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1 ), 3) 2 3 5, 4) , 4) , 5) Jatropha multifida ) 4) 3, 5, 6 3 4) 8 2 LDLo 300 g/kg 7) - 1 -

2 mg/kg: (LDLo) 2mg/kg 7) 30mg, 3) 1/2 2, 3) LDLo 7 g/kg , 32), 4), , 4), 9-2 -

3 Ricinus communis, Castor bean Castor Bean Plant Castor Oil Plant Koll Mole Bean Moy Bean Palma Christi 11 11, CAS No ) ) 2) Abrus precatorius, 14 Buddhist Rosary Bead Crab's Eyes Indian Bead Indian Liquorice 14 Indian Licorice Seed Jequirity Bean Jungle Bead Love Bean Lucky Bean Mienie-mienie Ojo de pajaro Prayer Bead Rosary Pea Seminole Bead Weather Plant CAS No ) Robinia pseudoacacia, Black Acacia Black Locust 11 11, 11 Phasin CAS No ) Jatropha curcas, 14 Barbados nut - 3 -

4 Curcas bean Physic nut Jatropha multifida Physic nut Purge nut ) Jatropha hastata, Jatropha integerrima Perrigrina 18) 6)Jatropha multifida Coral Plant Physic nut Physic nut Jatropha Jatropha 15, 17, 18 Ricinus communis 12 ricin: 30 50% globrin, nucleoalbumin, glucoprotein,, lipase ricinine %

5 2 90% B A 2 [ ] 2) Abrus precatorius 22 abrin: abric acid ( ) abrine (N-methyltryptophan) 9), 22, ) Robinia pseudoacacia (phasin) (robin) (robitin ) 24, 25 4) Jatropha curcas curcin crotonoleic acid ) Jatropha hastata jatrophin curcin: 18 Jatropha 18 6)Jatropha multifida - 5 -

6 curcin 17 hell oil, pinhoen oil oleum infernale, oleum ricini majoris crotonoleic acid cm, 12 2m m cm cm < > 2 A (30000Da), B (33000Da) 23 2) 3cm, 14 Rhynchoseia precatprius Rhynchoseia precatprius, cm

7 < > Da 23 3) 15m cm cm cm 12 15mm , 26 < > 23 4) ), 15) cm 1/2 3/4 3 15) cm ) 15 5) )Jatropha multifida cm cm cm 1 17) 6)

8 ), 3) , 4) , 4)

9 12 5, 4) , 33) , 5) Jatropha multifida ) , 2, 3, 4 1.5, 1.5, 1, 0.9 g/l 1, 2 3, 4 0.3, 0.3 g/ 24 3, , 0.6 g/24h,5) 4) (1900 ) 28 3, 5, 6 3 4)

10 (1934 ) 28 3 [ ] ) 1 4) 1 4) 3.4% % % ) 1.9% poison control center LDLo 300 g/kg 7) mg/kg (LDLo) 2mg/kg 7) 30mg , 3) 1/2 2, 3) LDLo 7 g/kg 8 LDLo 43 g/kg 7)

11 g/kg LDLo 500 g/kg 7) LDLo 30mg/kg 7) 30mg/kg 7) 0.5mg/kg 7) LD50 20mg/kg 20 LD g/kg 20 LDLo 1600ng/kg 7) LD ng/kg 7) 5 g/kg ng/kg 7) LD ng/kg 7) 22 g/kg 20 2 g/kg 7) LD ng/kg 7) 24 g/kg 20 LD50 600ng/kg 7) LD50 5 g/kg 7) 5 g/kg 7) 5 g/kg 7) 0.5 g/kg 7) LDLo 300mg/kg 8 21mg/kg 8 LD50 20 g/kg 8 LD50 20 g/kg 8, g/kg(70ng/25g) LD50 0.2mg/kg 1 4)

12 32) ) / 2 A B B A 60 28SrRNA RNA, 29 A HELA 500, [ ] 2)

13 , 2, 3, 4 1.5, 1.5, 1, 0.9 g/l,5) (12%) ) , 2 3, 4 0.3, 0.3 g/ 24 3, , 0.6 g/24h,5)

14 2 28, 32), 4), , ARDS ARDS

15 42 28, Jatropa % 98% 24 48, ALT AST ALP -GTP [ALT 51 IU/L( :4 30IU/L), AST 150 IU/L( :10 50 IU/L), ALP 912 IU/L( :

16 IU/L), 14mg/dL, -GTP 150 IU/L ( 4 26 IU/L)] 1 2, , 33) ( ricine ) )

17 4 3, 27, 30 28, 30 28, 3 25 storage albumin (Ric ci ) (IgE )

18 1 Jatropha multifida 15, 17, storage albumin (Ric ci ) (IgE ) Jatropa Jatropa %,

19 , 4), , 4), 9 1 A B 1 9 C

20 2 A B C D E. F. 9 AST ALP -GTP 2) 3) RAST IgE A

21 A B C 2 A B C (44 ), 8 (41 ) 2 (12 ), 10 (8 )

22 , , 2, 3, 4 1.5, 1.5, 1, 0.9 g/l 1, 2 3, 4 0.3, 0.3 g/ 24 3, , 0.6 g/24h,5) (1900 ) cc (1934 ) 28 (ELISA) Vero

23 Rumack BH & Spoerke DG(eds):PLANTS-TOXALBUMINS. POISINDEX(R) Information System.MICROMEDEX,Inc., Colorado,VOL.113, pp ) Hart M:Hazards to health.jequirity-bean poisoning. New Engl J Med 1963;268(16): ) Challoner KR, McCarron MM:Castor bean intoxication.ann Emerg Med 1990;19(10): ) Kopferschmitt J, Flesch F, Lugnier A et al.:acute voluntary intoxication by ricin.hum Toxicol 1983;2(2): ) Levin Y, Sherer Y, Bibi H, et al.:rare Jatropha multifida intoxication in two children.j Emerg Med 2000;19(2): ) Ricin:RTECS,TOMES Plus(R).MICROMEDEX,Inc., Colorado,Vol.53, ) Abrin:RTECS,TOMES Plus(R).MICROMEDEX,Inc., Colorado,Vol.53, ) Ellenhorn MJ, Schonwald S, Ordog G et al. eds. Medical Toxicology -Diagnosis and Treatment of Human Poisoning -(2nd Ed.),Williams&Wilkins, ) Gossel TA Bricker JD:Principles of Clinical Toxicology(3rd Ed.), Raven Press, New York, 1994 pp )Rumack BH & Spoerke DG(eds):RICINUS COMMUNIS.POISINDEX(R) Information System. MICROMEDEX,Inc.,Colorado,VOL.113, pp Rumack BH & Spoerke DG(eds):JATROPHA CURCAS.POISINDEX(R) Information System.MICROMEDEX,Inc.,Colorado,VOL.113, , pp Rumack BH & Spoerke DG(eds):JATROPHA MULTIFIDA.POISINDEX(R) Information System. MICROMEDEX,Inc.,Colorado,VOL.113, Rumack BH & Spoerke DG(eds):JATROPHA HASTATA.POISINDEX(R) Information System.MICROMEDEX, Inc.,Colorado,VOL.113, pp U.S.Army:Medical aspect of Chemical and Biological Warfare, Olsnes S, Kozlov JV:Ricin.Toxicon 2001;39(1: Rumack BH & Spoerke DG(eds):ABRUS PRECATORIUS. POISINDEX(R) Information System.MICROMEDEX,Inc., Colorado,VOL.113,

24 23 The Merck Index.(12th Ed).Merck&Co.Inc., Haddad LM, Shannon MW, Winchester JF, Clinical Management of Poisoning and Drug Overdose.(3rded). Saunders, Rumack BH & Spoerke DG(eds):ROBINIA PSEUDOACACIA. POISINDEX(R) Information System.MICROMEDEX,Inc., Colorado,VOL.113, ,pp )Malizia E, Sarcinelli L, Andreucci G: Ricinus poisoning: a familiar epidemy. Acta Pharmacol Toxicol 1977; 41: Rauber A, Heard J:Castor bean toxicity re-examined: a new perspective.vet Hum Toxicol 1985;27(6): Anthony T.Tu, 2001,pp Balint GA:Ricin: the toxic protein of castor oil seeds.toxicology 1974 ;2(: Makalinao IR: A descriptive study on the clinical profile of Jatropa seed poisoning. Vet Hum Toxicol 1993; 35: Palatnick W, Tenenbein M:Hepatotoxicity from castor bean ingestion in a child. J Toxicol Clin Toxicol 2000;38(: )Wedin GP, Neal JS, Everson GW, et al:castor bean poisoning. Am J Emerg Med 1986;4(3):

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