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Cucurbita maxima Myrciaria dubia

Department of Science and Technology on Food Safety, Kinki University, 930 Nishimitani, Kinokawa, Wakayama 649 6493 RI Center, Wakayama Medical University School of Medicine, 811 1 Kimidera, Wakayama 641 8509 Chrebp, Pparα, Fxr, Lxrα Srebf 1 c, Abca 1 Acaca, Fasn, Scd 1, Me 1 β Cpt1a Hmgcr, Ldlr, Srebf 2, Acat2 Shp, Lrh-1, Hnf4a, Cyp7a1, Cyp27a1 Dgat1, Dgat2 Mttp Abcg 5, Abcg 8, Abcb 11, Cd 36 Key wordscitrus limonoids, lipid metabolism, gene expression, rats, high-fat high-cholesterol diet

!" AcacaFasn Scd1Me1Srebf1c ChrebpLxrα HmgcrLdlrSrebf2 PparαCpta Fxr, LxrαShpLrh-1Hnf4aCyp7 a1cyp7a1 Abca1Abcg5Abcg8 Abcb11 Mttp Dgat1Dgat2 Acat2 Cd36 Ribosomal protein S18Rps18

Acetyl-CoA carboxylase alpha Acaca Fatty acid synthase Fasn Stearoyl-Coenzyme A desaturase 1 Scd1 Malic enzyme 1, NADP(+)-dependent, Me1 cytosolic Sterol regulatory element binding Srebf1c transcription factor 1 transcript variant 2 MLX interacting protein-like (Mlxipl) Chrebp Also known as Chrebp 3-Hydroxy-3-methylglutaryl-CoA reductase Hmgcr Low density lipoprotein receptor Ldlr Sterol regulatory element binding Srebf2 transcription factor 2 Peroxisome proliferator activated Pparα receptor alpha Carnitine palmitoyltransferase 1a, liver Cpt1a nuclear gene encoding mitochondrial protein Nuclear receptor subfamily 1, group H, Fxr member 4 (Nr1h4), Also known as Fxr Nuclear receptor subfamily 1, group H, Lxrα member 3 (Nr1h3), Also known as Lxrα Nuclear receptor subfamily 0, group B, Shp member 2 (Nr0b2), Also known as Shp Nuclear receptor subfamily 5, group A, Lrh-1 member 2 (Nr5a2), Also known as Lrh-1 Hepatocyte nuclear factor 4, alpha Hnf4a Cytochrome P450, family 7, subfamily a, Cyp7a1 polypeptide 1 Cytochrome P450, family 27, subfamily Cyp27a1 a, polypeptide 1 ATP-binding cassette, subfamily A Abca1 (ABC1), member 1 ATP-binding cassette, subfamily G Abcg5 (WHITE), member 5 ATP-binding cassette, subfamily G Abcg8 (WHITE), member 8 ATP-binding cassette, subfamily B Abcb11 (MDR/TAP), member 11 Microsomal triglyceride transfer protein Mttp Diacylglycerol O-acyltransferase 1 Dgat1 Diacylglycerol O-acyltransferase 2 Dgat2 Acetyl-CoA acetyltransferase 2 Acat2 CD36 molecule (thrombospondin receptor) Cd36 Ribosomal protein S18 Rps18

Me1ChrebpHmgcrLdlrAcat 2Srebf1cPparαAbca 1Abcg5 ChrebpPparαFxrLxrα Srebf1cAbca1

!"!"! Me1ChrebpHmgcrLdlrAcat2Srebf 1cPparαAbca1Abcg5

Acaca Fasn Scd1 Me1 Srebf1c Chrebp Hmgcr Ldlr Srebf2 Pparα Cpt1a Fxr Lxra Shp Lrh-1 Hnf4a Cyp7a1 Cyp27a1 Abca1 Abcg5 Abcg8 Abcb11 Mttp Dgat1 Dgat2 Acat2 Cd36 Rps18 β %& ChrebpPparαFxr LxrαSrebf1cAbca1! Srebf1cChrebpLxrα " Pparα # FxrLxrα $ Abca1 α

α β α α LxrαFxr Cyp7a1 α LxrαAbca1!" ChrebpPparαFxrLxrα Srebf1cAbca1 Acaca, Fasn, Scd1Me 1β Cpt1aHmgcr, Ldlr, Srebf2Acat2Shp, Lrh-1Hnf4a, Cyp7 a1cypa1dgat1dgat2 MttpAbcg5Abcg8 Abcb11Cd Biol. Pharm. Bull J. Agric. Food Chem Nutr. Res Am. J. Clin.Nutr Citrus Limonoids Biochem. Biophys. Res. Commun

Nutr Res Pract Nutr. Res Food Chem Mol. Nutr. Food Res J. Agric. Food Chem Eur J Nutr Gene Mol. Cell J. Biol. Chem

Cucurbita maxima Kagoshima Prefectural Institute of Food Processing and Utilization, 2200, Oono, Kinpou-cho, Minamisatsuma-shi, Kagoshima 899 3401 Kagoshima Prefectural Institute for Agricultural Development, 2200, Oono, Kinpou-cho,Minamisatsuma-shi,Kagoshima 899 3401 Kagoshima Prefectural Soo Promotional Center of Field Irrigation Agriculture, 5677, Iwagawa, Oosumi-cho, Soo-shi, Kagoshima 899 8102 Kagoshima Prefectural Institute for Agricultural Development Tokunoshima Branch, 2092, Omonawa, Isen-cho, Ooshima-gun, Kagoshima 891 8114 Key wordsstorage at chilling temperatures, chilling injury, starch content, sugar content, firmness

Cucurbita maxima!!!!!!!! "!!! " "" "" # #!!! "!!

" "!

! " # $ Helv. Chim. Acta

! Solanum tuberosum Phytochem

Agricultural Technology Institute of Nagano Farmers Federation, 787 1 Suzaka, Suzaka, Nagano 382 0084 Faculty of Agriculture, Shinshu University, 8304 Minamiminowa, Kamiina, Nagano 399 4598 a b Key wordsapple cultivar, cloud type juice, process suitability, Nagano prefecture

$ $" #! α

p p p

SENSORS Penicillium expansum, Food Presevation Sci J. Food Sci

Myrciaria dubia Department of Food and Cosmetic Science, Faculty of Bio-industry, Tokyo University of Agriculture, 196 Yasaka, Abashiri 099 2493 Myrciaria dubia n Staphylococcus aureus µ! µ! S. aureus Key wordsantimicrobial activity, rhodomyrtone, acylphloroglucinol, Myrciaria dubia, peel, Myrciaria dubia, Myrciaria dubia C Staphylococcus aureus S. aureus

"# # # # # % n! n % n $ n!! n $ $ # $ n n $! $! Bacillus subtilis Bacillus cereus Micrococcus luteus Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Escherichia coli Pseudomonas aeruginosa Salmonella typhimurium Saccharomyces cerevisiae Candida albicans & µ& µ& µ& µ& & µ& λ! α c calcd. n n B. subtilis, B. cereus, M. luteus, S. aureus, S. epidermidis S. mutansµ! µ! E. coli, P. aeruginosa, S. typhimurium, S. cerevisiae C. albicans n n n n

Myrciaria dubia n n µ! n n Bacillus subtilis Bacillus cereus Micrococcus luteus Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Escherichia coli Pseudomonas aeruginosa Salmonella typhimurium Saccharomyces cerevisiae Candida albicans n n n n Rhodomyrtus tomentosa Rhodomyrtus tomentosa δ δ δ δ δ δ

δ δ J δ δ J δ δ J δ δ δ et al. δ δ δ δ δ δ δ et al Bacillus Micrococcus Staphylococcus Streptococcus

Myrciaria dubia et al n n Rhodomyrtus tomentosa S. aureus Enterococcal Myrciaria dubia J. Am. Diet. Assoc. Food Comp. Anal Myrciaria dubia Food Chem. Myrciaria dubia J. Agric. Food Chem Spondiascitherea Myrciaria dubia Eugenia stipitata Theobromagrandiflorum J. Agric. Food Chem Flav. Fragr. J. J. Food Agric. Environ Food Sci. Technol. Res Rhodomyrtus tomentosa, AUST. J. Chem Rhodomyrtus tomentosa, Teterahedron Rhodomyrtus tomentosa, Phytomedicine Tetrahedron J. Nat. Prod myrtus communis J. Pharmacolo. Exp. Ther. Myrtus communis Apoptosis Staphylococcus aureus

Plos one J. Med. Microbiol Myrciaria dubia n µ! µ!