Mode of Action of Strobilurin Fungicides Hiroto TAMURA and Akira MIZUTANI * Pesticide Chemistry Laboratory, Department of Agricultural Chemistry, Facu
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1 Mode of Action of Strobilurin Fungicides Hiroto TAMURA and Akira MIZUTANI * Pesticide Chemistry Laboratory, Department of Agricultural Chemistry, Faculty of Agriculture, Meijo University, Shiogamaguchi, Tempaku-ku, , Nagoya Japan *Aburahi Laboratories, Shionogi & Co. Ltd., 1405 Gotanda, Koka-cho, Koka-gun, Shiga , Japan Key words; alternative oxidase, mitochondria, active oxygen species, flavonoids, complex III.
2 Inhibition site I Strobilurin A (Mucidin) Azoxystrobin Kresoxim methyl Methominostrobin Inhibition site II Myxothiazol A Undecylhydroxydioxobenzothiazol (UHDBT) Inhibition site III Antimycin A Alternative oxidase Salicylhydroxamic acid (SHAM) Fig. 1 List of inhibitors. Fig. 2 Schematic representation for the quinone mediated electron flow in complex III.
3 Journal of Pesticide Science 24 (2) May
4 Riske iron-sulfur protein Riske iron-sulfur protein Hydrophobic site Hydrophobic site cytochrome b cytochromeb a) interaction with ubiquinol b) interaction with fungicide Fig. 3 Putative binding model of ubiquinol (a) and methominostrobin (b) at inhibition site.
5 Journal of Pesticide Science 24 (2) May
6 Fig. 4 Proposed mode of action of strobilurin fungicides.
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