抗19-各8-フェニコール(7103).indd
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1 解説 報告 動物用抗菌性物質を取り巻く現状 (ⅩⅨ ) 動物用抗菌剤の各論 ( その 8) フェニコール系抗菌剤 白川崇大 ( 農林水産省動物医薬品検査所検査第二部安全性検査第一領域 ) 1 フェニコール系抗菌剤とは Streptomyces venezuelae,, EU,, S S, NO,, CAT cat, 2 人医療におけるフェニコール系抗菌剤,,, data/taiseikin_rank_.pdf WHO FAX takahiro_shirakaw@maff.go.jp
2 主成分 投与経路 対象動物 牛馬豚鶏犬猫 適応症 使用禁止期間 Highly Important 3 獣医療におけるフェニコール系抗菌剤 113 t t.kg
3 (1) フロルフェニコール (2) チアンフェニコール (3) クロラムフェニコール 4 フェニコール系抗菌剤に対する耐性機構 suis cmla CmlA cmla Klebsiella pneumoniae P. aeruginosa flor fexa flor E. coli Salmonella enterica serovar Typhimurium DT, fexa Staphylococcus lentus AcrABTolC FloR AcrABTolC MIC, S. aureus S rrna A cfr Cfr S rrna 5 動物における感受性調査 JVARM CAT cat cat Escherichia coli Staphylococcus aureus Pseudomonas aeruginosa Streptococcus 114 Campylobacter jejuni Campylobacter coli
4 E. coli E. coli cat1 cmla flor S. Typhimurium DTSalmonella enterica serovar. Agona SGI Salmonella genomic island, flor fexa cfr 6 おわりに. flor. α, 参考文献 The Joint FAO/WHO Experts Committee on Food Additives (JECFA) : Chloramphenicol: Toxicological evaluation of certain veterinary drug residues in food, WHO Food Additives Series, () Lashev L, Haritova A : Comparative allometric analysis of pharmacokinetics of florfenicol and tiamphenicol, Bulgarian Journal of Veterinary Medicine,, () Tao W, Lee MH, Wu J, Kim NH, Kim JC, Chung E, Hwang E, Lee SW : Inactivation of chloramphenicol and florfenicol by a novel chloramphenicol hydrolase, Appl Environ Microb,, () Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A : Molecular basis of bacterial resistance to chloramphenicol and florfenicol, FEMS Microbiol Rev,, () Schlünzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Francesch F : Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria, Nature,, () Shukla P, Bansod FW, Singh RK : Chloramphenicol toxicity: a review, Journal of Medicine and Medical Sciences,, () Nitzan O, Kennes Y, Colodner R, Saliba W, Edelstein H, Raz R, Chazan B : Chloramphenicol use and susceptibility patterns in Israel: a national survey, Isr Med Assoc J,, () JECFA : Thiamphenicol, WHO Food Additives Series, () 115
5 WHO : Critically Important Antimicrobials for Human Medicine, th revision () HPhttp://www. maff.go.jp/nval/iyakutou/hanbaidaka/attach/pdf/ h-koukinzai_re.pdf Murray IA, Martinez-suarez, JV, Close TJ, Shaw W : Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenza, which are sensitive to inhibition by thiol-reactive reagents, Biochem J,, () Brückne R, Matzura H : Regulation of the inducible chloramphenicol acetyltransferase gene of the Staphylococcus aureus plasmid pub, EMBO J,, () White PA, Stokes HW, Bunny KL, Hall RM : Characterisation of a chloramphenicol acetyltransferase determinant found in the chromosome of Pseudomonas aeruginosa, FEMS Microbiol Lett,, () Takamatsu D, Osaki M, Sekizaki T : Chloramphenicol resistance transposable element TnSs1 of Streptococcus suis, a transposon flanked by IS6family elements, Plasmid,, () Poirel L, Le Thomas I, Naas T, Karim A, Nordmann P : Biochemical sequence analyses of GES, a novel class A extended-spectrum lactamase, and the class integron In from Klebsiella pneumoniae, Antimicrob Agents Ch,, () Riccio ML, Docquier JD, Dell Amico E, Luzzaro F, Amicosante G, Rossolini GM : Novel -N-aminoglycoside acetyltransferase gene, aac(3)-ic, from a Pseudomonas aeruginosa integrin, Antimicrob Agents Ch,, () Bissonnett L, Champetier S, Buisson JP, Roy PH : Characterization of the nonenzymatic chloramphenicol resistance (cmla) gene of the In 4 Iintegron of Tn1696: similarity of the product to transmembrane transport proteins, J Bacteriol,, () White DG, Hudson C, Maurer JJ, Ayers S, Zhao S, Lee MD, Bolton L, Foley T, Sherwood J : Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea, J Clin Microbiol,, () Boyd D, Peters GA, Cloeckaert A, Boumedine KS, Chaslus-Dancla E, Imberechts H, Mulvey MR : Complete nucleotide sequence of a -Kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT and its identification in phage type DT and serovar Agona, J Bacteriol,, () Kehrenberg C, Schwarz S : fexa, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol, Antimicrob Agents Ch,, () Baucheron S, Tyler S, Boyd D, Mulvey MR, Chaslus- Dancla E, Cloeckaert A : AcrAB-TolC directs effluxmediated multidrug resistance in Salmonella enterica serovar Typhimurium DT, Antimicrob Agents Ch,, () Lee A, Mao W, Warren MS, Mistry A, Hoshino K, Okumura R, Ishida H, Lomovskaya O : Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance, J Bacteriol,, () Toro CS, Lobos SR, Calderón I, Rodríguez M, Mora GC : Clinical isolate of a porinless Salmonella typhi resistant to high levels of chloramphenicol, Antimicrob Agents Ch,, () Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Veste B : The Cfr rrna methyltransferase confers resistance to phenicols, lincosamides, Oxazolidinones, pleuromutilins, and streptogramin A antibiotics, Antimicrob Agents Ch,, () Li BB, Wu CM, Wang Y, Shen JZ : Single and dual mutations at positions, and of S rrna and their relationship to resistance to antibiotics that target the large ribosomal subunit, J Antimicrob Chemoth,, () HPhttp:// HP html Harada K, Asai T, Kojima A, Ishihara K, Takahashi T : Role of coresistance in the development of resistance to chloramphenicol in Escherichia coli isolated from sick cattle and pigs, Am J Vet Res,, () Boyd D, Cloeckaert A, Chaslus-Dancla E, Mulvey MR : Characterization of variant Salmonella genomic island multidrug resistance regions from serovars Typhimurium DT and Agona, Antimicrob Agents Ch,, () BRDC Photobacterium damselae subsp. picicida RAPD Aquaculture Science α Lactococcus garvieae Aquaculture Science 116
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