research Laboratory, Wright- Patterson Air Force Base, Ohio, USA. 4Keller, W. C. et al.1982evaluation of the Embryotoxicity of Hydrazine in Rat. AFAMRL-TR-82-29AD/A119706Air Force Aerospace Medicine Research Laboratory, Wright Patterson Air Force Base, Ohio, USA , 40 : Environmental Health Criteria 68, IPCS1987. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 41974; supplement 71987; Volume

12 IRISIntegrated Risk Information System, No.0352,Hydrazine/Hydrazine sulfate, U.S. EPA Documentation of the Threshold Limit Values and Biological Exposure Indices, Sixth Edition, Hydrazine, ACGIH1996. (4) U.S.EPAAQUIRE Ref. No. 673:Slonim,A.R. (1977): Acute Toxicity of Selected Hydrazines to the Common Guppy. Water Res. 11(10): :Fisher,J.W., D.S.Myers, and M.L.Meyers (1980): The Effects of Selected Hydrazines upon Fish and Invertebrates. AMRL-TR-79-93, Tech. Rep. Aerosp. Med. Res. Lab., Wright- Patterson Air Force Base, OH:25 p. (U.S. NTIS AD-A082391). 5999:Fisher,J.W., C.B.Harrah, L.K.Weaver, and W.I.Wingo (1978): Acute and Behavioral Effects of Hydrazine on Lepomis macrochirus. Aerospace Med. Res. Lab., Wright-Patterson Air Force Base, OH:10 p. (U.S. NTIS AD-A057072). 7358:Harrah,C.B. (1978): Biological Effects of Aqueous Hydrazine Solutions. In: Proc. Conf. Environ. Chem. Hydrazine Fuels, Tyndall AFB, FL, Sept. 13, 1977, CEEDO- TR-78-14: TR : p. 7405:Henderson,V., J.W.Fisher, and R.D'Allessandris (1981): Toxic and Teratogenic Effects of Hydrazine on Fathead Minnow (Pimephales promelas) Embryos. Bull. Environ. Contam. Toxicol. 26(6): :Velte,J.S. (1984): Acute Toxicity of Hydrazine Hydrate to the Fathead Minnow (Pimephales promelas) and Daphnid (Daphnia pulex). Bull. Environ. Contam. Toxicol. 33(5): :Slonim,A.R. (1986): Acute Toxicity of Some Hydrazine Compounds to Salamander Larvae, Ambystoma spp. Bull. Environ. Contam. Toxicol. 37(5): :Evans,D.W. and L.M.Coughlin (1992): Effect of Lithium/Hydrazine Water Chemistry on Short-Term Survival of Zebra Mussel. J. Shellfish Res. 11(1): (ABS).

化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]

化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質] 1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )