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DNA DSB HR NHEJ NHEJ NHEJ DSB NHEJ DNA DNL DNA ligaseiv-nej -Lif YKU HDF YKU HDF LIF NEJ DNL MRE RAD XRS micro-homology dependent NHEJ POL RAD ligase IV NHEJ classical-nhej HR DNA DSB CDK G NHEJ NHEJ Mre Mre Rad Rad SMC Xrs Nbs MRX N Dnl DNA ligase IV NHEJ DNA Lif Xrcc ligase IV Nej XLF ligase IV Ku Hdf Ku DSB Ku Hdf Ku DSB DNA-PKcs PI Pso Artemis DSB Pol Polµ DNA Polλ DNA Rad FEN- Flap NHEJ DNL Nej NHEJ
NHEJ Xrs FHA NHEJ Mre -Rad -Xrs MRX Mre -Rad -Nbs MRN DSB DSB xrs -SH MRX foci DSB A Xrs Mre FHA Xrs DSB Mre B HO DSB DSB DNA FHA NHEJ
DSB DNA MRX HR NHEJ MRN NHEJ Mre Rad sbccd structural maintenance of chromosomes SMC DSB Xrs Nbs Nijmegen breakage syndrome NBS Nbs N Xrs Nbs N Xrs Nbs N fork-head associated FHA FHA DNA Rad FHA Rad Xrs FHA FHA MRX A DNA DNA MMS DNA NHEJ DNA Xrs FHA NHEJ FHA XRS FHA FHA xrs xrs - M FHA xrs -SH DNA HO DSB B G HO DSB NHEJ LIF DSB DSB NHEJ FHA DSB Xrs FHA NHEJ NHEJ FHA Lif FHA NHEJ NHEJ Xrs NHEJ DNA DNL Lif Xrs FHA DSB DSB MRX Xrs FHA DNL DSB Xrs Lif FHA Nbs Xrcc Nbs NHEJ Lif Lif C Xrs Lif N Nej Dnl C Xrs Xrs CK Lif CK
Lif Xrs DSB DNA DNA Xrs FHA FHA Lif CDK NHEJ Matsuzaki et al., unpublished result Xrs NHEJ Hefferin, M.L. & Tomkinson, A.E. DNA Repair Amst,,. Ira, G., Pellicioli, A., Balijja, A., Wang, X., Fiorani, S., Carotenuto, W., Liberi, G., Bressan, D., Wan, L., Hollingsworth, N. M., Haber, J.E., & Foiani, M. Nature,,. Valencia, M., Bentele, M., Vaze, M.B., Herrmann, G., Kraus, E., Lee, S.E., Schar, P., & Haber, J.E. Nature,,. Frank-Vaillant, M. & Marcand, S. Genes Dev.,,. Moore, J.K. & Haber, J.E. Mol. Cell Biol.,,. Wiltzius, J.J., Hohl, M., Fleming, J.C., & Petrini, J.H. Nat. Struct. Mol. Biol.,,. Sun, Z., Hsiao, J., Fay, D.S., & Stern, D.F. Science,,. Shima, H., Suzuki, M., & Shinohara, M. Genetics,,. Matsuzaki, K., Shinohara, A., & Shinohara, M. Genetics,,. Palmbos, P.L., Daley, J.M., & Wilson, T.E. Mol. Cell Biol.,,. Regulation mechanism of non-homologous end joining through the Lif phosphorylation Miki Shinohara Department of Integrated Protein Functions, Institute for Protein Research, Osaka University, Ymada-oka, Suita, Osaka, Japan plant secondary product glycosyltransferases PSPG Arabi-