1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5 log Pow-1.52 5 6 0.18 1, 2-5 m/z 58 1.0 31 0.17 27 0.51 7 8 Koc = 30 Pow 40.5 % w/w20 2 1 ppm = 2.41 mg/m 3, 20 1 mg/m 3 = 0.414 ppm O
2 2. 5 157,977 t 157,977 t 0 9 1 3. 1 10 4 100 30 mg l mg l BOD 9398 % OH = 0.451.310-12 cm 3 / sec 11 = 0.5210-12 cm 3 / sec 25 12 OH = 510 5 110 6 /cm 3 1531 = 1.410-8 l / secoh = 10-17 /cm 3 15.7 12 1,2- ph 7-9 11.6 ph 5 6.6 3% NaCl ph 7-9 4.1 ph 5 1.5 25 90%1- -2-10%2- -1-12 2 Pow 13 log Pow = 0.18 log Pow = -1.06 1- -2- log Pow = 0.137 2- -1- log Pow = 0.357 0.070.00420.0660.109
3 14 3 ppb ppb ppm B/A B/A B/A B/A 55 0 / 36 0.25 0 / 12 24 B/A 4. LC 50 mg l EC 50 mg l OECD : Selenastrum capricornutum 15, 240 96-h : 16 15, 16 Daphnia magna Lepomis macrochirus 4, 11, 12, 15, 16 Gambusia 4, 11, 12, 15 affinis Mugil 11, 12, 15, 16 ceohalus Salmo mykiss 15 Bacillus subtillus 15 Dacus dorsalis 15 215 96-h 141 96-h 89 96-h 52 96-h 18.5 2-h 350 48-h : 3,300 160-m harmful OECD OECD OECD
4 5. 11, 16, 17 1 LD 50 520-1,140 mg/kg 630 mg/kg 660-690 mg/kg LC 50 4,000 ppm 4-h 1,740 ppm 4-h LD 50 7,168 mg/kg 1,244-1,500 mg/kg 11 2 16 3 11, 16 4 1 100 mg/kg/day 5 / 18 26 0.052 mg/kg/day 0.520 mg/kg/day 2 6 / 5 / 13 300 ppm 600 ppm 1500 ppm 6 / 5 / 7 300 ppm 7 / 5 / 104 195 ppm7 / 5 / 6 11, 16, 17 5 In vitro TA1535/pSK1002 umu HGPRT CHO In vivo 100-500 mg/kg CD-1 300 mg/kg SD 298 ppm 7 / 5 CD-1 50-250 mg/kg 14 298 ppm 7 / 5 / 1-9
5 11, 16, 17, 18, 19, 20, 21 6 EPA 1994 EU 1994 B2 2 NTP 1994 IARC 1995 2B ACGIH 1996 A3 1996 2B 1996 1 SD 1560 mg/kg/week 112 2 NTP B6C3F 1 200400 ppm 6 / 5 / 103 400 ppm 400 ppm 400 ppm 1/50 400 ppm 2/50 NTP F344 200400 ppm 6 / 5 / 103 400 ppm 3 NMRI 0.1 0.3 1.0 2.5 mg/ 1 / 95 1.0 mg/ 11 7 1 389 ppm 2 300 ppm 6 / 2 12 500 ppm 7 / 3 1-6 6 7-16 10 389 ppm 2 500 ppm 7 / 1-19 19 100 300 ppm 7 / 5 / 2
6 11, 16, 17, 20, 21 6. 1 1,500 ppm 15 2 2 3 116 0.01 mg/m 3 1-2 20 0.8-27.5 mg/m 3 135 mg/m 3 2 29,139 52 20 39 18 4 ACGIH 1996 20 ppm 48 mg/m 3 1996 11 7. In vitro 2 1 1 1,2-1,2- in vitro DNA
7 8. OECD 1 4 4 5 3-5 2 harmful 9. 1 in vitro in vivo 1.511.6 1531 OH OECD harmful 2 1 2 3
8 1 1996. 2,, 1995. 3,, 1985. 4 Handbook of Environmental Data on Organic Chemicals, 2nd Ed., Van Nostrand Reinhold Co. 1983. 5,, 1988. 6 C Log P,. 7 NIST Library of 54K Compounds. 8 Lyman, W. J., et al., Handbook of Chemical Property Estimation Method, pp.4-9 1990. 9 5,. 10,,, 1992. 11 IPCS, Environmental Health Criteria 56 1985. 12 Hazardous Substance Data Bank HSDB, National Library of Medicine, 1996. 13 Mackay, D., Environ. Sci. Technol. 16, 274 1982. 14, 1996. 15 IUCLID International Uniform Chemical Information Data Base, EU. 16 BUA Report 94 1992. 17 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 36, 1985. 18 JETOC,,, 3 1997. 19 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, List of IARC Evaluations 1995. 20 ACGIH, Threshold Limit Values and Biological Exposure Indices 1996. 21, 38, 172-181 1996. 1 2 3
9 mg/ l 10,000 1,000 100 240 96-h 350 48-h 215 96-h 141 96-h 89 96-h 52 96-h LC 50 EC 50 10 1 1 Handbook of Environmental Data on Organic Chemicals, 2nd Ed., Van Nostrand Reinhold Co. 1983. 2 IPCS, Environmental Health Criteria 56 1985 3 Hazardous Substance Data Bank HSDB, U.S. National Library of Medicine 1995. 4 IUCLID International Uniform Chemical Information Data Base, EU. 5 BUA Report 94 1992.
10 B6C3F 1 200400 ppm 6 / 5/ ppm 0 200 400 0 200 400 1-3 103 0/50 0/50 5/50 0/50 0/50 3/50 0/50 0/50 5/50 0/50 0/50 2/50 1/50 1/50 2/50 F344 200400 ppm 1-3 6 / 5/ ppm 0 200 400 0 200 400 103 0/50 0/50 2/50 0/50 0/50 3/50 SD 1560 mg/kg/week 1,2 112 mg/kg/week 0 200 400 0/50 2/50 19/50 NMRI 0.10.31.02.5 mg/mouse :1/ 95 mg/mouse 0 0.1 0.3 1.0 2.5 4/200 3/100 2/100 12/100 15/100 1-3 1 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 36 1985. 2 IPCS, Environmental Health Criteria 56 1985. 3 BUA Report 94 1992.
11 ppm 6h/d5d/w13w 6h/d5d/w103w 6h/d5d/w103w 2y 7h/d3w+6-10d 1,000 600 500 400 400 389 300 100 20 10