ナノ材料の有害性評価
|
|
|
- ちとら はかまや
- 5 years ago
- Views:
Transcription
1 CRM CRM 181
2 TG424 TG TG407 PBPK PBPK DNA DNA
3 PBPK C C art vein Ramsey & Andersen (1984) ( Qalv Cinh Qt Cvein ) ( Qt Qalv PN ) = + + { ( )} Qi Ci = i Pi ( C ) art Ci dai dt = Qi Qt Pi ( C ) art Cl max ( Cl ) ( Cl ) = Q P + dal dt l V Pl Km Pl l GST P450 Q alv = Cinh = Qt = PN= Pi= Qi = V max KmMickaelis-Menten l=
4 PBPK AUC AUC Approaches for the Application of PBPK Models and Supporting Data in Risk Assessment (EPA/600/R-05/43A, June 2005, External Review Draft)
5 % DCM: B6C3F1 P450 GST AUC(DCM) (Andersen et al., 1987) GST AUC(DCM) DCM GST P450 GST mg DCM/liter tissue mg DCM/liter tissue ppm 250 a mg/kg/day b AUC(DCM) (mg/liter) x hr a NTP, 1986 b National Coffee Association, 1983
6 PBPK GST 1,4- DNA- AUC
7 TG424 TG TG407 PBPK PBPK DNA DNA
8 PBPK GST 1,4- * * * DNA-* AUC *
9 (Aplastic anemia), (acute myelogenous leukemia,aml) (lymphoid malignancies) Absolute lymphocyte count): : 5-19 ppm ---> () Ha-ras gene
10 Protein adducts DNA adducts P4502E1 Benzene O Benzene oxide Oxepin Fe/OH GSH O GSH-Transferase Epoxide hydrolase OH O [ O ] O O trans,trans -Muconaldehyde* OH (MUC) (highly reactive, hematotoxic, topoisomerase trans,trans-muconic acid (MA) (excreted in Urine: exposure marker in human) inhibition) OH S-CH 2 -CH(NHCOCH 3 )COOH S-Phenylmercapturic acid Glucuronide Sulfate P4502E1 HO Phenol OH HO Glucuronide Sulfate Hydroquinone* Protein adducts P450 DNA adducts OH Glucuronide OH OH 1,2,4-Benzene triol* P450 Catechol* NQO1 OH OH OH (polymorphism) 1,2-Benzene dihydrodiol* Peroxidases/autooxidation (Myeloperoxidase: MPO) *:mutagenic NQO1? Protein adducts O O O O o-benzoquinone O O Protein adducts NQO1 4,4'-Diphenoquinone p-benzoquinone (highly reactive, oxidative stress, topoisomerase inhibition, inhibits pre-il-1 to IL-1) OH OH 4,4'-Biphenol NQO1: NAD(P)H:quinone oxidoreductase
11 (U.S.EPA, 2002) CYP2E1 GSH transferases >> NAD(P)H:quinone oxidoreductase CYP2E1xNQO1 CYP2E1 NQO1 (95% CI) ( ) ( ) ( )
12 > >
13 EU / WHO-IPCS The Sapphire Group U.S. EPA WHO Canada TERA European Risk Assessment Report, ACRYLONITRILE (Final Report, 2004) Environmental Health Criteria 28, Acrylonitrile (1983) Toxicological Review of Acrylonitrile (Final Draft, 2004) TOXICOLOGICAL PROFILE FOR ACRYLONITRILE, 1990 Concise International Chemical Assessment Document 39, ACRYLONITRILE (2002) Priority Substances List Assessment Report Acrylonitrile (2000) Acrylonitrile: Inhalation Cancer Risk Assessment (1997)
14 U.S. EPA NICNAS WHO / Ambient Water Quality Criteria for the Protection of Human Health: Acrylonitrile (1998) Acrylonitrile Priority Existing Chemical Assessment Report No. 10 ( 2000) Air quality Guidelines for Europe, Second Edition, Chapter 5.1 Acrylonitrile (2000) Chronic Toxicity Summary, ACRYLONITRILE(2001)
15 IARC BUA ECB ATSDR NICNAS EPA CANADA CRM
16 CRM (a) (b) (c) CRM CRM
17 NOAEL 2004 The Sapphire 2004 Group, Inc. The California Saophire OEHHA Group, Inc. 2 x 10-3 mg/m 3 (UF=500) RfD=0.2 mg/kg/ (UF=180) RfC=0.7 mg/m 3 (UF=10) Cancer Value = 0.1 mg/m 3 RfC5 x 10-3 mg/m 3 (UF=30) Cancer Value = mg/kg/ NOEL 1 mg/m 3 (Muto et al., 1992) NOAEL 32 mg/kg// NOAEL 21.7 mg/m 3 NOAEL( 7.4 mg/m 3 BMD 05 (Maltoni et al., 3.3 mg/m 1977,1987; Toxicology 3 BMD Research Laboratory, ; Johannsen and 0.15 mg/m Levinskas, 2002a; b; Quast, 2002) in vivo 5/7 PBPKNOAELBMD (Gagnaire et al., 1998) LED 1SD = NOAEL NOAEL(21.7 mg/m 3 ) (10 m 3 /day20 m 3 /)250/ (Sakurai et CEOBMD5% al., 1978) 365/ (LED 05 )(0.014 mg/l) NOAEL(7.4 mg/m 3 ) Point of Departure (POD) POD CEOKedderis PBPK(21.3 mg/m 3 ) et al. (1996)PBPK UF=220 BMD5%BMD Toxicology Research 05 ) (3.3 mg/m Laboratory, 1980) 3 ) Cancer Value CEOMD5% (0.15 mg/m 3 )UF=305 x 10-3 mg/m 3 (LED 05 )(0.014 mg/l) Point of Departure (POD) POD PBPK(1.7 mg/kg/) UF=200 WHO 2002 TC 05 = 6.0 mg/m 3 95%LCL = 4.5mg/m x 10-2 / (mg/m 3 ) TD 05 = 2.3 mg/kg/ (95%LCL = 1.4 mg/kg/) 2.2 x 10-2 / (mg/kg/) Toxicology Research Laboratory, 1980) (Johannsen and Levinskas, 2002b) 6 TC 05 TC 05 =35 mg/m 3 ()52 mg/m 3 24 [(6hr/)/(24hr/)] x [(5 /)/(7 /)] TC 05 TC 05 TD 05 =2.0 mg/kg/() 1.8 mg/kg/() TD 05 () x (26/24) x (26/24) 2
18 (U.S. EPA, 1998) EU (2004) The Sapphaire Group, Inc. (2004) NOAEL RfD= 1 g/kg/ RfD=200 g/kg/ 1 mg/kg/ 0.25 mg/kg/ 32 mg/kg/ (Tandon et al. 1988) (Johannsen and Levinskas, 2002 (Gagnaire et al., 1998) UF=1,000 PBPKNOAEL UF=180TERA PBPK PBPK Gagnaire et al.(1998) (ASAP) ASAP) BMDNOAEL
19 (ASAP) 5/ mg/kg/ (7/) mg/kg/ ASAP (V) MeanS.D (n=10) (n=12) (n=12) (n=12) BMD BMD (mg/kg/) BMDL (mg/kg/) p Linear Polynomial Power Hill BMDBMDL:BMD95% RfD = 20g/kg/ g/kg/
20 (U.S. EPA, 1998) EU (2004) The Sapphaire Group, Inc. (2004) CRM NOAEL RfD=1 g/kg/ RfD=200 g/kg/ RfD =20 g/kg/ 1 mg/kg/ 0.25 mg/kg/ 32 mg/kg/ 20 mg/kg/ (Tandon et al. 1988) (Johannsen and Levinskas, 2002 (Gagnaire et al., 1998) (Gagnaire et al., 1998) UF=1,000 PBPKNOAEL UF=180 TERA BMDNOAEL UF=1,000
21 CRM / EU European Risk Assessment Report (2004) WHO-IPCS Environmental Health Criteria 28 (1983) The Sapphire Group Toxicological Review (Final Draft, 2004) U.S. EPA Toxicological Profile (1990) WHO Canada Concise International Chemical Assessment Document 39 (2002) Priority Substances List Assessment Report (2000) CRM NICNAS Priority Existing Chemical Assessment Report No. 10 ( 2000) 64 62
22 PBPK
23
24 P450 2E1 MOF GSTH (+) GSH (-) ) (-) 0.25, 0.2, 0.02) 75, 5, 5)
25 / Ca
26
27 PBPK
CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
http://www.who.int/ipcs/publications/ehc/en/index.html EHC 1 2 3 4 / EHC http://www.nihs.go.jp/dcbi/publist/ehchsg/ 1-8) WHO/IPCS CICAD (Concise Inter
3 [ ] Priority IARC JMPR 2004 10 Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) http://www.cerij.or.jp/ceri_jp/koukai/sheet/sheet_indx4.htm http://www.safe.nite.go.jp/data/sougou/pk_list.html?table_name=hyoka&rank=sh
橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
橡96-01.PDF
1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
t 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
0 0 0 0............ PNEC.............................. PNECsed.................. 0 0 0 0 PNEC logpow. * Oncorhynchus mykisslc0. mg/l UFs0,000 0.000 mg/l0. µg/lpnec PNECwater PNECwater * Sangster, J. ()
橡99-24_00 アリルアルコール.PDF
1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log
CAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
1 I ( )
1 I. 3 1. 4 2. 6 3. 7 4. 8 4.1 8 4.2 ( ) 9 4.3 13 4.4 16 4.5 17 5. 19 5.1 20 5.2 25 5.3 33 6. 37 6.1 37 6.2 41 6.3 44 7. 46 7.1 46 7.2 47 II. 48 A 50 1 50 2 51 3 56 4 59 60 B 61 1 61 2 62 3 65 4 67 68
,161 t 9,753 t 2,408 t LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum 6 3 Selenastrum h, Sb
1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
橡フタル酸ブチルベンジル.PDF
1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
初期リスク評価報告書作成指針（案）
BCF: Bioconcentration Factor EC 50 : Median Effect Concentration 1 50 EEC: Estimated Environmental Concentration EHI: Estimated Human Intake EUSES: Europian Union System for the Evaluation of Substances
橡アジポニトリル.PDF
1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log
橡三酸化二アンチモン.PDF
1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
環境基準項目等の設定根拠等
7440-43-9 Cd 112.4 ph (CdCl 2 ) (CdO) (CdSO 4 ) 80 8.6 4.1 6.95 4.7 75.5g/100ml (0) 2,471,566t( ) 12 251kg( ) 3,916,204kg( ) (1) 0.01mg/l 0.0310g/l 0.01mg/l 60 (2) 0.003mg/l 0.005mg/l 0.005mg/l 0.01mg/l
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/104/163316306.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
(1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/39/20157433.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )
（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果
1 ( ) DBDPO CAS 1163-19-5 C 12 Br 10 O 959.2 2 1) 305 2) 3.0 1) 1- / (logp ow ) 1) 5.03 mmhg306 1) 1) 3) 4) 5) 1.010-4 6) mg/l25 3 7) OH 8) 4 9) 6 BOD 0% 14 100 mg/l 30 7) 10) BCF 5 < 42 60 mg/l 7) 50
- 108 -
3-107- - 108 - 3.1 3.1.1 3.1.2 3.1.2.1 5 LD50 LC50 ATE 3.1.1 1 2 3 4 5 (mg kg ) 5 50 300 2000 5000 a (mg kg ) 50 200 1000 2000 a (ppm) 100 500 2500 5000 a b mg 0.5 2.0 10 20 a b c d 0.05 0.5 1.0 5 (mg
PAH ; XAD-2 ( XAD-2) PAH - LH-20 (HPLC) (SE-54 SE-52) ; -C18 HPLC PAH 1.3 PAH PAH PAH ( ) ( ) (, ) ( ) PAH : - bitumen ; - ; - ; - ; - ; - environment
No.202 Environmental Health Criteria No.202 (PAH) Selected Non-heterocyclic Polycyclic Aromatic Hydrocarbons ( 883 1998 ) 1. 1.1 (PAH) PAH PAH PAH 33 (31 PAH 2 ) ( 1) 8 10 PAH PAH 10-15 ; 1.2 ' ' 2 PAH
DCHP
2. 2 1. 1) 2) 2 Crj:CD(SD)IGS SPF 0 240 1200 6000 ppm 2 F0 10 F0 10 F1 21 F1 3 10 F1 3 10 F2 21 0 240 1200 6000 ppm 1 F0 0 15.88 79.57 401.8 mg/kg/day F0 0 20.80 104.19 510.7 mg/kg/day F1 0 17.84 89.89
1 ( 2)
2016 1 24 1. 10km 2. 1 50g 1 3. 1 4. 1mSv 5. 2 (0 ) 1 1 (http://www.itarda.or.jp/materials/statistical.php) (http://www.airia.or.jp/number/) 1 1 km 0.1691 1 1) 2) () ( km) (/ km) 2008 725 3847 0.1884 2009
4 2 10 4 10 22 5 8 3 3 1. 2. 3. 4. 4 2
25 1 H25.11.20 1. 2. 3. 4. 5. 1 2 1 4 2 10 4 10 22 5 8 3 3 1. 2. 3. 4. 4 2 1. 2. 3., 4. 5 1. 1 2. 1 6 3 434 365 600 100 25 5 15 7 1 4200 8 4 9 ADI = ND 10 5 11 - NOEL NOAEL ADI 12 6 DNA 10 100 1 10-5 10-6
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/39/20150687.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
(1) 1,2- DMP CAS 131-11-3 C 10 H 10 O 4 194.2 2 1) 5.5 2,3) 283.7 2,3) 1.192 (20 ) 4) 133 Pa (1 mmhg) (20 ) 5) 1ppm=7.94 mg/m 3 at 25, n- / 1.56 ( ) 6) 4) ( )3.2 (30 ph 7)11.6 (30 ph 9)25 (18 ph 9) 5)
030514第１回資料２－４最終
97.5% 2.5% 1.76% 0.76% 0.01% 14km 3 15 1 12 % 0 20 40 60 80 100 62 81 85 0% - 25% 26% - 50% 51% - 75% 76% - 90% 91% - 100% 88 96 100 100 Global Water Supply and Sanitation Assessment 2000 Report 2 24 %
1 3 2 4 1983 2 1979 04 1 03 GDP 9.1% 1 GDP 1,000 04 3 10 04 01 12 WTO WTO 4 3 3 1979 1973 1974 1978 1978 11 1979 1982 1982 1984 1988 1989 1989 1998 SEPA 5 1979 1989 3 1,000 9 SEPA 10 1982 6 5 5 6 1993
untitled
19 m 3 m 3 m 3 /s m 3 3 m 3 m 3 m 3 m 3 m 3 m 3 m 3 2km 2km 4km 3km 2km 2km 16km () 2km 2km 4km 4km 2km 2km 16km m 3 m 3 m 3 264,970 m 3 1,209.6 m 3 36,850 m 3 1,728 m 3 m 3 m 3 m 3 m 3 m 3 m 3 m
untitled
1 2 21-3 CS VOC- CS syasuma@tc4.so-net.ne.jp 4 [] MCS, 200501212B () SHSMCS CS 66 14 16 5 () MCS 16 (GSTs) 14 (8ppb40ppb) 2002192155-161) 6769 68 68 EPA Terr, 1989 69 QEESI 3 70 6 EPA MCS 10 9 8 MCS 6
資料３ 諸外国における位置づけ
1 1. ( 1) ) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) 15) 16) ( 1) ) 2) 3) 4) 5) 6) 7)28 8)Ames 9) 10) 11) ( 1) ) 2) 3) 4) ( 1) ) 2) 3) 4) 2 TSCA (a) FIFRA (b) (c) FFDCA (d) FFDCA (e) FFDCA (f) (g) PMN
1. PVC PVC DEHP DEHP PVC PVC PVC PVC , PVC , ,596 PVC ,472 16% PVC
(2- ) 2003 5 1. PVC PVC DEHP DEHP 2. 2.1 PVC PVC PVC 1930 1941 PVC 1943 37,000 1944 116 200500 PVC 1950 1,493 2000 268 2,596 PVC 2000 1,472 16% PVC 1948 190 2000 36 470 8% 80% DEHP 60% 50% DEHP PVC % 2.2
H J
H J qt q w e r t qt q w e r t qt q w e r t qt q w e r t qt q w e r t qt q w e r t qt q w e r t H qt q w e r t qt q w e r t J qt q w e r t D qt q w e r t qt q w e r t qt q w e r t qt D q w e r t qy q w
HydroxypropylcelluloseCellulose 2-hydroxypropyl ether CH 2 OR R=H H O O H CH H 3 OR H CH 2 CH O m H OR m1 n 30,000n 100 1,000,000n 2,500 13) 1 14 C 14
HPC 1), 2), 3) HPC 4) 5) 6), 7), 8) GMPGood Manufacturing Practice EU 9) 10), 11) GMP 9) FAO/WHO JECFA 1989 35 7 HPC ADI not specified 12) 14 7 JECFA EU 46 HPC 16 8 16 EU - 1 - HydroxypropylcelluloseCellulose
化学物質の内分泌かく乱作用に関する環境省の今後の対応方針について
ExTEND2005 2005 3 ExTEND2005 Enhanced Tack on Endocrine Disruption 10 (1998 )5 - SPEED'98-12 (2000 )11 2000 11 ( SPEED'98 ) 14 (2002 )8 (WHO)/ (ILO)/ (UNEP) Global Assessment of the State-of-the-Science
資料７
SNUR TSCA EPA TSCA SNUR 600 SNUR SNUR SNUR EPA SNUR SNUR SNUR SNUR - 1 - Tris(2,3-dibromopropyl)phosphate; 126-72-7; SNUR 1,2,4,5-Tetrachlorobenzene; 95-94-3; SNUR 10,000 Benzenediazonium, 4-(dimethylamino)-,
橡H1102答申別添1.PDF
1993 10mg/ Walton 1951 WHO 1993 1992 Walton American Journal of Public Health 41 1951 10ppm 10mgN/, 50mg/ 1993 1990 1997 10 HAN TEAN HAN 61%, TEAN19%, 20% WHO FAO JECFA 0, 0.1, 1, 5, 10% 5 NOEL % 500mg/kg/day
50mg 75mg (1) H 3 C O OH HO H O O H OH SO H 3 Na H H N H 2 N NH OH H N O O H H O OH H 3 C H O O N H H H HO H NH CH 3 HN HO H OH O H OH H NH
3240 14 8 8 50mg 75mg 13 6 25 1-(1) H 3 C O OH HO H O O H OH SO H 3 Na H H N H 2 N NH OH H N O O H H O OH H 3 C H O O N H H H HO H NH CH 3 HN HO H OH O H OH H NH O N O C 56 H 70 N 9 NaO 23 S 1292.26 5-[(1S,2S)-2-
橡核の軍事利用と商業利用(2).PDF
(2) (1) 1952 12 12 1957 10 10 14 (2) 1961 1 3 SL-1 3 2-3 1966 10 5 (3) 1979 3 28 1981 3 8 1-4 3 (4) 1986 1 6 1986 4 26 31 30km 13 5 4 320 kw 100 kw 1983 12 (5) 1995 12 5 1997 3 11 8 35 1999 9 30 JCO 2
untitled
1 2 3 4 5 (1834) 1834 200 6 7 8 9 10 11 (1791) (17511764) (1824) 1843 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 (1791) (1791) (17511764) (17511764) (1824)1843
... - 1 -... - 1 -... - 1 -... - 1 -... - 1 -... - 1 -... - 1 -... - 1 -... - 3 -... - 4 -... - 4 -... - 4 -... - 5 -... - 6 -... - 6 -... - 6 -... - 6 -... - 6 -... - 7 -... - 7 -... - 7 -... - 7 -...
14 88 7 1 3 4 75 14 9 13 51 16 22 16 69 22 134 54 40 27 5 29 29 3 31 11 2-1 - 12 22 20 150 200 4.1993 22 22 250 400 2011 576 2011 2 2010 2 3 3 4 77 1990 448 1,298 3 2-2 - 1990 7 5,000 100 5 8 1996 75 85
地域再生計画
22 6,491ha 80 5,244ha 85.7 5,540ha 50km1 10,793 H17.5.1 15 35 51.7 1,943 1 50 9.5 351 12 2.4 130 2 16 13 5 14 1,545 1,019 35 1 20 10 3 15 3 3 H17.5.1 282 99 130 15 3 15 3 11 2 20 H16.12. 3 50km JR 9 4
近畿中国四国農業研究センター研究報告 第７号
230 C B A D E 50m 558 0 1km (mg L 1 ) T N NO 2 3 N NH 4 N 2.0 0 (a) 2001 1.5 6 20 21 5 1.0 0.5 0.0 2.0 1.5 1.0 0.5 0.0 14:00 17:00 (b) 2001 7 3 4 20:00 23:00 2:00 (h) 5:00 8:00 11:00 10 0 5 10 15
1 20 NTTGroup Environmental Protection Activity Report 1999
Chapter 4. 19 20 25 30 36 41 44 hapter 4. 1 20 NTTGroup Environmental Protection Activity Report 1999 NTTGroup Environmental Protection Activity Report 1999 21 22 NTTGroup Environmental Protection Activity
356 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No.1, -/0-0+ (,**1) 44 For Quality Control and Quality Assurance in Food Analysis Akemi Yasui Analyt
356 Nippon Shokuhin Kagaku Kogaku Kaishi Vol. /., No.1, -/0-0 (,**1) 44 For Quality Control and Quality Assurance in Food Analysis Akemi Yasui Analytical Science Division, National Food Research Institute,
ｽﾗｲﾄﾞ ﾀｲﾄﾙなし
2395 20 3 2008 5 16 SHIN NIPPON BIOMEDICAL LABORATORIES,LTD. 1 2 CONTENTS. 20 3 CFO. 2008 CEO... Translational Translational 3 . 20 3 CFO 4 20 3 P/L 19 3 20 3 17,289 19,500 19,647 +2,358 +147 1,125 1,453
橡H8フィリピン報告書_日本語） PDF
1 2 7,000 7,000 3 1986 Execut ive Order 192 Depart ment of Environment and Natural Resources Department of Natural Resources Ministry of House Settlements 8 4 8 6 4 35,000 5,000 30,000 7,000 192 Environmental
温泉の化学 １
H O 1,003 516 149 124 2,237 1974 90 110 1km 2,400 ( 100 Mg 200 (98 ) 43,665 mg 38,695 mg 19,000 mg 2000 2000 Na-Ca-Cl 806 1970 1989 10 1991 4 ph 1 981 10,000 1993... (^^; (SO_4^{2-}) " " 1973-1987 1970
gofman2.eps
2011 7 10 4 7 1 ICRP(2007) 5.7 10 2 Sv 1 1 13 (=4600 =11 =660 ) 10mSv 5.7 10 4 4600[] =2.6[] ICRP 0 1 licrp 1 2 1 DDREF ICRP(2007) (ICRP 2007, p.178) - (idem., p.174) 1Sv - (DDREF: dose and dose-rate effectiveness
外因性内分泌攪乱化学物質調査暫定マニュアル（水質、底質、水生生物）
p,p -DDT p,p -DDE p,p -DDD trans- cis- trans- cis- (PBB) (BaP) 25ng/L 5µg/kg GC/MS-SIM GC/MS-SIM GC/MS-SIM GC/MS-SIM (2-, 3-, 4- ) (4,4'- ) p,p'-ddt- 13 C 12 HCB- 13 C 6 BaP-d 12 -d10 -d 10 p- -d 14 1000
030514第１回資料２－４最終
1 2 3 4 1 136 1312 143 2 3 16 17 4 3 1 165 2 168 3 1611 1617 8 97.5% 2.5% 1.76% 0.76% 0.01% 14km 3 15 1 12 % 0 20 40 60 80 100 62 81 85 0% - 25% 26% - 50% 51% - 75% 76% - 90% 91% - 100% 88 96 100 100
14 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 20 0 0 0 0 0 0 0 0 0 0 0 0 21 0 0 0 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 0 0 0 0 0 0
カズノコの栄養機能性.ppt
1.4 1.3 2.4 1.4 1.3 1.2 1.1 1.0 0.9 0.8 1.2 2.0 1.1 1.0 0.9 0.8 1.6 1.2 0.8 1.3 1.2 1.1 1.0 0.9 0.8 R-COOH R CH -O-CO-R 2 1 CH-O-CO-R 2 R CH -O-CO-R 2 3 3. CH -O-CO-R 2 1 CH-O-CO-R2 O CH -O-P-O-X 2 -
001-002_...j.f......_..
1 2 1 Chapter of Export 1 10 2 12 3 14 4 16 5 18 6 20 7 22 8 24 9 26 10 28 11 30 12 32 13 34 14 36 15 38 16 40 17 42 18 44 19 46 3 20 48 21 50 22 52 23 54 24 56 25 58 26 60 27 62 28 64 29 66 30 68 Chapter
PowerPoint プレゼンテーション
ICH 日本シンポジウム 2015 平成 27 年 7 月 23 日 M7 Addendum: DNA 反応性 ( 変異原性 ) 不純物の評価及び管理 国立医薬品食品研究所 変異遺伝部 本間正充 これまでの経緯と進捗状況 2010 年 6 月タリン会議 SC でトピック化決定 2010 年 11 月福岡対面会議 (1) ガイドラインタイトルの変更, 適用範囲, 一般原則 2012 年 11 月サンディエゴ対面会議
14 15 12 17 3 24 iii 1 1. 1 1 1. 2 1 1. 3 2 1. 4 3 2 2. 1 6 2. 2 7 2. 2. 1 7 2. 2. 2 12 3 3. 1 14 3. 2 15 4 4. 1 17 4. 2 17 4. 2. 1 17 4. 2. 2 17 4. 2. 3 20 4. 2. 4 22 4. 2. 5 25 4. 3 25 4. 3. 1 25 4.
2001 2003 2005 2006 2007 2008
2001 2003 2005 2006 2007 2008 60 etc. http://nosmoke.hp.infoseek.co.jp/yuugaibussitu.htm http://nosmoke.hp.infoseek.co.jp/yuugaibussitu.htm 23.5% 2.8% 2.8% 3.4% 30.3% 9.9% 11.5% 15.8% AAN 65
Providing Care for HIV-infected Woman Amneris E. Luque, MD SMH AIDS Center Medical Director 2002/07/01
Providing Care for HIV-infected Woman Amneris E. Luque, MD SMH AIDS Center Medical Director 2002/07/01 8000 6000 4000 2000 0 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 30 25
参考 ( 案 ) 優先評価化学物質のリスク評価 ( 一次 ) 人健康影響に係る評価 Ⅱ 物理化学的性状等の詳細資料 1,3- ブタジエン 優先評価化学物質通し番号 平成 2
参考 0 ( 案 ) 優先評価化学物質のリスク評価 ( 一次 ) 人健康影響に係る評価 Ⅱ 物理化学的性状等の詳細資料,- ブタジエン 優先評価化学物質通し番号 0 平成 年 月 経済産業省 目 次 評価対象物質の性状... - 物理化学的性状及び濃縮性... - 分解性... 付属資料... - 物理化学的性状等一覧... - その他... i 0 0 評価対象物質の性状 本章では モデル推計に用いる物理化学的性状データ
untitled
... 4...5...6...7...10...11... 12...12...12...13...14...15...15...16...16...17...17...18...18...19...19...19 Hill...20...20...21...21...22...23...24...25... 34...34...35...38-2 - ...41...49...51...51...51...52...53...56...56...57...60...60-3
2 21 211,,, (Hz), AM (1MHz), 300m, 24 (245GHz), 12cm, 212 (electromagnetic fields), (electromagnetic radiations) (NIR),X,,,, RF, ELF,,, 22 221,, 2005
1 2003 6 7500 2 1 1 1 WHO, IARC, 2004 2 1973 1993 16 1997 SAR 2002 6, SAR 2W/kg, WHO ICNIRP 2 21 211,,, (Hz), AM (1MHz), 300m, 24 (245GHz), 12cm, 212 (electromagnetic fields), (electromagnetic radiations)
環境報告書2015.indd
ENVIRONMENTAL and SOCIAL REPORT 2015 1 C O N T E N T S 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 1 2 4 5 6 7 8 14 18 20 22 24 25 28 29 2 1 37.1 62.9 2 3 1 4 2 5 6 3 1 4 1 2 7 8 8 5 1 9 2 10 10 2 11 2
2.2 (1967) (1997,2003) 2.2 ( ) 11
( ) 2.1 10 2.2 (1967) (1997,2003) 2.2 ( ) 11 12 ( ) 90150 (684) (887) (1099) (1361) (1605) (1707) (1854) 21(1946) 8 2.3 (1854) 13 (1997) (1854.12.23) (M8.4) (24 ) (M8.4) 70,000 3000 ( ) 7 2 3 3 (,1997)
埼環協ニュース第229号
General incorporated association Saitama-Prefecture Environmental Measurement Association URLhttp://www.saikankyo.jp () 29 . (1) (2) (3) 4.0 . 2013 2014 7 22 109 2013 2013 BOD COD 90 875 /974 BOD
1 2 D- D- 1206 D- D- -2003 120 /2004 D-FDA GRAS D D- 3 5 5 D- 75 10g/kg 14 40 20 D-101520 90 1520 20%101520 1520 D- 5(D- 2300-6700mg//) () 2024 615 D- 41220g/kg/ 1220g/kg/ 20g/kg/ 1220g/kg/ () 50 D- 10%
09_organal2
4. (1) (a) I = 1/2 (I = 1/2) I 0 p ( ), n () I = 0 (p + n) I = (1/2, 3/2, 5/2 ) p ( ), n () I = (1, 2, 3 ) (b) (m) (I = 1/2) m = +1/2, 1/2 (I = 1/2) m = +1/2, 1/2 I m = +I, +(I 1), +(I 2) (I 1), I ( )
4 1 Ampère 4 2 Ampere 31
4. 2 2 Coulomb 2 2 2 ( ) electricity 2 30 4 1 Ampère 4 2 Ampere 31 NS 2 Fleming 4 3 B I r 4 1 0 1.257 10-2 Gm/A µ 0I B = 2πr 4 1 32 4 4 A A A A 4 4 10 9 1 2 12 13 14 4 1 16 4 1 CH 2 =CH 2 28.0313 28 2
1 2 3 (1) (2) (3) (4) (5) 4 (2007) 1 (1) 2 (2) (3) 3 (1)(3) 1 Gautama, A.K., Kumarb, S., and Sabumon, P.C. (2007). Preliminary Study of Physico-chemical Treatment Options for Hospital Wastewater. Journal
untitled
26 3 31 BDF BDF BDF FAME BDF BDF BDF BDF BDF BDF BDF BDF BDF FAME BDF BDF 80.0 97.0% BDF 120 330 0.8% 2.2% 1. 1 1-1 1 1-2 1 2. 2 2-1 2 2-2 5 2-3 6 3. BDF 7 3-1 7 3-2 7 3-3 14 3-4 JOY 21 3-5 32 3-6 39 3-7
2
5 15.8% 17.1% 13.7% 15 1 34.0%3 1 3 25.7 4 1 76.5 3.3 2 23 3225 36 72.0 13.3 1 26 38 ( 77.8 87.8 69.5 2010 3 20 60 7 20 2 3 1 2 ( 77.8 87.8 69.5 2010 87.9 66.5 3 20 83.030 92.240 93.6 50 91.660 6065 72.9
untitled
Cd: cr : 2MG: 2-1MG: 1- RBP: 1.8 2.8 20 5.2 5.2.1 WHO 5.2.1 1 298 g/l 5 g/l Peplow D, Edmonds R. 230mg/kg 2.5mg/kg 246µg/L 161µg/L Lee JS, 2005 5.2.1 11-19 µg/ 0.17-0.30 µg/kg / PTWI 17-30% 0.5µg/ 0.02µg/
土壌の観察・実験テキスト −土壌を調べよう！−
( ) 2006 7 20 i 21 1962 1969 1987 1992 2005 65 1972 1977 1997 1977 1998 1982 1998 2002 2004 2005 SPP 1999 ii 1 g cm m 6378km ( ) 4.2, 4.3 5.1 7.1 8.1 4.1 7.3, 7.4 7.1 1 2 7.1 8.2 2 5 6 1, 2 2.3 4.2, 4.3
040202PC用.doc
15 48 15 8 25 15 1321 15 8 25 0825002 15 8 25 6 8 15 2 18 15 6 27 2 15 3 13 28 35 (1) 51 198 7 (2) 3 6 1 100g (1) 1 (1) 1 2 1 astaxanthin;3,3 -dihydroxy-, -carotene-4,4 -dione (2) 1 2 C40H52O4 596.86 97.0
参考資料５ 農薬評価書 メタアルデヒド（食品安全委員会資料）
1 3 3 4 5. 6 1. 6 2. 6 3. 6 4. 6 5. 6 6. 6 7. 6. 7 1. 7 2. 8 (1) 8 (2) 9 (3) 9 (4) 10 (5) 10 3. 11 (1) 11 (2) 11 (3) 11 (4) 12 4. 12 (1) 12 (2) 12 (3) 13 5. 13 6. 13 7. 14 8. 15 9. 16 10. 16 (1) 90 16-1
untitled
19 11 13 300 18 3 31 1300mg 4 6 C 15 H 22 FN 3 O 6 359.35 + -1-5--β-D--5--1,2--2- -4- 19 11 13 300 18 3 31 A B B A 30 1 2 21 7 1 1 1.31m 2 900mg 1.31m 2 1.64m 2 1,200mg 1.64m 2 1,500mg B 30 1 2 14 7 1
エディロールカプセルインタビューフォーム
2012 4 5 873112 2008 () 1 0.5g 0.5g 0.75g 0.75g JAN EldecalcitolJAN 2011 1 21 2011 3 11 2011 4 11 TEL0120-591-818 03-3985-5599 8:3017:00 http://www.taishotoyama.co.jp/ 20124 http://www.info.pmda.go.jp/
1 2 3 1 34060120 1,00040 2,000 1 5 10 50 2014B 305,000140 285 5 6 9 1,838 50 922 78 5025 50 10 1 2
0120-563-506 / 9001800 9001700 123113 0120-860-777 163-8626 6-13-1 Tel.03-6742-3111 http://www.himawari-life.co.jp 1 2 3 1 34060120 1,00040 2,000 1 5 10 50 2014B 305,000140 285 5 6 9 1,838 50 922 78 5025
2006
2006.11.25 92 1869 H 92 U 19 1895 X 1896. 20 92 X X 1 ev DNA ev DNA DNA 300 28 JCO 1999 9 JCO DNA 1934 66 X X 15 40 2 2.4 3 BEIR-VII 0.01 50 50 0.5 100 0.5 5000 30 1.6 2.25 2.25 1000 0.2 0.1 2000 10 245
気象庁委託調査
ART - 103 1. (2-1) 2-1 : 61 20km 1 2 6 10km 6 12 7 1 100km 1 1 34 7 300km 7 3 3 1300km 1 *1 *1 6 3 *2 300km 6 *3 *1 15 3 GPV 15 *2 15 *3 16 *2 1 7 1 15 2. (1 ) 15 1 15 ( GPV=Grid Point Value) 104 1 / 2-1
1 1 1 11 25 2 28 2 2 6 10 8 30 4 26 1 38 5 1 2 25 57ha 25 3 24ha 3 4 83km2 15cm 5 8ha 30km2 8ha 30km2 4 14
3 9 11 25 1 2 2 3 3 6 7 1 2 4 2 1 1 1 11 25 2 28 2 2 6 10 8 30 4 26 1 38 5 1 2 25 57ha 25 3 24ha 3 4 83km2 15cm 5 8ha 30km2 8ha 30km2 4 14 60 m3 60 m3 4 1 11 26 30 2 3 15 50 2 1 4 7 110 2 4 21 180 1 38
リスクコミュニケーション概論
1 2005 7 2 http://hideyukihirakawa.com/ Contents 1. 2. 3. 4. 2 1. (Alvin Weinberg, 1972) e.g. etc 3 4 2. 5 NRC, 1989; Codex, 2004 ( ) ( ) NGO 6 2 (TRUSTNET: Dubreuil et al, 2002) www.trustnetgovernance.com
100 100 6 1 8 10 18 5 12 9 26 2 9 80 2500 7 1400 1 20 7 5 1 3 16 16 16 16 No No.010101 020301 No.020302 021301 TP+3.00 3.06 TP+3.06 3.14 Ho To Ho 1.35m 3.0m To 5.6s 6.8s Ho 2.49m 3.0m
研究レポート表紙.PDF
No.118 November 2001 ISO ISO takeishi@fri.fujitsu.co.jp ISO14001 CEAR A4823 1. ISO14000 ISO14000 ISO14001 2. ISO ISO. ISO14001 ISO9000 OHSAS18001 18002 ISO14001 ISO IEC13335 ISO10006. ISO ISO14001 ISO9000
PowerPoint プレゼンテーション
食品等に含まれる化学物質のリスク評価の経験とそこから見えてきた課題 国立医薬品食品衛生研究所 広瀬明彦 日本リスク研究学会第 26 回シンポジウム (2013.06.14) 遺伝毒性発がん性の評価の課題定量的評価方法汚染化学物質の評価添加物の不純物の評価アクリルアミドの評価 暴露評価と MOE 法の課題 基準値設定と管理の課題 遺伝子ベンチマーク手法を用いた遺伝子 (DNA) 障害を引き起こす場合の実質安全量
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 2 16 17 18 19 20 29 1 21 22 23 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21... 1... 1... 1 PNEC... 2... 2... 3... 4... 4... 5... 6... 6... 6... 6... 6... 7...
( ( ( (
2005 11 1...- 1-2...- 6-2.1...- 6-2.2...- 6-3...- 7-4...- 9-4.1...- 9-4.2...- 15 - (1...- 16 - (2...- 17 - (3...- 18 - (4...- 19-5...- 20 - 1 A ( BPA 1961 2003 40 (p.5 9 ( PC ( EX BPA PC CD DVD OA EX BPA
取扱説明書 ［F-05E］
F-05E 12.11 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 a b 22 c d e 23 24 a o c d a b p q b o r s e f h i j k l m g f n a b c d e f g h 25 i j k l m n o p q r s a X b SD 26 27 28 X 29 a b c