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1 172( 38 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr (PBP) PBP pbp1a, pbp2x, pbp2b 121 (49%), pbp1a, pbp2x 30 (12%), pbp2x, pbp2b 16 (6%), pbp2x 61 (24%), pbp1a 1 (1%), pbp2b 1 (1%) 24 (9%) cefditoren cefcapene panipenem, biapenem, imipenem meropenem tosufloxacin sparfloxacin mefa, ermb mefa 74 (29%) ermb 134 (53%), mefa ermb 10 (4%) 36 (14%) % % % %
2 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 39 ) Penicillin resistant Streptococcus pneumoniae (PRSP) 6 11/ % % % PRSP 29 Pulsed Filed Gel Electrophoresis 15 1) penicillin-resistant Streptococcus pneumoniae (PRSP) ) 3,4) 5) I penicillin-susceptible S. pneumoniae (PSSP) 24 penicillin-intermediate S. pneumoniae (PISP) PCR Polymerase chain reaction (PCR) (PRSP) PCR (LytA) PCR 3,4,6) PCR PSSP, PISPS PRSP pbp1a, pbp2x, pbp2b PSSP 1 2PISP 3 PRSP 3. penicillin G (PCG), piperacillin (PIPC), amoxicillin (AMPC), cefaclor (CCL), cefixime (CFIX), cefdinir (CFDN), cefteram (CFTM), cefpodoxime (CPDX), cefditoren (CDTR), cefcapene (CFPN), imipenem (IPM), panipenem (PAPM), meropenem (MEPM), biapenem
3 174( 40 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. (BIPM), levofloxacin (LVFX), ciprofloxacin (CPFX), tosufloxacin (TFLX), sparfloxacin (SPFX), clarithromycin (CAM), azithromycin (AZM), minocycline (MINO), clindamycin (CLDM) 22 5% 80 C MIC 37 C, 5% PRSP PRSP PRSP 29 Sma I 7) Pulsed Field Gel Electrophoresis (PFGE) II MIC2000, MIC2000, SEPTOR System, SN (34%), 83 (33%), 65 (26%), 14 (6%), 2 (1%) (55%), (6%), (16%), (22%), 7 (3%) (10%), 1 45 (18%), 2 15 (6%), 3 31 (12%), 4 19 (7%), 5 4 (2%) 60 (24%), 106 (41%), 62 (24%), 9 (4%), 17 (7%) 3. PCG PSSP 4 (21%) PISP 15 (79%), PSSP 64 (45%) PISP 77 (54 ), PSSP 23 (15%) PISP 96 (85%), PSSP 7 (14%) PISP 45 (86%), PSSP 18 (56%) PISP 14 (44%), PSSP 93 (18%) PISP 434 (82%) PSSP 24 PISP b - pbp1a, pbp2x, pbp2b Table 1 pbp1a, pbp2x, pbp2b (PRSP) 121 (48%), pbp1a, pbp2x (PISP) 30 (12%),
4 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 41 ) Table 1. Isolation frequency of abnormal penicillin binding protein (PBP) genes in Streptococcus pneumoniae isolated from hospitals in Gifu area. Table 2. Isolation frequency of macrolide-resistant genes in Streptococcus pneumoniae isolated from hospitals in Gifu area. pbp2x, pbp2b (PISP) 16 (6%), pbp2x (PISP) 61 (24%), pbp1a (PISP) 1 (1%), pbp2b (PISP) 1 (1%), (PSSP) 24 (9%) pbp1a, pbp2x, pbp2b 50% pbp1a, pbp2x pbp2b (p 0.05) mefa, ermb Table 2 mefa74 (29%), ermb 134 (53%), mefa, ermb 10 (4%), 36 (14%) mefa, ermb (p 0.05) 4. S. pneumoniae PSSP, PISP PRSP Table 3 MIC 50, MIC 90,
5 176( 42 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. Table 3. Antibacterial activity of antibacterial compounds against Streptococcus pneumoniae clinical isolates of normal and harboring abnormal penicillin binding protein (PBP) genes.
6 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 43 ) Table 3. (Continued)
7 178( 44 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. Table 3. (Continued)
8 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 45 ) Table 3. (Continued)
9 180( 46 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. Table 3. (Continued)
10 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 47 ) Table 3. (Continued) MIC rangepbp1a PBP2b 1 MIC range PCG PSSP PISP pbp1a; 1 pbp2x; 61 pbp2b; 1 pbp1a pbp2x; 30 pbp2x pbp2b; 16 3 PRSP 121 PCG PSSP, PISP PRSP MIC m g/ml, 0.06 m g/ml 0.5 m g/ml 2 mg/ml PIPC AMPC PCG CCL CFIX PSSP 1 PISP PRSP CFDN CPDX PSSP PISP CFTM PSSP PISP CDTR PSSP, PISP PRSP MIC m g/ml, 0.25 m g/ml 1 mg/ml 1 m g/mlcfpn CDTR PRSPMIC 8 mg/ml 2 4 mg/ml 3 CFPN PISP MIC 4 mg/ml 1 PRSP 16 m g/ml 5 8 mg/ml 3 PSSP, PISP PRSP PSSP MIC m g/mlprsp MIC m g/ml 0.5 m g/ml
11 182( 48 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. PSSP 8 16pbp1a 2 1 LVFX CPFX MIC 90 1 mg/ml 2 mg/mltflx SPFX MIC mg/ml 0.5 mg/ml CAM AZM PSSP MIC mg/ml m g/ml CLDM MINO 5. S. pneumoniae Table 4 PSSP CAM, AZM CLDM MIC m g/ml, m g/ml 0.06 mg/ml mefa CLDM PSSP CAM AZM ermb mefa ermb 6. Table (17/55, 30.9%), 40 (8/55, 14.5%), 9 (6/55, 10.9%), 15 (5/55, 9.1%) PRSP 6 (11/29, 37.9%), 9 (3/29, 10.3%), 15 (3/29, 10.3%) 7. PRSP 29 PFGE Table 6 15 Table 4. Antibacterial activity of macrolide antibiotics against Streptococcus pneumoniae clinical isolates of normal and harboring mefa and ermb gene.
12 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 49 ) Table 5. Serotypes of Streptococcus pneumoniae isolates in Matsubara Otorhinolaryngology Clinic. H, M B N 5 43 III APPELBAUM PRSP 8) ) PRSP PRSP 3,4,11) ) CDTR MIC 8 mg/ml 2 4 mg/ml 3 PRSP CFPN MIC 4 m g/ml 1 PISP, 16 mg/ml 5 8 m g/ml 3 PRSP PRSP CDTR 1 mg/ml
13 184( 50 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. Table 6. Diversity of PRSP isolates in Matsubara Otorhinolaryngology Clinic using pulsed field gel electrophoresis. Time above MIC mg/ml CDTR 30% pharmacokinetics/pharmacodynamics (PK/PD) PK/PD PRSP 9,12) PFGE PRSP 7) PFGE PRSP PK/PD 9) ) , km 2, /km 2
14 Apr. THE JAPANESE JOURNAL OF ANTIBIOTICS ( 51 ) 13) 1) KLUGMAN, K. P.: Pneumococcal resistance to antibiotics. Clin. Microbiol. Rev. 3: , ) b : , ) UBUKATA, K.; Y. ASAHI, K. OKUZUMI, et al.: Incidence of penicillin-resistant Streptococcus pneumoniae in Japan, J. Infect. Chemother. 2: 77 84, ) UBUKATA, K.; T. MURAKI, A. IGARASHI, et al.: Identification of penicillin and other b -lactam resistance in Streptococcus pneumoniae by PCR. J. Infect. Chemother. 3: , ) FELMINGHAM, D.; R. R. REINERT, Y. HIRAKATA & A. RODLOFF: Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin. J. Antimicrob. Chemother. 50 (Suppl. S1): 25 37, ) NAGAI, K.; Y. SHIBASAKI, K. HASEGAWA, et al.: Evaluation of the primers for PCR to screen Streptococcus pneumoniae isolates, b-lactam resistance and to detect common macrolide resistance determinants. J. Antimicrob. Chemother. 48: , ) SHIMADA, J.; N. YAMANAKA & M. HOTOMI: Household transmission of Streptococcus pneumoniae among siblings with acute otitis media. J. Clin. Microbiol. 40: , ) APPELBAUM, P. C.; A. BHAMJEE, J. N. SCRAGG, et al.: Streptococcus pneumoniae resistant to penicillin and chloramphenicol. Lancet 2: , ) Streptococcus pneumoniae 51: 60 70, ) HORVAT, R. T.; N. E. KLUTMAN, M. K. LACY, D. GRAUER & M. WILSON: Effect of duplicate isolates of methicillinsusceptible and methicillin-resistant Staphylococcus aureus on antibiogram data. J. Clin. Microbiol. 41: , ) Jpn. J. Antibiotics 53: , ) Streptococcus pneumoniae 51: , ) pp
15 186( 52 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 2 Apr. EPIDEMIOLOGY OF Streptococcus pneumoniae ISOLATES IN GIFU PREFECTURE Gifu Working Group of Forum on Microbial Resistance HIROSHIGE MIKAMO Department of Obstetrics and Gynecology, Division of Organ Pathobiology, Gifu University School of Medicine HIROYUKI SUEMATSU Clinical laboratories, Chuno General Hospital KAORI TANAKA and KUNITOMO WATANABE Division of Anaerobe Research, Life Science Research Center, Gifu University HARUKI SAWAMURA Gifu University School of Medicine SHIGENORI MATSUBARA Matsubara Otorhinolaryngology Clinic YOKO MATSUKAWA Clinical laboratories, Gifu Prefectural Tajimi Hospital SHIOMI ISHIGO Depatment of Clinical Laboratory Medicine, Ogaki Municipal Hospital MASASHI MIYASATO and ETSUJI ICHIKAWA Meiji Seika Kaisha, Ltd. We analyzed Streptococcus pneumoniae isolates confirmed by direct PCR in Gifu prefecture between May 2002 and August We analyzed isolates of 254 strains from 6 hospitals to determine antibiotic susceptibility, genotype of penicillin-binding protein (PBP) genes and macrolide resistant genes, and the serotypes distribution of isolates from Matsubara Otorhinolaryngology Clinic. Isolates in which abnormal PBP genes of pbp1a, pbp2x, and pbp2b were identified by PCR were classified based on PCR results as follows; (i) penicillin-susceptible (PSSP) with 3 normal PBP genes, (ii) penicillin-intermediate (PISP) with an abnormal pbp2x, (iii) PISP with an abnormal pbp2b, (iv) PISP with abnormal pbp2x and pbp2b, (v) PISP with abnormal pbp1a and pbp2x, (vi) penicillin-resistant (PRSP) with 3 abnormal PBP genes. The overall incidence of PRSP, PISP and PSSP was 121 (49%), 109 (42%) and 24 (9%), respectively, and there was a significant difference among some hospitals (p 0.05). However, there was no significant difference among the hospitals for the incidence of abnormal macrolide-resistant genes (mefa, ermb). Panipenem showed an excellent antimicrobial activity for injectable carbapenems against PRSP, following biapenem, imipenem, and meropenem. Cefditoren (CDTR) showed an excellent antimicrobial activity for oral cephalosporins against PRSP, following cefteram and cefcapene. Interestingly, there were 2 and 3 strains on MIC of CDTR for 8 and 4 m g/ml, respectively. The prevalent pneumococcal serotypes of isolates in Matsubara Clinic were 6 (17/55), following by 40 (8/55), 9 (6/5) and 15 (5/ 55). The endemic strains were observed in this study using pulsed field gel electrophoresis. These findings suggest the needs to continue the surveillance of bacterial resistance not only in the nationwide but also in the distict.
2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 1 Feb. 2012 CLSI M100-S17benzylpenicillin PCG MIC 0.05 g/ml S. pneumoniae penicillin-susceptible S. pneumon
Feb. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 1 1 1 2008 2009 2011 10 25 2008 6 2009 4 Streptococcus pneumoniae 377 penicillin-binding protein: PBP 2004 S. pneumoniae 160 2 2 THE JAPANESE JOURNAL OF
Oct THE JAPANESE JOURNAL OF ANTIBIOTICS Pseudomonas aeruginosa 186 P. aeruginosa piperacillin PIPC, taz
Oct. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 5 327 27 2013 2014 2016 7 5 2013 2014 Pseudomonas aeruginosa 186 P. aeruginosa piperacillin PIPC, tazobactam/piperacillin TAZ/PIPC, ceftazidime CAZ, cefepime
Feb THE JAPANESE JOURNAL OF ANTIBIOTICS Tebipenem pivoxil 1 1, Meiji Seika 2 Meiji Seika G 3 Meiji Seika Tebipen
Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 53 53 Tebipenem pivoxil 1 1, 3 2 2 1 1 Meiji Seika 2 Meiji Seika G 3 Meiji Seika 2015 12 15 Tebipenem pivoxil 10% 2010 4 2013 3 3,547 3,540 3,540 3,331
180 ( 64 ) THE JAPANESE JOURNAL OF ANTIBIOTICS June 2011 A b group A Streptococcus: GAS GAS 10 meta-analysis 1) 2,3) GAS potential pathogens Tab
June 2011 THE JAPANESE JOURNAL OF ANTIBIOTICS 64 23 179 ( 63 ) A b cefditoren pivoxil 5 amoxicillin 10 1,2) 1,3) 1) 1) 1) 4) 5) 6) 7) 1) 2) 3) 4) 5) 6) 7) 2011 4 8 2007 5 2009 4 A b GAS cefditoren pivoxil
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13 11 30 14 4 22 Streptococcus pneumoniae Haemophilus influenzae amoxicillin AMPC cefditoren pivoxil CDTR AMPC 50 mg kg day CDTR 9mg kg day CDTR 18 mg kg day S. pneumoniae H. influenzae 8 17 25 1 25 S.
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518( 30 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 25 2003 1. * * Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 519( 31 ) 9 5 2003 8 2004 7 14 565 701 258 (36.8%) 443 (63.2%) Staphylococcus aureus
VOL. 43 NO. 4
VOL. 43 NO. 4 Fig. 1. Frequency of Enterococcus species from complicated UTI, 1988-1992. the number * of Enterococcus species/the number of cases with complicated UTI. Fig. 3 Epidemiologic characteristics
VOL. 40 S- 1 Table 1. Susceptibility of methicillin-resistant Staphylococcus aureus to meropenem Table 2. Coagulase typing of methicillin-resistant St
CHEMOTHERAPY VOL. 40 S- 1 Table 1. Susceptibility of methicillin-resistant Staphylococcus aureus to meropenem Table 2. Coagulase typing of methicillin-resistant Staphylococcus aureus CHEMOTHERAPY Table
2 2 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 Feb Neisseria gonorrhoeae ceftriaxone CTRX % 2010 CTRX 20 FQ staphylococci, E. faecium, N.
Feb. 2016 THE JAPANESE JOURNAL OF ANTIBIOTICS 69 1 1 1 2013 69 11,762 2015 11 16 1994 2013 69 19 11,762 FQ 33 Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae
CHEMOTHERAPY aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Prote
aureus 0.10, Enterococcus faecalis 3.13, Escherichia coli 0.20, Klebsiella pneumoniae, Enterobacter spp., Serratia marcescens 0.78, Proteus mirabilis 3.13, Proteus vulgaris 1.56, Citrobacter freundii 0.39,
Staphylococcus epidermidis Streptococcus pneumoniae Staphylococcus epidermidis Streptococcus pneumontae S. epidermidis Table 1. Summary of the organis
Staphylococcus aureus S. aureus (MRSA) vancomycin (VCM), arbekacin (ABK) Streptococcus pneumoniae cefuzonam (CZON), cefpirome (CPR) S. pneumoniae Enterococcus faecalis ampicillin (ABPC), imipenem (IPM)
THE JAPANESE JOURNAL OF ANTIBIOTICS 68 3 June 2015 Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis % 2 S. pneumon
June 2015 THE JAPANESE JOURNAL OF ANTIBIOTICS 68 3 189 49 1 : 14 1 2 2 3 1 2 3 2015 4 3 1 : 14 CVA/AMPC 1 : 14 27 CVA/AMPC 1 : 14 88.5% Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis
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Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae Key words β Streptococcus pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae μ μ S. pneumoniae H. influenzae S. pneumoniae
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β β Moraxella catarrhalisescherichia colicitrobacter Klebsiella pneumoniaeenterobacter cloacaeserratia marcescens Proteus Providencia Pseudomonas aeruginosaacinetobacter Bacteroides fragilis β β E. colik.
感染症学雑誌第77巻第8号
1 2 µ Streptococcus pneumoniae µ S. pneumoniae µ S. pneumoniae pbp β β pbp1a pbp2x pbp2b pbp mefe ermb pbp pbp1a pbp2x pbp2b pbp pbp pbp pbp 2x pbp1a pbp2x pbp 2b mefe ermb pbp β pbp2x β β β µ µ pbp3 µ
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,
VOL.47 NO.5 Table 1. Susceptibility distribution of Ĉ- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus
MAY 1999 VOL.47 NO.5 Table 1. Susceptibility distribution of ƒà- lactams against clinical isolates of MRSA MRSA: rnethicillin- resistant Staphylococcus aureus (oxacillin MIC: 4ƒÊg/ ml) FMOX: flomoxef,
日本化学療法学会雑誌第53巻第S-3号
moxifloxacin in vitro moxifloxacin in vitro 17 9 6 17 11 21 moxifloxacinmflx in vitro cefdinir CFDNclavulanic acidamoxicillincvaampcclarithromycincamclindamycincldm levofloxacinlvfx 1MFLX Clostridium clostridiiformeclostridium
Table 1.Resistance criteria Fig.1.The resistance rates of piperacillin,ceftazidime, cefsulodin,imipenem,aztreonam,gentamicin,tobramycin,amikacin,isepamicin,fosfomycin and ofloxacin against 2,793 strains
CHEMOTHERAPY
CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin
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β Moraxella catarrhalis Escherichia coli Citrobacter Klebsiella pneumoniae Enterobacter cloacae Serratia marcescens Proteus Pseudomonas aeruginosa Acinetobacter Bacteroides fragilis β Haemophilus influenzae
Table 1. Antimicrobial drugs using for MIC
Table 1. Antimicrobial drugs using for MIC Table 2. Susceptibilities determined with the VITEK 2 system and agar dilution reference by interpretive eategory for Staphylococcus aureus Table 3. Interpretive
Key words : R-plasmid, Urinary tract infection, E. coli Fig. 1. MIC distribution against E. coli isolated from urinary tract (366 strains) and isolation - frequencies of drug-resistant strains Table 1.
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Enterococcus faecalis Klebsiella pneumoniae, Morganella
Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile
Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Key words: temafloxacin, TA-167, Bacteroides fragilis,
400 46 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 LVFX 100 mg 3 / 7 150 mg 2 / 7 2 2006 2008 9 LVFX PK PD 2009 7 100 mg 1 3 500 mg 1 1 AUC/MIC
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 399 45 2012 11 5 LVFX 500 mg 1 1 20 Chlamydia trachomatis C. trachomatismycoplasma genitalium M. genitalium LVFX 1 500 mg 1 1 7 22 22 C. trachomatis 17
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THE JAPANESE JOURNAL OF ANTIBIOTICS 57 5 425( 1 ) Telithromycin 7 20 PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin) Telithromycin (TEL) TEL ermb mefa
Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml
CHEMOTHERAPY SEPT. 1992 cefoperazone ceftazidime (CAZ), imipenem (IPM) Staphylococcus sp., Enterococcus (CPZ), faecalis, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae,
Fig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
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Streptococcus pneumoniae Haemophilus influenzae Moraxella catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S. pneumoniae H. influenzae M. catarrhalis S.
Streptococcus pneumoniae,streptococcus pyogenes,streptococcus agalactiae,neisseria gonorrhoeae,h.influenzae,moraxella subgenus Branhamella catarrharis
Streptococcus pneumoniae,streptococcus pyogenes,streptococcus agalactiae,neisseria gonorrhoeae,h.influenzae,moraxella subgenus Branhamella catarrharis, E.coil,Klebsiella pneumoniae,klebsiella oxytoca,proteus
小児感染症分離株における感受性サーベイランス
小児感染症分離株における 感受性サーベイランス 公益社団法人日本化学療法学会, 一般社団法人日本感染症学会, 日本小児感染症学会小児用キノロン薬適正使用推進委員会委員長 : 渡辺彰委員 : 岩田敏, 坂田宏, 佐藤吉壮, 鈴木賢二, 宮下修行, 堀誠治, 山口禎夫協力委員 : 小田島正明, 交久瀬善隆, 長谷川寿一, 牧展子, 和田光市 はじめに 2009 年 12 月に耐性菌感染症治療のために二次選択薬として承認された小児用キノロン薬の再審査期間の
CHEMOTHERAPY APRIL 1992 VOL. 40 S- 1 Table 1-1. Comparative in vitro activity of meropenem against clinical isolates CNS: coagulase-negative staphylococci CHEMOTHERAPY APRIL 1992 Table 1-2. Comparative
Table 1 Antibacterial spectra of CPM and other antimicrobials against anaerobes Fig. 1 In vitro activity of CPM and other antibiotics against B. fragilis (136 strains) Fig. 2 In vitro activity of CPM and
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200( 96 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 2 Apr. 585 1 17 MIC 1. (Transtracheal aspiration: TTA) TTA TTA TTA 1400 TTA (diffuse panbronchiolitis, DPB) 1) erythromycin(em) EM 12.5% 87.5% 2,3) EM EM
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone (inoculum size= 106 CFU/ml) (Ĉ-lactamase producer : 2 strains) Fig. 1. Sensitivity distribution of
Table 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background
208 ( 2 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 63 _ 3 June 2010 Cefditoren pivoxil (CDTR-PI) MS MS 10%
207 ( 1 ) Cefditoren pivoxil G 2010 2 2 2006 3 Cefditoren pivoxil CDTR-PI MS 10% CDTR-PI 305 2,144 2,006 1,958 1.79% 36 2,006 26 (1.30%) CDTR-PI CDTR-PI (9 mg/kg/day) 1.5 2 (2.70%) 2 (1.92%) 93.5% 1,831
Table 1. Antibacterial activity of cefdinir, cefixime, cefteram, cefuroxime, cefaclor and amoxicillin against standard strains Inoculum size: 108 cells/ml CFDN: cefdinir, CFIX: cefixime, CFTM: cefteram,
THE JAPANESE JOURNAL OF ANTIBIOTICS 63 13 243 ( 37 ) 2007 12 2008 5 19 863 methicillin-susceptible Staphylococcus aureus (MSSA) Escherichia coli levof
242 ( 36 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 63 _ 3 prulifloxacin * ** ** CMC * ** 2010 2 22 Prulifloxacin ulifloxacin (UFX) 3 1 2003 12 2004 5 19 534 2 2005 12 2006 5 19 805 3 THE JAPANESE JOURNAL OF
Table 1.Quality control of MICs for reference strains Table 2.Antimicrobial activity of gatifloxacin against aerobic bacteria Table 4.Antimicrobial activity of gatifloxacin and other quinolones against
1272 CHEMOTHERAPY MAR. 1975
1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides
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P P Streptococcus pneumoniae S. pneumoniae Key words Streptococcus pneumoniae Fig. 1. Capsular swelling reaction of S. pneumoniae type 6B. Cells are stained dark blue using a methylene blue. Capsule is
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VOL.30 NO.12 CHEMOTHERAPY Fig. 1 Effect of temperature on the growth curve of A. calcoaceticus A. calcoaceticits Ac 54 A. calcoacetictts Ac 164 Fig. 2 Effect of medium ph on the growth curve of A. calcoaceticus
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the
VOL.48 NO.7 lase negative staphylococci, Escherichia coli, Klebsiella spp., Citrobacter freundii, Enterobacter spp., indole-positive Proteus, Serratia
ceftazidime, cefpirome, cefepime, cefoperazone/sulbactam (2: 1), imipenem Staphylococcus aureus oxacillin coagulase negative staphylococci Escherichia coli piperacillin Klebsiellac spp. Citrobacter Pseudomonas
Fig.1 MICs of penicillins against 24 strains of B. pertussis Fig.2 MICs of cepherns against 24 strains of B. pertussis Fig.3 MICs of macrolides against 24 strains of B. pertussis Fig.4 MICs of nalidixic
Helicobacter pylori Helicobacter pylori Helkobacter pylori erythromycin (EM) Mueller Hinton broth (Difco) H. pylori Staphylococcus aureus ATCC 29213 Escherichia coli ATCC25922 amoxicillin (AMPC), clarithromycin
70( 70 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 Feb. Meropenem 2002 * * * * * * * * * * * * * * * * * * * * * * NTT Feb. THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 71( 71 ) * * * * 2003 12 22 Meropenem
VOL.42 S-1
CHEMOTHERAPY APR. 1994 VOL.42 S-1 CHEMOTHERAPY APR. 1994 Table 1. Criteria for evaluation of clinical efficacy by the Japanese Society of Oral and Maxillo-Facial Surgeons Grades of symptoms and numerical
CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Kle
VOL. 29 NO.8 CHEMOTHERAPY 865 CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Klebsiella pneumoniae GN-69
988 CHEMOTHERAPY NOV. 1971
988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical
VOL. 34 S-2 CHEMOTH8RAPY 913
VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(
366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -
Dec. 2012 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 365 11 sita oxacin 1 1 1 1 1 1 2 2 3 3 1 1 1 2 3 2012 9 14 sita oxacin STFX 50 mg 10% 2008 1 2008 12 2010 11 2 STFX 1,452 91.4% 1,235/1,351 95.9% 466/486
CHEMOTHERAPY
CHEMOTHERAPY CHEMOTHERAPY Table 1 Antibacterial activity of Sulbactam/CPZ against standard strains MIC mg/ml Inoculum size 106 CFU/ml * Sulbactam/CPZ= 1: 1 ** Concentration of Sulbactam+ CPZ CHEMOTHERAPY
PCG = Benzylpenicillin ABPC= Ampicillin AMPC= Amoxicillin MPIPC = Oxacillin MCIPC = Cloxacillin SBPC= Sulbenicillin PIPC= Piperacillin
Key words : Clinical isolates, Antibacterial susceptibility, Scale of hospital PCG = Benzylpenicillin ABPC= Ampicillin AMPC= Amoxicillin MPIPC = Oxacillin MCIPC = Cloxacillin SBPC= Sulbenicillin PIPC=
Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates
CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus
VOL. 32 S-4 CHEMOTHERAPY Fig. 1 Chemical structure of sodium cefoperazone Fig. 2 Chemical structure of sodium cefoperazone CHEMOTHERAPY JUN. 1984 Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter
Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Assoc
J Infect Chemother (2012) 18:609 620 DOI 10.1007/s10156-012-0434-3 SURVEILLANCE Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of
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VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak
CHEMOTHERAPY Methicillin-resistant S.aureus(MRSA) coccus epidermidis 105 Streptococcus pyogenes E.faecali senterococcus avium Enterococcus faecium Str
cefaclor(ccl),cefuroxime(cxm),cefixime (CFIX),cefteram(CFTM),cefdinir(CFDN) pneumoniae,streptococcus pyogenes Moraxella catarrhalis,haemophilus influenzae,escherichia coli, Klebsiella pneumoniae,proteus
1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, 1949.-2) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3)
Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS XXXVII (45)
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000 000 0 000 0 Methicillin resistant Staphylococcus aureusmrsa.methicillin resistant S. epidermidismrse.0 MRSA MRSE arbekacinabkquinupristindalfopristinqprdpr vancomycin MIC0. ml Streptococcus pneumoniae
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia Table 3. Overall clinical efficacy of cefozopran in
CHEMOTHERAPY APRIL 1992 Table 2. Concentration of meropenem in human prostatic fluid Table 1. Background of 21 chronic complicated UTI cases * NB + BPH, NB + Kidney tumor, NB + Kidney tuberculosis Table
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346 ( 78) THE JAPANESE JOURNAL OF ANTIBIOTICS 62 _ 4 2007 72 12,919 NTT THE JAPANESE JOURNAL OF ANTIBIOTICS 62 44 347 ( 79) 348 ( 80) THE JAPANESE JOURNAL OF ANTIBIOTICS 62 _ 4 THE JAPANESE JOURNAL OF
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VOL.32 S-7 CHEMOTHERAPY Table 1 MIC of standard strains of CTRX Fig. 2 Cumulative curves of MIC S. aureus (26 strains )
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CHEMOTHERAPY Fig. 1 Chemical structure of carumonam Disodium(+)-(Z)-CCE1-(2-amino-4-thiazoly1)-2-[[(2S, -(carbamoyloxymethyl)-4-oxo-1-sulfonato-3-azetidinyll -2-oxoethylidene] amino] oxy] acetate 3S)-2
日本化学療法学会雑誌第57巻第4号
Streptococcus pneumoniae Haemophilus influenzae β β Key words I β Enterococcus faecium Pseudomonas aeruginosa Streptococcus pneumoniae S. pneumoniae Haemophilus influenzae S. pneumoniae H. influenzae Table.
cover
日本耳鼻咽喉科感染症研究会会誌 (2012.05) 30 巻 1 号 :133~136. 急性中耳炎 急性鼻副鼻腔炎における抗菌薬の選択基準とバリアンス 林達哉 第 41 回日本耳鼻咽喉科感染症研究会 シンポジウム 上気道感染症治療の最前線 タイトル名 : 急性中耳炎 急性鼻副鼻腔炎における抗菌薬の選択基準とバリアンス 著者名 : 林達哉 ( はやしたつや ) 所属 : 旭川医科大学耳鼻咽喉科 頭頸部外科
Key words:group D streptococci,classification,enterococcal infections, Antibiotic susceptibility,vancomycin
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Dec. 2010 THE JAPANESE JOURNAL OF ANTIBIOTICS 63 46 431 ( 45 ) 2006 1) 1) 2) 2) 3) 4) 4,5) 6) 6) 7) 8) 8) 9) 10) 11) 11) 12) 13) 13) 14) 14) 15) 15) 16) 16) 17) 17) 1) 1) 1) 2) 3) 4) 5) 6) 7) 8) 9) 10)
E Societe de Pathologie Infectieuse de Langue Francaise (, 1991) E Spanish Thoracic Society (1992) E American Thoracic Society (ATS : 1993. ü ù2001 ) E British Thoracic Society (1993, ü è2001 ) E Canadian
Table1MIC of BAY o 9867 against standard strains
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coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F
VOL.43 S-1 coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, Flavobacter- Table 1. Concentration of grepafloxacin
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CHEMOTHERAPY NOV S. aureus, S. epidermidis, E. coli, K. pgeumoniae, E. cloacae, S. marcescens, P. mirabilis, Proteus, P. aeruginosa Inoculum siz
VOL.33 S-5 CHEMOTHERAPY 381 Fig. 1 Chemical structure of HAPA-B Chemical name 1-N-[(2S)-3-Amino-2-hydroxypropiony1]-4-0-(6-amino- 6-deoxy-a-D-glucopyranosyl)-6-013-deoxy-4-C-methyl- 3-(methylamino)-ƒÀ-L-arabinopyranosyl]-2-deoxystreptamine
Fig. 1 Chemical structure of TE-031 Code number: TE-031 Chemical name: (-) (3R, 4S, 5S, 6R, 7R, 9R, 11R, 12R, 13S, 14R)-4-[(2, 6-dideoxy-3-C-methyl-3-
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VOL. 37 NO. 3 Key words: Drug allergy, LMIT, Penams, Cephems, Cross-reactivity
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VOL.42 S-1 methicillin-susceptible Staphylococcus aureus (MSSA), Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneum
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ペ ニ シ リ ン耐 性 肺 炎 球 菌 のPBPsとPBP2B遺 NO.11 VOL.42 お,PCR混 合 液AとB(そ ク ス にDNAポ 1227 伝 子 につ いて れ ぞ れの プ ライ マー ミ ッ リ メ ラ ー ゼ 等 を加 え た も の21))用 に,1 菌 株 につ き2本 の マ イ ク ロ チ ュ ー ブ を 準 備 し た チ ュ ー ブ は,Gene Amp PCR
8 The Bulletin of Meiji University of Integrative Medicine API II 61 ASO X 11 7 X-4 6 X m 5 X-2 4 X 3 9 X 11 7 API 0.84 ASO X 1 1 MR-angio
7-14 2010 1 1 1 2 1 1 1 2 Fontaine II ASO61 3 API ASO ASO ASO API API KKKKKKKKKK ASO Fontaine II API Received April 14, 2009; Accepted July 16, 2009 I arteriosclerosis obliterans: ASO ASO 50 70 1,2 Fontaine
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2001 2002 Guidelines for the Prevention and Treatment of Infective Endocarditis (JCS 2003) h 1 1 2 3 4 5 6 7 8 9 2 1 2 3 1 2 3 4 1 2 5 1 2 1 G Streptococcus viridans Streptococcus bovis 2 G Streptococcus
1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
Table 1. Antibacterial activity of azithromycin and other agents against gram-positive anaerobic bacteria and facultative anaerobic bacteria a Facultative anaerobic bacteria. Table 2. Antibacterial activity
Table 1 Sensitivity distribution of clinical isolates 1. Escherichia coli Inoculum size: 106cells/ml 2. Klebsiella pneumoniae 3. Enterobacter cloacae 4. Serratia marcescens Inoculum size: 106cells/nil
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VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml
CHEMOTHERAPY
CHEMOTHERAPY CHEMOTHERAPY Table 1 Antibacterial activity of BRL 28500 against standard strains of bacteria Fig, 1 Sensitivity distribution of ABPC-resistant E. coli isolated from urinary tract Fig. 2 Sensitivity
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Genus Corynebacteria Non-lipophilic The nonlipophilic bacteria may be classified as fermentative and non-fermentative: Fermentative Corynebacteria Cor
Corynebacterium kroppenstedtii Genus Corynebacteria Non-lipophilic The nonlipophilic bacteria may be classified as fermentative and non-fermentative: Fermentative Corynebacteria Corynebacterium diphtheriae