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かげたつみやくぼ
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1 ARF-like GTPase RAS G RAS, RHO RAC, RAB, ARF ARL, RAN ARF RAB G ARF-like ARL GTPase ARF G ARL GTPase ARF ARL GTPase G ARF ARL GTPase-activating proteins GAPs ARF G N ARF N ARF GDP GTP N ARL ARL ARF N ARL N ARL ARL GEFs GAPs ARF ARL G SAR ARF ARF GDP GTP SAR ARFARF guanine-nucleotide exchange factors GEFs Regulation of membrane dynamics by ARF-like GTPases Kenji Kontani Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan ARL8 ARLARL GTPase ARL A ARL B N ARL ARL G G ARL pp.

2 ARF ARL G ARF ARL G SAR SAR A, SAR BARF ARF ARF ARL ARLARL ARL A B ARL sheath cell ARL

VPS HOPS G Rab tethering factor ARL ARL VPS HOPS HeLa ARL ARL ARL arl- ARL ARL ARL GTPase Sonic

3 ARL C. elegans ARL arl- coelomocyte arl- coelomocyte arl- sheath cell arl- G Rab ARL G ARL ARL GTP HOPS VPS HOPS G Rab tethering factor ARL ARL VPS HOPS HeLa ARL ARL ARL arl- ARL ARL ARL GTPase Sonic hedgehog ARL GTPase ARL ARLARLb ARL ARLb Bardet-Biedl syndrome BBS Joubert syndrome ARL ARL G IFT ciliary necklace transition fibers ARLb inositol polyphosphate -phosphatase INPP E ARL BBS BBSome

4 TR ARL GTP ARL GDP TR ARL GDP GTP ARL BBSome ARL GTP BBSome BBS ARL BBSome ARLb ARLb ARLb ARLb intraflagella transport ARLb ARLb inositol polyphosphate -phosphatase INPP E GTP Arlb ARLb ARL GTPase ARL MHC II ARL ARL ARL GTPase ARL GTPase ARL GTPase G G ARL GTPase ARL GTPase Donaldson, J G. Jackson, C L.Nat. Rev. Mol. Cell Biol.,, Hofmann, I. Munro, S.J. Cell Sci.,,. Luzio, J P., Pryor, P.R., Bright, N.A.Nat. Rev. Mol. Cell Biol.,,. Kinchen, J.M. Ravichandran, K.S.Nat. Rev. Mol. Cell Biol.,,. Nakae, I., Fujino, T., Kobayashi, T., Sasaki, A., Kikko, Y., Fukuyama, M., Gengyo-Ando, K., Mitani, S., Kontani, K., Katada, T.Mol. Biol. Cell,,. Sasaki, A., Nakae, I., Nagasawa, M., Hashimoto, K., Abe, F., Saito, K., Fukuyama, M., Gengyo-Ando, K., Mitani, S., Katada, T., Kontani, K.Mol. Biol. Cell,,. Garg, S., Sharma, M., Ung, C., Tuli, A., Barral, D.C., Hava, D. L., Veerapen, N., Besra, G.S., Hacohen, N., Brenner, M.B. Immunity,,. Korolchuk, V.I., Saiki, S., Lichtenberg, M., Siddiqi, F.H., Roberts, E.A., Imarisio, S., Jahreiss, L., Sarkar, S., Futter, M., Menzies, F.M., O Kane, C.J., Deretic, V., Rubinsztein, D.C. Nat. Cell Biol.,,. Rosa-Ferreira, C. Munro, S.Dev. Cell,,. Klassen, M.P., Wu, Y.E., Maeder, C.I., Nakae, I., Cueva, J.G., Lehrman, E.K., Tada, M., Gengyo-Ando, K., Wang, G.J., Goodman, M., Mitani, S., Kontani, K., Katada, T., Shen, K. Neuron,,. Goetz, S.C. Anderson, K.V.Nat. Rev. Genet.,, Satir, P. Christensen, S.T.Annu. Rev. Physiol.,,. Li, Y., Ling, K., Hu, J.J. Cell Biochem.,,. Kobayashi, T., Hori, Y., Ueda, N., Kajiho, H., Muraoka, S., Shima, F., Kataoka, T., Kontani, K., Katada, T.Biochem. Biophys. Res. Commun.,,. Nachury, M V., Seeley, E.S., Jin, H.Annu. Rev. Cell Dev. Biol.,,. Caspary, T., Larkins, C.E., Anderson, K V.Dev. Cell,,. Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S., Hopkins, N.Development,,. Cevik, S., Hori, Y., Kaplan, O.I., Kida, K., Toivenon, T., Foley-Fisher, C., Cottell, D., Katada, T., Kontani, K., Blacque, O.E.J. Cell Biol.,,. Hori, Y., Kobayashi, T., Kikko, Y., Kontani, K., Katada, T. Biochem. Biophys. Res. Commun.,,. Humbert, M.C., Weihbrecht, K., Searby,C.C.,Li,Y.,Pope,R. M., Sheffield, V.C., Seo, S.Proc. Natl. Acad. Sci. USA.,,.

5 Dr. Joel Rothman G G f u-tokyo ac jp seiri