1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20 )52 ( 0.15 ) 7) 700 mg l (22) 8) 0.054 %(v/w) 9) 10) 1 ppm = 3.25 mg/m 3 (, 20) 1 mg/m 3 = 0.308 ppm
2. 5 3,110,169 t( 3,073,286 t 36,883 t) 11) 2 1) 3. 1) 12) ( ) 2 100 mg l 30 mg l BOD 3941 % BOD 20 40 72 120 99 13, 14) OH 2) =1.210-12 cm 3 /sec 13) OH =5.0 10 5 110 6 /cm 3 6.713.4 4.3 ( )30 ( )153-225 ( ) 14)
15) 3) ppb ppb ppm ppb B/A B/A B/A B/A () 0/3 0/3 52 ( 2 ) ( 4.0 ) 60 61 4) 11/19 0.020.9 ( 0.02 ) 19/112 0.032.1 ( 0.03 ) 12/18 0.53.6 ( 0.2 ) 37/98 0.530.0 ( 0.5 ) 16) (1) 3 37/114 3.088 ( 3.0 ) B/A 47-64 ppb 6.83 ppb 2.50.8 ppb 51 ppb ( N=198) 8 ppb ( N=322 ) 14) (2) 0.6 ppb 104.7 ppb 9 1-8 ppm 1-20 ppm 4. LC 50( mg l ) EC 50 ( mg l ) OECD : Selenastrum Capricorntam 17) ( ) 29 (72-h): harmful Ankistrodesmus 310 (4-h): Falcatus 17) ( )
4 LC 50( mg l ) EC 50 ( mg l ) OECD : Artemia salina 17) 21 (48-h) ( ) Gammarus pulex 17) ( ) Daphnia magma 17) ( ) 42 (48-h): 18 (24-h): (harmful) Oncorhynchus nerka 17) ( ) Oncorhynchus mykiss 17) ( ) Salvelinus malma 17) () Oryzias latipes 17) ( ) Poecilia reticulata 17) ( ) Pimephales promelas 17) 4.9 (96-h) 5.3 (96-h) 5.5 (96-h) 54 (48-h) 28.6 (96-h) 12.6 (96-h) toxic (harmful) harmful harmful ( ) Lepomis 22.49 (24-h) (harmful) macrochirus 17) ( ) Ischnura elegans 17) ( ) Cloeon dipterumy 17) ( ) Hydra oligactis 17) ( ) Dugesia lugubris 17) ( ) 10 (48-h) 34 (48-h) 24(48-h) 74 (48-h) OECD ( ) OECD
5 5. 13, 14) 1) LD50 3,000 mg/kg LC50 13,700 ppm (4-h) 10,000 ppm (7-h) LD50 LD50 2,940 mg/kg 300 mg/kg 14) 2) 10-20 3) 13, 17) 4) (1) 4 5 / 6 50 mg/kg/day NOAEL 1 mg/kg/day 4 8 mg/kg/day 3 / 26 50 mg/kg NOAEL 1 mg/kg/day (2) 6 / 5 / 16 316 ppm NOAEL 25 ppm 6 / 5 / 13 300 ppm NOAEL 30 ppm 6 / 5 / 13 300 ppm NOAEL 30 ppm 300 ppm 6 / 5 / 13 300 ppm 6 / 5
6 13) 5) 10 ppm S9 TA1535 in vivo (1,750 mg/kg) (1,750 mg/kg) 4 (28 ppm) 6 ( 9.9 ppm 3.0 ppm) 6 22 /) (0.04 ppm ) 2 (56 mg/kg )120 (25 mg/kg ) 5 (88 mg/kg ) 13, 14, 18, 19, 20) 6) EPA (1996 ) EU (1996 ) NTP (1994 ) IARC (1996 ) A 1 1 ACGIH (1996 ) A2 (1996 ) 1 (1) B6C3F1 2550100 mg/kg/day 5 / 103 / / 25 mg/kg/day F344 50100200 mg/kg/day 2550100 mg/kg/day 5 / 103 50 mg/kg/day 25 mg/kg/day 50 mg/kg/day (2) CD-1 C57BL/6 1,200 ppm 6 / 5 / SD 200-300 ppm 15 104
7 13, 14) 7) (1) 0.5 1.0 ml/kg (2) 20 ppm 6 / 6-15 10 500 ppm 7 / 6-15 10 2,156 ppm 6 / 6-15 10 924 ppm 24 / 500 ppm 6-18 13 300 ppm 6 / 5 / 13 20 ppm 10-15 3 6,600 ppm 7 / 5 / 93 80 ppm 7 / 5 / 6 88 ppm 7 / 5 / 6 13, 14, 16, 17, 18, 19, 21, 23, 24) 6. 1) 25 ppm (8 ) 50-150 ppm (5 ) 500 ppm (1 ) 1,500 ppm (1 ) 7,500 ppm (30 ) 20,000 ppm (5-10 ) 125 mg/kg 2) (0.2-12.4 ppm) (50-100 ppm) (ppm) () 40-200 3 200-400 12
8 3) OSHA (1985 ) 11 4) ACGIH (1996 ) 10 ppm (32 mg/m 3 ) (1996 ) 10 ppm (32 mg/m 3 ) ACGIH 1990 TLV-TWA 0.1 ppm A1; OSHA 1987 1 ppm (TWA) 13) 7. P-450 1,4- DNA 8. OECD 1) 5 2) OECD harmful toxic 9 1)
9 OSHA 99.8% 10 ppm 6.713.4 700 mg l OECD harmful toxic 2)
10 1) () (1996). 2),,,, (1991). 3),, (1995). 4) Handbook of Environmental Data on Organic Chemicals, 2nd Ed., Van Nostrand Reinhold Co. (1983). 5),, (1988). 6) C Log P, (). 7) NIST Library of 54K Compounds. 8) (1979). 9),, (1984). 10) The Merck Index, 11th Ed., Merck &Co., Inc. (1989). 11) 5,. 12),, (1992). 13) ATSDR, Toxicological Profile for Benzene (1992). 14) IPCS, Environmental Health Criteria 150, Benzene (1993). 15), (1995). 16), (1992). 17) ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices (1991). 18) IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 29, 93-127 (1987). 19) IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, Supplement 7, 120-121 (1987). 20) JETOC,,, 3 (1997). 21),, (1994). 23) ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices (1996). 24), 38, 172-181 (1996). 1) 2)
(mg/l) LC 50 EC 50 1) IUCLID (International Uniform Chemical Information Data Base), EU.
ppm 10,000 (6 h/d, 5 d/w, 16 w) (6 h/d, 5 d/w, 13 w) (15W, 104 w) 316 LOAEL 300 LOAEL 200 1,000 50-100 25 NOAEL 30 NOAEL 0.2-12.4 100 10 ACGIH 10