Size: px
Start display at page:

Download ""

Transcription

1 Pharmacodynamics Itsuo Kodama of Amiodarone JPN. J. ELECTROCARDIOLOGY Vol.22 No

2

3

4

5

6

7

8

9 6) Kodama I, Kamiya K, Toyama J : Amiodarone : ionic and cellular mechanisms of action of the most promising Class III agent. Am J Cardiol,1999 ; 84 : 20R `28R 7) Nishimura M, Follmer CH, Singer DH : Amiodarone blocks calcium current in single guinea pig ventricular myocytes. J Pharmacol Exp Ther,1989 ; 251: 650 `659 8) Watanabe Y, Hama Y, Tamagawa M, Nakaya H : Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells. J Pharmacol Exp Ther,1996 ; 279: 617 `624 9) Mori K, Saito T, Masuda Y, Nakaya H : Effects of class III antiarrhythmic drugs on the Na+-activated K+ channel in guinea pig ventricular cells. Br J Pharmacol, 1996 ;119 :133 `141 10) Takizawa T, Nakaya H : Amiodarone inhibits cardiac ATP-sensitive K + (KATP) channels but retards hypoxic or ischemic myocardial contracture. Jpn J Pharmacol, 1997 ; 73 : 4511 ) Sato R, Koumi S, Singer DH, Hisatome I, Hongjun JIA, Eager S, Wasserstrom JA : Amiodarone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells. J Pharmacol Exp Ther,1994 ; 269: ) Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I : Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K + current. Circulation, 2001;103 :1317 `1324 1) The cardiac Arrhythmia Suppression Trial (CAST) Investigators : Preliminary report : effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med,1989 ; 321: 406 `421 2) The Cardiac Arrhythmia Suppression Trial II Investigators : Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med,1992 ; 327 : 227 `233 3) Waldo AL, Camm AJ, deruyter H, Friedman PL, MacNeil DJ, Pauls JF, Pitt B, Pratt CM, Schwartz PJ, Veltri EP : Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet, 1996 ; 348 : 7 `12 4) Amiodarone Trial Meta-analysis Investigators : Effect of prophylactic amiodarone on mortality after acute myocardial infarction and congestive heart failure: meta-analysis of individual data from 6500 patients in randomized trials. Lancet, 1997 ; 350: 1417 `1424 5) Kodama I, Kamiya K, Toyama J : Cellular electropharmacology of amiodarone. Cardiovasc Res, 1997; 35: 13 `29 13) Varro A, Virag L, Papp JG : Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes. Br J Pharmacol,1996 ;117 :1181 ` ) Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A : Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action. Circulation, 1999 ;100 : 690 `692 15) Watanabe Y, Kimura J : Inhibitory effect of amiodarone on Na +/Ca2 + exchange current in guinea-pig cardiac myocytes. Br J Pharmacol, 2000 ;131: 80 `84 16) Cheng J, Kamiya K, Kodama I : Carvedilol : molecular and cellular basis for its multifaceted therapeutic potential. Cardiovasc Drug Rev, 2001;19 :152 `171 17) Ide T, Tsutsui H, Kinugawa S, Utsumi H, Kang D, Hattori N, Uchida K, Arimura K, Egashira K, Takeshita A : Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Cric Res,1999 ; 85 : 357 `363 18) Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A : Direct evidence for increased JPN. J. ELECTROCARDIOLOGY Vol.22 No

10 hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res, 2000 ; 86 :152 `157 19) Kodama I, Suzuki R, Kamiya K, Iwata H, Toyama J: Effects of long-term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle. Br J Pharmacol,1992 ;107 : 502 `509 20) Matsumori A, Ono K, Nishio R, Nose Y, Sasayama S: Amoodarone inhibits production of tumor necrosis factor by human mononuclear cells : a possible mechanism for its effect in heart failure. Circulation, 1997 ; 96 :1386 ` ) Oral H, Fisher SG, Fay WP, Singh SN, Fletcher RD, Morady F : Effects of amiodarone on tumor necrosis factor-ƒ levels in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol,1999 ; 83 : 388 `391 22) Bosch RF, Li GR, Gaspo R, Nattel S : Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes. J Pharmacol Exp Ther,1999 ; 289: 156 `165 23) Drvota V, Bronnegard M, Haggblad J, Barkhem T, Sylvð n C : Downregulation of thyroid hormone receptor subtype mrna levels by amiodarone during catecholamine stress in vitro. Biochem Biophys Res receptor mrna are downregulated by amiodarone in mouse myocardium. J Cardiovasc Pharmacol,1999 ; 34: 261 `267 25) Guo W, Kamiya K, Toyama J : Evidence of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes. J Mol Cell Cardiol,1997 ; 29 : 617 `627 26) Members of the Sicilian Gambit : Antiarrhythmic therapy : a pathophysiological approach. Armonk. NY: Futura, ) Sun W, Sarma JSM, Singh B : Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart. Comparison with amiodarone. Circulation, 1999 ;100 : 2276 ` ) Varro A, Takacs J, Nemeth M, Hala O, Virag L, Iost N, Balati B, Agoston M, Vereckei A, Pstor G, Delbruyere M, Gautier P, Nisato D, Papp JG : Electrophysiological effects of dronedarone (SR33589), a noniodinated amiodarone derivative in the canine heart : comparison with amiodarone. Br J Pharmacol, 2001;133 : 625 `634 29) van Opstal JM, Schoenmakers M, Verduyn SC, de Groot SHM, Leunissen JDM, van der Hulst FF, Molenschot MMC, Wellens HJJ, Vos MA : Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT Commun,1995 ; 3 : 991 `996 lengthening in an animal model of acquired long-qt 24) Shahrara S, Drvota V : Thyroid hormone 1 and 1 syndrome. Circulation, 2001;104: 2722 ` JPN. J. ELECTROCARDIOLOGY Vol.22 No

1315 (15)

1315 (15) (14) 1315 (15) 1316 (16) 1317 (17) 1318 (18) 1319 (19) 1320 (20) 1321 (21) 1322 quinidine, disopyramide, and procainamide in isolated atrial myocytes : Mediation by 2) Inoue H, et al: Effects of pentisomide

More information

C/NC : committed/noncommitted

C/NC : committed/noncommitted C/NC : committed/noncommitted 110 time post-icd implant 1) The Cardiac Arrhythmia Suppression Trial (CAST) Investigators Preliminary report : Effect of encainaide and flecainide on mortality in a

More information

21-07_後藤論文.smd

21-07_後藤論文.smd 2015; 21: 5866 Yoichi Goto: Current status and future perspective of cardiac rehabilitation in Japan. J Jpn Coron Assoc 2015; 21: 5866 I 1 1 3 1 2 3 QOL 2 Fig. 1 1 196070 AMI AMI 1980 AMI CABG comprehensive

More information

body size no effect mechanical stress GH-IGF1 system + no effect? collagen production of fibroblasts + receptor + + Ia, Ib, II aldosterone renin angiotensin system Mechanical and Endocrinological

More information

”RŠœ15-3 #50 ‘¬’X 4“Z+

”RŠœ15-3 #50 ‘¬’X 4“Z+ 15 3 45 57 2000 QOL 1950 Cardiac Arrhythmia Suppression Trial 10 WPW 1 10 1990 1996 409-3898 1110 2000 5 23 2000 6 2 4 46 2 2 3 2 1 1 3 3 40 1 10 6 12 Cardiac Arrhythmia Suppression Trial CAST 4 1 3 CAST

More information

1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):

More information

HEART'S Original A case of Brugada syndrome with a high defibrillation threshold in which defibrillation was successful by Active Can off defibrillation Keisuke Kawachi, Yukei Higashi, Yuuki Honda, Kouhei

More information

Microsoft Word - 「黄砂とその健康影響について」小冊子180323版

Microsoft Word - 「黄砂とその健康影響について」小冊子180323版 ...1...1...1...2...4...4...4...6...7...7...7...7...8...8...9...9...10... 11... 11... 11... 11...12...12...13...16...18...20 1 1-1 1-2 1 1 km 24.5 m/s 10 50 m 1 1-3 μm 1-4 1-5 2 8 http://www.jma-net.go.jp/sat/himawari/obsimg/image_dust.html

More information

Noninvasive estimation of pulmonary capillary wedge pressure and cardiac output by the analysis of pulmonary venous flow velocity patterns in patients

Noninvasive estimation of pulmonary capillary wedge pressure and cardiac output by the analysis of pulmonary venous flow velocity patterns in patients Noninvasive estimation of pulmonary capillary wedge pressure and cardiac output by the analysis of pulmonary venous flow velocity patterns in patients with acute congestive heart failure Jung-Myung Lee,

More information

Sulfonylurea Receptors Pancreatic Type: SUR1 Cardiac Type: SUR2A Smooth Muscle Type: SUR2B Kir Channels uka-rp-1/kir6.1 BIR/Kir6.2 1) Ho K, et al : Cloning and expression of an inwardly rectifying ATP-regulated

More information

研究成果報告書

研究成果報告書 21 4 25 peroxynitrite angiotensin II ETA MEK/ERK pathway endothelin-1 EDHF (EDHF) EDHF EDHF EDHF 2 [phosphodiesterase 3 (PDE3) cilostazol metformin thromboxane A2 ozagrel eicosapentaenoic acid (EPA) angiotensin

More information

2

2 2 3 4 5 6 7 8 9 1 2 3 4 5 10 11 12 1 2 1 2 1 2 13 14 3 17 15 1 2 3 D Usefulness of Tc-99m MIBI SPECT in predicting multidrug resistance gene expression level in non-small cell lung cancer a preliminary

More information

CAST Na Vaughan Williams Sicilian Gambit 1996 Sicilian Gambit CD-ROM CD-ROM J-GAMBIT 1Sicilian Gambit CD-ROM

CAST Na Vaughan Williams Sicilian Gambit 1996 Sicilian Gambit CD-ROM CD-ROM J-GAMBIT 1Sicilian Gambit CD-ROM 20022003 Guidelines for Drug Treatment of Arrhythmias (JCS 2004) a 1Sicilian Gambit 2J-GAMBIT 3 1 2 3 4 5 6 7 8 9 Circulation Journal Vol. 68, Suppl. IV, 2004 1055 20022003 20 CAST Na Vaughan Williams

More information

437“ƒ

437“ƒ et al., et al., et al., et al., et al., et al., 2 et al., et al., et al., Lancet Pharmacol Res. et al. Jpn J Cancer Res. et al. Jpn J Cancer Res. et al. Tohoku J Exp Med. et al. Jpn Circ J. et al. Cancer

More information

- 1 -

- 1 - - 1 - 35:261-262 2005.12 35:153-154 2005.12-2 - 15500383 15-17 2006.3 [] 1 17(5):161-165 2005.5 32(3):130-134 2005.6 Synovial fringe 1 22(3):322 2005.10 Pancoast 56(13):1663-1666 2005.12 [] 22(5):788-795

More information

日本臨床麻酔学会 vol.34

日本臨床麻酔学会 vol.34 392 Vol.34 No.3/May 2014 日本臨床麻酔学会第 32 回大会シンポジウム日臨麻会誌 Vol.34 No.3, 392 396, 2014 長期予後を考えた周術期管理とは? 周術期虚血性心疾患とニコランジル * 木下浩之 [ 要旨 ] ニコランジル投与が狭心症患者の長期予後を改善することは周知の事実である. 一方で, ニコランジル周術期投与の有用性については, 数少ない臨床研究で検討されているにすぎない.

More information

15K00827 研究成果報告書

15K00827 研究成果報告書 (TG) TG sterol regulatory element- binding protein (SREBP)-1c (Diabetes 53:560-569, 2004) SREBP-1c (1) SREBP-1c SREBP-1c liver X receptor (LXR)LXR O-Glc NAc (O-linked -N-acetyl glucosamine) (J Biol Chem

More information

Key words: Chlorpromarine Open-chest dog heart myocardial shortening direct effect of heart muscle

Key words: Chlorpromarine Open-chest dog heart myocardial shortening direct effect of heart muscle Key words: Chlorpromarine Open-chest dog heart myocardial shortening direct effect of heart muscle Fig. 1 Hemodynamic changes by intracoronary infusion of CP 0.1mg/ml. Segment length curve was defined

More information

研究成果報告書

研究成果報告書 21 5 28 2007 2008 CARElk CARPXR CAR CAR EST cdna CAR CAR 10FCS 96 SW480 HepG2 anti-lamin A/C anti-phospho-histone H3 anti-cyclin D1 G1 anti-cyclin A S CAR lamin A/C CAR Fig. 1 Lamin A/C /G1 lamin A/C G1

More information

2009年133巻3号3月号.indb

2009年133巻3号3月号.indb Folia Pharmacol. Jpn.133 1 2 Chiroscience UCB S RR-..% AA C IC C/A A/ A R- II/ III II/III Chiroscience UCB S 1 - E-mail: koji_taya@maruishi-pharm.co.jp Author: Koji Taya, Satoshi Shimizu Title: Levobupivacaine

More information

Response of pre-and postoperative Glucose- Insulin-Kalium (GIK) loading in patients with valve replacement. Isao Sakashita*, Takeshi Ando*, Tetsunosuk

Response of pre-and postoperative Glucose- Insulin-Kalium (GIK) loading in patients with valve replacement. Isao Sakashita*, Takeshi Ando*, Tetsunosuk Response of pre-and postoperative Glucose- Insulin-Kalium (GIK) loading in patients with valve replacement. Isao Sakashita*, Takeshi Ando*, Tetsunosuke Matsukawa* *Department and Ken-ichi Asano*. of Thoracic

More information

9) Rankin, A. C., Rae, A. P., Oldroyd, K. G., et al.: Adenosine or adenosine triphosphate for supraventricular tachycardia? Circulation 78 (Suppl II): 500,1988. 10) Motte, G., Waynberger, M., Lebars, A.,

More information

1) Stallmann, F. W., and Pipberger, H. V.: Automatic recognition of electrocardiographic waves by digital computer. Circulation Research, 9, 1138, 1961. 2) Whitemen, J. R., Gorman, P. A., Calataynd, J.

More information

VOL. 36 S-3 CHEMOTHERAPY 437

VOL. 36 S-3 CHEMOTHERAPY 437 VOL. 36 S-3 CHEMOTHERAPY 437 438 CHEMOTHERAPY JULY 1988 Fig. 1 Contractile response of gastrointestinal tract to intravenous administration of saline and EM in interdigestive state in dogs (a) : Saline,

More information

3) Narula OS, Samet P, Javier RP: Significance of the Sinus-Node Recovery Time. Circulation 45: 140-158, 1972. 4) Dreifus LS, Michelson EL, Kaplinsky E: Bradyarrhythmias: Clinical Significance and Management.

More information

Effects of Acebutolol, a New Beta-receptor Blockade, on Premature Ventricular Contractions Nobutaka DOBA*1 Yoshiaki INAGAKI*2 and Shigeaki HINOHARA*1

Effects of Acebutolol, a New Beta-receptor Blockade, on Premature Ventricular Contractions Nobutaka DOBA*1 Yoshiaki INAGAKI*2 and Shigeaki HINOHARA*1 Effects of Acebutolol, a New Beta-receptor Blockade, on Premature Ventricular Contractions Nobutaka DOBA*1 Yoshiaki INAGAKI*2 and Shigeaki HINOHARA*1 *1 The Life Planning Center *2 The 3rd. Department

More information

22●24頁●6-16▲救急外来▲.ppt

22●24頁●6-16▲救急外来▲.ppt No. 98 No. 62 No. 92 No. 60 No. 61 No. 99 GQM No.172 A B GRMRM RM 4B 5 No.337 No.357 No.359 No.112 No.200 151226 25 No. 31 1461 30mg/dl 0.15mg/l mg/dl 20-50 51-100 101-200 201-300 301-400 401-450- 10 No.201

More information

Effect of Sympathetic and parasympathetic agents on cholesterol metabolism in mice salivary glands. Eriko, NEZU and Haruo, NAKAMURA (Department of Ora

Effect of Sympathetic and parasympathetic agents on cholesterol metabolism in mice salivary glands. Eriko, NEZU and Haruo, NAKAMURA (Department of Ora Effect of Sympathetic and parasympathetic agents on cholesterol metabolism in mice salivary glands. Eriko, NEZU and Haruo, NAKAMURA (Department of Oral Physiology, Hokkaido University School of Dentistry,

More information

*4 Drug Delivery System original article Cytodegenerative and growth-inhibitory effects on LY-80 cells by methotrexate and 5-fluorouracil in combinati

*4 Drug Delivery System original article Cytodegenerative and growth-inhibitory effects on LY-80 cells by methotrexate and 5-fluorouracil in combinati *4 Drug Delivery System original article Cytodegenerative and growth-inhibitory effects on LY-80 cells by methotrexate and 5-fluorouracil in combination with angiotensin II induced hyperten sion chemotherapy

More information

; cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml Mφ 6 7, 8 9

; cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml Mφ 6 7, 8 9 32, 21-25, 2012 CASLE 1 1 80 26 6 5 4 cm 1 2 CEA 3 4 CEA 2 44 22 2 3 1.5 cm 22 1. 1 ; 6 5 4 cm 4. ; 2. ; 3. ; 5. 2 ; 120 ng/ml 0-40 5 Mφ 6 7, 8 9 23 6. ; 9. ; 7. ; 10. ; 8. 7 10 CK3 CK3 24 1,2 3 2 8% 4,5

More information

慢性膵炎

慢性膵炎 - - 121 , g CCK g g - kgkcal kgkcal - g,,, - G.I.Res ; 10 : - ; 13 : - ; 22 : - Meier RF, Beglinger C. Nutrition in pancreatic diseases. Best Pract Res Clin Gastroenterol ; 20 : - Pfutzer RH, Schneider

More information

放射線ホルミシス太田成男

放射線ホルミシス太田成男 Key words: hormesis horme ( to excite) Radiation hormesis 1978 D 20! T.D. ( ), ( ) : (2011/08) 1,000 msv 3,000 400 (Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII-Phase 2 BEIR

More information

Juntendo Medical Journal

Juntendo Medical Journal The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical

More information

教室業績2014

教室業績2014 MFICU MFICU : - : - : -,,, : - : -- - : - : - : - - - : - - - - : - : - : - : -, : - Takano Y, Furukawa S, Ohashi M, Michikata K, Sameshima H, Ikenoue T J Obstet Gynaecol Res, : -, CTG - CTG - : - Katsuragi

More information

Upper limit of reference value of QT interval for rest electrocardiograms Hiroshi Goto, Noriaki Ikeda, Masuo Shirataka, Hideo Miyahara of healthy young Japanese men 13) Efron B, Tibshirani, RJ

More information

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書(案)

特殊病態下感染症における抗菌薬治験の手引き作成委員会報告書(案) VOL.51 NO.6 JUNE 2003 JUNE 2003 9) Niederman MS et al: Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy and prevention.

More information

1272 CHEMOTHERAPY MAR. 1975

1272 CHEMOTHERAPY MAR. 1975 1272 CHEMOTHERAPY MAR. 1975 VOL. 23 NO. 3 CHEMOTHERAPY 1273 Fig. 2 Minimal inhibitory concentration of aminoglycosides against 50 strains of Klebsiella Fig. 1 Minimal inhibitory concentration of aminoglycosides

More information

CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection

More information

9) Labori. H. Reaction oraganique a L dgres- 11) Honda M et al. Studies on the relationship between the brain and the heart as an electric rhythmical organ (V). regarding on the mechanism of myocardial

More information

スライド 1

スライド 1 QOL 1 Goldberg, JCO 22:23-30, 2004 N9741: Oxaliplatin in First Line (US) IR 200 mg/m 2 OX 85 mg/m 2 every 3 weeks Efficacy IFL FOLFOX4 > IFL IROX FOLFOX4 IROX OS TTP RR 15.0 mo 6.9 mo 31 % P=0.0001 P=0.0014

More information

日本皮膚科学会雑誌第121巻第11号

日本皮膚科学会雑誌第121巻第11号 β Clin Rheumatol Arthritis Rheum Am J Cardiol J Rheumatol J Rheumatol Arthritis Rheum Arthritis Rheum Arthritis Rheum Rheumatology Oxford Rheumatology Oxford Br J Dermatol Arch Dermatol Ann Rheum Dis

More information

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates

Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,

More information

岡山医学 会雑 誌 May 第116巻 特別 2004,pp.9-16 依頼原稿 心不全 にお ける酸化 ス トレス の関与:基 礎 的 な らび に臨床的検討 中 村 一 文a*,草 岡 山大 学医学 賞(結 城 賞)を 受賞 して 野 研 吾a,垣 下 幹 夫a,三 浦 綾a,久 松 研 一a 西 井 伸 洋a,伴 場 主 一a,渡 邊 敦 之a,藤 尾 栄 起a 宮 地 克 維a,永 瀬 田

More information

VOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence

More information

橡

橡 TP T-13i AST ALT ALP Y CTP LOH CHE CRP 8.7 id 0.4 mg/d 21 AWL 131U/L 257 LU/L 12 111/L 234 11J/L 344 IU/L 0.30 mid No K a BUN ORE UA 142 meq/1 4.3 meqa 108 meqa 15.8 met! 0.71 mg/di 5.0 mg/d CEA 5_5 n8/m1

More information

2) Dolphin, A., Jenner, P., Marsden, C,D., Pycock, C. and Tarsy, D. : Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodents, Psychopharmacologia, 41 : 133, 1975.

More information

GL_小川(聡)班_D.indd

GL_小川(聡)班_D.indd J-RHYTHM Pill-in-the-pocket Up-stream Circulation Journal Vol. 72, Suppl. IV, 2008 1639 Sicilian GambitSicilian Gambit CAST Sicilian Gambit Sicilian Gambit Sicilian Gambit Sicilian Gambit CD-ROM ACC/AHA/ESC

More information

08-g-”O−}„j‹ê-4.02

08-g-”O−}„j‹ê-4.02 200( 96 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 2 Apr. 585 1 17 MIC 1. (Transtracheal aspiration: TTA) TTA TTA TTA 1400 TTA (diffuse panbronchiolitis, DPB) 1) erythromycin(em) EM 12.5% 87.5% 2,3) EM EM

More information

橡'98寺尾班報告書.PDF

橡'98寺尾班報告書.PDF (OHSS) interleukin-8 (IL -8) 33 histamine prostaglandin angiotensin 8 IL-8 OHSS 1 IL-8 23 Wistar rat pregnant mare serum gonadotropin 10 unit 48 human chorionic gonadotropin(hcg) 10 unit IL-8 0.2, 2.0,

More information

TABLE 1. CHANGES IN HEMODYNAMIC PARAMETERS DURING EXERCISE Figure 1. Hemodynamic changes in right atrial pressure (RAP) bee, and after. Figure 2. Hemo

TABLE 1. CHANGES IN HEMODYNAMIC PARAMETERS DURING EXERCISE Figure 1. Hemodynamic changes in right atrial pressure (RAP) bee, and after. Figure 2. Hemo Yozu Ryohei, Inoue T, Shimomitsu T, Morilnoto T, Sugita Y, Watanabe T, Ishikawa M, Stacy G, Jacobs G, Harasaki H, Nose Y. EXERCISE RESPONSE IN CHRONIC NONPULSATILE (NPBVB) AND PULSATILE TAH ANIMALS. Treadmill

More information

多目的な障害予防のための「ニコニコ体操」

多目的な障害予防のための「ニコニコ体操」 "Enjoyable Exercises" as multipurpose prevention exercise Koji Yamashita1) Department of Physical Therapy, Faculty of Health Sciences, Aomori University of Health and Welfare 13)Marras WS, Ferguson

More information

4.4 R............................................. 13 4.5 q.............................................. 13 4.6 s....................................

4.4 R............................................. 13 4.5 q.............................................. 13 4.6 s.................................... 2014.04.12 2014.12.12 1 3 2 4 2.1............................................ 4 2.2 Einthoven triangle........................................ 4 2.3............................................ 4 2.4.............................................

More information

untitled

untitled 1 2 3 4 5 6 7 8 9 10 11 12 13 µ µ µ 14 15 16 17 1. Fabris P, Betterle C, Floreani A, Greggio NA, de Lazzari F, Naccarato R, Chiaramonte M: Development of type 1 diabetes mellitus during interferon alfa

More information

Clinical Study of Effect of Intrathecal Use of Alpha-tocopherol on Chronic Vasospasm Hirotoshi Sano, Motoi Shoda, Youko Kato, Kazuhiro Katada, Youichi

Clinical Study of Effect of Intrathecal Use of Alpha-tocopherol on Chronic Vasospasm Hirotoshi Sano, Motoi Shoda, Youko Kato, Kazuhiro Katada, Youichi Clinical Study of Effect of Intrathecal Use of Alpha-tocopherol on Chronic Vasospasm Hirotoshi Sano, Motoi Shoda, Youko Kato, Kazuhiro Katada, Youichi Shinomiya and Tetsuo Kanno Department of Neurosurgery,

More information

/‚“1/ŒxŒ{‚×›î’æ’¶

/‚“1/ŒxŒ{‚×›î’æ’¶ 60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:

More information

Measurements of cardiac troponin T in patients with heart failure Yukihito Sato, Toru Kita, Takeshi Kimura. *Department of Cardiovascular Medicine Gra

Measurements of cardiac troponin T in patients with heart failure Yukihito Sato, Toru Kita, Takeshi Kimura. *Department of Cardiovascular Medicine Gra Measurements of cardiac troponin T in patients with heart failure Yukihito Sato, Toru Kita, Takeshi Kimura. *Department of Cardiovascular Medicine Graduate School of Medicine, Kyoto University., 1)

More information

1) K. J. Laidler, "Reaction Kinetics", Vol. II, Pergamon Press, New York (1963) Chap. 1 ; P. G. Ashmore, "Catalysis and Inhibition of Chemical Reactio

1) K. J. Laidler, Reaction Kinetics, Vol. II, Pergamon Press, New York (1963) Chap. 1 ; P. G. Ashmore, Catalysis and Inhibition of Chemical Reactio 1) K. J. Laidler, "Reaction Kinetics", Vol. II, Pergamon Press, New York (1963) Chap. 1 ; P. G. Ashmore, "Catalysis and Inhibition of Chemical Reactions", Butterworths, London (1963) Chap. 7, p. 185. 2)

More information

Jpn. J. Clin. Immun., 13 (4) : 320 `327, 1990. The protective effects of Sho-saiko-to in an experimental, immunologically-induced allergic hepatic cell injury Yasuhiro Mizoguchi, Tohkan Shin, Norifumi

More information

研究成果報告書

研究成果報告書 500μm Before ATP After 10 Sikora J, Orlov SN, Furuya K, and Grygorczyk R (2015) Hemolysis is a primary and physiologically relevant ATP release mechanism in human. Blood 125: 1845 (Response to a letter)

More information

-1 - -2 - -3 - -4 - -5 - -6 - -7 - -8 - -9 - - 10 - -11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - - 19 - - 20 - - 21 - - 22 - - 23 - - 24 - - 25 - - 26 - - 27 - - 28 - - 29 - - 30 - - 31 - - 32

More information

5) Kawada T, Hagihara K, Iwai K (1986) Effects of capsaicin on lipid metabolism in rats fed a high fat diet. J Nutr 116 : 1272-8. 6) Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai K (1986) Capsaicin-induced

More information

32 1 BRONJ BRONJ II BRONJ BRONJ 4 BP BRONJ 6 1 III BP BRONJ

32 1 BRONJ BRONJ II BRONJ BRONJ 4 BP BRONJ 6 1 III BP BRONJ 29 1 31 40 2014 31 Bisphosphonate related osteonecrosis of jaw; BRONJ 2008 4 2012 3 36 98 8 11 19 BRONJ 0 13 2 5 3 1 1 0 BP 4 15 10 5 α-streptococcus 0 BRONJ BRONJ BP I Paget 1 409-3898 1110 2014 1 27

More information

passive passive active 1 ( ) LTP 1 1) 2) 1 1

passive passive active 1 ( ) LTP 1 1) 2) 1 1 11 8 25 passive passive active 1 ( ) LTP 1 1) 2) 1 1 1997 CA1 12 13 1990 2 K A K 1997 transient 3 transient 4-aminopyridine 4- AP A K A A [ 1 conductivity recording transient 4 ] 2 ( K ) i) A K CA1 A K

More information

1. Sugimura, T. and Fujimura, S.: Tumor production in glandular stomach of rat by N-methyl-N'-nitro- N-nitrosoguanidine. Nature, 216, 943-944, 1967. 2. Fujimura, S., Kogure, K., Sugimura, T. and Takayama,

More information

The Heart Healthy Tocotrienol Complex Tocomin SupraBio

The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio The Heart Healthy Tocotrienol Complex Tocomin SupraBio 1. Fact Sheet No. 317; World Health Organization (WHO), 2007 2. LLOYD-JONES D. et al. Circulation

More information

研究成果報告書

研究成果報告書 系 レニン 1. Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Muroya Y, Takashima K, Shimokawa H, Kohzuki M. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure.

More information

VOL. 17 NO. 7 CHEMOTHERAPY 1305 1) W. BRumFirr et al. : Clinical and laboratory studies with carbenicillin. Lancet 1: 1289~ 1293, 1967 2) E. T. KNUDSEN et al. : A new semisynthetic penicillin active against

More information

098青沼班DGfinal修正0506.indd

098青沼班DGfinal修正0506.indd 1 2011 Brugada QT 2005 2006 2007 Brugada Brugada 20 QT 70 2007 Brugada ICD ICD 5 2 QT Brugada 2012 QT QT QT Brugada Brugada 5 AHA/ACC ESC I II III A B C I II IIa IIb III A B C QT long QT syndrome LQTS

More information

untitled

untitled ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504

More information

VOL. 34 S-2 CHEMOTH8RAPY 913

VOL. 34 S-2 CHEMOTH8RAPY 913 VOL. 34 S-2 CHEMOTH8RAPY 913 914 CHEMOTHERAPY APR. 1986 Fig. 1 Chemical structure of T-2588 and T-2525 T- 2588 pivaloyloxymethyl (+ )- (6 R, 7 R)-7-[(Z)-2- (2-amino- 4-thiazolyl)-2-methox yiminoacetamido]-3-[(

More information

九州大学学術情報リポジトリ Kyushu University Institutional Repository 高齢心疾患患者における運動機能と身体的フレイル評価の意義 内藤, 紘一九州大学大学院人間環境学府 京都橘大学健康科学部 熊谷, 秋三九州大学大学院人間環境学府 九州大学基幹教育院 九州大

九州大学学術情報リポジトリ Kyushu University Institutional Repository 高齢心疾患患者における運動機能と身体的フレイル評価の意義 内藤, 紘一九州大学大学院人間環境学府 京都橘大学健康科学部 熊谷, 秋三九州大学大学院人間環境学府 九州大学基幹教育院 九州大 九州大学学術情報リポジトリ Kyushu University Institutional Repository 高齢心疾患患者における運動機能と身体的フレイル評価の意義 内藤, 紘一九州大学大学院人間環境学府 京都橘大学健康科学部 熊谷, 秋三九州大学大学院人間環境学府 九州大学基幹教育院 九州大学キャンパスライフ 健康支援センター https://doi.org/10.15017/1800856

More information

特別寄稿 PEDIATRIC CARDIOLOGY and CARDIAC SURGERY VOL. 26 NO. 4 ( ) Prospect of Pediatric Cardiac Surgery 50 年を振り返って Key word: prospect of pediatric

特別寄稿 PEDIATRIC CARDIOLOGY and CARDIAC SURGERY VOL. 26 NO. 4 ( ) Prospect of Pediatric Cardiac Surgery 50 年を振り返って Key word: prospect of pediatric 特別寄稿 PEDIATRIC CARDIOLOGY and CARDIAC SURGERY VOL. 26 NO. 4 (274 279) Prospect of Pediatric Cardiac Surgery 50 年を振り返って Key word: prospect of pediatric cardiac surgery, tetralogy of Fallot, single ventricle,

More information

PTCA CABG 2PTCA & CABG 3 4 PTCA CABG 1 2 3PTCA & CABG 4 5 PTCA CABG follow-up Japanese Circulation Journal Vol. 64, Suppl. IV, 2000

PTCA CABG 2PTCA & CABG 3 4 PTCA CABG 1 2 3PTCA & CABG 4 5 PTCA CABG follow-up Japanese Circulation Journal Vol. 64, Suppl. IV, 2000 19981999 JR PTCACABG 1 2 PTCA 3 PTCA 4 OP-CABG MID-CAB PTCACABG 1 PTCA PTCA CABG 2 1 PTCA PTCA PTCA PTCA PTCA 2CABG CABG CABG CABG 3PTCA CABG Japanese Circulation Journal Vol. 64, Suppl. IV, 2000 1009

More information

Medical Journal of Aizawa Hospital Medical Journal of Aizawa Hospital Vol. 10 (2012) Key words ö γ µ Graves disease and Hashimoto s thyroiditis are autoimmune thyroid diseases. Graves disease causes

More information

日本消化器外科学会雑誌第29巻第9号

日本消化器外科学会雑誌第29巻第9号 Table 1 Oligonucleotide primers used for RT-PCR and internal probes used for Southern blot hybridization Cytokine Primer Sequence (5'-3') 5' 3' Internal probe s' 3' Internal probe 5' 3' Internal probe

More information

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*,

Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, E mail : takaabe@mail.cc.tohoku.ac.jp Taro Tokui, Molecular identification of organic anion transporter

More information

02[021-046]小山・池田(責)岩.indd

02[021-046]小山・池田(責)岩.indd Developing a Japanese Enryo-Sasshi Communication Scale: Revising a Trial Version of a Scale Based on Results of a Pilot Survey KOYAMA Shinji and IKEDA Yutaka Toward exploring Japanese Enryo-Sasshi communication

More information

Key wards: cyclophosphamide, neutropenic mice, Pseudomonas aeruginosa, experimental pyelonephritis, G-CSF

Key wards: cyclophosphamide, neutropenic mice, Pseudomonas aeruginosa, experimental pyelonephritis, G-CSF Key wards: cyclophosphamide, neutropenic mice, Pseudomonas aeruginosa, experimental pyelonephritis, G-CSF Pseudomonas aeruginosa Fig. 1 Method of administration of cyclophosphamide and G-CSF CPM group

More information

BAANs理論に基づく保健指導プログラム暫定版

BAANs理論に基づく保健指導プログラム暫定版 WHO 4 5 10% L- -3 RNA L - 1960-3 RNA mrna Bio Activating Advanced Nutrients BAANs BAANs BAANs BAANs L- (NO) -3 EPA, DHA) RNA RNA DNA TNF- PAI-1 ( ) BAANs 40 50% 20% 1Kg 7,000Kcal 50Kcal 11 50Kcal

More information

Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,

More information

CHEMOTHERAPY APR. 1984

CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY dihydro-4-oxo-7-(1-piperazinyl)-1, 8-naphthyridine- CHEMOTHERAPY APR. 1984 VOL.32 S-3 CHEMOTHERAPY Table 1 Implantation rates and post- implantation survival rates in females mated

More information

Efficacy of Colestimide as a phosphate binder in patients on chronic hemodialysis Toshiyuki Date, Yoshiteru Kawashita, Nobuyoshi Satake Jin-ai-kai Dat

Efficacy of Colestimide as a phosphate binder in patients on chronic hemodialysis Toshiyuki Date, Yoshiteru Kawashita, Nobuyoshi Satake Jin-ai-kai Dat Efficacy of Colestimide as a phosphate binder in patients on chronic hemodialysis Toshiyuki Date, Yoshiteru Kawashita, Nobuyoshi Satake Jin-ai-kai Date Clinic In some patients on chronic hemodialysis,

More information

老人性不整脈

老人性不整脈 資料 : QOL CHADS NOAC はじめに common disease 高齢者の不整脈の頻度, AF AVB RBBB LBBB Cardiovascular Health Study, 137 表 1 Outpatient Atarashi Cardiovascular Health Study Monolio No F M Ectopic beats Supraventricular.

More information

_’£”R‡Ù‡©

_’£”R‡Ù‡© 29 31 38 2008 31 1) 2) 2) 3) 2) 1) 2008 302008 12 Activities of Daily Living ADL ADL 42 ADL ADL 1990 QOL Quality of Life QOL 1 QOL // 2 Activity of Daily Living ADL Performance Status PS ADL 3 1) 2) 3)

More information

2001 2003 2005 2006 2007 2008

2001 2003 2005 2006 2007 2008 2001 2003 2005 2006 2007 2008 60 etc. http://nosmoke.hp.infoseek.co.jp/yuugaibussitu.htm http://nosmoke.hp.infoseek.co.jp/yuugaibussitu.htm 23.5% 2.8% 2.8% 3.4% 30.3% 9.9% 11.5% 15.8% AAN 65

More information

審査報告書(案)

審査報告書(案) 19 83 7 18 628 1 19 8 3 7 18 6 28 30 MI 31 360 21700BZY00247000 5mm CEA 59 mm 2 50% 80 1. 2. 3 19 8 3 [ ] 7 [ ] [ ] [ ] [ ] 18 6 28 [ ] CEA 49mm 50 80 2 4 carotid endarterectomy CEA 1,2 CEA ECST 3 NASCET

More information

小児感染免疫第23巻第1号

小児感染免疫第23巻第1号 Vol. 23No. 163 42 HPV HPV 1113 HPV 42 HPV HPV HPV 1 1 510 1020 HPV 1020 510 HIV 0.1 0.005 HIV 2030 HIV 0.2 510 HPV 1020 15 HIV 2030 HIV HIV 0.2 0.1 Takeyuki Sato 2608677 181 64 2011 2 1 1518 6,000 513

More information

drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:

More information

9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00

9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00 9 : 00 11 : 00 12 : 00 12 : 10 12 : 50 13 : 30 14 : 40 16 : 00 17 : 00 ポスターについて 1. ポスター 貼 付 用 の 展 示 ボードは 縦 180 横 90cm の 大 きさです 2. 演 題 名 発 表 者 名 所 属 を 明 記 したもの(20 70cm) をご 用 意 ください 実 際 使 用 できるスペースは 155

More information

スライド 1

スライド 1 1 2006 msv 2 2011 3 CT 2011 10mSv 10 40mSv 4 2012 217mSv 5 (CT) 2012 50 60mSv 6 2012 510mSv BRCA25 310 10mSv3% BRCA60-280% 3 5m Sv 1m Sv 12% . http://www.rea.or.jp/ire/pdf/report4.pdf 1.10 20 SMR 1.00

More information

CHEMOTHERAPY JUNE 1986

CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml

More information

(1) Fujioka T, Nara F, Tsujita Y, Fukushige J, Fukami M and Kuroda M: The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor,

More information

untitled

untitled 1) American College of Surgeons:Advanced Trauma Life Support Course Manual. American College of Surgeons 1997;103-112 24 2) American Society of Anesthesiologists Task Force:Practice guideline for blood

More information

Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein

More information

Department of Anatomy & Developmental Biology and Centre for Neuroscience, Universiy College London Geoffrey Burnstock PURINERGIC SIGNALLING: HISTORICAL OVERVIEW AND CURRENT DEVELOPMENTS by Professor

More information

Study of the "Vortex of Naruto" through multilevel remote sensing. Abstract Hydrodynamic characteristics of the "Vortex of Naruto" were investigated b

Study of the Vortex of Naruto through multilevel remote sensing. Abstract Hydrodynamic characteristics of the Vortex of Naruto were investigated b Study of the "Vortex of Naruto" through multilevel remote sensing. Abstract Hydrodynamic characteristics of the "Vortex of Naruto" were investigated based on the remotely sensed data. Small scale vortices

More information

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F

coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, F VOL.43 S-1 coccus aureus Corynebacterium sp, Haemophilus parainfluenzae Klebsiella pneumoniae Pseudornonas aeruginosa Pseudomonas sp., Xanthomonas maltophilia, Flavobacter- Table 1. Concentration of grepafloxacin

More information

123 昭 和49年4月20日 写 真4 写 真1 写 真2 指摘 が最 初 の もの と思 わ れ る. イ菌 感 染症 は イ菌 が 抗 生 剤 に 感 受 性 を 有 す る限 り,そ の化 学 療 法 効 果 が 期 待 出 来 るが,化 学 療 法 を 中 止す る と再 度 出現 す る症 例 が 多 い こ とに気 付 き,エ コ ロジ カル に検 討 した と ころ,三 病型 に分

More information