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3 F344/DuCrlCrj mm PAS cytokeratin AE1/AE3 vimentin cytokeratin 4 vimentin 5 Tuburostromal adenoma downgrowth 2 1. Alison, R. and Morgan, K Ovarian neoplasms in F344 rats and B6C3F1 mice. Environ. Health Perspect

4 Iba 1 4 Lysozyme MHC Class II Vimentin Melan A S 100 CD3 CD20 CD79 cy 5 1. Naranjo, C., Dubeilzig, R. R., and Friedrichs, K. R Canine ocular histiocytic sarcoma. Vet. Ophthalmol

5 Bovine Respiratory Disease Complex; BRDC BRDC [1] BRDC BRDC BRDC BRDC Empiric therapy BRDC 1986

6 [2] in vitro [3] TP TS BRDC 88 TP [4] 50 [5] 2 Pasteurella multocida TP MIC g/ ml Mycoplasma bovis 25 g/ml in vitro in vivo BRDC 2004 NOSAI BRDC 2 3 M. bovis 4 5 [6 9] Primary pathogen M. bovis VSP Variable surface protein [10]

7 [11] [12] BRDC M. bovis M. dispar Ureaplasma diversum BRDC 6 BRDC BRDC Mannheimia haemolytica BRDC Primary pathogen

8 [13] 6 RS BVD 5 6 RS BRDC RS BVD MD BVD 1 2 [14 17]

9 L K BRDC [18] [14] BRDC BRDC [19 20] 30 [21] 7 BRDC BVD [18] 3 BRDC

10 / BRDC BRDC 100 [22] BRDC BRDC Ishizaki [23] km 3 CD4 /CD8 [24] 1 BRDC : : Katoh T., Sakai J., Itagaki M., Watanabe E., Watanabe D. and Ogata Y.1996.The Fractional Inhibitory Concentration Index of Antimicrobial Agents for Bacteria and Mycoplasma Isolated from the Nasal Swabs of Cattle with Respiratory Diseases. J. Vet. Med. Sci : Katoh T., Sakai J., Ogata Y. and Urushiyama Y Effect of Combination of Antimicrobial Agents for the Treatment of Respiratory Disease in Cattle. J. Vet. Med. Sci : : Mycoplasma bovis 23S

11 RNA V. 64 : Uemura R., Sueyoshi M. and Nagatomo H Antimicrobial Susceptibilities of Four Species of Mycoplasma Isolated in 2008 and 2009 from Cattle in Japan. J. Vet. Med. Sci. 72 : Gerchman I., Levisohn S., Mikula I., Lysnyansky I In vitro antimicrobial susceptibility of Mycoplasma bovis isolated in Israel from local and imported cattle. Vet. Microbiol. 137 : Rosenbusch RF., Kinyon JM., Apley M., Funk ND., Smith S., Hoffman LJ In vitro antimicrobial inhibition profiles of Mycoplasma bovis isolates recovered from various regions of the United States from 2002 to J. Vet. Diagn. Invest. 17 : Le Grand D. Solsona M., Rosengarten R., Poumarat F Adaptive surface antigen variation in Mycoplasma bovis to the host immune response. FEMS Microbiol Lett : Vanden Bush TJ. and Rosenbusch RF Mycoplasma bovis induces apoptosis of bovine lymphocytes. FEMS Immunol. Med. Microbiol : Thomas CB. Van Ess P., Wolfgram LJ., Riebe J, Sharp P, Schultz RD Adherence to bovine neutrophils and suppression of neutrophil chemiluminescence by Mycoplasma bovis. Vet. Immunol. Immunopathol : Katsuda K., Kohmoto M., Mikami O., Uchida I Antimicrobial resistance and genetic characterization of Fluoroquinolone resistant Mannheimia haemolytica isolates from cattle with bovine pneumonia. Vet. Microbiol. 139 : : Mannnheimia haemolytica. 55 : Mannheimia haemolytica. 64 : Pasteurella multocida, Mannheimia haemolytica, Historhilus somni. 65 : EBVM. 57 : : : : : Ishizaki, H., Hanafusa, Y., Kariya, Y Influence of truck transportation on the function of bronchoalveolar lavage fluid cells in cattle. Vet. Immunol. Immunopathol. 105 : :1 7.

12 12 12 [11] 9 [12] 3 6 E. acervulina E. maxima E. tenella 3 E. brunetti E. necatrix 2 E. necatrix 8 18 E. brunetti E. necatrix E. brunetti 1 1 2,000 [1] 1

13

14 [1] 3 3 TAM 6 E. acervulina E. maxima E. tenella [2] Paracox 5 E. acervulina E. maxima E. mitis E. tenella E. maxima 2 Neca E. necatrix 3 4 [3] E. necatrix E. brunetti E. brunetti [4] E. brunetti 1970 [6 7] 1990 E. brunetti [5] E. brunetti 3 TAM Paracox 5 Neca 10 E. brunetti E. brunetti E. brunetti

15 Neca E. brunetti E. necatrix 3 5 in vitro [9 10] 3 [8] 1. Shirley, M. W., Smith, A. L. and Tomley F. M The biology of avian Eimeria with an emphasis on their control by vaccination. Advances in Parasitology 60 : pp pp Kawahara F, Taira K, Nagai S, Onaga H, Onuma M, Nunoya T Detection of five avian Eimeria species by species specific real time polymerase chain reaction assay. Avian Diseases 52 : Nakamura, T., Kawaguchi, H., Imose, J Identification of Eimeria brunetti using glucose phosphate isomerase and lactate dehydrogenase. Nippon. Juigaku. Zasshi. 52 : Oikawa, H., Kawaguchi, H., Katagiri, K., Nakamoto, K Incidence of chicken coccidia from broiler houses in Japan, Zentralbl. Bakteriol. [Orig. A]. 244 : Oikawa, H., Kawaguchi, H., Nakamoto, K., Tsunoda, K Field surveys on coccidial infection in broilers in Japan results obtained in spring and summer in Nippon. Juigaku. Zasshi. 36 : Clark, J.D., Billington, K., Bumstead, J. M., Oakes, R. D., Soon, P. E., Sopp, P., Tomley, F. M., Blake, D. P., A toolbox facilitating stable transfection of Eimeria species. Molecular and Biochemical Parasitology 162 : McDonald, V. and Shirley, M.W Past and future : vaccination against Eimeria. Parasitology

16 : Shirley, M. W., Smith A. L. and Tomley F. M The biology of avian Eimeria with an emphasis on their control by vaccination. Advances in Parasitology 60 : In :. pp McDougald, L. R. and S. H. Fitz Coy Coccidiosis. In : Diseases of poultry, 12 th ed. Y. M. Saif, A. M. Fadly, J. R. Glisson, L. R. McDougald, L. K. Nolan, D. E. Swayne, eds. Blackwell Publishing Ames, IA. pp

Fig. 1 Chemical structure of DL-8280

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