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1 The Response of Ovarian Function to HMG-HCG and Bromocriptine Therapies in Hyperprolactinemic Patients Masateru MATSUOKA and Hiroo IMURA Second Division, Department of Internal Medicine, Kyoto University School of Medicine, Kyoto, Japan Takeshi ASO Department of Obstetrics and Gynecology, Fukui Medical School, Fukui, Japan Kiyoshi OKUDA Department of Obstetrics and Gynecology, Osaka Medical School, Osaka, Japan Synopsis: Plasma hormonal changes were analysed in patients with hyperprolactinemia who conceived following Bromocriptine therapy. Following the administration of HMG- HCG and Bromocriptine, serial plasma samples were collected from the cases. Plasma levels of FSH, LH, prolactin (PRL), estrone (E1), estradiol (E2 ), 17-hydroxyprogesterone (17-P), 20a-dihydroprogesterone (20a-P), progesterone (P) were determined simultaneously using specific radioimmunoassays. Pretreatment PRL levels, ng/ml, were normalized by mg/day of Bromocriptine treatment causing a rapid decrease in plasma PRL, reaching a plateau within several days. The first LH surge at midcycle after the start of the Bromocriptine treatment was established at 10 ^-750 days. In the patients the first midcycle LH surge was observed, but the luteal phase was definitely short, as demonstrated by

2 plasma progestins levels. The results from the present longitudinal studies on hyperprolactinemia revealed characteristic changes accompanied by the restoration of the hypothalamicpituitary-ovarian function during the treatment period.

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