5- Fc Fc fragment 5-hydroxytryptamine IgG H C B B cell B B lymphocyte) C H 2 C H 3 B Fc C1q B7 Fc Fc receptor T IgG Fc MHC B IgG CD2 CD2 antigen ADCC

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きよはるみおか
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1 5- Fc Fc fragment 5-hydroxytryptamine IgG H C BB cell B B lymphocyte) C H 2 C H 3 B Fc C1q B7 Fc Fc receptor T IgG Fc MHC B IgG CD2CD2 antigen ADCC T 50kD LFA-2 T11 H Heavy(H) chains E. H LFA-3 CD58 CD3 (CD3 antigen) T TCR H-2 H-2 gene complex TCR CD4CD4 antigen P. A. Gorer G. T HIV-IIISnell CD8CD8 antigen H-2 T CDClass of differentiation classification HLA C C-reactive protein CRP Human leucocyte antigen gene complex C HLA F(ab ) 2 F(ab ) 2 fragment IgG ph4.0 ICAM-1 Intercellular adhesion molecule-1 L CD54 LFA-1 H N ( V H 55kD C H 1 ) Fab Fab fragment J J chain IgG IgM IgA L H N ( V H C H 1 L Light(L) chain )

2 LFA-1 T T cell subset T Lymphocyte function-associated antigen-1 T T CTL CTL CD11a CD18 2 T T cell receptor TCR T MHC ICAM-1 ICAM-2 ICAM-3 / LFA-3 (TCR2) / Lymphocyte function-associated antigen-3 (TCR1) CD3 TCR CD58 T VCAM-1 Vascular cell adhesion molecule-1 50% 55 75kD IL-1 TNF IFN 11 CD2 LFA-2 MHCMHC restriction VLA-4 Very late activation antigen-4 T, MHC, VCAM-1 MHC T, MHC Adjuvant, MHC MHC MM cell Anaphylaxis IgE Th1Th1 cell T Anaphylatoxin T C3a C5a T Affinity IL2. Th2Th2 cell T Apoptosis B. DNA IL4 IL5 IL6 IL10 Arthus phenomenon Thy-1Thy-1 antigen T TT cell T T lymphocyte) Allergy 1906 von Pirquet (T )

3 Allergen IgE I Allotype H L Jerne Niels Kai Isotype Idiotype T Immunoassay Interferon IFN CD4T NK -1 Interleukin-1 IL-1 Edelman, Gerald Maurice H L L Ehrlich, Paul Epitope Effector cell Endosome autocrine Opsonin IgG C3b C Cationic protein 10 Kappa ( ) chain L Kinin Carrier Kupffer cell Class switch B H H Cloning Clonal selection theory 1959

4 Köhler, J.F. Georges 1946 Jenner, Edward: C. Milstein C.Milstein K.Jerne 1984 Swiss-type agammaglobulinemia T B Precipitin reaction in gel (SCID). Snell George Davis Cognate. T B B T T-B (H-2) 1980 B T Koch, Robert: serotonin 5- Defensin BCG Transgenic mouse Koch s phenomenon Dausset Jean Colony stimulating factor CSF (HLA) 1980 Cytokine Domain Signal transduction MHC MHC Natural killer (NK) cell T B LGL(Large granular lymphocyte) (null cell) T MHC

5 Network theory Histamine 1974 B Hinge domain H Fc Fab Hybridoma H S-S Hapten Pinocytosis Phagosome Burnet Frank MacFarlane Phagolysosome 1957 Bursa of Fabricius B 1960 Forssman antigen Perforin T NK 7. Framework segments. Payer s patch Flow cytometry M Pfeiffer phenomenon Bradykinin 1894 R.Pfeiffer B.Issaeff Pasteur, Louis: Bruton-type agammaglobulinemia X( ) ( ) B B DJ VDJ B vaccinia vaccination Plasmin pasteurization paracrine Paratope Prostaglandin PG T

6 Heterozygote Porter, Rodner Robert IgG THelper T cell Fab B Fc T IgG (Fab) 2 Fc 1967 T 1972 T Th1 B Th2 Pauling Linus Carl T MHC 1942 Behring, Emil von: Benacerraf Baruj Polymerase chain reaction PCR. DNA DNA DNA 1980 DNA Bence-Jones protein Mitogen DNA L Macrophage Homozygote Mast cell Formyl-methionyl peptide E Fc Bordet, Jules Jean Baptiste Vincent microglia 1919

7 Milstein, César 1927 Lambda ( ) chain 1963 L MRC 1970 Landsteiner Karl ABO Rh J.F.G.Köhler 1930 J.F.G. Köhler K. Jerne 1984 Langerhans' cell Medawar Peter Brian Fc MHC T Richet Charles Robert Metchnikiff, Elie Lysosome Chemical mediator Lysozyme Monokine Lipopolysaccharide LPS Monoclonal antibody B B Lymphocyte Yalow, Rosalyn Sussman I- B T (LGL) Lymphoid nodule Lymphoid follicle B 1959 T Lymph node 1977 Lactoferrin Radioimmunoassay RIA

8 Lymphokine E IgE Lymphokine activated killer cell LAK IL-2 NK IgE 1974 Ragin Heteroantigen IgE Lectin Graft rejection Receptor Gene locus Leukotriene Vaccinia virus Primary lymphoid organ. Vaccination Primary immune responce Waldeyer ring 1 - -antitrypsin 1 Large granular lymphocyte LGL NK K V Variable region 2 - -macroglobulin 2 H L N V H V L C - 2-microglobilin Granulocyte MHC Acquired immunity MHC Template theory Acquired immune response = TActivated T cell T Heterophile antigen Reactive oxygen

9 Complete antigen Inbred mouse bronchus-associated lymphoid tissue:balt DNARecombinant DNA technology) Memory cell DNA mrna Plasma cell B Fluorescent antibody technique Periarteritis nodosa Acute phase protein C Vasoactive amine C Megakaryocyte Platelet,Thrombocyte Costimulatory signal 11 T MHC Serum T Thymus T A Thymic hormone Serum amyloid A protein A Serum sickness Thymus-independent antigen T Limiting dilution B T Agglutination (Classical pathway) Widal Weil-Felix.. Forbidden clone. Basophil E F. 0.5 M.Burnet

10 Collagen disease Antigen presenting cell APC P.Klemperer 1942 MHC MHC II CD4 T Cross reaction B MHC I Eosinophil CD8 T 5 Antibody Eosinophil cationic protein ECP ( ) ( ) Antibody dependent cell-mediated cytotoxicity ADCC Neutrophil IgG Fc Fc (90 ) 48 antitoxin Antiserum ( ) Enzyme-linked antibody technique Antigen T ( ) 1 ELISA Antigenic determinant High endothelial venule HEV epitope T PCV PCV Antigen presentation T Bone marrow T T B CD4 MHC CD8 Myeloma MHC B TCytotoxic T cell T Killer T cell T CD8 MHC

11 Cell-mediated immunity Tumor necrosis factor TNF BCG Passive immunity Surface immunoglobulin B Dendritic cell B L T B Phagocyte Phagocytic cell) Oxygen-dependent killing Phagocytosis Self and non-self Normal flora Self tolerance Inoculation congenital tolerance Autoantigen Contact hypersensitivity. DNA Adhesion molecule Horror autotoxicus 1900 P.Ehrlich Innate immunity Autoimmune disease Systemic lupus erythematosus:sle) Major basic protein MBP Histiocyte Scavenger cell Major histocompatibility complex MHC T Interdigitating cell T Species specific antigen Chemotaxis

12 Chemotactic factor Organ specific antigen 1977 T. 59 Organ specific autoimmune disease Humoral immunity Somatic mutation MG AIHA ITP V V Alternative pathway C3 Organ non-specific autoimmune disease Systemic autoimmune Mononuclear cell disease. SLE Mononuclear phagocyte DM PSS RA SS Complementarity-determining region CDR Monocyte T MHC Side chain theory 1900 Delayed type hypersensitivity DTH T T Delayed-type hypersensitivity T cell Polymorphonuclear neutrophil leukocyte (DTH) PMN MHC CD4 + T T Th1.. 3 gut-associated lymphoid tissue:galt Fc ADCC

13 Hypervariable region Phagcytic activity T V Endogenous pyrogen V N IL-1 TNF Precipitation Endotoxin C Constant region H L T C S-S Infectious hepatitis 1981, A E Secondary lymphoid organ UCSD Ph.D. Secondary immune responce 1980 V D J DNA B V-D-J Opportunistic pathogen DNA T Mucosal-associated lymphoid tissue:malt Alloantigen, Isoantigen Active immunity Osteoclast H-2 HLA Isohemagglutinin Germinal center A B Rh B ( ) ( ) Alveolar macrophage Periarteriolar lymphoid sheath PALS

14 leukocyte [Memory (immunologic)] Leucopenia Immunoglobulin B Spleen H L Immunoglobulin superfamily. Incomplete antigen Immune response T Inapparent infection Immune response gene Ir gene Peritoneal macrophage MHC Immunological tolerance Immunogen Secretory component B T IgA J Immunogenicity B T Tonsil Immunoelectrophoresis Complement Immune complex Blastgenic reaction Complement receptor C3 ( )T Suppressor T cell T B T Immunity Follicular dendritic cell FDC

T ( ) Lymphocyte B T (LGL) T T cell T T lymphocyte) (T ) Immunity Inoculation Jenner, Edward Pasteur, Louis vaccinia vaccinatio 62 6

T ( ) Lymphocyte B T (LGL) T T cell T T lymphocyte) (T ) Immunity Inoculation Jenner, Edward Pasteur, Louis vaccinia vaccinatio 62 6 Acquired immune response = Self and non-self Graft rejection Receptor Innate immunity Acquired immunity Humoral immunity Cell-mediated immunity Acute phase protein C Lysozyme Complement Natural killer