初期リスク評価報告書作成指針(案)
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1 BCF: Bioconcentration Factor EC 50 : Median Effect Concentration 1 50 EEC: Estimated Environmental Concentration EHI: Estimated Human Intake EUSES: Europian Union System for the Evaluation of Substances EUSES 1997 GLP: Good Laboratory Practice IC 50 : Median Inhibition Concentration 1 50 LC 50 : Median Lethal Concentration 1 50 LD 50 : Lethal Dose LOAEL: Lowest Observed Adverse Effect Level LOEC: Lowest Observed Effect Concentration () LOEL: Lowest Observed Effect Level LOAEL MOE: Margin of Exposure NOAEL
2 NOAEL NOAEL: No Observed Adverse Effect Level NOEC: No Observed Effect Concentration NOEL: No Observed Effect Level IRIS MATC: Maximum Acceptable Toxic Concentration) (NOEC LOEC ) chronic value PNEC: Predicted No Effect Concentration ppm: parts per million 10-6 QSAR: Quantitative Structure-Activity Relationship SIDS: Screening Information Data Set OECDHPVC TDI: Tolerable Daily Intake 1 threshold 1 1 genotoxicity measures of effects () ()() trophic level
3 epidemiology Endpoint () odds ratio extra lifetime risk sensitization short-term toxicity 1 12 acute toxicity cross-reaction cohort study teratogenicity RfD reference dose
4 irritation NOAELLOAEL mg/kg / case-control study Slope factor (q*) 95% q* 1/(mg/kg /) reproductive and developmental toxicity biodegradation long-term toxicity 3 long-term (or chronic) toxicity NOEC percentile abiotic degradation Target organ Fugacity-model corrosive /
5 BMD Benchmark Dose (NOAEL) troposphere 10km immobilization OECD Unit risk 1g/L 1g/m L/g 1g/L 70 1,000, Dose-response
6 ACGIH: American Conference of Governmental Industrial Hygienists TLV:Threshold Limit Value A1: (Comfirmed human carcinogen) A2: (Suspected human carcinogen)a3: (Comfirmed animal carcinogen with unknown relevance to humans) A4: (Not classifiable as a human carcinogen) A5: (Not suspected as a human carcinogen) ATSDR: Agency for Toxic Substances and Disease Registry Toxicological Profile 260 CEPA: Commonwealth Environment Protection Agency CERHR: Center for the Evaluation of Risks to Human Reproduction NIEHS:National Institute of Environmental Health Science 1998 NTPNational Toxicology Program CICAD: Concise International Chemical Assessment Document IPCS EHC: Environmental Health CriteriaWHO UNEPILOWHO IPCS GDWQ: Guideline of Drinking Water QualityWHO WHO IARC: International Agency for Research on Cancer WHO
7 1:(The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans.) 2A:(The agent (mixture) is probably carcinogenic to humans. The exposure circumstance entails exposures that are probably carcinogenic to humans.) 2B:(The agent (mixture) is possibly carcinogenic to humans. The exposure circumstance entails exposures that are possibly carcinogenic to humans.) 3:(The agent (mixture, or exposure circumstance) is not classifiable as to carcinogenicity in humans.) 4:(The agent (mixture, or exposure circumstance) is probably not carcinogenic to humans) IPCS: International Programme on Chemical Safety WHOILOUNEP EHC ICSC IRIS: Integrated Risk Information System U.S.EPA 1986 A: (Human carcinogen) B: (Probable human carcinogen) B1: (Agents for which there is limited evidence of carcinogenicity from epidemiologic studies.) B2: (Agents for which there is sufficient evidence from animal studies and for which there is inadequate evidence or no data from epidemiologic studies.) C: (Possible human carcinogen) D: (Not classifiable as to human carcinogenicity) E: (Evidence of non-carcinogenicity for humans)
8 (Carcinogenic To Humans) (Likely to be carcinogenic to humans) (Suggestive evidence of carcinogenicity, but not sufficient to assess human carcinogenic potential) (Data are inadequate for an assessment of human carcinogenic potential) (Not likely to be carcinogenic to humans) NCI: National Cancer Institute DHHS:Department of Health and Human Services NICNAS: Australia s National Industrial Chemicals Notification and Assessment Scheme ( NICNAS NTP: National Toxicology Program DHHS K: Known Human Carcinogens R: Reasonably Anticipated To Be Human Carcinogens SIDS: Screening Information Data Set () OECD 1 1,000 (DSL) IARC 1 :
9 2 : 2A : 2B :
10 GHS 1. : The Globally Harmonized System of Classification and Labelling of Chemicals. ( 1 I 96 LC501mgL 48 EC501mgL ErC501mgL I L(E)C500.1mgL CERI GHS II 1 mgl 96 LC5010mgL 1 mgl 48 EC5010mgL 1 mgl ErC5010mgL CERI GHS II III 10 mgl 96 LC50100mgL 10 mgl 48 EC50100mgL 10 mgl ErC50()100mgL L(E)C50 100mgL CERI GHS III 2 I 96 LC501mgL 48 EC501mgL ErC501mgL log Kow4 BCF500 CERI GHS II 1 mgl 96 LC5010mgL 1 mgl 48 EC5010mgL 1 mgl ErC5010mgL log Kow4 BCF500 NOEC1mgL CERI GHS II III 10 mgl 96 LC50100mgL 10 mgl 48 EC50100mgL 10 mgl ErC50100mgL log Kow4 BCF500 NOEC1mgL CERI GHS III IV
11 log Kow4 BCF500 NOEC1mgL CERI GHS IV () 48 LC50 (EC50) mg/l ( 110 mg/l) GHS II 1 mg/l GHS I mg/l GHS GHS I GHS III 100 mg/l GHS 2. The Globally Harmonized System of Classification and Labelling of Chemicals ( 1LD50LC50 (mgkg) (mgkg) (ppm) a mgl a b c (mgl) d a e ppmv (a) (b) (c) 1(100ppm) 2(500ppm) 3(2500ppm) 4(5000ppm)ppm OECD
12 (d) OECD (e) 5 LD mgkg 5 (i) LD 50 (LC 50 ) 5 5 (ii)
1 I ( )
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More informationhttp://www.who.int/ipcs/publications/ehc/en/index.html EHC 1 2 3 4 / EHC http://www.nihs.go.jp/dcbi/publist/ehchsg/ 1-8) WHO/IPCS CICAD (Concise Inter
3 [ ] Priority IARC JMPR 2004 10 Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) http://www.cerij.or.jp/ceri_jp/koukai/sheet/sheet_indx4.htm http://www.safe.nite.go.jp/data/sougou/pk_list.html?table_name=hyoka&rank=sh
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1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
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1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
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2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
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1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
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1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
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