http://nibs.lin.gr.jp/
2 18 1985 29 1982 2013 3 12 7800 14.4 1997 35 44 2013 7 25 44 2020 3 6
60 2 2014 3 19 8 kg 1 Metastrongylus 2 3 4 1.. 2013.. 66 4 243 247. 2.. 2012.. 65 6 429 435.
4 20 2000 [1 2] [3 6] 1 2 [7] 114 [8] MGH 120 kg 500 kg [5 6 9 20 13 14 21 ] 1993 NIBS [22] NIBS 1, 3 GalT KO MGH 30 NIBS 1 2 8 GalT KO MGH 1 3 10 Koo [23] 6 [24] [25] NIBS GalT KO MGH 1 5 23 NIBS 13 5 NIBS 1.0 1. A
60 2 2014 5 21 1 3 1 13 351 85.17 g 6 4 GalT KO MGH 1. B 330 108.6 g 0.3 2 1 GalT KO #3 11 2 1 GalT KO #4 4 6 1 GalT KO 14 2 GalT KO #1 2 GalT KO #3 GalT KO #4 PCR 2. A 2 GalT KO #5 6 2. B D GalT
6 22 SPF GLP [14] NIBS 4.2 [22] 5 7 [25 28] NIBS 1 1 2 [7] 0.2 0.9 [14 21] GalT KO MGH GalT KO MGH 0.2 [6] 0.3 [29 31] [32] NIBS 351 85.17 g 403 75.3 g [33 34] 21 114 MGH 35 [8 34] 1, 3 [35 36] 2 2002 GalT KO [4 6] GalT KO MGH [37] GalT KO [4 6 20 38] GalT KO GalT KO 3 NIBS
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8 24 9. AHN KS, KIM YJ, KIM M et al. 2011. Theriogenology 75 :933 939. 10. ESTRADA JL, COLLINS B, YORK A et al. 2008. Cloning Stem Cells 10 : 287 296. 11. HOSHINO Y, UCHIDA M, SHIMATSU Y et al. 2005. Cloning Stem Cells 7 : 17 26. 12. KAWARASAKI T, UCHIYAMA K, HIRAO A et al. 2009. J Biomed Opt 14 : 054017. 13. KOO OJ, PARK HJ, KWON DK et al. 2009. Zygote 17 : 203 207. 14. KUROME M, ISHIKAWA T, TOMII R et al. 2008. J. Reprod. Dev. 54 :156 163. 15. LEE SL, KANG EJ, MAENG GH et al. 2010. J. Reprod. Dev. 56 : 256 262. 16. LIU HB, LV PR, HE RG et al. 2010. Cell Reprogram 12 :543 550. 17. LI Y, LIU J, DAI J et al. 2010. Reprod. Domest. Anim. 45 :608 613. 18. MIYOSHI K, INOUE S, HIMAKI T et al. 2007. Mol. Reprod. Dev. 74 : 1568 1574. 19. HAO YH, YONG HY, MURPHY CN et al. 2006. Transgenic Res. 15 :739 750. 20. ZHAO J, ROSS JW, HAO Y et al. 2009. Biol. Reprod. 81 :525 530. 21. WAKAI T, SUGIMURA S, YAMANAKA K et al. 2008. Cloning Stem Cells 10 : 249 262. 22. NUNOYA T, SHIBUYA K, SAITOH T et al. 2007. J. Toxicol. Pathol. 20 :125 132. 23. KOO OJ, JANG G, KWON DK et al. 2008. Theriogenology 70 :1111 1118. 24. IM GS, SAMUEL M, LAI L et al. 2007. Mol. Reprod. Dev. 74 : 1158 1164. 25. SHIMATSU Y, UCHIDA M, NIKI R et al. 2004. Vet. Rec. 155 : 633 635. 26. BOUCHARD G, MCLAUGHLIN RM, EL- LERSIECK MR et al. 1995. Lab. Anim. Sci. 45 :408 414. 27. CONLEY AJ, JUNG YC, SCHWARTZ NK et al. 1988. J. Reprod. Fertil. 82 :595 601. 28. PANEPINTO LM, PHILLIPS RW, WHEELER LR et al. 1978. Lab. Anim. Sci. 28 :308 313. 29. HILL JR, ROUSSEL AJ, CIBELLI JB et al. 1999. Theriogenology 51 : 1451 1465. 30. KATO Y, TANI T, TSUNODA Y. 2000. J. Reprod. Fertil. 120 :231 237. 31. WELLS DN, MISICA PM, TERVIT HR. 1999. Biol. Reprod. 60 : 996 1005. 32. WAKAYAMA T, YANAGIMACHI R. 1999. Nat. Genet. 22 :127 128. 35. 33. SACHS DH, SYKES M, ROBSON SC et al. 2001. Adv. Immunol. 79 :129 223. 34. SACHS DH. 1994. Vet. Immunol. Immunopathol. 43 :185 191. 35. GALILI U, RACHMILEWITZ EA, PELEG A et al. 1984. J. Exp. Med. 160 : 1519 1531. 36. GALILI U. Anti alpha galactosyl (anti Gal) antibody damage beyond hyperacute rejection. In: COOPER DKC, KEMP E, PLATT JL, WHITE DJG, eds. Xenotransplantation. Heidelberg: Springer, 1997 :95 103. 37. YAMADA K, YAZAWA K, SHIMIZU A et al. 2005. Nat. Med. 11 :32 34. 38. COWAN PJ, CHEN CG, SHINKEL TA et al. 1998. Transplantation 65 :1599 1604.
60 2 2014 9 25 2013 9 23 25 The 6th Asian Pig Veterinary Society Congress APVS 2013 JASV APVS2013 29 1 15 2 3 5 307 69 238 26 79.1 15.94.3 0.7 1265 24 31 31.5 13.9 12.2 11.8 8.8 7.6 2.5
10 26 PEDV Lawsonia intracellularis Isospora suis Balantidium coli Porcine reproductive and respiratory syndrome PRRS PigRISK Vietnam Salmonella Weltevreden Campylobacter Streptococcus suis MRSA HACCP PRRSV Parma university Paolo Martelli PRRSV INFECTION Immunity and control 1990 PRRS in vivo MA 104 2 PRRSV in vivo Yuan et al., 1999, Murtaugh et al., 2002 PRRS
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