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2 no.588 vol.57 no CODE CN1588
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5 CLINICIAN 10 NO
6 3 CLINICIAN 10 NO. 588
7 Göteborg Kuopio Nun Göteborg leukoaraiosis Rotterdam CLINICIAN 10 NO
8 Skoog Snowdon Ott Kivipelto Solomon Bennet Göteborg study BP AD VD BP BP Nun study MMSE n AD Rotterdam study DM AD DM AD VD AD VD Kuopio studyad SBPTch AD AD Kuopio study Tch AD MCI Tch MCI Religious Orders study NIA/Reagan AD Stage ADVDMMSESBP TchMCI 5 CLINICIAN 10 NO. 588
9 ε4 Kuopio Göteborg CLINICIAN 10 NO
10 Kuopio Bennet Skoog, I., et al. : 15-year longitudinal study of blood pressure and dementia. Lancet, 347, (1996) Kivipelto, M., et al. : Midlife vascular risk factors and Alzheimer s disease in later life : longitudinal, population based study. BMJ, 322, (2001) Whitmer, R.A., et al. : Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64, (2005) Snowdon, DA., et al. : Brain infarction and clinical expression of Alzheimer disease : the Nun study. JAMA, 277, (1997) 7 CLINICIAN 10 NO. 588
11 Solomon, A., et al. : Serum cholesterol changes after Med., 11, (2007) membrane rafts, isoprenoids and statins. J. Cell Mol. Reid, P. C., et al. : Alzheimer s disease : cholesterol, and aging. Am. J. Epidemiol., 156, (2002) a prospective analysis from the Canadian study of health Lindsay, J., et al. : Risk factors for Alzheimer s disease : nerve system. Neurosci. Biobehav., 25, (2001) Park, C. R. : Cognitive effects of insulin in the central 74(2006) 1942(1999) Biessels, G. J., et al. : Risk of dementia in diabetes mellitus : a systematic review. Lancet Neurol., 5, 64 dementia : the Rotterdam study. Neurology, 53, 1937 Ott, A., et al. : Diabetes mellitus and the risk of without cognitive impairment from two communitybased studies. Neurology, 66, (2006) Bennett, D. A., et al. : Neuropathology of older persons Neurol., 58, (2001) impairment and dementia in elderly persons. Arch. Laurin, D., et al. : Physical activity and risk of cognitive Neurology, 67, (2006) consumption with age-related cognitive change. Morris, M.C., et al. : Associations of vegetable and fruit Aging, 24, (2003) dementia : the Honolulu-Asia aging study. Neurobiaol. Tyas, S. L., et al. : Mid-life smoking and late-life midlife and late-life cognition : twenty-one-year followup study. Neurology, 86, (2007) CLINICIAN 10 NO
12 dementia depression delirium 9 CLINICIAN 10 NO. 588
13 abcd A A A A CLINICIAN 10 NO
14 α attenuation 11 CLINICIAN 10 NO. 588
15 American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders-IV(DSM-IV). (1994) CLINICIAN 10 NO
16 13 CLINICIAN 10 NO. 588
17 T1 CLINICIAN 10 NO
18 secondary NPH : snph idiopathic NPH : inph CSH CSH 15 CLINICIAN 10 NO. 588
19 Evans Index0.3 Evans Index= aba b CLINICIAN 10 NO
20 inph 17 CLINICIAN 10 NO. 588
21 Iseki, C., et al. : Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly : a prospective study in a Japanese population. J. Neurol. Sci., 277, 54 57(2009) Ogino, A., Kazui, H., et al. : Cognitive impairment in patients with idiopathic normal pressure hydrocephalus. Dement. Geriatr. Cogn. Disord., 21, (2006) Kitagaki, H., et al. : CSF spaces in idiopathic normal pressure hydrocephalus : morphology and volumetry. AJNR Am. J. Neuroradiol., 19, (1998) CLINICIAN 10 NO
22 Reisberg Global Deterioration Scale (GDS) Stage 3 Petersen 19 CLINICIAN 10 NO. 588
23 Petersen Dubois Va Dubois Va CLINICIAN 10 NO
24 21 CLINICIAN 10 NO. 588
25 Dubois CLINICIAN 10 NO
26 Roman Mild Prichep, LS., et al. : Prediction of longitudinal cognitive decline in normal elderly with subjective complaints 23 CLINICIAN 10 NO. 588
27 Dubois, B., et al. : Research criteria for the diagnosis of 352, 1 10(2005) treatment of mild cognitive impairment. N. Eng. J. Med., Petersen, RC., et al. : Vitamin E and donepezil for the Psychogeriatr., 1, 1 9(2008) disease in a community : The Osaki-Tajiri Project. Int. metabolism in converters from CDR 0.5to Alzheimer s Ishii, H., Meguro, K., et al. : Decreased cortical glucose Tajiri Project. Neuroepidemiology, 33, (2009) converters to dementia in a community : The Osaki- function tests can screen mild cognitive impairment and Nakata, E., et al. : Combined memory and executive Sci., 260, (2007) (2004) Meguro, K., et al. : Incidence of dementia and associated risk factors in Japan : The Osaki-Tajiri Project. J. Neurol. Alzheimer s disease? Lancet Neurol., 3, Dubois, B., Albert, ML. : Amnestic MCI or prodromal (1999) clinical characterization and outcome. Arch. Neurol., 56, Petersen, RC., et al. : Mild cognitive impairment : 27, (2006) using electrophysiological imaging. Neurobiol. Aging, 59, 23 30(2000) vascular dementia in clinical trials. J. Neural. Transm., Erkinjuntti, T., et al. : Research criteria for subcortical vascular dementia. J. Neurol. Sci., 226, 81 87(2004) 746(2007) Roman, GC., et al. : Vascular cognitive disorder : a new category updating vascular cognitive impairment and criteria-a Position Paper. Lancet Neurology, 6, 734 Alzheimer s disease : Revising the NINCDS-ADRDA CLINICIAN 10 NO
28 Mini-Mental State Examination MMSE Alzheimer s disease : AD Frontotemporal dementia : FTD Dementia with Lewy bodies : DLB Vas- 25 CLINICIAN 10 NO. 588
29 cular dementia : VaD Test Your Memory Verbal fluency category fluency semantic fluency letter fluency mild cognitive impairment : MCI DLB+VaD Alzheimer sdisease Assessment Scale cog Wechsler Memory Scale-revised verbal fluency Verbal fluency category fluency letter fluency category fluency CLINICIAN 10 NO
30 letter fluency category fluency letter fluency category fluency 27 CLINICIAN 10 NO. 588
31 CLINICIAN 10 NO
32 Folstein, MF., et al. : Mini-Mental State ; a practical method for grading the cognitive state for the clinician. J. Psychiatr. Res., 12, (1975) O Bryant, SE., et al. : Detecting dementia with the Mini- Mental State Examination in highly educated individuals. Arch. Neurol., 65, (2008) Hanyu, H., et al. : The 1-minute mental status examination in the memory clinic. J. Am. Geriat. Soc, 57, (2009) Hanyu, H., et al. : Differentiation of dementia with Lewy bodies from Alzheimer s disease using the Frontal Assessment Battery test. Int. J. Geriatr. Psychiatry, 24, (2009) Solomon, PR., et al. : A 7 minute neurocognitive screening battery highly sensitive to Alzheimer s disease. Arch. Neurol., 55, (1998) Brown, J., et al. : Self administered cognitive screening test (TYM) for detection of Alzheimer s disease : cross sectional study. Brit. Med. J., 338, (2009) 29 CLINICIAN 10 NO. 588
33 Alzheimer s disease Ach Ach CLINICIAN 10 NO
34 31 CLINICIAN 10 NO. 588
35 pre synaptic neuron pre-sn pre-sn pre-sn Ach CLINICIAN 10 NO
36 pre-sn Honma, A., et al. : Donepezil treatments with severe Alzheimer s disease in a Japanese populations : results from a 24-week, double-blind, placebo-controlled, randomized trial. Dement. Geriatr. Cog. Disord., 25, (2008) Honma, A., et al. : Long-term safety and efficacy of Donepezil in patients with severe Alzheimer s disease : results from a 52-week, opne-label, multicenter, extension study in japan. Dement. Geriatr. Cog. Disord., 27, (2009) donepezil Nozawa, M., et al. : Clinical effects of high dose of donepezil for patients with Alzheimer s disease in Japan. Psychogeriatrics, 9, 50 55(2009) donepezil 33 CLINICIAN 10 NO. 588
37 CLINICIAN 10 NO
38 35 CLINICIAN 10 NO. 588
39 CLINICIAN 10 NO
40 37 CLINICIAN 10 NO. 588
41 CLINICIAN 10 NO
42 39 CLINICIAN 10 NO. 588
43 Clinical Dementia CLINICIAN 10 NO
44 Rating CDR CDR CDR very mild AD 41 CLINICIAN 10 NO. 588
45 CLINICIAN 10 NO
46 43 CLINICIAN 10 NO. 588
47 CLINICIAN 10 NO
48 45 CLINICIAN 10 NO. 588
49 donepezil (Suppl 1)113(2009) CLINICIAN 10 NO
50 Neuropsychiatric Inventory NPI 47 CLINICIAN 10 NO. 588
51 CLINICIAN 10 NO
52 49 CLINICIAN 10 NO. 588
53 CLINICIAN 10 NO
54 51 CLINICIAN 10 NO. 588
55 Rodda Lyketsos, C., et al. : Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. Results from the cardiovascular health study. JAMA, 288, (2002) Lövheim, H., et al. : Sex differences in the prevalence of behavioral and psychological symptoms of dementia. International Psychogeriatrics, 21, (2009) Liperoti, R., et al. : Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). Current Neuropharmacology, 6, (2008) Gauthier, S., et al. : Improvement in behavioural symptoms in patients with moderate to severe Alzheimer s disease by memantine : a pooled data analysis. Int. J. Geriatr. Psychiatry, 23, (2008) CLINICIAN 10 NO
56 International Psychogeriatrics, 21, (2009) trials of donepezil, rivastigmine and galantamine. systematic review of randomized, placebo-controlled symptoms of dementia in Alzheimer s disease? A in the management of the behavioral and psychological Rodda, J., et al. : Are cholinesterase inhibitors effective 53 CLINICIAN 10 NO. 588
57 CLINICIAN 10 NO
58 amantadine Notch 55 CLINICIAN 10 NO. 588
59 Notch modulator Flurizan CLINICIAN 10 NO
60 active immunization passive immunization Bapineuzumab Vasogenic Edema 57 CLINICIAN 10 NO. 588
61 Solanezumab symptomatic treatment disease modification symptomatic treatment disease modification symptomatic treatment disease modification CLINICIAN 10 NO
62 disease modification 59 CLINICIAN 10 NO. 588
63 CLINICIAN 10 NO
64 Announcement by Neurochem and Ellan, The 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy, April , Montreal, Canada http : //phx.corporate ir.net/phoenix.zhtml?c=78193&p= irol newsarticle&id= &highlight= Holmes, C., et al. : Long-term effects of Aβ42 immunisation in Alzheimer s disease : follow-up of a randomised, placebo-controlled phase I trial, Lancet, 372, (2008) 61 CLINICIAN 10 NO. 588
65 common disease Common disease CLINICIAN 10 NO
66 63 CLINICIAN 10 NO. 588
67 CLINICIAN 10 NO
68 common disease 65 CLINICIAN 10 NO. 588
69 CLINICIAN 10 NO
70 67 CLINICIAN 10 NO. 588
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72 69 CLINICIAN 10 NO. 588
73 Cognition and Dementia Geriatric Medicine CLINICIAN 10 NO
74 71 CLINICIAN 10 NO. 588
75 a b c CLINICIAN 10 NO
76 73 CLINICIAN 10 NO. 588
77 tap-test shunt LP-shunt VP-shunt shunt CLINICIAN 10 NO
78 shunt ope LP VP LP LP LP LP Tap test F.I. F.K. M.S. A.S. K.K. Y.K. I.D. A.Y. H.O. T.S. 75 CLINICIAN 10 NO. 588
79 CLINICIAN 10 NO
80 77 CLINICIAN 10 NO. 588
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83 .... CLINICIAN 10 NO
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87 CLINICIAN 10 NO
88 85 CLINICIAN 10 NO. 588 invariant
89 CLINICIAN 10 NO Airway HyperReactivity : AHR Umetsu CD1d /, Jα18 / alfa-galactosylceramide α-galcer Ig Holtzman
90 87 CLINICIAN 10 NO. 588 Umetsu CD1d tetramer invariant T New England Journal of Medicine NEJM
91 CLINICIAN 10 NO Dukanovic Fc α-galcer C-glycoside Akbari, O., et al. : Nat. Med., 9, (2003) Meyer, E.H., Goya, S., et al. : Proc. Natl. Acad. Sci. U. S. A., 103, (2005) Pichavant, M., Goya, S., et al. : J. Exp. Med., 205, 385
92 1422(2007) (2006) Vijayanand, P., et al. : N. Engl. J. Med., 356, 1410 Akbari, O., et al. : N. Engl. J. Med., 354, Kim, E.Y., et al. : Nat. Med., 14, (2008) 393(2008) 89 CLINICIAN 10 NO. 588
93 91 CLINICIAN 10 NO. 588
94 CLINICIAN 10 NO
95 magazine 93 CLINICIAN 10 NO. 588
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100 PIONET PIONET CLINICIAN 10 NO
101 99 CLINICIAN 10 NO. 588
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103 101 CLINICIAN 10 NO. 588
104 CLINICIAN 10 NO
105 103 CLINICIAN 10 NO. 588
106 CLINICIAN 10 NO
107 105 CLINICIAN 10 NO. 588
108 MDCT MRI PCI CTOPCI PCI ACS PCIMDCT ST PCI ACLS CLINICIAN 10 NO
109 107 CLINICIAN 10 NO. 588
110 CLINICIAN 10 NO
111 109 CLINICIAN 10 NO. 588
112 CLINICIAN 10 NO
113 JPS NEWS department/dgp/index-dgp-j.htm 111 CLINICIAN 10 NO. 588
114 CLINICIAN 10 NO
115 A BPSD A A B D ROT D Validation 113 CLINICIAN 10 NO. 588
116 p p p p p p p ns p p ns ns ns NA = not available ns ns NA ns NA NA NA ns ns ns p ns ns CLINICIAN 10 NO
117 115 CLINICIAN 10 NO. 588
118 Geriatric Medicine, 45, (2007) CLINICIAN 10 NO
119 117 CLINICIAN 10 NO. 588
120 B12 CLINICIAN 10 NO
121 FAST staged AD 119 CLINICIAN 10 NO. 588
122 CLINICIAN 10 NO
123 121 CLINICIAN 10 NO. 588
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125 123 CLINICIAN 10 NO. 588
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127 follow up follow up follow up 125 CLINICIAN 10 NO. 588
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129 127 CLINICIAN 10 NO. 588
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131 Onozato, Y., et al. : Endoscopic submucosal dissection for early gastric cancers and large flat adenomas. Endoscopy, 38(10), (2006) Onozato, Y., et al. : Endoscopic submucosal dissection for rectal tumors. Endoscopy, 39(5), (2007) Onozato, Y., et al. : Endoscopic management of duodenal diverticular bleeding. Gastrointest. Endosc., 66(5), (2007) Onozato, Y., et al. : Feasibility of endoscopic submucosal dissection for elderly patients with early gastric cancers and adenomas. Digestive Endoscopy, 20, 12 16(2008) Prog. Digest. Endosc., 68, 62 66(2006) Prog. Digest. Endosc., 72, 94 95(2008) 129 CLINICIAN 10 NO. 588
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Diagnosis of Dementia: Update
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Systematic Review of Psychological Assessment for elder clients, No. The review about Intelligence or Memory Scale for Dementia Kyoko WATANABE
Systematic Review of Psychological Assessment for elder clients, No. The review about Intelligence or Memory Scale for Dementia Kyoko WATANABE http://www.stat. go.jp. % Mini Mental State Examination MMSE
Soundcell Method（SCM）による高齢者の認知機能評価の可能性
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78 Dementia Japan 29 : 78-85, 78 2015 原著 要旨 4 FTD 87 6 2 1/3 Off - label medication for frontotemporal dementia in Japan Shunichiro Shinagawa 1, Yusuke Yatabe 2, Kazue Shigenobu 3, Ryuji Fukuhara 2, Mamoru
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108 Dementia Japan 28 : 108-115, 2014 原 著 要 旨 Key Words : 44 79.8±6.7 MMSE 1 : 44 16 4 20 11 28 47.87±27.0 16.2±3.5 mg 21 18 mg 2 : 5 MMSE 20 18.0±6.6 26.1±19.9 20.2±6.2 p=0.022 3 5 Rivastigmine transdermal
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Ⅰ診断 症候 鑑別診断 認知機能に関する訴え 正常ではなく認知症でもない 認知機能の低下あり 日常生活機能は正常 Amnestic n-amnestic 認知障害は記憶障害のみ 認知障害は１領域に限られる Amnestic Single 図1 表1 記憶障害 Amnestic Multiple n
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Dementia Japan 31 : 117-124, 2017 117 症例報告 要旨 1. はじめに 70 1 modified electroconvulsive therapy ; mect mect Modified electroconvulsive therapy in dementia with Lewy bodies with drug - resistant psychiatric
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