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1 3

2

3 up-date

4

5 40 5.8

6

7 Primary angle-closure PAC 3 4

8 2006 3

9

10 3 4 icare dynamic contour tonometer VEGF

11

12 Goldmann 3 4 5

13 QOL

14 van Herick

15 3 GDD

16

17 quality of life quality of vision

18 5

19

20 * ** Goldmann

21

22

23 4

24

25 5

26 1

27 2 glaucomatous optic neuropathy: GON primary glaucoma

28 primary glaucoma primary open angle glaucoma normal tension glaucoma, normal-pressure glaucoma primary angle closure glaucoma secondary glaucoma secondary open angle glaucoma: pretrabecular form secondary open angle glaucoma: trabecular form ghost cell glaucoma Schwartz Schlemm secondary open angle glaucoma posttrabecular form secondary open angle glaucoma hypersecretory form

29 secondary angle-closure glaucoma: posterior form with pupillary block secondary angle closure glaucoma: posterior form without pupillary block C secondary angle closure glaucoma: posterior form secondary angle closure glaucoma: anterior form ICE developmental glaucoma Sturge-Weber Axenfeld-Rieger Peters anomaly Marfan Weill- Marchesani Pierre Robin Lowe Rubinstein-Taybi Hallermann-Streiff

30 mm Hg mmhg mmhg 20 mmhg myocilin optineurin primary open angle glaucoma

31 ocular hypertension normal tension glaucoma, normal pressure glaucoma primary angle closure glaucoma 1 primary angle closure suspect: PACS peripheral anterior synechia: PAS appositional angle closure

32 2 primary angle closure: PAC 3 primary angle closure glaucoma: PACG static gonioscopy occludable angle 3 3/4 270 iridotrabecular contact: I TC 180 primary angle closure primary angle closure

33 1 relative pupillary block 2 plateau iris plateau iris configuration plateau iris mechanism plateau iris glaucoma plateau iris syndrome 3 lens factor 4 ciliochoroidal effusion, uveal effusion

34 mmhg acute primary angle closure 2

35 mixed glaucoma secondary glaucoma GON

36 Schlemm ICE

37 developmental glaucoma Marfan Axenfeld-Rieger Peters anomaly Sturge-Weber European Glaucoma Society: Terminology and Guidelines for Glaucoma, Second edition, Ritch R, Shields MB: TheSecondary Glaucomas. Mosby, St. Louis, Iwase A, Suzuki Y, Araie M, Shirato S, Kuwayama Y, Mishima HK, et al: Tajimi Study Group, Japan Glaucoma Society: Theprevalence of primary open-angle glaucoma in Japanese. The Tajimi Study. Ophthalmology , 2004.

38 3

39 ICE Haab Descemet Krukenberg spindle van Herick 1 2

40 mmhg 21 mmhg mmhg mmhg 2

41 mmhg Goldmann Goldmann Schi otz Tonopen Perkins icare Dynamic contour tonometer DCT Goldmann photorefractive keratectomy: PRK laser in situ keratomileusis: LASIK

42 Schwalbe 1 3 Schwalbe Schwalbe Descemet Schwalbe Schlemm Schwalbe Sampaolesi

43 Koeppe Goldmann Zeiss static gonioscopy dynamic gonioscopy indentation gonioscopy

44 Goldmann apostilbs asb 1 asb candela/m millilambert

45 Goldmann Goldmann 31.5 asb 30 cm 0 1/16 mm 2 1/4 mm 2 1 mm 2 4 mm 2 16 mm 2 64 mm 2 1 a 12.5 asb 4 e 1000 asb /4 e /4 e /3 e /2 e /1 e Humphrey Octopus 1 decibel db 0.1 log Unit 30 Blue on yellow perimetry short-wavelength automated perimetry: SWAP, Frequency doubling technology FDT, Flicker perimetry

46 1 4 5

47 4 quality of life QOL QOL

48 QOL 3

49 QOL 19 mmhg 16 mmhg 14 mmhg

50 QOL QOL QOL QOL QOL QOL QOL

51

52

53

54 QOL 3

55

56 Abraham Wise 1 Nd YAG mw

57 1000 mw Nd YAG Nd YAG Nd YAG 1 3

58 25 mmhg 1 1/4 1/ nm Q YAG selective laser trabeculoplasty SLT 1/ mw

59

60 mw

61 mm 1 1/2 3/ mw 2

62 mw viscocanalostomy

63

64 1 Schlemm Schlemm 2 3 1

65 Collaborative Normal-Tension Glaucoma Study Group: Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures Am J Ophthalmol , Collaborative Normal-Tension Glaucoma Study Group: The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma Am J Ophthalmol The AGIS Investigators: TheAdvanced Glancoma Intervention study AGIS : 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol , Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, et al: The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol ; discussion , Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M: Early Manifest Glaucoma Trial Group: Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol , Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E: Early Manifest Glaucoma Trial Group: Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol , 2003.

66 5 quality of life QOL 4 1

67 mmhg

68 10 mmhg mmhg 24 mmhg 5 24 mmhg

69 20 mmhg preperimetric glaucoma preperimetric glaucoma

70 1 residual glaucoma A i 1

71 a g/kg ml L 637 kcal b ml ml/kg

72 3 a 10 mg/kg b c d 4 a b c 1 2 A ii residual glaucoma

73 a b c d e f g PACS

74

75 1 1 A i vascular endothelial growth factor: VEGF

76 B i B ii B iii Posner-Schlossman Beh et B iv B v Schwartz 1 2 3

77 B vi C i A i

78 B i B ii C i ICE 1 2 3

79 Schlemm 3 4

80 5 Sturge-Weber Axenfeld-Rieger Peters anomaly Marfan Weill-Marchesani Pierre Robin Lowe Rubinstein-Taybi Hallermann-Streiff 1 1

81 1 1, Iwase A, Suzuki Y, Araie M, Yamamoto T, Abe H, Shirato S, et al: Tajimi Study Group, Japan Glaucoma Society: The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study. Ophthalmology , Yamamoto T, Iwase A, Araie M, Suzuki Y, Abe H, Shirato S, et al: Tajimi Study Group, Japan Glaucoma Society: The Tajimi Study report 2: prevalence of primary angle closure and secondary glaucoma in a Japanese population. Ophthalmology , 2005.

82 van Herick 60 Grade 1 1/4 Grade 2 1/4 Grade 3 1/4 1/2 Grade 4 Shaffer Grade 00 Grade 110 Grade 2 20 Grade Scheie Grade 0 Grade Grade Grade Grade Humphery 1 3 1

83 Glaucoma Hemifield Test 1 Anderson DR, Patella VM: Automated Static Perimetry. 2nd edtion, Mosby, St. Louis, , 1999.

84 1 2 a b Goldmann GP a GP b GP a GP 4 1/4 b GP 4 1/4 1/2 GP 4 1/2 a GP 4 b GP 4 GP 4 Aulhorn Greve 3 Stage db Mariotte 6 db Stage 1 10 db Mariotte Stage 2Mariotte Stage 3 Mariotte Stage 4 1 Stage 5

85 1 Stage 6 Humphery 4 6 db db 1 12 db db 5 15 db Greve EL, Langerhorst CT, van den Berg TTJP: Perimetry and other visual function tests in glaucoma. In Cairns JE ed : Glaucoma. Vol. 1. Grune & Stratton, London, 37 77, 1986.

86 4 Anderson DR. Patella VM: Automated Static Perimetry. 2nd edition. Mosby, St. Louis, , 1999.

87 Schlemm

88 1 1

89

90

91 Schlemm

92 Parkinson

93 ,000 mg

94 ,000 mg Stevens-Johnson Lyell Addison QT

95 ACTH D 20 D 15 D10 15 D5 D 5 15 ml/kg g D g

96 50 3 ml/kg ml

97 ml

98

99 D Goldmann 78 D 90 D 30 45

100 495 nm Heidelberg Retina Tomograph HRT, GDx Nerve Fiber Analyzer GDx optical coherence tomograph: OCT HRT GDx 780 nm HRT GDx 2 retardation OCT B 820 nm OCT 1 A 1 4 mm 6

101 30 OCT 5 26,000 A 1. 5 neuroretinal rim parapapillary atrophy PPA

102 bared vessel

103 laminar dot sign 3 ISN T bayoneting

104 PPA 2 PPA PPA 80 MD mean deviation CPSD corrected pattern standard deviation PPA PPA PPA PPA

105 D 90 D 2

106 2 cup-to-disc ratio, C/D R/D mm DD DM DM/DD pallor

107 DM/DD C/D 1 C/D C/D 2 C/D Gloster 1 C/D

108 C/D ab C/D C/D R/D 1 3 R/D R/D 6 C/D R/D Foster 3 C/D

109 R/D ab 5 7 R/D 0.1 C/D C/D R/D 0.05 C/D C/D R/D C/D

110 Heidelberg Retina Tomograph GDx Nerve Fiber Analyzer 80 1 Gloster J, Parry DG: Use of photographs for measuring cupping in the optic disc. Br J Ophthalmol , , Foster PJ, Buhrmann R, Quigley HA, Johnson GJ: Thedefinition and classification of glaucoma in prevalence surveys Br J Ophthalmol , 2002.

111 3 Glaucoma drainage devices : GDD GDD GDD GDD GDD GDD GDD Tube-shunt surgery Drainage-device surgery Drainage implant surgery 3 GDD Aqueous Shunts GDD Aqueous Shunts GDD Glaucoma

112 drainage devices GDD GDD a Baerveldt Glaucoma Implant GDD 3 BG , BG , Pars Plana BG BG BG

113 Pars Plana BG BG BG Pars Plana BG mm 0.30 mm 4 1, 2 GDD

114 8 10 mm 2 4 mm 2 3 mm 23 G

115 3.5 mm 23 G Hoffmann elbow , 2 GDD

116 encapsulation Dellen decompression retinopathy

117 b Ahmed TM Glaucoma Valve New World Medical Ahmed TM Glaucoma Valve GDD mm mm 8 12 mmhg AGV S FP S 2, FP 7 13 mm 16 mm 184 S 3, FP8 96 GDD pars plana clip PC 7, PC8 B 1, FX1 364

118 GDD AGV AGV AGV 8 9 mm 23 G AGV 6 6 mm

119 5 21 mmhg C 1, mmhg 11 GDD GDD a EX-PRESS Glaucoma Filtration Device Alcon EX-PRESS GDD GDD

120 GDD GDD GDD EX-PRESS delivery system, EDS R 50 PL P 50 PL P 200 PL 3 R 2.9 mm P 2.6 mm P 50 EX- PRESS EX- PRESS MRI GDD EX-PRESS

121 EX-PRESS C G EDS EX-PRESS EDS EX-PRESS EX- PRESS EX-PRESS mmhg EX-PRESS mmhg 21 mmhg64 14 mmhg

122 mmhg mmhg 23 EX-PRESS GDD YAG GDD encapsulation.

123 1 Minckler DS, Vedula SS, Li TJ, Mathew MC, Ayyala RS, Francis BA: Aqueous shunts in glaucoma. Cochrane Database Sys Rev. 2: CD004918, Minckler DS, Francis BA, Hodapp EA, Jampel HD, Lin SC, Samples JR, etal:aqueous shunts in glaucoma. A report by the American Academy of Ophthalmology. Ophthalmology , Krishina R, Godfrey DG, Budnez DL, Escalona-Camaa no E, Gedde SJ, Greenfield DS, etal: Intermediate-term outcomes of 350- Baerveldt glaucoma implants. Ophthalmology , Seah SK, Gazzard G, Aung T: Intermediate-term outcome of Baerveldt glaucoma implants in Asian eyes. Ophthalmology , Wang JC, See JL, Chew PT: Experience with the use of Baerveldt and Ahmed glaucoma drainage implants in an Asian population. Ophthalmology , Rolim de Moura C, Fraser-Bell S, Stout A, Labree L, Nilfors M, Varma R: Experience with the Baerveldt glaucoma implant in the management of pediatric glaucoma. Am J Ophthalmol , van Overdam KA, de Faber JT, Lemji HG, de Waard PW: Baerveldt glaucoma implants in paediatric patients. Br J Ophthalmol , Banitt MR, Sidoti PA, Gentile RC, Tello C, Liebmann JM, Rodriguez N, etal: Pars plana Baerveldt implantation for refractory childhood glaucomas. J Glaucoma , Witmer MT, Tiedeman JS, Olsakovsky LA, Conaway MR, Prum BE: Long-term intraocular pressure control and corneal graft survival in eyes with a pars plana Baerveldt implant and corneal transplant. J Glaucoma , Gedde SJ, Schiffman JC, Feuer WJ, Herndon LW, Brandt JD, Budenz DL; Tube Versus Trabeculectomy Study Group: Three-year follow-up of the Tube Versus Trabeculectomy Study. Am J Ophthalmol , Budenz DL, Barton K, Feuer WJ, Schiffman J, Costa VP, Godfrey DG, et al; Ahmed Baerveldt Comparison Study

124 Group: Treatment outcomes in the Ahmed Baerveldt Comparison Study after 1 year of follow-up. Ophthalmology , Coleman AL, Hill R, Wilson MR, Choplin N, Kotas-Neumann R, Tam M, etal:initialclinical experience with the Ahmed glaucoma valve implantation. Am J Ophthalmol , Topouzis F, Coleman AL, Choplin N, Bethlem MM, Hill R, Yu F, etal:follow-up of the original cohort with the Ahmed glaucoma valve implant. Am J Ophthalmol , Ayyala RS, Zurakowski D, Smith JA, Monshizadeh R, Netland PA, Richards DW, et al: A clinical study of the Ahmed glaucoma valve implant in advanced glaucoma. Ophthalmology , Ishida K, Netland PA, Costa VP, Shiroma L, Khan B, Ahmed II: Comparison of polypropylene and silicone Ahmed glaucoma valves. Ophthalmology , Chen TC, Bhatia LS, Walton DS: Ahmedglaucoma valve surgery for refractory pediatric glaucoma: a report of 52 eyes. J Pediatr Ophthalmol Strabismus , Maris PJ Jr, Ishida K, Netland PA: Comparison of trabeculectomy with Ex-PRESS miniature glaucoma device implanted under scleral flap. J Glaucoma , Good TJ, Kahook MY: Assessment of bleb morphologic features and postoperative outcomes after Ex-PRESS drainage device implantation versus trabeculectomy. Am J Ophthalmol , de Jong L, Lafuma A, Aguade AS, Berdeaux G: Five-year extension of a clinical trial comparing the EX-PRESS glaucoma filtration device and trabeculectomy in primary openangle glaucoma. Clin Ophthalmol , Traverso CE, De Feo F, Messas-Kaplan A, Denis P, Levartovsky S, Sellem E, etal:longtermeffect on IOP of a stainless steel glaucoma drainage implant Ex-PRESS in combined surgery with phacoemulsification. Br J Ophthalmol , Kanner EM, Netland PA, Sarkisian SR Jr, Du H: Ex-PRESS

125 miniature glaucoma device implanted under a scleral flap alone or combined with phacoemulsification cataract surgery. J Glaucoma , Wamsley S, Moster MR, Rai S, Alvim HS, Fontanarosa J: Results of the use of the Ex-PRESS miniature glaucoma implant in technically challenging, advanced glaucoma cases: a clinical pilot study. Am J Ophthalmol , Dahan E, Carmichael TR: Implantation of a miniature glaucoma device under a scleral flap. J Glaucoma , 2005.

126 TEL FAX E mail jgs@g-jimukyoku.jp 2012 JGS All Rights Reserved

.K.C.h...C...ren

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