35 ( 4 ) : 371 `382, 1985

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1 35 ( 4 ) : 371 `382, 1985

4 Effect of norepinephrine infusion (400 ng / min per kg) on mean arterial pressure, and the influence of concurrent infusions of subpressor and pressor doses of angiotensin II Three-day clipped rabbits (n= 6). See Figure 2 for description. ** = p<01 when compared to the pressor response to norepinephrine before infusion of the angiotensin II antagonist. Normal rabbits (n = 6). Effect of norepinephrine infused at 800 ng/ min per kg body wt (NE 800) on mean arterial pressure before and during infusion of the angiotensin II (A-II) antagonist, (1-sarcosine, 8-isoleucine) angiotensin II. Values are means±sem. Chronic renal hypertensive rabbits (n = 6). See Figure 2 for description. * =P <0.05 when compared to the pressor response to norepinephrine before infusion of the angiotensin II antagonist.

5 Cardiovascular effects of intravenous infusion of 5 mu Emin-"kg body wt-1 arginine vasopressin (AVP) in 8 one-kidney control rabbits and in 8 additional one-kidney control rabbits receiving infusion of 1 pg/ min [Sarl, Iles] -angiotensin II (A II). **= P<0.01, value during AVP infusion was different from preinfusion value. TPR, total peripheral resistance. Pressor responses to norepinephrine (800 ng 1 min 1 kg body weight) at the beginning of the experiment (first open bar), during captopril (SQ 14,225) (second open bar), and during captopril plus angiotensin II (A -II) infusions at 0.5, 1.0, and 2.0 ng I min/ kg body weight (shaded bars) in one -kidney, one clip (3-day) rabbits. Bars represent means } SEM for six rabbits. ** = P<0.01 and * = p <0.05 that the pressor response is less than during the control period. Cardiovascular effects intravenous infusion of 5 mu Emin-1 Ekg body wt" arginine vasopressin (AVP) in 8 one-kidney rabbits with renal artery stenosis of 3 days duration and in 8 additional one-kidney rabbits with renal artery stenosis of 3 days plus infusion of lyg/min [Sae, Ile8] angiotensin II (A II). **P <0.01, value during AVP infusion was different from preinfusion value. TPR, total peripheral resistance.

6 Effect of intravenons infusion of norepinephrine (NE) on pressor response before and during intravenous v.) of AIIA infusion (i. Mean Arterial Pressure (MAP) and Heart Rates (HR) in 2-day clipped and sham -operated rats. Effect of intravenous infusion of arginine vasopressin (AVP) on pressor response before and during intravenons v.) of A II A. infusion (i.

9 Mean Arterial Pressure (MAP) and Heart Rates (HR) in 2-day clipped and sham -operated rats. Effect of intravenous infusion of norepinephrine (NE) on pressor response before and during intraventricular (IVT) of Saralasin. infusion Effect of intraventricular Saralasin infusion (IVT) of on plasma renin activity (PRA). Effect of intravenous infusion (IV) of norepinephrine (NE) on pressor response before and during intravenous infusion of Saralasin (Sar.)

11 1) Ichikawa, S. et al. : Pressor responses to tensin II. Circ. Res., 43 : , ) Johnson, J.A. et al. : Pressor responses to vasopressin in rabbits with 3-day renal artery stenosis. Am. J. Physiol., 240 : H862-H867, ) Matsuo, H. et al. : The effect of the central iso-renin angiotensin system on pressor responsiveness to angiotensin II. Life Sci., 28 : , ) Khairallah P.A. et al. : Effects of angiotensin infusion on catecholamine uptake and reactivity in blood vessels. Circ. Res., 28/29 (suppl II) : , ) Sato, R. and Masuyama, Y.: Interaction of angiotensin and noradrenaline in rat's hindlimb preparation. Jpn. Circ. J., 35 : , ) Zimmerman, B.G. et al. : Action of angiotensin on vascular adrenergic nerve endings : Facilitation of norepinephrine release. Fed. Proc., 31 : , ) Zimmerman B.G.: Blockade of adrenergic potentiating effect of angiotensin II by 1-sar Ther. 185 : , ) Koivunen, D.G. et al. : Pressor responses to norepinephrine during captopril in renal prehypertensive rabbits. Hypertension, 5 : , ) Malik, K.U. and MacGiff, J.C. : Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat norepinephrine in rabbits with 3-day and 30 kidney. Circ. Res., 36 : , ) Armstrong, J.M., et al. : Effect of prostaglandin (PGI 2), 6-oxo PGF1 a and PGE 2 on sympathetic nerve function in mesenteric arteries and veins of the rabbit in vitro. Hypertension, 1 : , ) Yoshimura, N. et al. : The role of prostaglandins in the regulation of blood pressure with special reference to vascular reactivity. Jpn. Circ. J., 48 : , ) Ferrario, C.M. et al. : Cardiovascular effects of angiotensin mediated by the central nervous system. Circ. Res., 30 : , ) Jandhyala, B.S., et al. : Circulatory effects of chronic administration of angiotensin II into the cerebrolateral ventricles of dogs. Hypertension, 1 : , ) Fink, G.D., et al. : Effects of chronic intracerebro-ventricular infusion of angiotensin II on arterial pressure and fluid homeostasis. Hypetension, 4 : , ) Michelakis, A.M. et al. : Further studies on the exsistence of a sensitizing factor to pressor agents in hypertension. J. Clin. Endocrinol. Metab., 41 : 90-96, ) Skeggs, L.T. et al. : Chronic one-kidney

12 hypertension in rabbits. III. Renopressin, a new hypertensive substance. Circ. Res., 40 : , ) Self, L. E. et al. : A vasopressor potentiator for norepinephrine in hypertensive rats. Proc. Soc. Exptl. Biol. Med., 153 : 7-12, ) Brown, C.B. et al. : A smooth muscle active factor isolated from renal cortex of the rabbit. Am. J. Physiol., 232 : F84-F91, ) Susic, H. and Malik, K.U. : Attenuation by arachidonic acid of the effect of vasoconstrictor stimuli in the canine kideny. J. Phamacol. Exp. Ther., 219 : , ) Nasjletti, A. and Malik, K.U. : Interrelations between prostaglandins and vasoconstrictor hormones : contribution to blood pressure regulation. Fed. Proc., 41: , ) Ichikawa, S. et al. : Pressor response to norepinphrine in rabbits with 3-day renal artey stenosis. The role of prostaglandins. (Abstract). The 13th Conference on the Pathogenesis of Hypertension. Jpn. Circ. J., 48 : , ) Yu, R. and Dickinson, C.J. : Progressive pressor response to angiotensin in the rabbit : Role of the sympathetic nervous system. Arch. Int. Pharmacodyn. Ther., 191 : 24-36, ) Fukiyama, K. et. al. : Chronic hypertension elicited by infusion of angiotensin into the vertebral arteries of unanesthetized dogs. Clin. Sci., 40 : , ) Johnson, J.A. et al. : Fluid volumes and pressor responsiveness in two-kidney rabbits with renal artery stenosis. Am. J. Physiol., 243 : H779-H787, ) Aizawa, F. et al. : Existence of potentiating principle extracted from renal cortex of humans for responses of vasoactive substances on rabbit aortic strips. (Abstract). Clin. and Exp. Hyper.-Theroy AS : , and Practice, 29) Sato, K. et al. : A new vasoactive substance extracted from the renal cortex of rabbits. (Abstract). Jap. Circ. J., 47 : 965, ) Johnson, J.A. et al. : Humoral factor in pressor hyperresponsiveness in renal prehypertensive rabbits. Hypertension, 5 : ) Haddy, F.J. et al. : Humoral factors and the sodium-potassium pump in volume expanded hypertension. Life Sci., 24 : ) Blaustein, M.P. : Sodium ions, calcium ions, blood pressure regulation, and hypertension : a reassessment and a hypothesis. Am. J. Physiol., 232 : C165-C173, ) De. Wardner, H.E. and MacGregor, G.A. : The relation of a circulating sodium transport inhibitor (the natriuretic hormone?) to hypertension. Medicine, 62 : , ) Sakamaki, T. et al. : Pressor hyperresponsiveness in saline-infused rabbits. Hypertension, 6 : , ) Pamnani M, et al. : Demonstration of a humoral inhibitor of the Na-K pump in some models of experimental hypertension. Hypertension, 3 (suppl II) : , ) Haddy, F.J. : Abnormalities of membrane transport in hypertension. Hypertension, 5 (suppl V) : V-66-V-72, ) Kurz, K.D. et al. : Fluid volumes in one Proc. Soc. Explt. Biol. Med., 168 : , ) Flynn, T.G. et al. : The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties. Biochem. Biophys. Res. Commun., 117 : , ) Kangawa, K. and Matsuo H. : Purification and complete amino acid sequence of ƒ 118 : , 1984.

研究成果報告書

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