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1 2017 Yamamoto T, Murayama S, Takao M, Isa, T, Higo N, Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord: changes in patients with amyotrophic lateral sclerosis. Brain Research 1655, p , 2017 肥後範行 脳損傷後の神経可塑性 - 運動がもたらす効果と科学的根拠 -The effects of motor training on neural plasticity after brain damage 理学療法の科学と研究 vol.8 (1), p.3-7, 2017 村田弓 肥後範行 手の運動を担う大脳皮質の構造と機能 作業療法ジャーナル vol.51 (8), p , 2017 Nagasaka K, Yamanaka K, Ogawa S, Takamatsu H, Higo N, Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity. Scientific Reports 7(1):4305, 2017 Nagasaka K, Takashima I, Matsuda K, Higo N, Late-onset hypersensitivity after a lesion in the ventral posterolateral nucleus of the thalamus: A macaque model of central poststroke pain. Scientific Reports 7(1):10316, Murata Y, Higo N, Development and Characterization of a Macaque Model of Focal Internal Capsular Infarcts. PLoS ONE 11(5): e , 2016 Higo N, Kunori, N, Murata Y, Neural Activity during Voluntary Movements in Each Body Representation of the Intracortical Microstimulation-Derived Map in the Macaque Motor Cortex. PLoS ONE 11(8):e , Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H, Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys, Journal of Neuroscience, vol.35 (1), p.84-95, 2015 Murata Y, Higo N, Oishi T, Isa T, Increased expression of the growth-associated protein- 43 gene after primary motor cortex lesion in macaque monkeys, Neuroscience Research, vol.98, p.64-69, 2015 肥後範行 神経科学の最新動向とリハビリテーション第 2 章リハビリテーションによる脳の変化 p メジカルビュー社 2015 年 9 月 30 日出版 肥後範行 脳神経外科医が知っておくべきニューロサイエンスの知識 5. 運動機能損傷後の機能回復 7. 学習と記憶のメカニズム p 文光堂 2015 年 9 月 1 日出版 肥後範行 リハビリテーションのためのニューロサイエンス可塑性の実態分子レベル 細胞レベル 医歯薬出版株式会社 2015 年 6 月 1 日出版 肥後範行 最新の治療から導き出す痛みのメカニズムと疼痛治療薬開発第 7 節脳卒中後疼痛モデル 株式会社技術情報協会 2015 年 6 月 1 日出版 2014 Higo N, Effects of rehabilitative training on recovery of hand motor function: A review of

2 animal studies. Neuroscience Research, 78: 9-15, 2014 Higo N, Isa T, Strategies to understand and overcome brain/spinal cord injury. Neuroscience Research, 78: 1-2, 2014 肥後範行, 霊長類脳損傷モデルを用いた機能回復メカニズムの解明, 理学療法学, 40(8): , 2014 肥後範行 脳の可塑性と運動 (17 章 ) 筋機能改善の理学療法とそのメカニズム ( 分担執筆 ), 第 3 版 ナップ 2014 年 5 月 18 日出版 産業財産権 : 肥後範行 他 4 名 ( 発明者 ) 独立行政法人産業技術総合研究所 国立大学法人筑波大学 ( 出願者 ) 視床痛の非ヒト霊長類モデル 特願 年 8 月 27 日出願 産業財産権 : 村田弓 肥後範行 ( 発明者 ) 独立行政法人産業技術総合研究所 ( 出願者 ) 非ヒト霊長類を用いた内包脳卒中モデル動物 およびその作成方法 特願 年 6 月 9 日出願 2013 Yamamoto T, Oishi T, Higo N, Murayama S, Sato A, Takashima I, Sugiyama Y, Nishimura Y, Murata Y, Yoshino-Saito K, Isa T, Kojima T, Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery. PLoS One 8:e65701, 2013 Sugiyama Y, Higo N, Yoshino-Saito K, Murata Y, Nishimura Y, Oishi T, Isa T, Effects of early versus late rehabilitative training on manual dexterity after corticospinal tract lesion in macaque monkeys. Journal of Neurophysiology 109: , 2013 Kojima T, Higo N, et al. Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain Neurochemical Research, 38: , 2013 肥後範行 脳損傷後の機能回復に伴う神経システムの可塑的な変化 運動機能回復を促進するニューロモジュレーションの可能性 脳 21, 16(1):37-41, 2013 肥後範行 金子秀和 ニューロリハビリテーション (neurorehabilitation) 福祉技術ハンドブック 健康な暮らしを支えるために ( 分担執筆 ) , 産業財産権 : 肥後範行 松田圭司 独立行政法人産業技術総合研究所 侵襲性器具の生体内位置同定システム 特許 年 5 月 25 日登録 2011 Yamamoto T, Higo N, Sato A, et al. SPP1 is expression in spinal motorneurons of the macaque monkey. Neuroscience Research, 69:81-86, 2011 肥後範行 運動野での可塑性 Clinical Neuroscience, 29(7): , 2011

3 産業財産権 : 肥後範行 松田圭司 他 3 名 独立行政法人産業技術総合研究所 光ファイバーを用いた生体内組織可視化装置 特許 年 4 月 22 日登録 産業財産権 : 肥後範行 野崎展史 独立行政法人産業技術総合研究所 簡易式上肢運動モニター装置 特願 年 4 月 28 日出願 2010 Higo N, Sato A, Yamamoto T, et al. SPP1 is expressed in corticospinal neurons of the macaque sensorimotor cortex. The Journal of Comparative Neurology 518(13): , 2010 Wada M, Watanabe S, Chung UI, Higo N, Taniguchi T, and Kitazawa S. Noninvasive bioluminescence imaging of c-fos expression in the mouse barrel cortex. Behavioural Brain Research 208(1): , 2010 Wada M, Higo N, Moizumi S, and Kitazawa S. c-fos expression during temporal order judgment in mice. PLoS One 5(5):e10483, 2010 Higo, N, Training-induced recovery of manual dexterity after a lesion in the motor cortex Keio Journal of Medicine 59 (1): 4-9, Higo N, Nishimura, Y, Murata Y, et al. Increased expression of the growth-associated protein-43 gene in the sensorimotor cortex of the macaque monkey after lesioning the lateral corticospinal tract. The Journal of Comparative Neurology 516: , 2009 Takahata T, Higo N, Kaas JH, and Yamamori T. Expression of immediate-early genes reveals functional compartments within ocular dominance columns after brief monocular inactivation PNAS 106(29): , 2009 Watakabe A, Komatsu Y, Sadakane O, Shimegi S, Takahata T, Higo N, et al. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cerebral Cortex 19(8): , 2009 肥後範行 サルモデルを用いた脳機能回復メカニズムの解明 脳科学とリハビリテーション 9: 1-10, 2009 肥後範行 大脳皮質損傷後の上肢訓練による運動機能回復 脳 21 12(3):20-23, Murata Y, Higo N, et.al. Effects of motor training on the recovery of manual dexterity after primary motor cortex lesion in macaque monkeys. Journal of Neurophysiology 99(2): , 2008 Takahata T, Hashikawa T, Higo N, Tochitani S, and Yamamori T. Difference in sensory dependence of occ1/follistatin-related protein expression between macaques and mice. Journal of Chemical Neuroanatomy 35(1): , 2008 Takahashi K, Liu FC, Oishi T, Mori T, Higo N, et al. Expression of FOXP2 in the

4 developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2. The Journal of Comparative Neurology 509(2): , Higo N, Oishi T, Yamashita A, et.al. Expression of protein kinase-c substrate mrna in the motor cortex of adult and infant macaque monkeys. Brain Research, 1171: 30-41, 2007 Sato A, Nishimura Y, Oishi T, Higo N, Murata Y,et al. Differentially expressed genes among motor and prefrontal areas of macaque neocortex. Biochemical and Biophysical Research Communications, 362: , Higo N, Oishi T, Yamashita A, et.al. Northern blot and in situ hybridization analyses for the neurogranin mrna in the developing monkey cerebral cortex. Brain Research, 1078: 35-48, 2006 Higo N, Oishi T, et.al. Expression of protein kinase C-substrate mrnas in the basal ganglia of adult and infant macaque monkeys. The Journal of Comparative Neurology, 499: , 2006 Wada M, Yoshimi K, Higo N, Ren YR, Mochizuki H, Mizuno Y, and Kitazawa S. Statistical parametric mapping of immunopositive cell density. Neuroscience Research, 56: , Murata Y, Higo N, Oishi T, et.al. Developmental changes in the expression of GAP-43 mrna in the monkey thalamus: Northern blot and in situ hybridization studies. Neuroscience, 136: , Higo N, Oishi T, Yamashita A, et.al. Northern blot and in situ hybridization analyses for the development of Myristoylated alanine-rich C-kinase substrate mrna in the monkey cerebral cortex. Neuroscience, 129: , 2004 Higo N, Oishi T, et.al. Cell type- and region-specific expression of neurogranin mrna in the cerebral cortex of the macaque monkey. Cerebral Cortex, 14: , Higo N, Oishi T, et.al. Cell type- and region-specific expression of protein kinase C- substrate mrnas in the cerebellum of the macaque monkey. The Journal of Comparative Neurology, 467: , Higo N, Oishi T, et.al. Expression of MARCKS mrna in lateral geniculate nucleus and visual cortex of normal and monocularly deprived macaque monkeys. Visual Neuroscience, 19: , 2002 Higo N, Oishi, T., et.al. Northern blot and in situ hybridization analyses of MARCKS mrna expression in the cerebral cortex of the macaque monkey. Cerebral Cortex 12: , 2002

5 Oishi, T, Higo, N, et.al. Expression of super cervical ganglion-10 (SCG-10) mrna in the monkey cerebral cortex during postnatal development. Neuroscience Letters 323: , Higo N, Oishi T, et.al. Expression of GAP-43 and SCG10 mrnas in lateral geniculate nucleus of normal and monocularly-deprived macaque monkeys. The Journal of Neuroscience 20: , Higo N, Oishi T, et.al. Quantitative non-radioactive in situ hybridization study of GAP- 43 and SCG10 mrnas in the cerebral cortex of adult and infant macaque monkeys. Cerebral Cortex 9: , Higo N, Oishi T, et.al. Gene expression of growth-associated proteins, GAP-43 and SCG10, in the hippocampal formation of the macaque monkey: non-radioactive in situ hybridization study. Hippocampus 8: , 1998 Oishi, T, Higo, N, et.al. Development of GAP-43 mrna in the macaque cerebral cortex. Developmental Brain Research 109: 87-97, 1998

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