慢性膵炎GL-01.qxd

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3 GERD GERD RCT CQ Delphi Fass R, Shapiro M, Dekel R, et al. Systematic review : proton-pump inhibitor failure in gastrooesophageal reflux disease--where next? Aliment Parmacol Ther ; 22 : - Lundell LR, Dent J, Bennett JR, et al. Endoscopic assessment of oesophagitis : clinical and functional correlates and further validation of the Los Angeles classification. Gut ; 45 : - Adachi K, Fujishiro H, Katsube T, et al. Predominant nocturnal acid reflux in patients with Los Angeles grade C and D reflux esophagitis. J Gastroenterol Hepatol ; 16 : - Vela MF, Tutuian R, Katz PO, et al. Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and ph. Aliment Pharmacol Ther ; 17 : - Vela MF, Camacho-Lobato L, Srinivasan R, et al. Simultaneous intraesophageal impedance and ph measurement of acid and nonacid gastroesophageal reflux : effect of omeprazole. Gastroenterology ; 120 : - Sifrim D, Mittal R, Fass R, et al. Review article : acidity and volume of the refluxate in the genesis of gastro-oesophageal reflux disease symptoms. Aliment Pharmacol Ther ; 25 : - 13

4 Xenos ES. The role of esophageal motility and hiatal hernia in esophageal exposure to acid. Surg Endosc ; 16 : -PMID : Fouad YM, Katz PO, Castell DO. Oesophageal motility defects associated with nocturnal gastro-oesophageal reflux on proon pump inhibitors. Aliment Pharmacol Ther ; 13 : - Grande L, Lacima G, Ros E, et al. Lack of effect of metoclopramide and domperidone on esophageal peristalsis and esophageal acid clearance in reflux esophagitis : a randomized, double-blind study. Dig Dis Sci ; 37 : - Gastroenterol Endosc ; 47 : - Amano K, Adachi K, Katsube T, et al. Role of hiatus hernia and gastric mucosal atophy in the development of reflux esophagitis in the elderly. J Gastroenterol Hepatol ; 16 : - 14

5 GERD Helicobacter pylorih. pylori GERD GERD H. pylori GERD H. pylori. CI.. GERD H. pylori GERD H. pylori GERD GERD H. pylori 15

6 GERD H. pylori.. Raghunath A, Hungin AP, Wooff D, et al. Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease : systematic review. BMJ ; 326 : Koike T, Ohara S, Sekine H, et al. Helicobacter pylori infection inhibits reflux esophagitis by inducing atrophic gastritis. Am J Gastroenterol ; 94 : - a Shirota T, Kusano M, Kawamura O, et al. Helicobacter pylori infection correlates with severity of reflux esophagitis : with manometry findings. J Gastroenterol ; 34 : - bharuma K, Hamada H, Mihara M, et al. Negative association between Helicobacter pylori infection and reflux esophagitis in older patients : case-control study in Japan. Helicobacter ; 5 : - 16

7 ph ph ph NERD GERD ph NERD LES GERD 17

8 Kraus BB, Sinclair JW, Castell DO. Gastroesophageal reflux in runners : characteristics and treatment. Ann Intern Med ; 112 : - Peters HP, De Kort AF, Van Krevelen H, et al. The effect of omeprazol on gastro-oesophageal reflux and symptoms during strenuous exercise. Aliment Pharmacol Ther ; 13 : - Pandolfino JE, Bianchi LK, Lee TJ, et al. Esophagogastric junction morphology predicts susceptibility to exercise-induced reflux. Am J Gastroenterol ; 99 : - 18

9 19

10 NERD GERD Barrett NERD GERD NERD Barrett NERD Barrett. NERD ph. NERD Barrett SF- QOL NERD QOL NERD GERD NERD GERD QOL GERD QOL NERD QOL GERD NERD NERD NERD sensitivity index Barrett NERD 20

11 Fass R, Shapiro M, Dekel R, et al. Systematic review : proton-pump inhibitor failure in gastro-oesophageal reflux disease--where next Aliment Parmacol Ther ; 22 : - Martinez SD, Malagon IB, Garewal HS, et al. Non-erosive reflux disease (NERD)-acid reflux and symptom patterns. Aliment Pharmacol Ther ; 17 : - Joh T, Miwa H, Higuchi K, et al. Validity of endoscopic classification of nonerosive reflux disease. J Gastroenterol ; 42 : - Pace F, Negrini C, Wiklund I, et al. Quality of life in acute and maintenance treatment of non-erosive and mild erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 22 : - Wada T, Sasaki M, Kataoka H, et al. Efficacy of famotidine and omeprazole in healing symptoms of non-erosive gastro-oesophageal reflux disease : randomized-controlled study of gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 21 (Suppl ) : - Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 18 : - Miwa H, Minoo T, Hojo M, et al. Oesophageal hypersensitivity in Japanese patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 20 (Suppl ) : - 21

12 CQ Barrett Barrett Barrett Barrett Barrett LSBE SSBE Barrett Barrett r.p.barrett cm Barrett Barrett 22

13 mg/ mg/ Barrett Barrett PPI Barrett Fass R, Hell RW, Garewal HS, et al. Correlation of oesophageal acid exposure with Barrett s oesophagus length. Gut ; 48 : - Peters FT, Ganesh S, Kuipers EJ, et al. Endoscopic regression of Barett s oesophagus during omeprazol treatment : a randomized double blind study. Gut ; 45 : - 23

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