慢性膵炎GL-01.qxd

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1

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3 ST GER ph GER ph GER,./, GERD ph GERD ph GERD GERD PPI PPI. PPI. 97

4 Liuzzo JP, Ambrose JA. Chest pain from gastroesophageal reflux disease in patients with coronary artery disease. Cardiol Rev ; 13 : - Mehta AJ, de Caestecker JS, Camm AJ, et al. Gastro-oesophageal reflux in patients with coronary artery disease : how common is it and does it matter? Eur J Gastroenterol Hepatol ; 8 : - Lux G, Van Els J, The GS, et al. Ambulatory oesophageal pressure, ph and ECG recording in patients with normal and pathological coronary angiography and intermittent chest pain. Neurogastroenterol Motil ; 7 : - Singh S, Richter JE, Hewson EG, et al. The contribution of gastroesophageal reflux to chest pain in patients with coronary artery disease. Ann Intern Med ; 117 : - Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease : an analysis based on the ProGERD Study. Aliment Pharmacol Ther ; 17 : - Schofield PM, Whorwell PJ, Brooks NH, et al. Oesophageal function in patients with angina pectoris : a comparison of patients with normal coronary angiograms and patients with coronary artery disease. Digestion ; 42 : - Schofield PM, Brooks NH, Colgan S, et al. Left ventricular function and oesophageal function in patients with angina pectoris and normal coronary angiograms. Br Heart J ; 58 : - Cremonini F, Wise J, Moayyedi P, et al. Diagnostic and therapeutic use of proton pump inhibitors in non-cardiac chest pain : a metaanalysis. Am J Gastroenterol ; 100 : - 98

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6 GERD GERD GERD PPI PPI PPI PPI PPI Ing AJ, Ngu MC, Breslin AB. Pathogenesis of chronic persistent cough associated with gastroesophageal reflux. Am J Respir Crit Care Med ; 149 : - Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease : an analysis based on the ProGERD Study. Aliment Pharmacol Ther ; 17 : - Palombini BC, Villanova CA, Araújo E, et al. A pathogenic triad in chronic cough : asthma, postnasal drip syndrome, and gastroesophageal reflux disease. Chest ; 116 : - Mello CJ, Irwin RS, Curley FJ, et al. Predictive values of the character, timing, and complications of chronic cough in diagnosing its cause. Arch Intern Med ; 156 : - Jaspersen D, Labenz J, Willich SN, et al. Long-term clinical course of extra-oesophageal manifestations in patients with gastro-oesophageal reflux disease : a prospective follow-up analysis based on the ProGERD study. Dig Liver Dis ; 38 : - Allen CJ, Anvari M. Does laparoscopic fundoplication provide long-term control of gastroesophageal reflux related cough Surg Endosc ; 18 : - Chang AB, Lasserson TJ, Gaffney J, et al. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev ; CD Chang AB, Lasserson TJ, Kiljander TO, et al. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ ; 332 : - Ours TM, Kavuru MS, Schilz RJ, et al. A prospective evaluation of esophageal testing and a 100

7 double-blind, randomized study of omeprazole in a diagnostic and therapeutic algorithm for chronic cough. Am J Gastroenterol ; 94 : - Kiljander TO, Salomaa ER, Hietanen EK, et al. Chronic cough and gastro-oesophageal reflux : a double-blind placebo-controlled study with omeprazole. Eur Respir J ; 16 : - 101

8 GERD GERD GERD ph PPI PPI PPI - PPI PPI 102

9 Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease : an analysis based on the ProGERD Study. Aliment Pharmacol Ther ; 17 : - el-serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology ; 113 : - Williams RB, Szczesniak MM, Maclean JC, et al. Predictors of outcome in an open label, therapeutic trial of high-dose omeprazole in laryngitis. Am J Gastroenterol ; 99 : - El-Serag HB, Gilger M, Kuebeler M, et al. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology ; 121 : - Qadeer MA, Phillips CO, Lopez AR, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis : a meta-analysis of randomized controlled trials. Am J Gastroenterol ; 101 : - Vaezi MF, Richter JE, Stasney CR, et al. Treatment of chronic posterior laryngitis with esomeprazole. Laryngoscope ; 116 : - Steward DL, Wilson KM, Kelly DH, et al. Proton pump inhibitor therapy for chronic laryngo-pharyngitis : a randomized placebo-control trial. Otolaryngol Head Neck Surg ; 131 : - Eherer AJ, Habermann W, Hammer HF, et al. Effect of pantoprazole on the course of refluxassociated laryngitis : a placebo-controlled double-blind crossover study. Scand J Gastroenterol ; 38 ; - El-Serag HB, Lee P, Buchner A, et al. Lansoprazole treatment of patients with chronic idiopathic laryngitis : a placebo-controlled trial. Am J Gastroenterol ; 96 : - Issing WJ, Tauber S, Folwaczny C, et al. Impact of -hour intraesophageal ph monitoring with channels in the diagnosis of reflux-induced otolaryngologic disorders. Laryngorhinootologie. ; 82 : - 103

10 GERD GERD, GERD, GERD. 104

11 GERD GERD GERD.. GERD. GERD. GERD GERD,, GERD... GERD... GERD GERD - PPI PPI PPI COPD GERD GERD GERD mg mg mg GERD 105

12 mg grade C D GERD grade AB GERD PPI GERD Nissen fundoplication... GERD GERD GERD Nordenstedt H, Nilsson M, Johansson S, et al. The relation between gastroesophageal reflux and respiratory symptoms in a population-based study : the Nord-Trøndelag health survey. Chest. ; 129 : - Sontag SJ, O Connell S, Miller TQ, et al. Asthmatics have more nocturnal gasping and reflux symptoms than nonasthmatics, and they are related to bedtime eating. Am J Gastroenterol 106

13 ; 99 : - Field SK, Underwood M, Brant R, et al. Prevalence of gastroesophageal reflux symptoms in asthma. Chest. ; 109 : - El-Serag HB, Gilger M, Kuebeler M, et al. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology ; 121 : - Riccioni G, Della Vecchia R, Menna V, et al. Prevalence of bronchial asthma in patients with endoscopically-documented esophagitis. Ann Clin Lab Sci. ; 34 : - Havemann BD, Henderson CA, El-Serag HB. The association between gastro-oesophageal reflux disease and asthma : a systematic review. Gut ; 56 : - Ruigómez A, Rodríguez LA, Wallander MA, et al. Gastroesophageal reflux disease and asthma : a longitudinal study in UK general practice. Chest. ; 128 : - Chunlertrith K, Boonsawat W, Zaeoue U. Prevalence of gastroesophageal reflux symptoms in asthma patients at Srinagarind Hospital. J Med Assoc Thai ; 88 : - Locke GR rd, Talley NJ, Fett SL, et al. Prevalence and clinical spectrum of gastroesophageal reflux : a population-based study in Olmsted County, Minnesota. Gastroenterology ; 112 : - Hungin AP, Raghunath AS, Wiklund I. Beyond heartburn : a systematic review of the extraoesophageal spectrum of reflux-induced disease. Fam Pract ; 22 : - Gibson PG, Henry RL, Coughlan JL, et al. Gastro-oesophageal reflux treatment for asthma in adults and children. Cochrane Database Syst Rev. ; () : CD Coughlan JL, Gibson PG, Henry RL. Medical treatment for reflux oesophagitis does not consistently improve asthma control : a systematic review. Thorax ; 56 : - Field SK, Sutherland LR. Does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux? : a critical review of the literature. Chest ; 114 : - Littner MR, Leung FW, Ballard ED nd, et al. Effects of weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms. Chest ; 128 : - Shimizu Y, Dobashi K, Kobayashi S, et al. A proton pump inhibitor, lansoprazole, ameliorates asthma symptoms in asthmatic patients with gastroesophageal reflux disease. Tohoku J Exp Med ; 209 : - Jiang SP, Liang RY, Zeng ZY, et al. Effects of antireflux treatment on bronchial hyper-responsiveness and lung function in asthmatic patients with gastroesophageal reflux disease. World J Gastroenterol ; 9 : - Kiljander TO, Salomaa ER, Hietanen EK, et al. Gastroesophageal reflux in asthmatics : a double-blind, placebo-controlled crossover study with omeprazole. Chest ; 116 : -. Erratum in : Chest ; : Kiljander T, Salomaa ER, Hietanen E, et al. Asthma and gastro-oesophageal reflux : can the response to anti-reflux therapy be predicted? Respir Med ; 95 : - Teichtahl H, Kronborg IJ, Yeomans ND, et al. Adult asthma and gastro-oesophageal reflux : the effects of omeprazole therapy on asthma. Aust N Z J Med ; 26 : - Levin TR, Sperling RM, McQuaid KR. Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux. Am J Gastroenterol ; 93 : - Boeree MJ, Peters FT, Postma DS, et al. No effects of high-dose omeprazole in patients with severe airway hyperresponsiveness and (a)symptomatic gastro-oesophageal reflux. Eur 107

14 Respir J ; 11 : - Størdal K, Johannesdottir GB, Bentsen BS, et al. Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease. Arch Dis Child ; 90 : - Ford GA, Oliver PS, Prior JS, et al. Omeprazole in the treatment of asthmatics with nocturnal symptoms and gastro-oesophageal reflux : a placebo-controlled cross-over study. Postgrad Med J ; 70 : - QUEST ; 66 : - Larrain A, Carrasco E, Galleguillos F, et al. Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux. Chest ; 99 : - Gustafsson PM, Kjellman NI, Tibbling L. A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J. ; 5 : - Sontag SJ, O Connell S, Khandelwal S, et al. Asthmatics with gastroesophageal reflux : long term results of a randomized trial of medical and surgical antireflux therapies. Am J Gastroenterol. ; 98 : - Nagel RA, Brown P, Perks WH, et al. Ambulatory ph monitoring of gastro-oesophageal reflux in morning dipper asthmatics. BMJ ; 297 : - Tsugeno H, Mizuno M, Fujiki S, et al. A proton-pump inhibitor, rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux. Scand J Gastroenterol ; 38 : - Wong CH, Chua CJ, Liam CK, et al. Gastro-oesophageal reflux disease in difficult-to-control asthma : prevalence and response to treatment with acid suppressive therapy. Aliment Pharmacol Ther ; 23 : - Böcskei C, Viczián M, Böcskei R, et al. The influence of gastroesophageal reflux disease and its treatment on asthmatic cough. Lung ; 183 : - Nakase H, Itani T, Mimura J, et al. Relationship between asthma and gastro-oesophageal reflux : significance of endoscopic grade of reflux oesophagitis in adult asthmatics. J Gastroenterol Hepatol ; 14 : - Field SK, Gelfand GA, McFadden SD. The effects of antireflux surgery on asthmatics with gastroesophageal reflux. Chest. ; 116 : - 108

15 GERD -,. QUEST GERD ph GERD mg mg mg mg 109

16 PPI Johnson DA, Orr WC, Crawley JA, et al. Effect of esomeprazole on nighttime heartburn and sleep quality in patients with GERD : a randomized, placebo-controlled trial. Am J Gastroenterol ; 100 : - Chand N, Johnson DA, Tabangin M, et al. Sleep dysfunction in patients with gastrooesophageal reflux disease : prevalence and response to GERD therapy, a pilot study. Aliment Pharmacol Ther ; 20 : - Cohen JA, Arain A, Harris PA, et al. Surgical trial investigating nocturnal gastroesophageal reflux and sleep (STINGERS). Surg Endosc. ; 17 : - Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux : a population-based study of young adults in three European countries. Chest ; 121 : - Powitzky ES, Khaitan L, Garrett CG, et al. Symptoms, quality of life, videolaryngoscopy, and twenty-four-hour triple-probe ph monitoring in patients with typical and extraesophageal reflux. Ann Otol Rhinol Laryngol ; 112 : - Suganuma N, Shigedo Y, Adachi H, et al. Association of gastroesophageal reflux disease with weight gain and apnea, and their disturbance on sleep. Psychiatry Clin Neurosci ; 55 : - Janson C, Gislason T, De Backer W, et al. Daytime sleepiness, snoring and gastrooesophageal reflux amongst young adults in three European countries. J Intern Med ; 237 : - Guda N, Partington S, Vakil N. Symptomatic gastro-oesophageal reflux, arousals and sleep quality in patients undergoing polysomnography for possible obstructive sleep apnoea. Aliment Pharmacol Ther ; 20 : - Dickman R, Green C, Fass SS, et al. Relationships between sleep quality and ph monitoring findings in persons with gastroesophageal reflux disease. J Clin Sleep Med ; 3 : - 110

17 111

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20 CPAP GERD - OSAS GERD GERD OSAS OSAS GERD GERD OSAS Farrokhi F, Vaezi MF. Extra-esophageal manifestations of gastroesophageal reflux. Oral Dis. ; 13 : - Muñoz JV, Herreros B, Sanchiz V, et al. Dental and periodontal lesions in patients with gastro-oesophageal reflux disease. Dig Liver Dis. ; 35 : - el-serag HB, Sonnenberg A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology ; 113 : - Jecker P, Orloff LA, Wohlfeil M, et al. Gastroesophageal reflux disease (GERD), extraesophageal reflux (EER) and recurrent chronic rhinosinusitis. Eur Arch Otorhinolaryngol. ; 263 : - Raghu G, Freudenberger TD, Yang S, et al. High prevalence of abnormal acid gastrooesophageal reflux in idiopathic pulmonary fibrosis. Eur Respir J ; 27 : - Tobin RW, Pope CE nd, Pellegrini CA, et al. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med ; 158 : - Mokhlesi B, Morris AL, Huang CF, et al. Increased prevalence of gastroesophageal reflux symptoms in patients with COPD. Chest ; 119 : - Poelmans J, Tack J, Feenstra L. Chronic middle ear disease and gastroesophageal reflux disease : a causal relation? Otol Neurotol. ; 22 : - He Z, O Reilly RC, Bolling L, Soundar S, Shah M, Cook S, Schmidt RJ, Bloedon E, Mehta DI. Detection of gastric pepsin in middle ear fluid of children with otitis media. Otolaryngol Head Neck Surg. ; 137 : - Crapko M, Kerschner JE, Syring M, Johnston N. Role of extra-esophageal reflux in chronic otitis media with effusion. Laryngoscope. ; 117 : - Kim HN, Vorona RD, Winn MP, et al. Symptoms of gastro-oesophageal reflux disease and the severity of obstructive sleep apnoea syndrome are not related in sleep disorders center patients. Aliment Pharmacol Ther ; 21 : - Morse CA, Quan SF, Mays MZ, et al. Is there a relationship between obstructive sleep apnea and gastroesophageal reflux disease? Clin Gastroenterol Hepatol ; 2 : - Valipour A, Makker HK, Hardy R, et al. Symptomatic gastroesophageal reflux in subjects 114

21 with a breathing sleep disorder. Chest ; 121 : - Graf KI, Karaus M, Heinemann S, et al. Gastroesophageal reflux in patients with sleep apnea syndrome. Z Gastroenterol ; 33 : - Penzel T, Becker HF, Brandenburg U, et al. Arousal in patients with gastro-oesophageal reflux and sleep apnoea. Eur Respir J ; 14 : - Demeter P, Visy KV, Magyar P, et al. Correlation between severity of endoscopic findings and apnea-hypopnea index in patients with gastroesophageal reflux disease and obstructive sleep apnea. World J Gastroenterol ; 11 : - Wasilewska J, Kaczmarski M, et al. Sleep-related breathing disorders in small children with nocturnal acid gastro-oesophageal reflux. Rocz Akad Med Bialymst ; 49 : - OSAS ; 44 : - Frequency scale for the symptoms of GERD Med Postgrad ; 45 : - Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med ; 108 (Suppl a) : S-S Senior BA, Khan M, Schwimmer C, et al. Gastroesophageal reflux and obstructive sleep apnea. Laryngoscope ; 111 : - Kerr P, Shoenut JP, Millar T, et al. Nasal CPAP reduces gastroesophageal reflux in obstructive sleep apnea syndrome. Chest ; 101 : - Green BT, Broughton WA, O Connor JB, et al. Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure. Arch Intern Med ; 163 : - CPAP ; 14 : - a El-Serag HB, Gilger M, Kuebeler M, et al. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology ; 121 : - btasker A, Dettmar PW, Panetti M, et al. Reflux of gastric juice and glue ear in children. Lancet ; 359 : c Bortolotti M, Gentilini L, Morselli C, et al. Obstructive sleep apnoea is improved by a prolonged treatment of gastrooesophageal reflux with omeprazole. Dig Liver Dis ; 38 : - 115

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