THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr B 2 NTT

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1 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS Ph-ALL Liposomal amphotericin B 1 2. CBT MCFG L-AMBAML 2

2 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr B 2 NTT

3 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS Ph-ALL Liposomal amphotericin B 1 BL-AMB 28 33,000/ L 85% 6.1 g/dl / L 98% major minor bcr-ablph ALL JALSG-Ph ALL202 RELAL-88 2 HLA DR CPA VP-16 TBI 12Gy FK506 Short MTX FLCZ 200 mg/ Day 12 MCFG 150 mg/ Day 23 Day 30 Grade II agvhd PSL 1 mg/kg PSL Day 60 X CT 3 cm -D- MCFG VRCZ 1CT L-AMB 5 mg/kg Day 188 VATS video-assisted thoracoscopic surgery S1 S2c S3a S4a Fig. 12 cm PAS Grocott 3 L-AMB

4 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr Fig. 1. RELAL-88 L-AMB L-AMB L-AMB 9 VRCZ MCFG L-AMB

5 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS % B CHAMILOS early treatment 6 delayed treatment % 65% 12 48% 82% Kaplan-Meier Fig. 2 Fig B Fig. 3.

6 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr Fig. 4.

7 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS VRCZ VRCZ reversed halo sign MD ANDERSON CT reversed halo sign % %20 CT reversed halo sign B Posaconazole CPFG MCFG Fig. 3 deferasirox Fig. 4 RODEN 929 CID % 85% 76% % B reversed halo sign deferasirox Posaconazole

8 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr CBT MCFG L-AMBAML 2 B L-AMB AML AML with MRC WBC 4,100/ L Fig. 1. Reversed halo sign

9 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS % 25% Hb 8.7 g/dl Plt 30,000/ L CBT FLU 180 mg/m 2 MEL 80 mg/m 2 TBI 4 Gy GVHD TAC MMF 1.5 g VRCZ Day 1 Day537.6 C WBC 10/ L CRP 11.2 mg/dl Staphylococcus haemolyticus VRCZ Day mg/l Day mg/l Day 6 CT reversed halo sign reversed halo sign Fig. 1 Day 6 VRCZ L-AMB 5 mg/kg MCFG Fig. 2. 1

10 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr mg L-AMB 10 mg/kg Day 5 VCM CFPM Day 10 6 HHV-6 FCV Day 17 Fig. 2 Day 129VATS mm PCR Cunninghamella bertholletiae AMPH-B L-AMB ,650 mg K, Mg, Ca, Na Cre 0.5 mg/dl 1.2 mg/dl L-AMB TAC TAC 2 4 GVHD AML with MRC Ara-C MEC 2 MEC TBI 12 Gy ubmt Day 87 CAG Azacitidine 6WT16 OP PSL OP 2011 CT OP WBC 1,600/ L16% 3% Hb 6.8g/dL Plt 21,000/ L FLU 180 mg/m mg/kg MEL 80 mg/m 2 GVHD TAC VRCZ OP PSL 20 mg Day 0 Day 438 C WBC 10/ L CRP 9.4 mg/dl VRCZ 1 mg/l Day 5 CT 5 cm VRCZ L-AMB 10 mg/kg MCFG 150 mg VCM MEPM HHV-6 FCV

11 Apr THE JAPANESE JOURNAL OF ANTIBIOTICS PIR pre-engraftment immune reaction HC 50 mg 1 2 JC 20 Day 19 Fig. 3 Day 96 Day 119 VATS S mm HE PAS PCR Cunninghamella bertholletiae L-AMB 10 mg/kg MCFG L-AMB ,600 mg K, Mg, Ca, Na Cre 0.6 mg/dl 1.3 mg/dl AST, ALT 3 L-AMB TAC 2 4 Fig. 3. 2

12 THE JAPANESE JOURNAL OF ANTIBIOTICS 66 2 Apr GVHD HC 600 Rhizopus, Rhizomucor, Mucor, Absidia, Cunninghamella, Syncephalastrum HSCT % 2 2 HSCT 75% BAL 25% reversed halo sign IPA L-AMB 5 10 mg/kg Posaconazole L-AMB 5 2 L-AMB L-AMB 10 mg/kg Day 6 Day L-AMB 10 mg/kg MCFG 150 mg AML FCV VCM

051

051 June THE JAPANESE JOURNAL OF ANTIBIOTICS 57 3 295( 83 ) NTT 1. 2. 3. 4. CHOP-R 5. DNA 1 296( 84 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 3 June 3 1 2003 10 4 1 NTT June THE JAPANESE JOURNAL OF ANTIBIOTICS

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