2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7 mmhg20 3 0.16 kpa 1.2 mmhg200 3 log Pow7.74 3 7 8.63 4 m/z 149 1.0 57 0.32 113 0.10 279 0.07 8 2-1 mg/l25 6 1 ppm = 16.13 mg/m 3, 20 1 mg/m 3 = 0.062 ppm CH CH 2 (CH 2 ) 3 CH 3 CH 3 CH 3
2-2 2. 5 336,338 t 318,228 t 18,110 t 9 1 3. 1 10 4 100 mg/l 30 mg/l BOD 69% HPLC 89% 11, 12 = 143 11 2 8 1 1 mg/l 1.03.4 2 0.1 mg/l 1.329.7 14 3 ppb ppm ppm 69 / 111 49 176 / 375 0.0815 0.012 224 / 370 0.00317 0.0030.2 92 / 332 0.0119 0.021 0.0618 ppb 0.062 1 / 4 6,300 ppb 50
2-3 50 57 ppb ppm ppm 58 / 115 0.021.1 0.013 29 / 45 0.10.8 0.040.15 45 / 45 0.0093.5 0.0010.007 59 / 62 60 38790 ng/m 3 550 4. LC 50 mg/l EC 50 mg/l OECD : Daphnia magna 12 11 48-h harmful Daphnia pulex 12 Pimephales 12, 15 promelas 0.133 48-h Lepomis 12, 15 macrochirus 12, 15 Ictalurus punctatus Oncorhynchus 12, 15 mykiss >10 96-h >10 96-h >10 96-h >10 96-h Entosiphon sulcatum 15 Pseudomonas putida 15 EC 0 :19 72-h EC 0 :400 16-h Bufo fowlen 12 3.88 78-d Rana pipiens 12 4.44 78-d OECD very toxic harmful harmful harmful
2-4 OECD OECD 5. 12, 16, 17, 18, 19 1 LD 50 25,000-34,000 mg/kg 26,000-49,000 mg/kg 24,750-30,600 mg/kg 26,300 mg/kg LC 50 LD 50 25,000 mg/kg 10,000 mg/kg 16 2 16 3 12, 17 4 1 2,000 mg/kg/day 5 96% 2,000 mg/kg/day 7 50%15 100% 2,000 mg/kg/day 15 40% 50 mg/kg/day 9 2,000 mg/kg/day 15 2,000 mg/kg/day 7 P-450 MFO Mixed Function Oxidase 390 mg/kg/day 166 10 mg/kg/day 5 palmitoyl CoA oxidase carnitine acetyl transferase 50 mg/kg/day 21 50 mg/kg/day 9 P-450 2,000 mg/kg/day 15 600 mg/kg/day 14
2-5 2 1,000 mg/m 3 6 / 5 / 4 1,000 mg/m 3 6 / 5 / 4 12, 20, 16, 17, 18 5 In vitro TA100 UDS 7.5-20 µg/ml 25-50 µg/ml In vivo 12.7-25.5 g/kg ICR 12.5-15.0 g/kg 0.5-5.0 g/kg/day F344 12, 15, 16, 17, 18, 19, 21, 22, 23, 24 6 EPA 1994 B2 EU 1996 NTP 1994 IARC 1995 2B ACGIH A3 2B 1 B6C3F 1 6721,325 mg/kg/day 7991,821 mg/kg/day 103 1,325 mg/kg/day 799 mg/kg/day
2-6 F344 322674 mg/kg/day 394774 mg/kg/day 103 774 mg/kg/day 12, 17, 18 7 1 1,0002,000 mg/kg/day 91191292 mg/kg/day 130 mg/kg/day 166 1,000 mg/kg 7 3,000 mg/kg/day 20,000 mg/kg 7 12,500 mg/kg 90 6,000 mg/kg 2 1,700 mg/kg/day 4,882 mg/kg 9,756 mg/kg 12 2,000 mg/kg/day 14 130-390 mg/kg/day 166 390 mg/kg/day 2,000 mg/kg 14 2 12,800 mg/kg 2,000 mg/kg/day 35 9 100 mg/kg/day 5 30% 4,930 mg/kg/day 9,860 mg/kg/day 510 15 9,860 mg/kg/day 3 11.38 mg/kg/day 6-17 12, 23, 17, 24 6. 1 5,000 mg 10,000 mg
2-7 2 2- MEHP MEHP 3 10-30 10 0.09-0.16 mg/m 3 4 ACGIH 1996 5 mg/m 3 1996 5 mg/m 3 12, 17 7. DEHP 2- MEHP DEHP MEHP MEHP 2- -1 - MEHP DEHP -1 2- DEHP MEHP 2- -5-8. OECD 1 5 5 2 harmfulvery toxic
2-8 harmful 9. 1 In vivo DNA OECD harmful very toxic harmful 2 1 2 3 4 14 3
2-9 1 1996. 2,, 1984. 3,, 1988. 4,, 1985. 5 Richardson, M.L. et.al., The Dictionary of Substances and their Effects, Royal Society of Chemistry 1993-1995. 6 IPCS, International Chemical Safety Cards 1989. 7 C Log P. 8 NIST Library of 54K Compounds. 9 5. 10) (), 1998. 11 Hazardous Substance Data Bank HSDB, National Library of Medicine, 1996. 12 IPCS, Environment Health Criteria 131 1992. 13,, 1992. 14, 1996. 15 BUA Report 4 1986. 16 ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices 1991. 17 ATSDR, Toxicological profile for DEHP 1993. 18 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 29, 1982. 19 NTP, Technical Report on the Carcinogenesis Bioassay of DEHP in F344 Rats and B6C3F1 Mice 1982. 20 BUA Report 4 1986. 21 JETOC,,, 3 1997. 22 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, List of IARC Evaluations 1995 23 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 1996. 24, 38, 172-181 1996. 1 2 3
2-10 mg/ l 100 10 11 48-h 10 10 10 10 96-h 96-h 96-h 96-h 1 LC 50 0.1 0.133 48-h 1 IPCS, Environmental Health Criteria 131 1992. 2 BUA Report 4, 1986.
2-11 mg/kg/day 166 21 103 103 14 1,000 390 1,325 799 774 322 2,000 1,000-2,000 100 50
2-12 B6C3F 1 6721,325 mg/kg/day 1-6 7991,821 mg/kg/day mg/kg/day 0 672 1,325 0 799 1,821 103 6/50 11/48 10/50 1/50 5/50 1/50 9/50 14/48 19/50 0/50 7/50 17/50 F344 322674 mg/kg/day -6 394774 mg/kg/day mg/kg/day 0 322 674 0 394 774 103 2/50 5/49 7/49 0/50 4/49 5/50 1/50 1/49 5/49 0/50 2/49 8/50 1 ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices 1991. 2 ATSDR, Toxicological Profile for DEHP 1993. 3 IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 29 1982. 4 IPCS, Environment Health Criteria 131 1992. 5 BUA Report 4 1986. 6 NTP, Technical Report on the Carcinogenesis Bioassay of DEHP in F344 Rats and B6C3F1 Mice 1982.