1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17 6 36 g l 25 7 1 ppm = 2.50 mg/m 3, 201 mg/m 3 = 0.400 ppm
2 2. 8 27,514 t 25,215 t 2,299 8 24% 24% 19% 10% 6% 5% 12% 1 3. 1 9 2 100 mg l 30 mg l BOD 86 % OH = 6.210-12 cm 3 /sec 10 OH 5.010 5 110 6 /cm 3 1.12.3 NO 3 =2.310-15 m 3 /sec 25 NO 3 2.410 8 /cm 3 14.5 10 2 11 3 ppb ppb ppm B/A B/A B/A B/A 7 0/33 8 4/33 5002,640 270 16/18 9010,000ng/m 3 50 B/A
3 4. LC 50 mg l EC 50 mg l OECD : Scenedesmus >1,000 72-h: Subspicatus 10 10, 13 Daphnia magna 9,714 24-h: Crangon crangon 10 903 96-h Rasbora 4,200 96-h 10, 13 Heteomorpha Pimephales 6,120 96-h promelas 14 OECD OECD 5. 14, 15, 16, 17, 18 1 LD 50 3,600-4,475 mg/kg 1,870-5,500 mg/kg 5,000-8,000 mg/kg LC 50 216,240 ppm 2h 29,620 ppm 4h 12,000-22,583 ppm 8h LD 50 4,059-12,870 mg/kg LD 50 1,184-1,860 mg/kg 1,088 mg/kg 1,184 mg/kg LD 50 4,477-4,868 mg/kg 2,735-2,830 mg/kg 667 mg/kg LD 50 4,830 mg/kg LC 50 LD 50 LD 50 2,560 mg/kg 3,444-3,467 mg/kg 1,5005,00010,000 ppm 3,75012,50025,000 mg/m 3 * 6 10,000 ppm 5,000 ppm 10,000 ppm * p. 1641
4 5,000 ppm 1,500 ppm 1,500 5,000 ppm 5 19 7,872-25,682 ppm* 19,680-64,206 mg/m 3 8 19,680-21,648 ppm* 49,200-54,120 mg/m 3 17,712 ppm* 44,280 mg/m 3 20,664 ppm* 51,660 mg/m 3 17 4005,500 ppm 1,00013,750 mg/m 3 * 24 20 2 500 mg 10 mg 100 mg 15 3 4 1 1,0003,900 mg/kg/day 27 1,000 mg/kg/day 17 2-5 12 18 1,300 mg/kg/day 1 / 6 18 2 5002,5005,000 ppm 1,2506,25012,500 mg/m 3 * 6 / 5 / 78 2,500 ppm 5,000 ppm 104 2,500 ppm 5,000 ppm NOEL 500 ppm 21 40.8204 ppm 100500 mg/m 3 4 / 5 / 4 * p. 1641
5 204 ppm 17 0.2418.13 ppm 0.62.520 mg/m 3 86 8.13 ppm 17 2,0008,000 ppm 4,92019,680 mg/m 3 6 / 6 / 2 8,000 ppm S- 17 300 ppm 739 mg/m 3 6 / 5 / 5101621 1621 17 5,000 ppm 12,500 mg/m 3 * 90 18 8,000 ppm 20,000 mg/m 3 * 8 / 5 / 20 18 5 in vitro in vivo S9 17 TA98TA100TA1525TA1537 CHO S9 22 CHL S9 17 14 SA7/SHE 17 V79 ** 15, 17 ** 22 6 17 1 CD-1 5002,5005,000 ppm 1,2506,25012,500 mg/m 3 * 6 / 5 / 78 21 F344 5002,5005,000 ppm 1,2506,25012,500 mg/m 3 * 6 / 5 / 104 21 7 * p. 1641
6 1 400 800 1,200 mg/kg/day 6 15 10 800 mg/kg/day 23 2521,008 mg/kg/day 45 17 1,800 mg/kg/day 3 17 100500 1,000 mg/kg/day 2 500 mg/kg/day 1 12 1,000 mg/kg/day 23 2 24 120240 480 mg/kg/day 6 18 13 480 mg/kg/day 23 2 3,5007,00010,000 ppm 8,75017,50025,000 mg/m 3 * 7 / 1 19 19 7,000 ppm 10,000 ppm 7,000 ppm 25 5,000 ppm 12,500 mg/m 3 * 18 3,6597,4509,435 ppm 9,14818,62523,588 mg/m 3 * 7 / 1 19 19 9,435 ppm 7,450 ppm 7,450 ppm 9,435 ppm 17 3 2521,008 mg/kg/day 1 20 20 1,008 mg/kg/day 17 6. 1 14, 16, 17 * p. 1641
7 16 17 2 26, 27, 28 3 EPA 1996 1996 EU 1996 1996 NTP 1994 IARC 1996 1996 3 ACGIH 1996 1996 1997 1997 27, 28 4 ACGIH 1996 TWA : 400 ppm 983 mg/m 3 STEL : 500 ppm 1,230 mg/m 3 1997 400 ppm 980 mg/m 3 TWA : STEL : 7. 2.5-6.4 17 10-20 80-90 14, 16, 17-16 14, 16, 17 8. OECD 12 1 5 4-5 5
8 2 9. 1 in vitro in vivo OH 1 NO 3 1 2 1 2 10
9 1 1998. 2, 1994. 3 The Merck Index, 12th. Ed., Merck & Co., Inc. 1996. 4 IPCS, International Chemical Safety Cards 1989. 5 C Log P,. 6 NIST Library of 54K Compounds. 7 Handbook of Environmental Data on Organic Chemicals, 3rd. Ed., Van Nostrand Reinhold Co. 1996. 8 8,. 9 1993. 10 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 11, 1996. 12 OECD, Proposal for a Harmonized Classification System based on Acute Toxicity 1996. 13 AQUIRE/NUMERICA. 14 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 1995. 15 Registry of Toxic Effects of Chemical Substances RTECS, US NIOSH 1996. 16,,,, 1991. 17 IPCS, Environmental Health Criteria, 103 1990. 18 S. Dhillon, Journal of Applied Toxicology, 15 6, 501-506 1995. 19 Michael W. Gill, Journal of Applied Toxicology, 15 2, 77-87 1995. 20 Yoshihiro Ohashi, Journal of Applied Toxicology, 8 1, 67-71 1987. 21 H. Burleigh.Flayer, Fundamental and Applied Toxicology, 36 2, 95-111 1997. 22 Robert W. Kapp, Jr, Environmental and Molecular Mutagenesis, 22 2, 93-100 1993. 23 R. W. Tyl, Fundamental and Applied Toxicology, 22, 139-151 1994. 24 C. Bevan, Journal of Applied Toxicology, 15 2, 117-123 1995. 25 B. K. Nelson, Fd Chem. Toxic, 26 3, 247-254 1988. 26 JETOC,,, 3 1997. 27 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 1996. 28,, 39, 129-149 1997. 1 2
10 mg/l 10,000 9,714 24-h 4,200 96-h 6,120 96-h 1,000 1,000 72-h 903 96-h 100 LC 50 EC 50 10 1 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 2 AQUIRE/NUMERICA. 3 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 1995.
11 mg/kg/day 27 w 1h/d6 m 45 d 3 m 10,000 1,000 1,300 1,000 1,800 1,008 252 100
12 ppm 6 h 6h/d5d/w78w 6h/d5d/w104w 8h/d5d/w20w 6h/d5d/w78-104w 7h/d19d 7h/d19d 10,000 10,000 5,000 5,000 5,000 8,000 5,000 10,000 9,435 7,450 7,000 3,659 1,000 1,500 2,500 500 NOEL 2,500 500 NOEL 2,500 500 500 ACGIH STEL 400 ACGIH TWA 100