慢性膵炎GL-01.qxd
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2 GERD Barrett PPI H H RA PPI 44
3 - GERD. GERD, GERD QOL - QOL QOL QOL QOL PPI H RA QOL, Katelaris PH. An evaluation of current GERD therapy : a summary and comparison of effectiveness, adeverse effects and costs of drugs, surgery and endoscopic therapy. Best Prac Res Clin Gastroenterol : 18 (Suppl) : - Jones MP. Acid suppression in gasyro-oesophageal reflux disease : Why? how? how much and when? Postgrad Med J ; 78 : - Richter JE. Long-term management of gastroesophageal reflux disease and its complications.am J Gastroenterol ; 92 ( Suppl) : S- S. discussion : S- S, H Omeprazole ; 16 : - H AG- ; 29 : - Jankowski JA, Anderson M. Review article : management of oesophageal adenocarcinomacontrol of acid, bile and inflammation in intervention strategies for Barrett s oasophagus. Aliment Pharmacol Ther ; 20 (Suppl ) : - Pace F, Negrini C, Wiklund I, et al. Quality of life in acute and maintenance treatment of non-erosive and mild erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 45
4 ; 22 : - Ofman JJ. The economic and quality-of-life impact of symptomatic gastroesophageal reflux disease. Am J Gastroenterol ; 98 (Suppl) : S -S Velanovich V. Quality of life and severity of symptoms in gastro-oesophageal reflux disease : a clinical review. Eur J Surg ; 166 : - Robinson M, Fitzgerald S, Hegedus R, et al. Onset of symptom relief with rabeprazole : a community-based, open-label assessment of patients with erosive oesopagitis. Aliment Pharmacol Ther ; 16 : - Meineche-Schmidt V, Juhl HH, Østergaard JE, Luckow A, et al. Costs and efficacy of three different esomeprazole treatment strategies for long-term management of gastrooesophageal reflux symptoms in primary care. Aliment Pharmacol Ther ; 19 : - Ponce J, Argüello L, Bastida G, et al. On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice : effectiveness, health-related quality of life, and patient satisfaction. Dig Dis Sci ; 49 : - Mathias SD, Colwell HH, Miller DP, et al. Health-related quality-of-life and quality-days incrementally gained in symptomatic nonerosive GERD patients treated with lansoprazole or ranitidine. Dig Dis Sci ; 46 : - Liu JY. Symptoms and treatment burden of gastroesophageal reflux disease. : validating the GERD assessment scales. Arch Intern Med ; 164 : - Bytzer P. Goals of therapy and guideline for treatment success in symptomatic gastroesophageal reflux disease patients. Am J Gastroenterol ; 98 (Suppl) : S -S 46
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6 LES LES d e,f Kaltenbach T, Crockett S, Gerson LB, et al. Are lifestyle measures effective in patients with gastroesophageal reflux disease? Arch Intern Med ; 166 : - Pehl C, Wendl B, Pfeiffer A, et al. Low-proof alcoholic beverages and gastroesophageal reflux. Dig Dis Sci ; 38 : - a Murphy DW, Castell DO. Chocolate and heartburn : Evidence of increased esophageal acid exposure after chocolate ingestion. Am J Gastroenterol ; 83 : - b Becker DJ, Sinclair J, Castell DO, et al. A comparison of high and low fat meals on postprandial esophageal acid exposure. Am J Gastroenterol ; 84 : - c Schönfeld JV, Evans DF. Fat, spices and gastro-oesophageal reflux. Z Gastroenterol ; 45 : - d Johnson LF, DeMeester TR. Evaluation of elevation of the head of the bed, bethanechol, and antacid foam tablets on gastroesophageal reflux. Dig Dis Sci ; 26 : - e Stanciu C, Bennett JR, et al. Effects of posture on gastro-oesophageal reflux. Digestion ; 15 : - f Meyers WF, Herbst JJ. Effectiveness of positioning therapy for gastroesophageal reflux. Pediatrics ; 69 : - 48
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8 Graham DY, Patterson DJ. Double-blind comparison of liquid antacid and placebo in the treatment of symptomatic reflux esophagitis. Dig Dis Sci ; 28 : - Grove O, Bekker C, Jeppe-Hansen MG, et al. Ranitidine and high-dose antacid in reflux oesophagitis : a randomized, placebo-controlled trial. Scand J Gastroenterol ; 20 : - Weberg R, Berstad A. Symptomatic effect of a low-dose antacid regimen in reflux oesophagitis. Scand J Gastroenterol ; 24 : - Tran T, Lowry AM, El-Serag HB. Meta-analysis : the efficacy of over-the-counter gastrooesophageal reflux disease therapies. Aliment Pharmacol Ther ; 25 : - Mandel KG, Daggy BP, Brodie DA, et al. Review article : alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther ; 14 : - Castell DO, Dalton CB, Becker D, et al. Alginic acid decreases postprandial upright gastroesophageal reflux. Comparison with equal-strength antacid. Dig Dis Sci ; 37 : - Galmiche JP, Shi G, Simon B, et al. On-demand treatment of gastro-oesophgeal reflux symptoms : a comparison of ranitidine mg with cimetidine mg or placebo. Aliment Pharmacol Ther ; 12 : - Vivian EM, Thompson MA. Pharmacologic strategies for treating gastroesophageal reflux disease. Clin Ther ; 22 : - a Buts JP, Barudi C, Otte JB. Double-blind controlled study on the efficacy of sodium alginate (Gaviscon) in reducing gastroesophageal reflux assessed by h continuous ph monitoring in infants and children. Eur J Pediatr ; 146 : - b Stanciu C, Bennett JR. Alginate/ antacid in the reduction of gastro-oesophageal reflux. Lancet ; 1 : - c Poynard T, Vernisse B, Agostini H. Randomized, multicentre comparison of sodium alginate and cisapride in the symptomatic treatment of uncomplicated gastroesophageal reflux. Aliment Pharmacol Ther ; 12 : - d Ciociola AA, Pappa KA, Sirgo MA. Nonprescription doses of ranitidine are effective in the relief of episodic heartburn. Am J Ther ; 8 : - e Paul K, Redman CM, Chen M. Effectiveness and safety of nizatidine, mg, for the relief of episodic heartburn. Aliment Pharmacol Ther ; 15 : - f Freston JW, Malagelada JR, Petersen H, et al. Critical issues in the management of gastroesophageal reflux disease. Eur J Gastroenterol Heptol ; 7 : - 50
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10 H RA PPI H RA PPI, PPI H RA b NERD GERD PPI H RA NERD - NERD PPI NERD PPI, NERD functional heartburn NERD Hunt RH. Importance of ph control in the management of GERD. Arch intern Med ; 159 : - Pujol A, Grande L, Ros E, et al. Utility of inpatient -hour intraesophageal ph monitoring in diagnosis of gastroesophageal reflux. Dig Dis Sci ; 33 : - Masclee AA, de Best AC, de Graaf R, et al. Ambulatory -hour ph-metry in the diagnosis of gastroesophageal reflux disease : determination of criteria and relation to endoscopy. Scand J Gastroenterol ; 25 : - Kasapidis P, Xynos E, Mantides A, et al. Differences in manometry and -H ambulatory phmerty between patients with and without endoscopic or histological esophagitis in gastroesophageal reflux disease. Am J Gastroenterol ; 88 : - Saraswat VA, Dhiman RK, Mishra A, et al. Correlation of -hr esophageal ph patterns with clinical features and endoscopy in gastroesophageal reflux disease. Dig Dis Sci ; 39 : - Khan M, Santana J, Donnellan C, et al. Medical treatments in the short term management of reflux oesophagitis (review). Cochrane Database Syst Rev ; 18 ( ) : CD Hunt RH. The relationship between the control of ph and healing and symptom relief in gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 9 (Suppl ) : - 52
11 Soga T, Matsuura M, Kodama Y, et al. Is a proton pump inhibitor necessary for the treatment of lower-grade reflux esophagitis? J Gastroenterol ; 34 : - van Pinxteren B, Numans ME, Lau J, et al. Short-term treatment of gastroesophageal reflux disease : a systematic review and meta-analysis of the effect of acid-suppressant drugs in empirical treatment and in endoscopy-negative patients. J Gen Intern Med ; 18 : - Chiba N, De Gara CJ, Wilkinson JM, et al. Speed of healing and symptom relief in grade to gastroesophageal reflux disease : a meta-analysis. Gastroenterology ; 112 : - Kahrilas PJ, Fennerty MB, Joelsson B, et al. High- versus standard-dose ranitidine for control of heartburn in poorly responsive acid reflux disease : a prospective, controlled trial. Am J Gastroenterol ; 94 : - Festen HP, Schenk E, Tan G, et al. Omeprazole versus high-dose ranitidine in mild gastroesophageal reflux disease : short and long-term treatment. Am J Gastroenterol ; 94 : - Jansen JB, Van Oene JC. Standard- dose lansoprazole is more effective than high-dose ranitidine in achieving endoscopic healing and symptom relief in patients with moderately severe reflux oesophagitis. Aliment Pharmacol Ther ; 13 : - H Omeprazole ; 15 : - H AG- ; 29 : - van Pinxteren B, Numans ME, Bonis PA, et al. Short-term treatment with proton pump inhibitors, H -receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease (review). Cochrane Database Syst Rev ; 19 ( ) : CD Miner P Jr, Orr W, Filippone J, et al. Rabeprazole in nonerosive gastroesophageal reflux disease : a randomized placebo-controlled trial. Am J Gastroenterol ; 97 : - Armstrong D, Talley NJ, Lauritsen K, et al. The role of acid suppression in patients with endoscopy-negative reflux disease : the effect of treatment with esomeprazole or omeprazole. Aliment Pharmacol Ther ; 20 : - Damiano A, Siddique R, Xu X, et al. Reductions in symptom distress reported by patients with moderately severe, nonerosive gastroesophageal reflux disease treated with rabeprazole. Dig Dis Sci ; 48 : - Tack J, Fass R. Review article : Approaches to endoscopic-negative reflux disease : part of the GERD spectrum of a unique acid-related disorder? Aliment Pharmacol Ther ; 19 (Suppl ) : - Fass R. Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. Am J Gastroenterol ; 98 (Suppl) : S -S a Johansson KE, Ask P, Boeryd B, et al. Oesophagitis, signs of reflux, and gastric acid secretion in patients with symptoms of gastro-oesophageal reflux disease. Scand J Gastroenterol ; 21 : - b Tytgat GN. Are there unmet needs in acid suppression? Best Prac Res Clin Gastroenterol ; 18 (Suppl) : - 53
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13 PPI H RA - H RA - GERD H RA NERD PPI H RA, GERD PPI GERD PPI RCT PPI PPI,, PPI - mg grade A grade C D mg mg PPI PPI P CYP C CYP C 55
14 homozygous extensive metabolizer homem heterozygous extensive metabolizer hetem poor metabolizer PM PM homem PM homem hetem homoem, PPI CYP C PPI PPI PPI mg mg mg PPI PPI H RA nocturnal gastric acid breakthrough NAB GERD QOL H RA NAB a PPI H RA PPI H RA, -,,, PPI,, 56
15 GERD PPI NERD PPI PPI NERD mg mg, mg mg mg mg mg mg episodic treatment PPI GERD mg mg mg mg mg mg mg mg mg PPI NERD PPI GERD, PPI, H RA 57
16 PPI GERD, PPI b PPI CYP CYP c PPI H Therapeutic Research ; 21 : - ; 49 : - Caro JJ, Salas M, Ward A, et al. Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo : evidence from randomized clinical trials. Clin Ther ; 23 : - Chiba N, De Gara CJ, Wilkinson JM, et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease : a meta-analysis. Gastroenterology ; 112 : - Habu Y, Maeda K, Kusuda T, et al. Proton-pump inhibitor-first strategy versus step-up strategy for the acute treatment of reflux esophagitis : a cost-effectiveness analysis in Japan. J Gastroenterol ; 40 : - Cost-effectiveness ; 37 : - PPI first strategy Step-up strategy, PPI H RA Therapeutic Research ; 22 : - 58
17 H ; 58 : - PPI H H RA ; 30 : - GERD Medicina ; 42 : - Lansoprazole H -RA Prog Med ; 19 : - Stålhammar NO, Carlsson J, Peacock R, et al. Cost effectiveness of omeprazole and ranitidine in intermittent treatment of symptomatic gastro-oesophageal reflux disease. Pharmacoeconomics ; 16 : - van Pinxteren B, Numans ME, Bonis PA, et al. Short-term treatment with proton pump inhibitors, H -receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease (review). Cochrane Database Syst Rev ; 19 ( ) : CD Richter JE, Campbell DR, Kahrilas PJ, et al. Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease. Arch Intern Med ; 160 : - Klok RM, Postma MJ, van Hout BA, et al. Meta-analysis : comparing the efficacy of proton pump inhibitors in short-term use. Aliment Pharmacol Ther ; 17 : - Raghunath AS, Green JR, Edwards SJ. A review of the clinical and economic impact of using esomeprazole or lansoprazole for the treatment of erosive esophagitis. Clin Ther ; 25 : - Bytzer P, Morocutti A, Kennerly P, et al. Effect of rabeprazole and omeprazole on the onset of gastro-oesophageal reflux disease symptom relief during the first seven days of treatment. Scand J Gastroenterol ; 41 : - Pace F, Annese V, Prada A, et al. Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease : a randomised, double-blind, comparative study of rabeprazole and omeprazole mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole. Dig Liver Dis ; 37 : - PPI ; 42 : - CYP C Lansoprazole GERD Therapeutic Research ; 25 : - Mee AS, Rowley JL. Rapid symptom relief in reflux oesophagitis : a comparison of lansoprazole and omeprazole. Aliment Pharmacol Ther ; 10 : - PPI CYP C Ther Res ; 25 : - Holloway RH, Dent J, Narielvala F, et al. Relation between oesophageal acid exposure and healing of oesophagitis with omeprazole in patients with severe reflux oesophagitis. Gut ; 38 : - Adachi K, Komazawa Y, Mihara T, et al. Administration of H receptor antagonist with proton pump inhibitor is effective for long-term control of refractory reflux esophagitis. J Clin Gastroenterol ; 38 : - No. p - 59
18 , H Omeprazole ; 16 : - H AG- ; 29 : - GERD PPI H RA ; 62 : - ; 36 : - Kaplan-Machlis B, Spiegler GE, Zodet MW, et al. Effectiveness and costs of omeprazole vs ranitidine for treatment of symptomatic gastroesophageal reflux disease in primary care clinics in West Virginia. Arch Fam Med ; 9 : - Bytzer P, Blum A, De Herdt D, et al ; The Trial Investigators. Six-month trial of on-demand rabeprazole mg maintains symptom relief in patients with non-erosive reflux disease. Aliment Pharmacol Ther ; 20 : - Talley NJ, Venables TL, Green JR, et al. Esomeprazole mg and mg is efficacious in the long-term management of patients with endoscopy-negative gastro-oesophageal reflux disease : a placebo-controlled trial of on-demand therapy for months. Eur J Gastroenterol Hepatol ; 14 : - Talley NJ, Lauritsen K, Tunturi-Hihnala H, et al. Esomeprazole mg maintains symptom control in endoscopy-negative gastro-oesophageal reflux disease : a controlled trial of ondemand therapy for months. Aliment Pharmacol Ther ; 15 : - Lind T, Havelund T, Lundell L, et al. On demand therapy with omeprazole for the long-term management of patients with heartburn without oesophagitis --a placebo-controlled randomized trial. Aliment Pharmacol Ther ; 13 : - Tsai HH, Chapman R, Shepherd A, et al. Esomeprazole mg on-demand is more acceptable to patients than continuous lansoprazole mg in the long-term maintenance of endoscopynegative gastro-oesophageal reflux patients : the COMMAND Study. Aliment Pharmacol Ther ; 20 : - GERD ; 40 : - Norman Hansen A, Bergheim R, Fagertun H, et al. A randomised prospective study comparing the effectiveness of esomeprazole treatment strategies in clinical practice for months in the management of patients with symptoms of gastroesophageal reflux disease. Int J Clin Pract ; 59 : - Bigard MA, Genestin E. Treatment of patients with heartburn without endoscopic evaluation : on-demand treatment after effective continuous administration of lansoprazole mg. Aliment Pharmacol Ther ; 22 : - Gastroesophageal Reflux Disease GERD Proton Pump Inhibitor PPI On-demand ; 56 : - Meineche-Schmidt V, Juhl HH, Østergaard JE, Luckow A, et al. Costs and efficacy of three different esomeprazole treatment strategies for long-term management of gastrooesophageal reflux symptoms in primary care. Aliment Pharmacol Ther ; 19 : - 60
19 Prog Med ; 24 : - Prog Med ; 27 : - Pace F, Negrini C, Wiklund I, et al. Quality of life in acute and maintenance treatment of non-erosive and mild erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther ; 22 : - Ponce J, Arguello L, Bastida G, et al. On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice : effectiveness, health-related quality of life, and patient satisfaction. Dig Dis Sci ; 49 : - ; 31 : - PPI H Prog Med ; 23 : - Klinkenberg-Knol EC, Nelis F, Dent J, et al. Long-term omeprazole treatment in resistant gastroesophageal reflux disease : efficacy, safety, and influence on gastric mucosa. Gastroenterology ; 118 : - a Fackler WK, Ours TM, Vaezi MF, et al. Long-term effect of H RA therapy on nocturnal gastric acid breakthrough. Gastroenterology ; 122 : - b Cote GA, Howden CM. Potential adverse effects of proton pump inhibitors. Curr Gastroenterol Rep ; 10 : - c p- 61
慢性膵炎GL-01.qxd
12 GERD GERD RCT CQ Delphi Fass R, Shapiro M, Dekel R, et al. Systematic review : proton-pump inhibitor failure in gastrooesophageal reflux disease--where next? Aliment Parmacol Ther ; 22 : - Lundell LR,
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