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1 Pharmacodynamics Itsuo Kodama of Amiodarone JPN. J. ELECTROCARDIOLOGY Vol.22 No
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9 6) Kodama I, Kamiya K, Toyama J : Amiodarone : ionic and cellular mechanisms of action of the most promising Class III agent. Am J Cardiol,1999 ; 84 : 20R `28R 7) Nishimura M, Follmer CH, Singer DH : Amiodarone blocks calcium current in single guinea pig ventricular myocytes. J Pharmacol Exp Ther,1989 ; 251: 650 `659 8) Watanabe Y, Hama Y, Tamagawa M, Nakaya H : Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells. J Pharmacol Exp Ther,1996 ; 279: 617 `624 9) Mori K, Saito T, Masuda Y, Nakaya H : Effects of class III antiarrhythmic drugs on the Na+-activated K+ channel in guinea pig ventricular cells. Br J Pharmacol, 1996 ;119 :133 `141 10) Takizawa T, Nakaya H : Amiodarone inhibits cardiac ATP-sensitive K + (KATP) channels but retards hypoxic or ischemic myocardial contracture. Jpn J Pharmacol, 1997 ; 73 : 4511 ) Sato R, Koumi S, Singer DH, Hisatome I, Hongjun JIA, Eager S, Wasserstrom JA : Amiodarone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells. J Pharmacol Exp Ther,1994 ; 269: ) Kamiya K, Nishiyama A, Yasui K, Hojo M, Sanguinetti MC, Kodama I : Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K + current. Circulation, 2001;103 :1317 `1324 1) The cardiac Arrhythmia Suppression Trial (CAST) Investigators : Preliminary report : effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med,1989 ; 321: 406 `421 2) The Cardiac Arrhythmia Suppression Trial II Investigators : Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med,1992 ; 327 : 227 `233 3) Waldo AL, Camm AJ, deruyter H, Friedman PL, MacNeil DJ, Pauls JF, Pitt B, Pratt CM, Schwartz PJ, Veltri EP : Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet, 1996 ; 348 : 7 `12 4) Amiodarone Trial Meta-analysis Investigators : Effect of prophylactic amiodarone on mortality after acute myocardial infarction and congestive heart failure: meta-analysis of individual data from 6500 patients in randomized trials. Lancet, 1997 ; 350: 1417 `1424 5) Kodama I, Kamiya K, Toyama J : Cellular electropharmacology of amiodarone. Cardiovasc Res, 1997; 35: 13 `29 13) Varro A, Virag L, Papp JG : Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes. Br J Pharmacol,1996 ;117 :1181 ` ) Ide T, Tsutsui H, Kinugawa S, Utsumi H, Takeshita A : Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action. Circulation, 1999 ;100 : 690 `692 15) Watanabe Y, Kimura J : Inhibitory effect of amiodarone on Na +/Ca2 + exchange current in guinea-pig cardiac myocytes. Br J Pharmacol, 2000 ;131: 80 `84 16) Cheng J, Kamiya K, Kodama I : Carvedilol : molecular and cellular basis for its multifaceted therapeutic potential. Cardiovasc Drug Rev, 2001;19 :152 `171 17) Ide T, Tsutsui H, Kinugawa S, Utsumi H, Kang D, Hattori N, Uchida K, Arimura K, Egashira K, Takeshita A : Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. Cric Res,1999 ; 85 : 357 `363 18) Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A : Direct evidence for increased JPN. J. ELECTROCARDIOLOGY Vol.22 No
10 hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res, 2000 ; 86 :152 `157 19) Kodama I, Suzuki R, Kamiya K, Iwata H, Toyama J: Effects of long-term oral administration of amiodarone on the electromechanical performance of rabbit ventricular muscle. Br J Pharmacol,1992 ;107 : 502 `509 20) Matsumori A, Ono K, Nishio R, Nose Y, Sasayama S: Amoodarone inhibits production of tumor necrosis factor by human mononuclear cells : a possible mechanism for its effect in heart failure. Circulation, 1997 ; 96 :1386 ` ) Oral H, Fisher SG, Fay WP, Singh SN, Fletcher RD, Morady F : Effects of amiodarone on tumor necrosis factor-ƒ levels in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol,1999 ; 83 : 388 `391 22) Bosch RF, Li GR, Gaspo R, Nattel S : Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular myocytes. J Pharmacol Exp Ther,1999 ; 289: 156 `165 23) Drvota V, Bronnegard M, Haggblad J, Barkhem T, Sylvð n C : Downregulation of thyroid hormone receptor subtype mrna levels by amiodarone during catecholamine stress in vitro. Biochem Biophys Res receptor mrna are downregulated by amiodarone in mouse myocardium. J Cardiovasc Pharmacol,1999 ; 34: 261 `267 25) Guo W, Kamiya K, Toyama J : Evidence of antagonism between amiodarone and triiodothyronine on the K+ channel activities of cultured rat cardiomyocytes. J Mol Cell Cardiol,1997 ; 29 : 617 `627 26) Members of the Sicilian Gambit : Antiarrhythmic therapy : a pathophysiological approach. Armonk. NY: Futura, ) Sun W, Sarma JSM, Singh B : Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart. Comparison with amiodarone. Circulation, 1999 ;100 : 2276 ` ) Varro A, Takacs J, Nemeth M, Hala O, Virag L, Iost N, Balati B, Agoston M, Vereckei A, Pstor G, Delbruyere M, Gautier P, Nisato D, Papp JG : Electrophysiological effects of dronedarone (SR33589), a noniodinated amiodarone derivative in the canine heart : comparison with amiodarone. Br J Pharmacol, 2001;133 : 625 `634 29) van Opstal JM, Schoenmakers M, Verduyn SC, de Groot SHM, Leunissen JDM, van der Hulst FF, Molenschot MMC, Wellens HJJ, Vos MA : Chronic amiodarone evokes no torsade de pointes arrhythmias despite QT Commun,1995 ; 3 : 991 `996 lengthening in an animal model of acquired long-qt 24) Shahrara S, Drvota V : Thyroid hormone 1 and 1 syndrome. Circulation, 2001;104: 2722 ` JPN. J. ELECTROCARDIOLOGY Vol.22 No
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