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1 1) ) 2.GERD GERD ) ) GERD GERD ) H2 PPI ) V. A. 1. Annual Review ) GERD ) ) Q A ) ) GERD VS VS PPI ) Plummer-Vinson Mallory-Weiss ) ) Helicobacter pylori PWV H. pylori

2 15) Crystal violet Barrett ) GERD ) ) ) ) ) ) ) ) ) ) Medical Practice ) GERD Barrett Barrett ) Mallory-Weiss ) Hamamoto S, Uchida Y, Wada T, Moritani M, Sato S, Hamamoto N, Ishihara S, Watanabe M, Kinoshita Y. Changes in serum lipid concentrations in patients with chronic hepatitis C virus positive hepatitis responsive or non-responsive to interferon therapy. Journal of Gastroenterology and Hepatology 20(2): , ) Hamamoto N, Hashimoto T, Adachi K, Hirakawa K, Ishihara S, Inoue H, Taniura H, Niigaki M, Sato S, Kushiyama Y, Suetsugu H, Miyake T, Kinoshita Y. Comparative study of nizatidine and famotidine for maintenance therapy of 2

3 erosive esophagitis. Journal of Gastroenterology and Hepatology 20(2): , ) Mihara T, Adachi K, Komazawa Y, Yoshida M, Araki A, Maruyama R, Furuta K, Ishihara S, Amano Y, Kinoshita Y. Characteristics of gastritis in patients with Helicobacter pylori-positive reflux esophagitis. Journal of Gastroenterology and Hepatology 20(5): , ) Amano Y, Kushiyama Y, Ishihara S, Yuki T, Miyaoka Y, Yoshino N, Ishimura N, Fujishiro H, Adachi K, Maruyama R, Rumi MAK, Kinoshita Y. Crystal violet chromoendoscopy with mucosal pit pattern diagnosis is useful for surveillance of short-segment Barrett's esophagus. American Journal of Gastroenterology 100(1): 21-26, ) Ishimura N, Bronk SF, Gores GJ. Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogeneisis. Gastroenterology 128: , ) 5-FU CDDP QOL AFP 9(1): 47-53, ) , ) , ) Sato S, Furuta K, Mishiro T, Miyake T, Kohge N, Akagi S, Adachi K, Kinoshita Y. Serum adiponectin concentration in patients with hepatitis C virus. Journal of Clinical Gastroenterology 39(8): , ) Adachi k, Komazawa Y, Mihara T, Azumi T, Fujisawa T, Katsube T, Furuta K, Kinoshita Y. Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and Famotidine. Journal of Gastroenterology and Hepatology 20(7): , ) Adachi K, Fujisawa T, Furuta K, Kinoshita Y. Reply: Helicobacter pylori and tolerance to H2-blockers. Alimentary Pharmacology and Therapeutics 21(3): , ) Imaoka T, Miyaoka Y, Nishi K, Takarada A, Fujishiro H, Ohara S, Takashima T, Adachi K, Kinoshita Y. Prevalence of noncardiac chest pain in Japanese patients with recurrent chest pain. Journal of Gastroenterology 40(9): , ) Adachi K, Hashimoto T, Komazawa Y, Mihara T, Furuta K, Fujishiro H, Ishihara S, Amano Y, Hattori S, Kinoshita Y. Helicobacter pylori infection influences s ymptomatic response to anti-secretory therapy in patients with GERD-crossover comparative study with famotidine and low-dose lansoprazole-. Digestive and Liver Disease 37(7): , ) Mishima I, Adachi K, Arima N, Amano K, Takashima T, Moritani M, Furuta K, Kinoshita Y. Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese. Scandinavian Journal of Gastroenterology 40(9): , ) Kinoshita Y, Hashimoto T, Kawamura A, Yuki M, Amano K, Sato H, Adachi K, Sato S, Oshima N, Takashima T, Kitajima N, Abe K, Suetsugu H. Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia. Alimentary Pharmacology and Therapeutics 21(Suppl2): 37-41, ) Fukuhara H, Ishihara S, Amano K, Miyake T, Kazumori H, Furuta K, Kushiyama 3

4 Y, Uchida Y, Fujishiro H, Rumi MAK, Amano Y, Adachi K, Kumakura S, Kinoshita Y. Hereditary spherocytosis in an elderly woman with periodic attacks of jaundice. Geriatrics and Gerontology International 5: , ) Yagi J, Adachi K, Arima N, Tanaka S, Ose T, Azumi T, Sasaki H, Sato M, Kinoshita Y. A prospective randomized comparative study on the safety and tolerance of transnasal esophagogastroduodenoscopy. Endoscopy 37(12): , ) Yoshino N, Ishihara S, Rumi MAK, Ortega-Cava CF, Yuki T, Kazumori H, Takazawa S, Okamoto H, Kadowaki Y, Kinoshita Y. Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa. American Journal of Gastroenterology 100(10): , ) Moritani M, Adachi K, Arima N, Takashima T, Miyaoka Y, Niigaki M, Furuta K, Sato S, Kinoshita Y. A study of arteriosclerosis in healthy subjects with HBV and HCV infection. Journal of Gastroenterology 40(11): , ) Kinoshita Y, Sato S. Burden and cost of treatment for GERD. Journal of Gastroenterology 40(11): , ) Ashizawa N, Sakai T, Yoneyama T, Naora H, Kinoshita Y. Three-dimensional structure of peripheral exocrine gland in rat pancreas: reconstruction using transmission electron microscopic examination of serial sections. Pancreas 31: , ) PPAR 9: , ) TRPV1 G.I. Research 13: , ) Yamao K, Salem AA, Sawaki A, Takahashi K, Mizuno N, Kawai H, Tajika M, Isaka T, Okamoto Y, Shimizu Y, Yanagisawa A. Pancreatic endocrine neoplasm can mimic serous cystadenoma. International Journal of Gastrointestinal Cancer 35(3): , ) Ishimura N, Gores GJ. The death receptor TRAIL in cancer cell apoptosis. Annals of Cancer Research and Therapy 13(1-2): 1-10, ) Imaoka H, Yamao K, Salem AA, Sawaki A, Takahashi K, Mizuno N, Kawai H, Tajika M, Isaka T, Okamoto Y, Shimizu Y, Yanagisawa A. Pancreatic endocerine neoplasm can mimic serous cystadenoma. International Journal of Gastrointestinal Cancer 35(3): , ) NSAIDs 20: , APT Digest Vol8, No.1 APT Digest 8(8): 4-5, Nikkei Medical 446: 56-57, common disease 20: 272, GERD H. pylori GERD DIGEST 2: 1-3, GERD Medicina 42: 7,

5 33 Medicina 42(1): 50-51, GERD Medicina 42(1): , H. pylori 94 : 83, : , : 138, GERD Medicina 42: , IBS) IBS 129: 7-10, (2): 10, Nikkei Medical 448: 48-49, PPI Medical Tribune 38(11): 16-17, : , GERD Physicians' Therapy Manual 3(1): APR, Nikkei Medical 4(Suppl1): 34-35, Therapeutic Research 26: , Nikkei Medical 450: 62-63, PPI MEDICAMENT NEWS 1838: 6-8, PPI H2RA 6 20: , PPI H2RA H 3 PPI H2RA 20(8): , GERD 8: , : 874, GERD , : ,

6 55 1 Gastrointestinal Endoscopy 47(8): , now 30: 4-5, GERD Mebio 22(9): 57-63, : 185, : , H. pylori 94: , MERD( 41: , FD Medical Tribune 38(44): 27, , ) NERD(non-erosive reflux disease 102(11): , ) H. pylori H. pylori LPS 63: 69-74, ) GERD Pharma Medica 23: 47-51, ) : , ) Kean Sobonna 1 25: 60-64, ) 1 11: 93-98, ) 20(7): , ) 54(7): , ) 102(6): ,

7 73) 1 20(2): , ) EUS-FNAB 41(3): , ) TS1 EUS TS1 26(6): , ) Barrett 13: S5-S8, ) Helicobacter pylori 15 Helicobacter Research 9(2): , ) Barrett Pharma Medica 23(11)31-35, ) H. pylori Mebio 22(1): 96-99, ) GERD GERD 42(1): 46-48, ) E Zoonosis E , ) 17: , ) Ortega-Cava CF, Ishihara S, Rumi MAK, MM Aziz, Kazumori H, Yuki T, Mishima Y, Moriyama I, Kadota C, Oshima N, Amano Y, Kadowaki Y, Ishimura N, Kinoshita Y. Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Clinical and Diagnostic Laboratory Immunology 13(1): , ) Fujishiro H, Adachi K, Imaoka T, Hashimoto T, Kohge N, Moriyama N, Suetsugu H, Kawashima K, Komazawa Y, Ishimura N, Ishihara S, Amano Y, Kinoshita Y. Ulinastatin shows preventive effect on post-ercp pancreatitis in multicenter prospective randomized study. Journal of Gastroenterology and Hepatology 21(6): , ) Mishiro T, Hamamoto S, Furuta K, Ishimura N, Rumi MAK, Miyake T, Sato S, Ishihara S, Adachi K, Kinoshita Y. Quantitative measurement of hepatitis B virus DNA in different areas of hepatic lobules in patients with chronic hepatitis B. Journal of Medical Virology 78(1): 37-43, ) Rumi MAK, Ishihara S, Aziz M, Kazumori H, Ishimura N, Yuki T, Kadota C, Kadowaki Y, Kinoshita Y. RNA polymerase II mediated transcription from the 7

8 polymerase III promoters in short hairpin RNA expression vector. Biochemical and biophysical research communications 339: , ) 27(2): 36-37, ) Tool-like receptor Helicobacter pylori Tool-like receptor G.I. Research 14(2): , ) Ishimura N, Amano Y, Furuta K, Ishihara S, Adachi K, Kinoshita Y. Poor inter-observer agreement for classification of endoscopic diagnosis of non-erosive esophagitis. Gastrointestinal Endoscopy 63: AB128, ) Kazumori H, Ishihara S, Rumi MAK, Kioshita Y. Bile salt augments of caudal-related homeobox gene Cdx1 expression in esophageal keratinocytes in Barrett's epithelium. Gastroenterology 130(4, Suppl 2): A-563, ) Fukuhara H, Kadowaki Y, Ose T, Ishihara S, Kinoshita Y. Role of Reg1 for regeneration after gastric mucosal injury: a lesson from transgenic mice. Gastroenterology 130(4, Suppl 2): A-713, ) Aziz MD, Ishihara S, Rumi MAK, Mishima Y, Oshima N, Kadota C, Moriyama I, Ishimura N, Kazumori H, Kadowaki Y, Kinoshita Y. Expression and localization of MFG-E8 in mice gut. Digestion 73(suppl 2): 44, ) Kazumori H, Ishihara S, Rumi MAK, Kadowaki Y, Kinoshita Y. Bile acids directry augment caudal-related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Digestion 73(suppl 2): 48, ) Miki M, Adachi K, Azumi T, Koshino K, Furuta K, Kinoshita Y. Low-dose of lansoprazole after breakfast and before dinner can equally inhibit gastric acid secretion. Digestion 73(suppl2): 55, ) Ose T, Kadowaki Y, Fukuhara H, Kazumori H, Ishihara S, Kinoshita Y. Reg1 knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine. Digestion 73(suppl 2): 64, ) Barrett 9: 79-83, ) 9: , ) NERD Mebio 23: , ) IBS) IBS 64: , ) 9: , ) FD) FD 8

9 Physician's Therapy Manual 3(4): AUG, ) GERD Gastroenterological Endoscopy 48: , ) GERD BIO Clinica 21: , ) 4: 34-42, ) 3: , ) : , ) : , ) , ) FGIDs 70: 1-10, ) 55: , ) 9 3: 69-73, ) Medical Practice 23: 515, ) Medical Practic 23: 701, ) NERD : 34-35, ) Helicobacter pylori Toll-like receptor G.I. Research 14: , ) : 53-68, ) Therapeutic Research 27: , ) Zollinger-Ellison Medical Practic 23: 882, ) 3 21: , ) Helicobacter pylori Tool-like receptor G.I. Research 14: , ) Medical Practic 23: 1067,

10 122) GERD NERD 4285: 57-61, ) NERD Mebio 23: , ) Medical Practic 23: 1251, ) ALPHA CLUB 289: 16, ) van Zanten V.S.J. Malfertheiner P Patient-Oriented 56: 49-56, ) One Point Advice Medical Practic 23: 1438, ) GERD ENTONI 65; 42-48, ) 8(6): , ) MEDICAMENT NEWS 1880: 16, ) World Wide Topics 3: , ) 1 Medical Practice 23: 1629, ) Mebio 23(10): 69-73, ) : 68-70, ) GERD 55: , ) 683: , ) 2 Medical Practice 23: 1803, ) 36(9): , ) 73: 18-20, ) Q and A 179: 6, ) Medical Practice 23: 1983, ) GERD 9: , ) GERD GERD 98: , ) Medicina 43(12): , ) 103(11): 110, ) Overview 3: 289, ) NERD gradem Medical Practice 23: 10

11 2141, ) 4311: 90-91, ) Functional dyspepsia 4: , ) now 35: 6, ) Ashizawa N, Hashimoto T, Miyake T, Shizuku T, Imaoka T, Kinoshita Y. Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? Journal of Gastroenterology and Hepatology 21: , ) Kazumori H, Ishihara S, Rumi MAK, Kadowaki Y, Kinoshita Y. Bile acids directly augment caudal-related homeobox gene Cdx2 expression in esophageal keratinosytes in Barrett's epithelium. Gut 55: 16-25, ) Furuta K, Adachi K, Komazawa Y, Mihara T, Miki M, Azumi T, Fujisawa T, Katsube T, Kinoshita Y. Tolerance to H2 receptor antagonist correlates well with the decline in efficacy against gastro-esophageal reflux in patients with GERD. Journal of Gastroenterology and Hepatology 21: , ) Katsube T, Adachi K, Furuta K, Miki M, Fujisawa T, Azumi T, Kushiyama Y, Kazumori H, Ishihara S, Amano Y, Kinoshita Y. Difference in localization of esophageal mucosal breaks among grades of esophagitis. Journal of Gastroenterology and Hepatology 21: , ) Takahashi Y, Amano Y, Yuki T, Ose T, Miyake T, Kushiyama Y, Sato S, Ishihara S, Kinoshita Y. Influence of acid suppressants on gastric emptying: cross-over analysis in healthy volunteers. Journal of Gastroenterology and Hepatology 21: , ) Wong B.C.Y, Kinoshita Y. Systematic review on epidemiology of gastro-oesophageal reflux disease in Asia. Clinical Gastroenterology and Hepatology 4: , ) Ishihara S, Rumi MAK, Ortega C, Kinoshita Y. Therapeutic targeting of tool-like receptors in gastrointestinal inflammation. Current Pharmaceutical Design 12: , ) Yuki T, Amano Y, Takahashi Y, Ose T, Moriyama I, Miyake T, Kushiyama Y, Furuta K, Ishihara S, Adachi K, Kinoshita Y. A case report of mucosal Barrett's cancer with vessel involvement, with special reference to indications for endoscopic mucosal ablation therapy. Esophagus 3: 19-22, ) Sato S, Miyake T, Mishiro T, Furuta K, Azumi T, Oshima N, Takahashi Y, Rumi MAK, Ishihara S, Adachi K, Amano Y, Kinoshiota Y. Kinetics of indocyanine green removal from blood can be used to predict the size of the area removed by radiofrequncy ablation of hepatic nodules. Journal of Gastroenterology and Hepatology 21: , ) Sato S, Furuta K, Miyake T, Mishiro T, Kohge N, Akagi S, Uchida Y, Rumi MAK, Ishihara S, Adachi K, Kinoshita Y. Hemolytic anemia during 24 weeks of ribavirin and interferon-alpha2b combination therapy does not influence the cardiac function of patients with viral hepatitis C. Journal of Clinical Gastroenterology 40: 88-89, ) Kinoshita Y, Kazumori H, Ishihara S. Treatment of PPI-resistant patients with GERD. Journal of Gastroenterology 41: ,

12 162) Amano Y, Kushiyama Y, Yuki T, Takahashi Y, Moriyama I, Fukuhara H, Ishimura N, Furuta K, Ishihara S, Adachi K, Maruyama R, Kinoshita Y. Prevalence of and risk factors for Barrett's esophagus with intestinal predominant mucin phanotype. Scandinabian Journal of Gastroenterology 41: , ) Yuki T, Amano Y, Kushiyama Y, Takahashi Y, Ose T, Moriyama I, Fukuhara H, Ishimura N, Koshino K, Furuta K, Ishihara S, Adachi K, Kinoshita Y. Evaluation of modified crystal violet chromoendoscopy procedure using new mucosal pit pattern classification for detection of Barrett's dysplastic lesions. Digestive and Liver Disease 38: , ) Kinoshita Y, Kobayashi T, Kato M, Asahina K, Haruma K, Shimatani T, Inoue S, Kabemura T, Kurosawa S, Kuwayama H, Ashida K, Hirayama M, Kiyama S, Yamamoto M, Suzuki J, Suzuki H, Matsumoto K, Aoshima M. The pharmacodynamic effect of omeprazole 10mg and 20mg once daily in patients with non-erosive reflux disease in Japan. Journal of Gastroenterology 41: , ) Tobita H, Kajino K, Inami K, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O. Gene expression profile of dbpa (DNA binding protein A) transgenic mice. International Journal of Oncology 29: , ) Kinoshita Y, Adachi K. Hiatal hernia and gastroesophageal flap valve as diagnostic indicators in patients with gastroesophageal reflux disease. Journal of Gastroenterology 41: , ) Furuta K, Adachi K, Kowari K, Mishima Y, Imaoka H, Kadota C, Koshino K, Miyake T, Kadowaki Y, Furuta K, Kazumori H, Sato S, Ishihara S, Amano Y, Honda M, Kinoshita Y. A Japanese case of eosinophilic esophagitis. Journal of Gastroenterology 41: , ) Yuki T, Ishihara S, Rumi MAK, Ortega-Cava Cesar F, Kadowaki Y, Kazumori H, Ishimura N, Amano Y, Moriyama N, Kinoshita Y. Increased expression of Midkine in the rat colon during healing of experimental colitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 291: G735-G743, ) Adachi K, Matsumori Y, Fujisawa T, Kamada T, Kusaka M, Ohumi T, Iwakiri R, Yamaguchi K, Danjo A, Hori K, Tomita T, HayashiT, Haruma K, Fujimoto K, Miwa H, Kinoshita Y. Symptomatic diversity of patients with reflux esophagitis: Effect of omeprazole treatment. Journal of Clinical Biochemistry and Nutrition 39: 46-54, ) Ose T, Kadowaki Y, Fukuhara H, Kazumori H, Ishihara S, Udagawa J, Otani H, Takasawa S, Okamoto H, Kinoshita Y. Reg -knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine. Oncogene 26: , ) Amano Y, Ishimura N, Furuta K, Takahashi Y, Chinuki D, Mishima Y, Moriyama I, Fukuhara H, Ishihara S, Adachi K, Kinoshita Y. Which landmark results in a more consistent diagnosis of Barrett's esophagus, the gastric folds or the palisade vessels? Gastrointestinal Endoscopy 64: , ) Ose T, Okita K, Takahashi Y, Moriyama I, Kazumori H, Ishihara S, Amano Y, Adachi K, Kinoshita Y. Esophageal intramural pseudodiverticulosis improved by endoscopic dilatation. Esophagus 3: 71-74, ) Terano A, Arakawa T, Sugiyama T, Yoshikawa T, Haruma K, Asaka M, Shimosegawa T, Sakai N, Ishii H, Sakamoto C, Takahashi S, Kinoshita Y, Fujioka T, Kobayashi K. A pilot study to evaluate a new combination therapy for gastric 12

13 ulcer: Helicobacter pylori eradication therapy followed by gastroprotective treatment with rebamipide. Journal of Gastroenterology and Hepatology 21: , ) Moriyama N, Amano Y, Okita K, Mishima Y, Ishihara S, Kinoshita Y. Localization of early stage dysplastic Barrett's lesion in patients with short segment Barrett's esophagus. American Journal of Gastroenterology 101: , ) Amano Y, Ishimura N, Furuta K, Okita K, Miki M, Azumi T, Ose T, Koshino K, Ishihara S, Adachi K, Kinoshita Y. Inter-observer agreement on classifying endoscopic diagnoses of non-erosive esophagitis. Endoscopy 38 : , ) Ashizawa N, Hamamoto N, Kinoshita Y. The morphological changes of pancreatic ducts in Otsuka Long-Evans Tokushima fatty rats. Pancreas 32: , ) Miki M, Adachi K, Azumi T, Koshino K, Furuta K, Kinoshita Y. A comparative study of intragastric acidity during post-breakfast and pre-dinner administration of low-dose proton pump inhibitors: a randomized three-way crossover study. Alimentary Pharmacology and Therapeutics 24: , ) Yamao J, Yajima H, kikuchi E, Matsumoto M, Nakayama M, Ann T, Kojima H, Mitoro A, Yoshida M, Yoshikawa M, Miyauchi Y, Ono H, Akiyama K, Sakurai G, Kinoshita Y, Haruma K, Takakura Y, Fukui H. Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy(force-famotidine Or Rebamipide in Comparison by Endoscopy). Journal of Gastroenterology 41: , ) Kinoshita Y. Recent trends of upper gastrointestinal diseases in Japan. Journal of Ningxia Medical College 28: 1, ) Amano Y, Chinuki D, Yuki T, Takahashi Y, Ishimura N, Kazumori H, Kushiyama Y, Rumi MAK, Ishihara S, Kinoshita Y. Efficacy of proton pump inhibitors for cellular proriferation and apoptosis in Barrett's oesophagus with different mucin phenotypes. Alimentary Pharmacology and Therapeutics 24(suppl.4): 41-48, ) modern Physician 26: , ) 26: , ) CMV) 1 12: 87-89, ) , ) GERD) 11: 1-4, ) GERD NERD 71: 1-8, ) 103: , ) NERD H2RA PPI The GI front 2(2): ,

14 189) Ishimura N, Isamoto H, Bronk SF, Gores GJ. Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 290(1): G , ) Baskin-Bey ES, Huang W, Ishimura N, Isamoto H, Bronk SF, Braley K, Craig RW, Moore DD, Gores GJ. Constitutive androstane receptor(car) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology 44(1): , ) 30(3): , ) 21 14(1): 12-16, ) Amano Y, Ishihara S, Yuki T, Moriyama N, Kinoshita Y. Reg expression in Barrett's esophagus.rregulatory Peptide 135(3): 116, ) 65(1): 38-43, ) 30(10): , ) Medical Practice 23( ): , ) 17(7): , ) 30(10): , ) 26(3): 1-6, ) Inflammatory Myofibroblastic Tumor IMT) 12: 77-85, ) NAFLD) 44(3): , ) 44(4): , ) Sawaki A, Mizuno N, Takahashi K, Nakamura T, Tajika M, Kawai T, Isaka T, Imaoka H, Okamoto Y, Inoue H, Aoki M, Salem A.A.S, Yatabe Y, Yamao K. Long-term follow up of patients with small gastrointestinal stromal tumors in the stomach using endoscopic ultrasonography-guided fine-needle aspiration biopsy. Digestive Endoscopy 18: 40-44, ) Imaoka H, Yamao K, Salem AA, Mizuno N, Takahashi K, Sawaki A, Isaka T, Okamoto Y, Yanagisawa A, Shimizu Y. Pseudomyxoma peritonei caused by acute 14

15 pancreatitis in intraductal papillary mucinous carcinoma of the pancreas. Pancreas 32: , ) Yamao K, Sawaki A, Takahashi K, Imaoka H, Ashida R, Mizuno N. EUS-guiuded choledochoduodenostomy for palliative biliary drainage in case of papillary obstruction: report of 2 cases. Gastrointestinal Endoscopy 64: , ) 21 18: , ) : , ) GERD Medical Tribune 39(21): 48-49, ) Review Article:8 Barrett Review of Gastroenterology&Clinical Gastroenterology and Hepatology 1: 66-69, ) Ishimura N, Bronk SF, Gores GJ. Inducible nitric oxide synthase upregulates Notch-1 in mouse cholangiocytes: implication for carcinogenesis. 96th Annual Meeting of the American Association for Cancer Research. Anaheim, USA, ) Yuji Amano, Takafumi Yuki, Yoshiko Takahashi, Daisuke Chinuki, Yoshinori Kushiyama, Shunji Ishihara, Yoshikazu Kinoshita. An evaluation of the factors for squamous re-epithelialization of Barrett's epithelium after endoscopic biopsy. 11th Taishotoyama International Symposium on Gastroenterology. Shimoda, Japan, ) Hideaki Kazumori, Shunji Ishihara, Mohammad A. Rumi, Yasunori Kadowaki, Yoshikazu Kinoshita. Bile acid directly augment caudal-related homeobox gene Cdx2 expression in esophageal keratinocytes in Barrett's epithelium. 106th Annual Meeting of the American Gastroenterological Association (DDW2005). Chicago, USA, Edwina Baskin-Bey, W. Huang, Norihisa Ishimura, Steven Bronk, Nathan Werneburg, D.D. Moore, Gregory Gores. Constitutive androstane receptor(car)ligand, TCPOBOP, blocks Fas-induced liver injury by reducing bax and bak. DIGESTIVE DISEASE WEEK 2005 (AASLD). Chicago, USA, ) Takayuki Ose, Yasumori Kadowaki, Hiroyuki Fukuhara, Shunji Ishihara, Yoshikazu Kinoshita. Reg knockout mice reveal its role in regulation of cell growth, that is required in generation and maintenance of the villous structure of small intestine. 106th Annual Meeting of the American Gastroenterological Association (DDW2005). Chicago, USA, ) Shunji Ishihara, Nagisa Yoshino, MAK Rumi, Takafumi Yuki, Hideaki Kazumori, Hiroyuki Fukuhara, Takayuki Oose, Yasunori Kadowaki, Kyoichi Adachi, Yuji Amano, Yoshikazu Kinoshita. Interleukin-8 regulates expression of Reg protein in Helicobacter Pylori-infected gastric mucosa. 106th Annual Meeting of the 15

16 American Gastroenterological Association (DDW2005). Chicago, USA, ) Kouichiro Furuta, Tomoko Mishiro, Tatsuya Miyake, Shuichi Sato, Kyoichi Adachi, Yoshikazu Kinoshita. Serum adiponectin concentration in patients with hapatitis C virus. 106th Annual Meeting of the American Gastroenterological Association (DDW2005). Chicago, USA, ) Adachi K, Katsube T, Furuta K, Miki M, Azumi T, Koshino K, Kinoshita Y. Difference in localization of esophageal mucosal breaks among grades of esophagitis. 10th WORLD CONGRESS OF THE INTERNATIONAL SOCIETY FOR DISEASES OF THE ESOPHAGUS. Adelaide, Australia, ) Furuta K, Adachi K, Komazawa Y, Mihara T, Miki M, Azumi T, Fujisawa T, Koshino K, Katube T, Kinoshita Y. Tolerance to H2 receptor antagonist correlates well with the decline in efficacy against gastro-esophageal reflux in patients with GERD. 10th WORLD CONGRESS OF THE INTERNATIONAL SOCIETY FOR DISEASES OF THE ESOPHAGUS. Adelaide, Australia, ) Ishimura N, Amano Y, Furuta K, Ishihara S, Adachi K, Kinoshita Y. Poor inter-observer agreement for classification of endoscopic diagnosis of non-erosive esophagitis. DIGESTIVE DISEASE WEEK 2006 (ASGE). LosAngeles, USA, ) Kazumori H, Ishihara S, Rumi MAK, Kinoshita Y. Bile salt augments caudal-related homeobox gene Cdx1 expression in esophageal keratinocytes in Barrett's epithelium. DIGESTIVE DISEASE WEEK LosAngeles, USA, ) Fukuhara H, Kadowaki Y, Ose T, Ishihara S, Kinoshita Y. Role of Reg I for regeneration after gastric mucosal injury: A lesson from transgenic mice. DIGESTIVE DISEASE WEEK 2006 (ASGE). LosAngeles, USA, ) M.D. Aziz, S. Ishihara, M.A.K. Rumi, Y. Mishima, N. Oshima, C. Kadota, I. Moriyama, N. Ishimura, H. Kazumori, Y. Kadowaki, Y. Kinoshita. Expression and localization of MFG-E8 in mice gut. 12th International Conference on Ulcer Research(ICUR)&GI Satellite of IUPHAR Osaka, Japan, ) H. Kazumori, S. Ishihara, M.A.K. Rumi, Y. Kadowaki, Y. Kinoshita. Bile acid directly augment caudal-related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. 12th International Conference on Ulcer Research(ICUR)&GI Satellite of IUPHAR Osaka, Japan, ) M. Miki, K. Adachi, T. Azumi, K. Koshino, K. Furuta, Y. Kinoshita. Low-dose of lansoprazole after breakfast and before dinner can equally inhibit gastric acid secretion. 12th International Conference on Ulcer Research (ICUR)&GI Satellite of IUPHAR Osaka, Japan, ) T. Ose, Y. Kadowaki, H. Furuta, H. Kazumori, S. Ishihara, Y. Kinoshita. Reg I knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous. 12th International Conference on Ulcer Research(ICUR)&GI Satellite of IUPHAR Osaka, Japan, ) Amano Y, Ishihara S, Yuki T, Moriyama N, Kinoshita Y. Reg expression in Barrett's esophagus. 16th Internatiinal Symposium on Regulatory Peptides. Hakone, Japan, ) 1 ESD 1 16

17 ) 2 H ) 6 GIST Gastrointestinal Stromal Tumor(GIST) ) Helicobacter pylori ) Reg ) ) ITP MALT lymphoma ) 20mm ) ) Maltoma ) Biotherapy Toll ) PPI Barrett ) 13C 17

18 ) X ) ) NAFLD ) C adiponectin ) GERD ) dsdna decoy ) Barrett Crystal violet Barrett HIV/HCV FibroScan

19 EUS-FNAB NSAID USAIDs user Crystal violet Barrett Barrett B C SLE/SSc over lap syndrome dbpa transgenic mouse NSAID

20 H2 famotidine H2 H2RA tolerance ESD ) GVHD

21 PPI) DNA microarray dbpa transgenic mouse growth factor Barrett HEV Zoonosis DDW-Japan HCV EUS-FNAB biliary stenting 70 21

22 ) ) ) ) ) ) ) ) ) Stage IV ) Low grade malignancy GIST 22

23 ) ) ) ) CEA ) ) ) ) ) ) ) ) ) 23

24 ) PPI) neuroendocrin carcinoma ) ) groove pancreatitis ) ) LES detecter ph monitor ) BRAVO ph ) ) ) ) I B ) I IFN 2 HCV dynamics vitamina )

25 ) ) ) ) ) PEMVest ) ) H2 H2RA)tolerance GERD ) Reg transgenic mouse ) HCV ) ) GERD ) 25

26 ) ) ) ) LESdetecter ph moniter ) PPI) ) ) CD5 B Toll ) Toll ) Cdx2 Barrett ) ) Minimal Change Barrett minimal change Barrett inter-observer variance ) Endoscopy Negative GERD(NERD) GERD NERD) ) AST ) 26

27 ) ) ) ) ) ) ) ) ) ) SAPHO ) ) ) malignant-gist )

28 158) ) ) ) Reai-time vietual sonography(rvs) ) Endocrine carcinoma ) ) GERD) MonoScan360TM 36ch ) Endoluminal gastroplication:elgp ) ) ) ) sm

29 170) ) expandable metallic stent(ems) ) GERD DDW-Japan 2006( 48 ) ) PPI DDW-Japan 2006( 48 ) ) Barrett FAS Fatty Acid Synthetase DDW-Japan 2006( 48 ) ) Barrett Cdx DDW-Japan 2006( 48 ) ) stage I ct1n0m0.ddw-japan 2006( 48 ) ) DDW-Japan 2006( 48 ) ) 70 DDW-Japan 2006( 48 ) ) Helicobacter pylori BMI DDW-Japan 2006( 48 ) ) NSAIDs DDW-Japan 2006( 48 ) ) Barrett Barrett DDW-Japan 2006( 48 ) ) DDW-Japan 2006( 48 ) ) 29

30 CD5 B B1 DDW-Japan 2006( 48 ) ) Low grade fibromyxoid sarcoma 1 DDW-Japan 2006( 48 ) ) PTGBA DDW-Japan 2006( 48 ) ) NF- B dsdna decoy DDW-Japan 2006( 48 ) ) DDW-Japan 2006( 48 ) ) DDW-Japan 2006( 48 ) ) 9 GAS ) ) B ) ) ) 30

31 ) ) S ) ) ) ) Bacterial Translocation ) ) Schwannoma ) B ) )

32 206) TS1 CDDP CR Stage IV ) ESD ESD ) ESD ESD ) ) T