Database Center for Life Science Online Service Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara,
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1 Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara, horikosh@iam.u-tokyo.ac.jp
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drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:
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Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
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Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol
Spatio-temporal regulation of ERK1/2 MAP kinase 20) Murphy, L. 0., MacKeigan, J. P., Blenis, J.: Mol. Cell. Biol., 24, 144-153 (2004) 21) Harada, T., Morooka, T., Ogawa, S., Nishida, E.: Nature Cell
The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Database Center for Life Science Online Service Key words Shigey
The function and structure of NAD kinase: the key enzyme for biosynthesis of NADP (H) Key words Shigeyuki Kawai, Chikako Fukuda, Kousaku Murata E-mail : kawais@kais.kyoto-u.ac.jp, chikakko@kais.kyotou.ac.jp,
Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap
Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan] Molecular Basis of Triplet Repeat Diseases : Genetic Instabillity and Unusual DNA
Review Column 1) Extavour, C. G., Akam, M. : Development, 130, 5869-5884 (2003) 2) Saitou, M. et al.: Philos. Trans. R. Soc. Lond. B. Biol. Sci., 358,1363-1370(2003) 3) Eddy, E. M. : Int. Rev.
E-mail : tmatsumo@house.rbc.kyoto-u.ac.jp htm Spindle checkpoint : Cell cycle regulation by a signal emitted from kinetochores http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index. 19) Yao, X., Abrieu,
Kazumitsu Ueda, E-mail : uedak@kais.kyoto-u.ac.jp http : //cseika-1, kais.kyoto-u.ac.j p Molecular mechanism of multidrug transporter MDR I : ABC in host-defense machinery 32P-ATP 1) Chen, C., Chin,
Review Database Center for Life Science Online Service Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Review Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge E-mail : m.mishima @gurdon.cam.ac.uk http://www.gurdon.cam.ac.uk/groups/mishima.html Cytokinesis :
Database Center for Life Science Online Service [Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome,
[Department of Molecular Physiology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome, Bunkyo-ku, Tokyo 113, Japan] [Graduate School of Agricultral Bioscien- ces, The University of Tokyo,
Short Review E-mail : kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases 2) Anfinsen, C. B.: Harvey Lect., 61, 95-116 (1967) 3) Carrel, R. W., Lomas, D. A.
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1999 No. 5 CHAPERONE NEWSLETTER CONTENTS 2 3 4 JEM JEM JEM, SEC, SCJ JEM JEM SCJ jem, scj 5 in vitro S. cerevisiae 6 K 7 in vitro Cell Mol. Cell in vitro 8 9 E. coli E. coli 10 in vitro ssc - b 11 in vivo
Database Center for Life Science Online Service archlaboratories, 4-1-1 Miyazaki, Miyamae-ku, Kawasaki-shi, Kanagawa 213, Japan] Developmental Genetics of Caenorhabditis elegans Database Center for
Database Center for Life Science Online Service Chiharu Ueguchi, Molecular mechanism and biological function of t
Chiharu Ueguchi, E-mail : cueguchi@agr.nagoya-u.ac.jp Molecular mechanism and biological function of the cytokinin signal tansduction pathway 1) Miller, C. 0., Skoog, F., von Saltza, M. H., Strong,
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Atg Atg Mizushima, N.Cell Death Differ.,,. Nakatogawa, H., Ichimura, Y., & Ohsumi, Y.Cell,,. Baba, M., Takeshige, K., Baba, N., & Ohsumi, Y.J. Cell Biol.,,. Baba, M., Osumi, M., & Ohsumi, Y. Cell Struct.
Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)
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TRANSPORTSOME QUARTERLY Winter 2009 1 2 3 4 5 6 Synaptobrevin, Synaptotagmin, rab3 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Dev Cell 2002, Curr Opin Cell Biol 2006, J Cell Biol 2008, Curr
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Database Center for Life Science Online Service Natronobacterium pharaonis Crystal structure of phoborhodopsin : Mechanisms of color tuning and signal
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図8SINEの SINEと3'末 親 と な って い るLINEの 系 統 関係 端 を共 有 して い るLINEは 赤 色 で 示 す, 報 告 さ れ て い るす べ て のLINEは11の ら れ る.そ れ ぞ れ のLINEの グル ー プ に分 け あ い だ にお い て 水 平 的 な交 流 が な い と仮 定 す る と,こ の11に 分 け られ る こ のLINE え
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Molecules that regulate morphology of the plasma membrane Shiro Suetsugu, Kazunori Takano E-mail : suetsugu@iam.u-tokyo.ac.jp 1326 Vol.53 No. 11 (2008) Vol.53 No. 11 (2008) 1327 1328 Vol.53 No. 11 (2008)
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Amyloid Fibril Formation and Protein Science Yuji GOTO Institute for Protein Research, Osaka University E-mail: ygoto@protein.osaka-u.ac.jp Abstract: Amyloid fibrils have been a critical subject in recent
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膜結合型転写因子SREBP 図7GFPとsREBP-2 HLH-Zip領 域 と の 融 合 蛋 白 質 の 模 式 図 とimportinβ ア ミ ノ 酸343-460 を 介 した 核 輸 送 ジ ギ トニ ン処 理 に よ り細 胞 膜 に穴 を 開 け たHeLa細 GFP-HLH-Zip蛋 55 胞 を用 い て 白 質の 核 輸 送 を観 察 した importinβ のみで は核 膜
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アデノウイルスベクターの改良と応用 7 ン トネ ガ テ ィ ブ を用 い てRel NF-κBの シグナル の不 活 化 を 試 み た そ の 結 果 IκBの ド ミナ ン トネ ガ テ ィ ブ を ニ ワ ト リ胚 肢 芽 に 接 種 した 群 で は 発 現 率 は低 い もの の 四 肢 の 形 成 阻 害 が 認 め られ この 結 果 は頂 堤 AER)を 除 去 した も の の表
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Regulation of mrna decay in eukaryote ARE : AU-rich element eef1a : eukaryotic elongation factor 1A eif : eukaryotic initiation factor erf : eukaryotic releasing factor NMD : nonsense-mediated mrna decay
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pp. ATP ε ATP ATP ATP ε Bacillus PS ATP ATP H H µ H ATP ATP ADP µ H ATP FoF -ATP FoF -ATP µ H H ADP ATP H Na On the regulatory role of the epsilon subunit in ATP synthase Yasuyuki Kato-Yamada Department
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Yeast one-hybrid system niimi@agr.nagoya-u.ac. jp て い る しか し す べ て のDNA結 合 タンパク 質 が 酵 母 で 転 写 活 性 化 因 子 と して 働 く と は限 らな い この 場 合 に は VPI6やGa14の 転写活 性 化 領 域 と のfusionタ ン パ ク質 を作 る こ と に よって酵母 で転写活 性化
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Establishment and progress of Sendai virus engineering 2) Schnell, M. J., Mebatsion, T., Conzelmann, K.-K.: EMBO J., 13,4195-4203(1994) 3) Kato, A. et al.: Genes Cells, 1, 569-579 (1996) 4) Nagai,
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J. Jpn. Soc. Colour Mater., 79 [3], (2006) Anthocyanins : Structural Diversity, Color, and in Vivo Behavior Yuko NAKAGAWA, Takashi ICHIYANAGI,
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J. Cell Biol.,,. Segev, N.Curr. Opin. Cell Biol.,,. Lafont, F., Lecat, S., Verkade, P., & Simons, K.J. Cell Biol.,,. Mostov, K.E., Verges, M., & Altschuler, Y.Curr. Opin. Cell Biol.,,. Sato, T., Mushiake,
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2) Shin, S. I., Fredman, V. H., Risser, P., Pol lack,r.: Proc. Natl. Acad. Sci. USA, 72, 4435-4439 (1975) 3) Marquardt, H., Todaro, G. J.: J. Biol. Chem., 256, 6859-6865 (1981) 4) Dicker, P., Pohjanpelto,
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Short Review Shou Takashima, Masafumi Tsujimoto, E-mail : staka@postman.riken.go.jp Shuichi Tsuji, Functional analysis of sialylglycoconjugates by sialyltransferase deficient mice GINAcT : N-acetylglucosaminyltransferase,
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Database Center for Life Science Online Service Key words Kikuya Kato, E-mail : kkato@bs.aist-nara. ac.jp http://love2.aist-nara.ac.jp Shin Ishii, E-mail : ishii@is.aist-nara.ac.jp http://hawaii.aist-nara.
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Database Center for Life Science Online Service School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferati
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School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferation and Activation Mechanism of GTP Binding Proteins by the Enzyme 3) Nishizuka, Y.: Nature,
Database Center for Life Science Online Service Structure and function of nitric oxide synthases
Structure and function of nitric oxide synthases 3) Furchgott, R. F., Zawadzki, J. V. : Nature, 288,373-376 (1980) 4) Palmer, R. M., Ferrige, A. G., Moncada, S.: Nature, 327,524-5260987) 5) Alderton,
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BRC 61 JF1 F1 LDH 62 (Macaca fascicularis) DBA/2 ddy BDF1 C57BL/6 B6 TG BDF1 C57BL/6 Publications 1.Itoh M., Matsuda J., Suzuki O., Ogura A., Oshima A., Tai T., Suzuki Y. and Takashima S.: "Development
2) Pytela, R., Pierschbacher, M. D., Ruoslahti, E.: Cell, 40, 191-198 (1985) 3 z Thunberg, L., Backstrom, G., Lindahl, U.: Carbohydr. Res., 100, 393-410 (1982) 4) Petitou, M.: Nelle. Rev. Fr. Hematol.,
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論文についての覚え書き 2016 年 9 月 14 日改訂 津釜大侑 研究を進めていく上で論文を読むのは最も基本的で重要な作業です 論文を読む上で気を 付けると良いと思われることについて以下に挙げます 論文の種類 Research article 実験解析の結果を載せる 論文というと普通これを指す ゼミではこれを扱います Short communication 量は多くないが重要性が高いデータを迅速に公表するためのもの
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Kazuo Emoto, Masato Umeda, E-mail : emoto@rinshoken.or.jp pliakov, 0., De Camilli, P.: Neuron, 24, 143-154 (1999) 8) Takei, K., Haucke, V., Slepnev, V., Farsad, K., Salazar, M., Chen, H., De Camilli,
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MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic
Tomohiro Terada, Ken-ichi Inui, Peptide transporter family situ 1) Matthews, D.M. : Physiol. Rev., 55, 537-608(1975) 2) Ganapathy, V.. Leibach, F.H.: Am. J. Physiol. Gastro intest. Liver Physiol.,
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Natuo Komoto, E-mail : natuo@affrc.go. jp http://cse.nias.affrc.go.jp/natuo/index.htm Silkworm mutants whose deficiency of epidermal orate granules causes translucent larval skin phenotypes 図3 カイ コ幼 虫
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H., Hoshino, K., Kaisho, T., Kuwata, H., Takeushi, O., Takeshige,K.,Saitoh,T.,Yamaoka,S.,Yamamoto,N.,Yamamoto, S., Muta, T., Takeda, K., & Akira, S.Nature,,. Yamazaki, S., Muta, T., Matsuo, S., & Takeshige,