1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21 5 Koc1351,585 2 2 2 1 ppm = 4.91 mg/m 3, 20 1 mg/m 3 = 0.204 ppm
2 2. 10 22,753 t 22,753 t 0 6 ABS 1 3. 1 7 2 100 mg/l 30 mg/l BOD 0 8 2 100 mg/l 30 mg/l BOD 100 OH = 5.210-11 cm 3 / sec 25 9 OH 510 5 110 6 /cm 3 48 = 1.36510-16 cm 3 / sec 25 2 710 11 /cm 3 2 290 nm 2 2 8 1 0.3 mg/l 15140 2 0.03 mg/l 12113
3 10 3 52 9 ppb ppm ppm B/A B/A B/A B/A 0/3 0/3 4 0.01 0/36 0.3 0/33 0.0055 B/A 4 LC 50 mg/l EC 50 mg/l : *11 Selenastrum 6.94 72-h: 2 capricornutum 12 Daphnia magna 12 Daphnia magna 12 Oryzias latipes 12 Oryzias latipes 12 2.62 48-h: 2 0.40 21-d: NOEC 7.28 96-h 2 > 6.78 14-d 1.04 14-d: NOEC * OECD 5. 2, 13, 14 1 LD 50 4,500 mg/kg 4,900-5,603 mg/kg LC 50 LD 50
4 13 3,4486,89613,792 mg/kg 3,448 mg/kg 1 6,896 mg/kg 10 1 13,792 mg/kg 10 30 1 30 6,896 mg/kg 4/5 13,792 mg/kg 5/5 14 SD 7,94010,00012,60015,800 mg/kg 10,000 mg/kg 1/5 12,600 mg/kg 2/5 15,800 mg/kg 2/5 7,940 mg/kg 10,000 mg/kg 1-4 2-5 7 15 2,500 ppm, 20 8 5 1 30 4 5 7 2/6 14 6,89613,792 mg/kg 6,896 mg /kg 13,792 mg/kg 13,792 mg/kg 3/7 14 3,1605,0107,940 mg/kg 7,940 mg/kg 1/1 5,010 mg/kg 7,940 mg/kg 4 15 2 0.1 ml 15 14 13, 16 0.5 ml 15 30 20 2
5 3 4 1 SD 402001,000 mg/kg/day 14 43 3 1,000 mg/kg/day 1 200 mg/kg/day ALT 1,000 mg/kg/day 17 NOEL 40 mg/kg/day 17 2 B6C3F 1 6008001,000 ppm 6 / 5 / 12 1 600 ppm 6 1/18 800 ppm 56 10/18 1,000 ppm 21 5/24 12 600 ppm 18 3,000 ppm 3-4 16 F344 NBR 125250500 ppm 6 / 5 / 9 250 ppm F344 18 F344 6001,000 ppm 6 / 5 / 12 600 ppm 18 800 ppm 7 / 5 / 27 19, 16 200 ppm 7 / 5 2, 16, / 5-6 19 5 * in vitro S9-20 TA98TA100TA1535 TA1537 WP2uvrA12.5-400 µg/plate S9 -/+ 17
6 * TA97TA98TA100 TA1535 1-3333 µg/plate S9 -/+ 21 in vitro 1-2 mms9 -/+ 22 48 13, 23 330 µmol/l S9 19 CHO S9 19 CHO S9 * 6 7 1 SD 402001,000 mg/kg/day 14 43 3 1,000 mg/kg/day 2/8 4 NOEL 1,000 mg/kg/day 200 mg/kg/day 200 17 2 SD 250 mg/kg/day 1-15 24 6. 1 2, 19 4 200600 ppm 200 ppm 2, 16, 600 ppm 19 2 2, 19 658 5.1 25 128 73.4
7 3.9 Drop and compression 25 26, 27, 28 3 EPA 1999 EU 1999 NTP 1999 IARC 1999 ACGIH 2000 2001 27, 28 4 ACGIH 2000 50 ppm 2001 7. 19.5 mg/cm 2 0.048-0.256 mg/cm 2 2 - -- - - - 29 11 8. OECD * 5 2 * OECD OECD
8 9. 1 in vitro OH 2 1 2 3 4 13 12
9 1 2001. 2 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 2001. 3 IPCS, International Chemical Safety Cards 1989. 4 KowWin ver 01.66, Syracuse Research Corporation 2001. 5 NIST Library of 54K Compounds 1998. 6 10, 1999. 7, 1988. 8, 2000. 9 AOPWIN ver1.86, Syracuse Research Corporation 2001. 10, 2001. 11 OECD, Harmonised integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. OECD Series on Testing and Assessment No. 33 2001. 12 8, 1997. 13 US NIOSH, Registry of Toxic Effects of Chemical Substances RTECS2001. 14 EPA/OTS 0515608, Range Finding Toxicity Studies of α-methylstyrene 1987. 15 EPA/OTS 0570562, Initial Submission : Toxicological Investugatuib of Alpha Methyl Styrene with Cover Letter dated 081392 1992. 16 S. Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry 1999. 17,, 3 1996. 18 D. L. Morgan, Toxicological Sciences, 47, 187-194 1999. 19 ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices 1992. 20 H. Norppa, J. Scand., Work environ. Health, 9, 108-114 1983. 21 E. Zeiger, Environmental Molecular Mutagenesis, 19 Suppl 21, 2-141 1992. 22 H. Norppa, Basic Life Science, 29B, 547-559 1984. 23 H. Norppa, Mutation Research, 116, 379-387 1983. 24 EPA/OTS 0000105-0 Testing of Selected Workplace Chemicals for Teratogenic Potential 1982. 25 EPA/OTS 0000517-1, Toxic Control Act Substantial Risk Reporting on Alpha-Methyl Styrene : Dermal Sensitization with Attachments and Cover Letter Dated 121688 Sanitized 1988. 26 JETOC,,, 4 1999. 27 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 2000. 28,,, 43, 95-119 2001.
10 29 The Alkyl Benzenes, Metabolism of Alkyl Benzenes, 219-263 1981. 1 2
11 mg/l 10 6.94 72-h 7.28 96-h 6.78 14-d 2.62 48-h LC 50 EC 50 1 1 8, 1997.
12 6h/d 5d/w 12d 3-4d 6h/d 5d/w 12d 6h/d 5d/w 9d 7h/d 5d/w 27d 7h/d 5d/w 5-6month ppm 10,000 3,000 1,000 100 600-1,000 600-1,000 800 250-500 200 125 10 1