Acute myocardial infarction with Cholesteryl-Ester Transfer Protein(CETP) deficiency // / Marohito Nakata, Namio Higa, Tami Mashidori, Mamoru Manita, Tomohiro Asahi, Kazuhiko Tabata Department of Cardiology, Naha City Hospital 急性心筋梗塞 Cholesteryl-Ester Transfer Protein(CETP) 欠損症 high-density lipoprotein cholesterol(hdl-c) 2016. 1. 12 2016. 7. 4 high density lipoprotein cholesterolhdl C Cholesteryl Ester Transfer ProteinCETP CETP ₅₉ HDL C 心臓 Vol. 48 No.1 2(2016)
WBC ₅₅₀₀ /L T Bil ₁. ₀ mg/dl RBC ₄₆₁ ₁₀ ₄ /L AST ₃₁ IU/L Hb ₁₄. ₉ g/dl ALT ₂₉ IU/L Ht ₄₃. ₂ % LDH ₂₁₅ IU/L Plt ₁₉. ₀ ₁₀ ₄ /L CK ₁₅₂ IU/L CK MB ₃. ₆ mg/dl Na ₁₃₉ meq/l Troponinl ₀. ₀₂₈ ng/ml K ₃. ₈ meq/l Cl ₁₀₂ meq/l T CHO ₂₉₁ mg/dl BUN ₁₉. ₅ mg/dl HDL C ₁₃₄ mg/dl Cre ₀. ₇₇ mg/dl TG ₉₇ mg/dl LDL C ₁₂₈ mg/dl HbA₁c ₅. ₃ % CETP ₁. ₄ g/ml NGSP lipoprotein electrophoresis ₄₇%Pre ₂₁% ₃₂% ₁ ₁₅₉. ₅ cm ₄₉. ₀ kgbmi ₁₉. ₃ kg/m ₂ ₁₅₂/₉₄ mmhg ₇₅ / SpO ₂ ₉₆% T CHO ₂₉₁ mg/dlhdl C ₁₃₄ mg/dltg ₉₇ mg/dl LDL C ₁₂₈ mg/dlcetp ₁. ₄ g/ml ₁. ₅ ₃. ₄ g/mlt CHO HDL C CETP ₅₂% ⅡⅢaV ST coronary angiographycag CAG ₁₄ PCI Launcher EBU ₃. ₅ ₇Fr Medtronic ASAHI SION blueasahi
Intecc Thrombuster Ⅱ ₇Fr Kaneka Thrombolysis in Myocardial Infarction TrialTIMIgrade ₀ ₈₀ TIMI grade ₁ TENKU ₂. ₅ ₁₂ mmabbott Vascular Promus PREMIER TM ₂. ₅ ₁₂ mmboston Scienitific Door to balloon ₇₆ CK ₁₂₄₅ IU/LCK MB ₁₈₄. ₀ IU/L intravascular ultrasoundivus intima media thicknessimt ₁. ₀ mm brachial ankle Pulse Wave VelocitybaPWV ₁₅₅₁ cm/ ₁₅₆₈ cm/ ₁₁ HDL C ₁₀₀ mg/dl HDL C CETP ₂ HDL C HDL C ₁ HDL C CETP HDL C TorcetrapibDalcetrapib Torcetrapib HDL C ₇₀%low density lipoprotein cholesterolldl C ₂₅% ₂Dalcetrapib HDL C ₃₁₄₀% ₃ HDL C ₄HDL 心臓 Vol. 48 No.1 2(2016)
CETP HDL C CETP LDL LDL cholesterol esterce HDL LDL CE Small dense LDL Small dense LDL LDL bapwv IMT CAG PCI CETP HDL C ₁₀₀ mg/dl HDL C CETP HDL C
₅ ₆ CETP HDL C ₁₀₀ mg/dl ₇ HDL C ₁₃₄ mg/dl CETP CETP ₁. ₄ g/dl CETP ₈₁₄₅₂G/AD₄₄₂GCETP CETP ₁ ₅₀ ₁ CETP HDL C ₁₀₀ mg/dl ₉ HDL eicosapentaenoic acidepa ₁₀ CETP HDL C ₁₁ EPA CETP ₁ CETP ₅₀ ₁ ₁₀₀ mg/dl HDL C 文献 ₁Gordon T, Castelli WP, Hjortland MC, et alhigh density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med ₁₉₇₇62₅₇₀₇ ₇₁₄ ₂Barter PJ, Caulfield M, Eriksson M, et aleffects of torcetrapib in patients at high risk for coronary events. N Engl J Med ₂₀₀₇357₂₁₂₁₀₉ ₂₁₂₂ ₃Schwartz GG, Olsson AG, Abt M, et aleffects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med ₂₀₁₂367₂₂₂₀₈₉ ₂₀₉₉ ₄Saleheen D, Scott R, Javad S, et alassociation of HDL cholesterol efflux capacity with incident coronary heart disease eventsa prospective case control study. Lancet Diabetes Endocrinol ₂₀₁₅3₇₅₀₇ ₅₁₃ ₅Walsh BW, Schiff I, Rosner B, et aleffects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med ₁₉₉₁325₁₇₁₁₉₆ ₁₂₀₄ ₆Hirano K, Matsuzawa Y, Sakai N, et alpolydisperse low density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer protein activity. Metabolism ₁₉₉₂41₁₂₁₃₁₃ ₁₃₁₈ ₇Weitzman JB, Vladutiu AOVery high values of serum high density lipoprotein cholesterol. Arch Pathol Lab Med ₁₉₉₂116₈₈₃₁ ₈₃₆ ₈Inazu A, Brown ML, Hesler CB, et alincreased High Density Lipoprotein Levels Caused by a Common Cholesteryl Ester Transfer Protein Gene Mutation. N Engl J Med ₁₉₉₀323₂₂₁₂₃₄ ₁₂₃₈ ₉Hirano K, Yamashita S, Nakajima N, et algenetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan. Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler Thromb Vasc Biol ₁₉₉₇17₆₁₀₅₃ ₁₀₅₉ ₁₀Tanaka N, Ishida T, Nagao M, et aladministration of high dose eicosapentaenoic acid enhances anti inflammatory properties of high density lipoprotein in Japanese patients with dyslipidemia. Atherosclerosis ₂₀₁₄ 237₂₅₇₇ ₅₈₃ ₁₁Yamashita S, Hbujo H, Arai H, et allong term probucol treatment prevents secondary cardiovascular eventsa cohort study of patients with heterozygous familial hypercholesterolemia in Japan. J Atheroscler Thromb ₂₀₀₈15₆₂₉₂ ₃₀₃ 心臓 Vol. 48 No.1 2(2016)