1,2) 3-5) 6) 7) Table 1 Table 1 Number of subjects Age (y.o.) Men / Women Weight (kg) Height (cm) Body mass index Systolic BP (mmhg) Diastolic BP (mmh

Size: px

Start display at page:

Download "1,2) 3-5) 6) 7) Table 1 Table 1 Number of subjects Age (y.o.) Men / Women Weight (kg) Height (cm) Body mass index Systolic BP (mmhg) Diastolic BP (mmh"

なぎさひきぎ
5 years ago
Views:

1 Received: Jun 19, 2007 Accepted: Dec 6, 2007 Published online: Jan 29, 2008 Original Article The effects of walking with pedometers on quality of life and various symptoms and issues relating to aging Yoshikazu Yonei 1), Yoko Takahashi 1), Sawako Hibino 1), Miwako Watanabe 2), Toshikazu Yoshikawa 3) 1) Anti-Aging Medical Research Center, Doshisha University 2) Mareesia Garden Clinic 3) Department of Internal Medicine, Kyoto Prefectural University of Medicine Anti-Aging Medicine 5 (1) : 22-29, 2008 Anti-Aging Medicine 5 (1) : 22-29, 2008 (c) Japanese Society of Anti-Aging Medicine

2 1,2) 3-5) 6) 7) Table 1 Table 1 Number of subjects Age (y.o.) Men / Women Weight (kg) Height (cm) Body mass index Systolic BP (mmhg) Diastolic BP (mmhg) Total cholesterol (mg/dl) HDL-cholesterol (mg/dl) LDL-cholesterol (mg/dl) Triglyceride (mg/dl) Blood sugar (mg/dl) HbA1c (%) Number of smokers (tabaco/day) Number of drinkers Amount of alcohol(g/day) Exercise(day/week) Compliance The background profiles of participants ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ~ 100% ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ~ 100% Mean ± SD, by t test

3 7) Table 2 Table 2 Karvonen s formula Table 3A, 3B Table 3 Clinical laboratory test data for (A) study group with watch-type pedometer and (B) control group after 8 weeks of aerobic walking exercises (A) Target heart rate = (Maximum heart rate Resting heart rate) Exercise intensity + Resting heart rate Maximum heart rate: [220 actual age] Resting heart rate: pulse rate (heart rate) per minute at rest. Exercise intensity: 40% to 60% (0.4 to 0.6) 3-5) Weight (kg) Total body water (l) Muscle volume (kg) Lean body weight (kg) Skeletal muscle volume (kg) Body fat amount (kg) Body mass index Body fat percentage (%) Waist-hip ratio Basal metabolism (kcal) Systolic blood pressure(mmhg) Diastolic blood pressure (mmhg) Leukocyte count (/µl) Erythrocyte count (10 4 /µl) Hemoglobin content (g/dl) Hematocrit (%) Mean corpuscular volume (fl) Mean corpuscular hemoglobin (pg) Mean corpuscular hemoglobin concentration (%) Platelet count(10 4 /µl) Total protein (g/dl) GOT (IU/l) GPT (IU/l) LDH (IU/L) Alkaline phosphatase (IU/l) γ-gtp (IU/l) Total bilirubin (mg/dl) Blood creatinine (mg/dl) BUN (mg/dl) Uric acid (mg/dl) Creatine phosphokinase (mg/dl) Total cholesterol (mg/dl) HDL-cholesterol (mg/dl) LDL-cholesterol (mg/dl) Triglyceride (mg/dl) Na (meq/l) K (meq/l) Cl (meq/l) Ca (mg/dl) IP (mg/dl) Fasting blood sugar (mg/dl) Glycohemoglobin (%) IGF-I (ng/ml) DHEA-s (ng/ml) Cortisol (µg/dl) Estradiol (pg/ml) Total testosterone (pg/ml) 62.2 ± ± 43.5 ± 46.1 ± 25.4 ± 16.2 ± 23.5 ± 25.9 ± 0.89 ± ± ± 92.3 ± ± ± 14.4 ± 44.6 ± 93.8 ± 30.4 ± 32.4 ± 22.7 ± 7.63 ± 25.4 ± 26.5 ± ± ± 89.5 ± 0.65 ± 0.72 ± 14.8 ± 5.58 ± ± ± 62.7 ± ± ± ± 4.17 ± ± 9.20 ± 3.76 ± ± 5.3 ± ± ± 8.9 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ** 0.009** 0.009** 0.002** 0.025* ** 0.005** 0.010** 0.028* 0.011* ** 0.002** * * 0.404

4 (B) Weight (kg) Total body water (l) Muscle volume (kg) Lean body weight (kg) Skeletal muscle volume (kg) Body fat amount (kg) Body mass index Body fat percentage (%) Waist-hip ratio Basal metabolism (kcal) Systolic blood pressure (mmhg) Diastolic blood pressure (mmhg) Leukocyte count (/µl) Erythrocyte count (10 4 /µl) Hemoglobin content (g/dl) Hematocrit (%) Mean corpuscular volume (fl) Mean corpuscular hemoglobin (pg) Mean corpuscular hemoglobin concentration (%) Platelet count (10 4 /µl) Total protein (g/dl) GOT (IU/l) GPT (IU/l) LDH (IU/l) Alkaline phosphatase (IU/l) γ-gtp (IU/l) Total bilirubin (mg/dl) Blood creatinine (mg/dl) BUN (mg/dl) Uric acid (mg/dl) Creatine phosphokinase (mg/dl) Total cholesterol (mg/dl) HDL-cholesterol (mg/dl) LDL-cholesterol (mg/dl) Triglyceride (mg/dl) Na (meq/l) K (meq/l) Cl (meq/l) Ca (mg/dl) IP (mg/dl) Fasting blood sugar (mg/dl) Glycohemoglobin (%) IGF-I (ng/ml) DHEA-s (ng/ml) Cortisol (µg/dl) Estradiol (pg/ml) Total testosterone (pg/ml) 66.1 ± 33.2 ± 45.2 ± 47.9 ± 26.1 ± 18.2 ± 24.9 ± 27.3 ± 0.91 ± ± ± 88.7 ± ± ± 13.9 ± 42.2 ± 94.0 ± 31.0 ± 32.9 ± 22.4 ± 7.35 ± 24.9 ± 25.1 ± ± ± 50.1 ± 0.73 ± 0.76 ± 15.4 ± 6.03 ± ± ± 56.6 ± ± ± ± 4.23 ± ± 9.01 ± 3.59 ± 96.5 ± 5.1 ± ± ± 18.6 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± * 0.041* 0.039* 0.027* 0.049* ** 0.040* ** 0.001** ** ** * * Table 4 Physical symptoms (derived from survey questions) for (A) study group with watch-type pedometer and (B) control group after 8 weeks of aerobic walking exercises (A) Tired eyes Blurry eyes Eye pain Stiff shoulders Muscular pain/stiffness Palpitations Dyspnea Tendency to gain weight Weight loss; thin Lethargy No feeling of good health Thirst Skin problems Anorexia Early satiety Epigastralgia Liable to catch colds Coughing and sputum Diarrhea Constipation Headache Dizziness Tinnitus Lumbago Arthralgia Edematous Easily breaking into a sweat Frequent urination Hot flash Cold skin 2.53 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 0.86 (B) Tired eyes Blurry eyes Eye pain Stiff shoulders Muscular pain/stiffness Palpitations Dyspnea Tendency to gain weight Weight loss; thin Lethargy No feeling of good health Thirst Skin problems Anorexia Early satiety Epigastralgia Liable to catch colds Coughing and sputum Diarrhea Constipation Headache Dizziness Tinnitus Lumbago Arthralgia Edematous Easily breaking into a sweat Frequent urination Hot flash Cold skin 2.67 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± * 0.020* * * 0.027* 0.017* 0.028*

5 Table 4A, 4B Table 5 Mental symptoms (derived from survey questions) for (A) study group with watch-type pedometer and (B) control group after 8 weeks of aerobic walking exercises (A) Irritability Easily angered Loss of motivation No feeling of happiness Nothing to look forward to in life Daily life is not enjoyable Lose confidence Reluctance to talk with others Depressed Feeling of uselessness Shallow sleep Difficulty in falling asleep Pessimism Lapse of memory Inability to concentrate Inability to solve problems Inability to make judgments readily Inability to sleep because of worries A sense of tension Feeling of anxiety for no special reason Vague feeling of fear 2.27 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± 0.59 (B) Irritability Easily angered Loss of motivation No feeling of happiness Nothing to look forward to in life Daily life is not enjoyable Lose confidence Reluctance to talk with others Depressed Feeling of uselessness Shallow sleep Difficulty in falling asleep Pessimism Lapse of memory Inability to concentrate Inability to solve problems Inability to make judgments readily Inability to sleep because of worries A sense of tension Feeling of anxiety for no special reason Vague feeling of fear 2.07 ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± * * ** Table 5A, 5B Table 6A, 6B, 6C Table 6 Comparison of study group with watch-type pedometer and control group for (A) findings of clinical laboratory tests, (B) physical symptoms, and (C) mental symptoms after 8 weeks of aerobic walking exercises (A) (Clinical laboratory tests) Weight (kg) Total body water (l) Muscle volume (kg) Lean body weight (kg) Skeletal muscle volume (kg) Body fat amount (kg) Body mass index Body fat percentage (%) Waist-hip ratio Basal metabolism (kcal) Systolic blood pressure (mmhg) Diastolic blood pressure (mmhg) Leukocyte count (/µl) Erythrocyte count (10 4 /µl) Hemoglobin content (g/dl) Hematocrit (%) Mean corpuscular volume (fl) Mean corpuscular hemoglobin (pg) Mean corpuscular hemoglobin concentration (%) Platelet count (10 4 /µl) Total protein (g/dl) GOT (IU/l) GPT (IU/l) LDH (IU/l) Alkaline phosphatase (IU/l) γ-gtp (IU/l) Total bilirubin(mg/dl) Blood creatinine (mg/dl) BUN (mg/dl) Uric acid (mg/dl) Creatine phosphokinase (mg/dl) Total cholesterol (mg/dl) HDL-cholesterol (mg/dl) LDL-cholesterol (mg/dl) Triglyceride (mg/dl) Na (meq/l) K (meq/l) Cl (meq/l) Ca (mg/dl) IP (mg/dl) Fasting blood sugar (mg/dl) Glycohemoglobin (%) IGF-I (ng/ml) DHEA-s (ng/ml) Cortisol (µg/dl) Estradiol (pg/ml) Total testosterone (pg/ml) ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ** ** Mean ± SD, *p<0.05, **p<0.01, by Wilcoxon s signed rank test

6 (B) (physical symptoms) Tired eyes Blurry eyes Eye pain Stiff shoulders Muscle pain/stiffness Palpitations Dyspnea Tendency to gain weight Weight loss; thin Lethargy No feeling of good health Thirst Skin problems Anorexia Early satiety Epigastralgia Liable to catch colds Cough and sputum Diarrhea Constipation Headache Dizziness Tinnitus Lumbago Arthralgia Edematous Easily breaking into sweat Frequent urination Hot flashes Cold skin ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Mean ± SD, *p<0.05, **p<0.01, by Wilcoxon s signed rank test ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± * * * * * (C) (mental symptoms) Irritability Easily angered Loss of motivation No feeling of happiness Nothing to look forward to in life Daily life is not enjoyable Lose confidence Reluctance to talk with others Depressed Feeling of uselessness Shallow sleep Difficulty in falling asleep Pessimism Lapse of memory Inability to concentrate Inability to solve problems Inability to make judgments readily Inability to sleep because of worries A sense of tension Feeling of anxiety for no special reason Vague feeling of fear ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± Mean ± SD, *p<0.05, **p<0.01, by Wilcoxon s signed rank test ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± * 0.050*

7 8) 9) 10) 11,12)

8 13,14) 15) 16) 17,18) 01) 02) 03) 0 4) 5) 6) 0 7) 8) 9) 10) Yonei Y, Mizuno Y. The human dock of tomorrow annual health checkup for anti-aging. Ningen Dock 19:5-8, Rowe JW, Kahn RL. Human aging: usual and successful. Science 237(4811): , Yonei Y, Mizuno Y, Togari H, et al. Muscular resistance training using applied pressure and its effects on the promotion of growth hormone secretion. Anti-Aging Medical Research 1:13-27, Yonei Y, Mizuno Y, Katagiri E. Effects of cosmetics therapy using isoflavone and pine bark extract on the skin and QOL: a doubleblind placebo-controlled trial. Anti-Aging Medical Research 1:48-58, Yonei Y, Iwaita Y, Muramatsu K, et al. The anti-aging secrets of Japanese executives. Anti-Aging Medical Research 2:61-69, The National Health and Nutrition Survey in Japan, 2004: Ministry of Helth, Labour and Welfare of Japan. Web site: (in Japanese) Omiya K, Itoh H, Osada N, et al. Impaired heart rate response during incremental exercise in patients with acute myocardial infarction and after coronary artery bypass grafting: evaluation of coefficients with Karvonen's formula. Jpn Circ J 64: , Weuve J, Kang JH, Manson JE, et al. Physical activity, including walking, and cognitive function in older women. JAMA 292: , Abbott RD, White LR, Ross GW, et al. Walking and dementia in physically capable elderly men. JAMA 292: , Shih TT, Chang CJ, Hsu CY, et al. Correlation of bone marrow lipid water content with bone mineral density on the lumbar spine. Spine 29: , ) 12) 13) 14) 15) 16) 17) 18) Kalantaridou SN, Makrigiannakis A, Zoumakis E, et al. Stress and the female reproductive system. J Reprod Immunol 62:61-68, Blumenthal JA, Fredrikson M, Matthews KA, et al. Stress reactivity and exercise training in premenopausal and postmenopausal women. Health Psychol 10: , Omiya K, Itoh H, Osada N, et al. Impaired heart rate response during incremental exercise in patients with acute myocardial infarction and after coronary artery bypass grafting: evaluation of coefficients with Karvonen's formula. Jpn Circ J 64: , Miyatake N, Nishikawa H, Morishita A, et al. Re-evaluation of exercise intensity for overweight Japanese men by ventilatory threshold. Diabetes Obes Metab 7: , Mitani Y, Sakuma H, Fukunaga M, et al. (A study of self-paced walking for the promotion of health). Psychosomatic Medicine 44: , (in Japanese) Kawaguchi T, Yamamoto H. (Relationship of caloric consumption between pace counts with a pedometer and intensive strength exercises). Physical Therapy Research 20:21-25, (in Japanese) Sakaguchi M, Ono N, Ohashi T. (Development of a mobile indicator for measuring physical exertion) BME 14: , (in Japanese) Sakaguchi M, Ono N, Yoshikura H, et al. (Development of a mobile indicator for measuring physical exertion). Medical Engineering and Biocybernetics 99:25-30, (in Japanese)

1-4) 1) Fuscoporia obliqua 5,6) 2,8,9)

1-4) 1) Fuscoporia obliqua 5,6) 2,8,9) ANTI-AGING MEDICINE Received: Jan 29, 2007 Accepted: May 19, 2007 Published online: June 1, 2007 Original Article Double Blind Study of Health Claims for Food Containing Extract of Kabanoanatake (Charga: