BSE CJD TSE PrD Glatzel Greenberg PrD Aguzzi PrD CJD Aguzzi PrD AD AD PrD AD APP PrD PrPc APP Aβ PrPc PrPSc Aβ PrPSc PrD astrocyte microglia Budka CJD
|
|
|
- きゅういち あいきょう
- 7 years ago
- Views:
Transcription
1 Human Prion Diseases Toshikiyo SHOHMORI Abstract Compared with that of other human pathogens such as bacteria and virus, the proposed replicative process of prions is very simple. It means misfolding of a single protein, the normal cellular prion protein (PrPc), into a disease associated form called PrPSc. This is followed by PrPSc aggregation and fragmentation of aggregates, which may increase the number of replicative products. Although the correctness of this model has not yet been proved formally, much evidence indicates that pathogen encoded DNA and RNA are not needed for prion replication. Despite the simplicity of the replicative process, the human phenotypic range of prion diseases is very variable and includes the sporadic, inherited, and acquired forms of Creutzfeldt Jacob disease. In addition, prion diseases occur in a wide range of animals and can be propagated within and between animal species. This article reviews selected papers dealing with molecular and clinical aspects of human prion diseases. Key words prion, Creutzfeldt Jacob disease, BSE, dementia PrPc PrPSc PrPSc DNA RNA Department of Mental Health and Welfare, School of Social Welfare, KIBI International University 8, Iga machi, Takahashi city, Okayama, Japan ( )
2 BSE CJD TSE PrD Glatzel Greenberg PrD Aguzzi PrD CJD Aguzzi PrD AD AD PrD AD APP PrD PrPc APP Aβ PrPc PrPSc Aβ PrPSc PrD astrocyte microglia Budka CJD PrD PrPSc, Sc PrPc, c PrP PrD Legname recmoprp recmoprp MoPrP Tg PrP FVB PrP Tg TSE CJD Glatzel scjdfcjd
3 icjdvcjd scjd Glatzel Brandel x Brandel CJD CJD CJD scjd Hsiao fcjd Gerstmann Straussler PRNP Brown icjd TSEs CJD icjd TSE vcjd vcjd BSE Bruce BSE scjd vcjd BSE vcjd TSEs BSE TSE TSE BSE Kirkwood PrP PRNP PRNP exon exon PrP PrP PRNP PrD Palmer scjd scjd scjd PrPc CNS CNS PrPc
4 PrPc α β C N PrPc C PrPc PrD Bueler PrPc Prn p PrD PrD PrPc PrPc Solforosi in vivo PrPc PrPc PrPc PrPSc Alper UV TSEs McKinley PrP PrP PrP Prusiner protein only PrPc β PrPSc PrPc PrPSc PrPSc PrPSc PrPc
5 PrPSc PrPSc PrPc PrPSc PrPc PrD PrPSc PrPSc PrPSc PrPSc PrD PrD Zerr scjd MMMMMVMVW W CJD EEG, CSF MRI MM MV CSF MV EEG CSF MRI MV CJD scjd PrD CSF PrD CSF PrD MRI PrD Tribl CJD DWIZeidler vcjd T MRI vcjd scjd MRI PrD
6 PrPSc PrD CNS PrPSc vcjd scjd Hill PrD PrPSc PrPSc PrP vcjd PrPSc PrD Zanusso scjd PrPSc PrPSc Glatzel scjd PrPSc PrD PrD PRNP CJD Windl PrD PRNP D N PrD PrD scjd vcjd PrD PrD PrPSc PrPc K PrPSc N Parchi CJD PrP PrP PrPSc PrPSc
7 PrPSc PrPSc PrPSc PrPSc vcjd PrPSc BSE PrPSc BSE vcjd PrP PrP scjd scjd scjd scjd PrPSc PrPSc scjd PrPSc fcjd, Gerstmann Straussler Scheinker FFI PRNP fcjd PRNP PRNP PRNP Gerstmann Straussler Scheinker
8 PrD Gerstmann Straussler Scheinker PrP PRNP Gerstmann Straussler Scheinker P L G V D N CJD CJD PrD CJD PrD vcjd BSE vcjd vcjd vcjd vcjd vcjd vcjd scjd vcjd scjd vcjd vcjd scjd vcjd PrP PrD PrD
9 PrPc PrD PrD PrD PrPc PrPSc Meier PrPc Fcgamma PrP Fc! PrPSc PrP PrP Fc! PrPSc PrP Fc! PrP Fc! PrP Caughey PrP res TSE curcumin diferoylmethane neuroblastoma nm PrP res cell free PrP PrP res in vitro in vivo PrPSc Aguzzi A, Montrasio F, Kaeser PS. Prions : health scare and biological challenge. Nat Rev Mol Cell Biol ; 2 : Aguzzi A, Polymenidou M. Mammalian prion biology : one century of evolving concepts. Cell ; 116 : Glatzel M, Stoeck K, Seeger H, Luehrs T, Aguzzi A. Human prion diseases. Arch Neurol ; 62 : Greenberg DA, Aminoff MJ, Simon RP. Clinical neurology Creutzfeldt Jakob disease 51 55, 2002, McGraw Hill, New York,
10 fifth edition Aguzzi A, Haass C. Games played by rogue proteins in prion disorders and Alzheimer s disease. Science ; 302 : Budka H, Aguzzi A, Brown P, et al. Neuropathological diagnostic criteria for Creutzfeldt Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol ; 5 : Legname G, Baskakov IV, Nguyen HO, et al. Synthetic mammalian prions. Science ; 305 : Glatzel M, Ott PM, Lindner T, et al. Human prion diseases : epidemiology and integrated risk assessment. Lancet Neurol ; 2 : Brandel JP, Delasnerie Laupretre N, Laplanche JL, Hauw JJ, Alperovitch A. Diagnosis of Creutzfeldt Jakob disease : effect of clinical criteria on incidence estmates. Neurology ; 54 : Glatzel M, Rogivue C, Ghani A, Streffer JR, Amsler L, Aguzzi A. Incidence of Creutzfeldt Jakob disease in Switzerland. Lancet ; 360 : Hsiao K, Baker HF, Crow TJ, et al. Linkage of a prion protein missense variant to Gerstmann Straussler syndrome. Nature ; 338 : Brown P, Preece M, Brandel JP, et al. Iatrogenic Creutzfeldt Jakob disease at the millennium. Neurology ; 55 : Bruce ME, Will RG, Ironside JW, et al. Transmissions to mice indicate that new variant CJD is caused by the BSE agent. Nature ; Kirkwood JK, Cunningham AA. Epidemiological observations on spongiform encephalopathies in captive wild animals in the British Isles. Vet Rec ; 135 : Palmer MS, Dryden AJ, Hughes JT, Collinge J. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt Jakob disease. Nature ; 352 : Drisaldi B, Stewart RS, Adles C, et al. Mutant PrP is delayed in its exit from the endoplasmic reticulum but neither wild type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation. J Biol Chem ; 278 : Naslavsky N, Stein R, Yanai A, Friedlander G, Taraboulos A. Characterization of detergent insoluble complexes containing the cellular prion protein and its scrapie isoform. J Biol Chem ; 272 : Bueler H, Aguzzi A, Sailer A, et al. Mice devoid of PrP are resistant to scrapie. Cell ; 73 : Solforosi L, Criado JR, McGavern DB, et al. Cross linking cellular prion protein triggers neuronal apoptosis in vivo. Science ; 303 : Alper T. The scrapie enigma : insights from radiation experiments. Radiat Res ; 135 : McKinley MP, Bolton DC, Prusiner SB. A protease resistant protein is a structural component of the scrapie prion. Cell ; 35 : Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science ; 216 : Aguzzi A, Weissmann C. Prion research : the next frontiers. Nature ; 389 : Prusiner SB. Prions. Proc Natl Acad Sci USA ; 95 : Jarrett JT, Lansbury PT Jr. Seeding one dimensional crystallization of amyloid : a pathogenic mechanism in Alzheimer s disease and scrapie? Cell ; 73 : King CY, Diaz Avalos R. Protein only transmission of three yeast prion strains. Nature ; 428 : Collins SJ, Lawson VA, Masters PC. Transmissible spongiform encephalopathies. Lancet ; 363 : Zerr I, Schulz Schaeffer WJ, Giese A, et al. Current clinical diagnosis in Creutzfeldt Jakob disease : identification of uncommon variants. Ann Neurol ; 48 : Tribl GG, Strasser G, Zeitlhofer J, et al. Sequential MRI in a case of Creutzfeldt Jakob disease. Neuroradiology ; 44 : Zeidler M, Sellar RJ, Collie DA, et al. The pulvinar sign on magnetic resonance imaging in variant Creutzfeldt Jakob disease.
11 Lancet ; 355 : Zeidler M, Collie DA, Macleod MA, Sellar RJ, Knight R. FLAIR MRI in sporadic Creutzfeldt Jakob disease. Neurology ; 56 : 282. Hill AF, Butterworth RJ, Joiner S, et al. Investigation of variant Creutzfeldt Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet ; 353 : Zanusso G, Ferrari S, Cardone F, et al. Detection of pathologic prion protein in the olfactory epithelium in Creutzfeldt Jakob disease. N Engl J Med ; 348 : Glatzel M, Abela E, Maissen M, Aguzzi A. Extraneural pathologic prion protein in sporadic Creutzfeldt Jakob disease. N Engl J Med ; 349 : Windl O, Giese A, Schulz Schaeffer W, et al. Molecular genetics of human prion disease in Germany. Hum Genet ; 105 : Alperovitch A, Zerr I, Pocchiari M, et al. Codon 129 prion protein genotype and sporadic Creutzfeldt Jakob disease. Lancet ; 353 : Parchi P, Castellani R, Capellari S, et al. Molecular basis of phenotypic variability in sporadic Creutzfeldt Jakob disease. Ann Neurol ; 39 : Hill AF, Joiner S, Wadsworth JD, et al. Molecular classification of sporadic Creutzfeldt Jakob disease. Brain ; 126 : Parchi P, Giese A, Capellari S, et al. Classification of sporadic Creutzfeldt Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol ; 46 : Notari S, Capellari S, Giese A, et al. Effects of different experimental conditions on the PrPSc core generated by protease digestion : implications for strain typing and molecular classification of CJD. J Biol Chem ; 279 : Aguzzi A. Understanding the diversity of prions. Nat Cell Biol ; 6 : Gambetti P, Kong Q, Zou W, Parchi P, Chen SG. Sporadic and familial CJD : classification and characterisation. Br Med Bull ; 66 : Harder A, Jendroska K, Kreuz F, et al. Novel twelve generation kindred of fatal familial insomnia from Germany representing the entire spectrum of disease expression. Am J Med Genet ; 87 : Ghetti B, Dlouhy SR, Giaccone G, et al. Gerstmann Straussler Scheinker disease and the Indiana kindred. Brain Pathol ; 5 : Padovani A, D Alessandro M, Parchi P, et al. Fatal familial insomnia in a new Italian kindred. Neurology ; 51 : Will RG, Ironside JW, Zeidler M, et al. A new variant of Creutzfeldt Jakob disease in the UK. Lancet ; 347 : Valleron AJ, Boelle PY, Will R, Cesbron JY. Estimation of epidemic size and incubation time based on age characteristics of vcjd in the United Kingdom. Science ; 294 : Aguzzi A, Glatzel M, Montrasio F, Prinz M, Heppner FL. Interventional strategies against prion diseases. Nat Rev Neurosci ; 2 : Montrasio F, Frigg R, Glatzel M, et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science ; 288 : Meier P, Genoud N, Prinz M, et al. Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease. Cell ; 113 : Caughey B, Raymond LD, Raymond GJ, Maxson L, Silveira J, Baron GS. Inhibition of protease resistant prion protein accumulation in vitro by curcumin. J Virol ; 77 : Collins SJ, Lewis V, Brazier M, Hill AF, Fletcher A, Masters CL. Quinacrine does not prolong survival in a murine Creutzfeldt Jakob disease model. Ann Neurol ; 52 :
/‚“1/ŒxŒ{‚×›î’æ’¶
60 1 pp.3-8 2010 1. H1N1 1) 2) 3) 4) ERATO 2009 H1N1 21 H1N1 HA PB2 2009 3 Pandemic H1N1 2009 WHO 6 11 21 2009 11 2010 4 21 H1N1 H1N1 2009 4 15 CDC 108-8639 4-6-1 TEL: 03-5449-5281 FAX: 03-5449-5408 E-mail:
2
1 2 3 4 5 ( ) 6 7 8 "proteinaceous infectious particles" ( ) (PrP Sc ) (PrP C ) PrP C PrP Sc PrP Sc 9 10 (1) (2) 11 12 13 14 15 16 (1) (2) (3) 17 (4) (5) 18 19 20 21 22 23 24 (1) Creutzfeldt-Jakob - -.
表1.eps
Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol
Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
16_.....E...._.I.v2006
55 1 18 Bull. Nara Univ. Educ., Vol. 55, No.1 (Cult. & Soc.), 2006 165 2002 * 18 Collaboration Between a School Athletic Club and a Community Sports Club A Case Study of SOLESTRELLA NARA 2002 Rie TAKAMURA
Core Ethics Vol. : - : : : -
Core Ethics Vol... : : : DC Core Ethics Vol. : - : : : - ............ Core Ethics Vol. : : : : :...... : Core Ethics Vol. : .. : : : : Core Ethics Vol. http:// www.psy-jinken-osaka.org/?page_id= : - -
Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth
Studies of Foot Form for Footwear Design (Part 9) : Characteristics of the Foot Form of Young and Elder Women Based on their Sizes of Ball Joint Girth and Foot Breadth Akiko Yamamoto Fukuoka Women's University,
Graduate School of Clinical Psychology, Kibi International University 8 Iga-machi, Takahashi, Okayama, Japan(716-8508) Research Institute of Clinical Psychology, Kibi International University Department
et al No To Shinkei Clin Neurol Neurology et al J Neurosurg et al Arch Neurol et al Angiology
37 Recommendations for the Management of Moyamoya Disease A Statement from Research Committee on Spontaneous Occlusion of the Circle of Willis (Moyamoya Disease) Research on intractable diseases of the
Juntendo Medical Journal
* Department of Health Science Health Sociology Section, Juntendo University School of Health and Sports Science, Chiba, Japan (WHO: Ottawa Charter for Health promotion, 1986.) (WHO: Bangkok Charter
狂牛病調査第２巻1章，２章.doc
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 2.1 A LD50/30mg () 10 ND 1 2.8 ND ND ND 11 ND 2.3 1.0 ND ND 11 ND ND 1.3 1.7 ND 13 ND
橡自動車~1.PDF
CIRJE-J-34 2000 10 Abstract In this paper, we examine the diversity of transaction patterns observed between a single pair of one automaker and one auto parts supplier in Japan. Assumed reasonably that
udc-2.dvi
13 0.5 2 0.5 2 1 15 2001 16 2009 12 18 14 No.39, 2010 8 2009b 2009a Web Web Q&A 2006 2007a20082009 2007b200720082009 20072008 2009 2009 15 1 2 2 2.1 18 21 1 4 2 3 1(a) 1(b) 1(c) 1(d) 1) 18 16 17 21 10
Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST
Key words : Adverse reactions, Egg allergy, IgG antibody, Mills allergy, FAST 13) Danaeus, A., Johansson, S. G. O., Foucard, T. & Ohman, S.: Clinical and immunogical aspects of food allergy in childhood.
社会技術論文集
STS Studies on Kanemi-Yusho Case with Special Interests on the Accident Investigation 1 1 M.Sc. (E-mail:tnakaji@plum.ocn.ne.jp) 1968 PCB 1. 2003 15 5 23 9;37 1900 2003 33 2 2 BSE 3 8; 14 2001 9 BSE 1 BSE
Short Review E-mail : kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases 2) Anfinsen, C. B.: Harvey Lect., 61, 95-116 (1967) 3) Carrel, R. W., Lomas, D. A.
On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new e
On the Wireless Beam of Short Electric Waves. (VII) (A New Electric Wave Projector.) By S. UDA, Member (Tohoku Imperial University.) Abstract. A new electric wave projector is proposed in this paper. The
<4D F736F F D A442D89758A AA2092B28DB889EF8CE38F4390B394C5202E646F63>
変 異 型 クロイツフェルト ヤコブ 病 (vcjd)の 発 生 状 況 及 び 疫 学 1. vcjd に 関 する 背 景 変 異 型 クロイツフェルト ヤコブ 病 (variant Creutzfeldt-Jakob disease; vcjd)は ヒトの 伝 達 性 海 綿 状 脳 症 (TSE) 1 の 一 つであり BSE と vcjd の 時 系 列 的 な 発 生 数 の 推 移 には
1) Michaelis L. Biochem Z., 59, 78, 1914. 2) Ferris H. C. Dent. Cosmos Phila., 63, 10, 93, 1921. 3) Bloomfield A. L. Bull Johns Hopk. Hosp. Bait., 31, 118, 1920. 4) Starr H. C. J. Biol. Chem. Bait., 54,
Degradation Mechanism of Ethylene-propylene-diene Terpolymer by Ozone in Aqueous Solution Satoshi MIWA 1 *, 2, Takako KIKUCHI 1, 2, Yoshito OHTAKE 1 a
Degradation Mechanism of Ethylene-propylene-diene Terpolymer by zone in Aqueous Solution Satoshi MIWA 1, 2, Takako KIKUCHI 1, 2, Yoshito TAKE 1 and Keiji TANAKA 2 ( 1 Chemicals Evaluation and Research
untitled
ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504
Juntendo Medical Journal
The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical
3) Stedmann, E. et al.: Biochem. J., 29; 2107, 1935. 4) Reiss, M.. Hemphill, R. E. E ENature, 161 ; 18, 1948. 5) Tower, D. B. & D. MeEachern: Canada J. Reserch., 27; 105, 120, 132, 1949. 6) Wolleman, M.
<95DB8C9288E397C389C88A E696E6462>
2011 Vol.60 No.2 p.138 147 Performance of the Japanese long-term care benefit: An International comparison based on OECD health data Mie MORIKAWA[1] Takako TSUTSUI[2] [1]National Institute of Public Health,
202
201 Presenteeism 202 203 204 Table 1. Name Elements of Work Productivity Targeted Populations Measurement items of Presenteeism (Number of Items) Reliability Validity α α 205 α ä 206 Table 2. Factors of
Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates
第124回日本医学会シンポジウム
III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2
1) Asa, S. L., et al.: Immunohistochemical localization of neuron-specific enolase in the human hypophysis and pituitary adenoma, Arch. Pathol. Lab. Med., 108: 40 `43, 1984. 2) Chi, B. H. and Kim, R. C.:
_念3）医療2009_夏.indd
Evaluation of the Social Benefits of the Regional Medical System Based on Land Price Information -A Hedonic Valuation of the Sense of Relief Provided by Health Care Facilities- Takuma Sugahara Ph.D. Abstract
1) Waardenburg PJ : A new syndrome combining developmental anomalies of the eyelids, eyebrows and nose root with pigmentary defects of the iris and head hair and with congenital deafness. Am J Hum Genet
23 7 24 3 49 237 24 3 (1) 23 7 7 (2) 4 23 1) European Fedaration of Neurological Societies, Sep 10-13, 2011Budapest, Hungary the 1 st Korea-Japan NeuroRehabilitation Coference, March 17, 2012, Seoul, Korea
220 28;29) 30 35) 26;27) % 8.0% 9 36) 8) 14) 37) O O 13 2 E S % % 2 6 1fl 2fl 3fl 3 4
Vol. 12 No. 2 2002 219 239 Λ1 Λ1 729 1 2 29 4 3 4 5 1) 2) 3) 4 6) 7 27) Λ1 701-0193 288 219 220 28;29) 30 35) 26;27) 0 6 7 12 13 18 59.9% 8.0% 9 36) 8) 14) 37) 1 1 1 13 6 7 O O 13 2 E S 1 1 17 0 6 1 585
Fig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
その他／ＳＰ０３ 栂尾 ０１６‐０２６（４）Ｙ◎
CLINICIAN 11 NO. 602 16 Chemical Exchange Saturation Transfer Forsen Hoffman Balaban Exchange Magnetization Transfer CEST agent -NH -OH CEST agent CEST agent 17 CLINICIAN 11 NO. 602 A B Z- CEST CLINICIAN
Tab 5, 11 Tab 4, 10, Tab 3, 9, 15Tab 2, 8, 14 Tab 1, 7, 13 2
COMPANION 20 MULTIMEDIA SPEAKER SYSTEM Owner s Guide Tab 5, 11 Tab 4, 10, Tab 3, 9, 15Tab 2, 8, 14 Tab 1, 7, 13 2 Tab1, 7, 13 Tab 2, 8, 14 Tab 3, 9, 15 Tab 4, 10, Tab 5, 11 This product conforms to all
Author Workshop 20111124 Henry Cavendish 1731-1810 Biot-Savart 26 (1) (2) (3) (4) (5) (6) Priority Proceeding Impact factor Full paper impact factor Peter Drucker 1890-1971 1903-1989 Title) Abstract
840 Geographical Review of Japan 73A-12 835-854 2000 The Mechanism of Household Reproduction in the Fishing Community on Oro Island Masakazu YAMAUCHI (Graduate Student, Tokyo University) This
% 1% SEM-EDX - X Si Ca SEM-EDX SIMS ppm % M M T 100 % 100 % Ba 1 % 91 % 9 % 9 % 1 % 87 % 13 % 13 % 1 % 64 % 36 % 36 % 1 % 34 46
Review on Hair Analysis in the Wakayama Arsenic Case Jun KAWAI Department of Materials Science and Engineering, Kyoto University Sakyo-ku, Kyoto 606-8501, Japan Received 6 December 2014, Revised 29 December
1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, 1949.-2) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3)
CHEMOTHERAPY JUNE 1986
VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml
24 Depth scaling of binocular stereopsis by observer s own movements
24 Depth scaling of binocular stereopsis by observer s own movements 1130313 2013 3 1 3D 3D 3D 2 2 i Abstract Depth scaling of binocular stereopsis by observer s own movements It will become more usual
A5 PDF.pwd
DV DV DV DV DV DV 67 1 2016 5 383 DV DV DV DV DV DV DV DV DV 384 67 1 2016 5 DV DV DV NPO DV NPO NPO 67 1 2016 5 385 DV DV DV 386 67 1 2016 5 DV DV DV DV DV WHO Edleson, J. L. 1999. The overlap between
25 fmri A study of discrimination of musical harmony using brain activity obtained by fmri
25 fmri A study of discrimination of musical harmony using brain activity obtained by fmri 1140359 2014 2 28 fmri fmri BCI(Brain Computer Interface) 6 (C C# D D# E F) 6 (Cm C#m Dm D#m Em Fm) 12 fmri fmri
Jpn.J.Leprosy 67, (1998)
Jpn.J.Leprosy 67,287-291(1998) Fig.1. Macroscopic appearance of the cultured slides stained by the Ziehl-Neelsen method. Up to bottom: kept at 4 C, 18 weeks, cultured for 6 weeks, 8 weeks, 10 weeks, 12
7,, i
23 Research of the authentication method on the two dimensional code 1145111 2012 2 13 7,, i Abstract Research of the authentication method on the two dimensional code Karita Koichiro Recently, the two
IPSJ SIG Technical Report Vol.2016-CE-137 No /12/ e β /α α β β / α A judgment method of difficulty of task for a learner using simple
1 2 3 4 5 e β /α α β β / α A judgment method of difficulty of task for a learner using simple electroencephalograph Katsuyuki Umezawa 1 Takashi Ishida 2 Tomohiko Saito 3 Makoto Nakazawa 4 Shigeichi Hirasawa
untitled
2010 58 1 39 59 c 2010 20 2009 11 30 2010 6 24 6 25 1 1953 12 2008 III 1. 5, 1961, 1970, 1975, 1982, 1992 12 2008 2008 226 0015 32 40 58 1 2010 III 2., 2009 3 #3.xx #3.1 #3.2 1 1953 2 1958 12 2008 1 2
medicaljournal8.pdf
Medical Journal of Aizawa Hospital Vol. 8 (2010) Key words Neuropsychopharmacology Neuroscientist Curr Opin Neurol Clin Rehabil J Neurol Neurosurg Psychiatry J Neurol Neurosurg Psychiatry Lancet
/‚“3/fl‰„´„™‹ê’æ’¶
59 2 pp.155-166 2009 3. 1 8 9 CJD2 3 PrP Sc PrP Sc PrP Sc BSE CJD vcjd 1996 215 2009 9 NCJDSU CJD vcjd PrP Sc vcjd 2 5 transmissible spongiform encephalopathy TSE ; Creutzfeldt-Jakob diseases CJDs scrapie
Introduction ur company has just started service to cut out sugar chains from protein and supply them to users by utilizing the handling technology of
Standard PA-Sugar Chain Catalogue Masuda Chemical Industries Co., LTD. http://www.mc-ind.co.jp Introduction ur company has just started service to cut out sugar chains from protein and supply them to users
Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood
Key words: bacterial meningitis, Haemophilus influenzae type b, Streptococcus pneumoniae, rapid diagnosis, childhood Fig.1 Distribution of the cases with bacterial meningitis by age and pathogens Chiba
01-加藤 実-5.02
Bull. Natl. Mus. Nat. Sci., Ser. E, 30, pp. 1 13, December 21, 2007 1 2 3 1 169 0073 3 23 1 2 523 0058 961 3 248 0036 3 5 6 The Mechanism of the Automatic Wari-koma Dial in the Japanese Clocks and its
2) Goetz, A., Tsuneishi, N.: Application of molecular filter membranes to the bacteriological analysis of water, J. Am. Water Works Assn., 43 (12): 943-969,1951. 3) Clark, H.F. et al.: The membrane filter
Biology of spermatogenesis and spermatozoa in mammals. Biophys. Biochem. Cytol. Arch. Biochem. Biophys. Anat. Rec. Biol. Reprod. Mol. Hum. Reprod. Biol. Reprod. Reprod. Biol. Endocrinol. Aust. J. Zool.
GNH Gross National Happiness Criteria living standard cultural diversity emotional well being health education time use eco-system community vitality
GNH Gross National Happiness Criteria living standard cultural diversity emotional well being health education time use eco-system community vitality good governance Dimensions and Indicators of GNH The
E Societe de Pathologie Infectieuse de Langue Francaise (, 1991) E Spanish Thoracic Society (1992) E American Thoracic Society (ATS : 1993. ü ù2001 ) E British Thoracic Society (1993, ü è2001 ) E Canadian
＠０８４７００３０ヨコ／篠塚・窪田 ２２１号
Abstract Among three distinctive types of Japanese writing systems Kanji, Hiragana and Katakana, a behavioral experiment using 97 university students as subjects implies that Katakana is regarded as most
Squamous metaplasia in the uterine cervix Kiichiro NODA Department obstetrics and gynecology, School of Medicine, Tohoku University The process of squamous metaplasia in the uterine cervix might be discussed
56: Hands-on 4 Meet the Expert.
56:136 57 2016 28 5 18 21. 650-0046 6-9-1 650-0046 6-11-1 650-0046 6 10-1 2016 2 9 7 13 Hands-on 4 Meet the Expert. http://www.neurology-jp.org/sokaitiho/neuro2016/ 15,000 18,000 3,000 3,000 3,000 3,000
Fig. 1 Trends of TB incidence rates for all forms and smear-positive pulmonary TB in Kawasaki City and Japan. Incidence=newly notified cases of all fo
Kekkaku Vol. 79, No. 1: 17-24, 2004 17 (Received 21 Aug. 2003/Accepted 18 Nov. 2003) Fig. 1 Trends of TB incidence rates for all forms and smear-positive pulmonary TB in Kawasaki City and Japan. Incidence=newly
Microsoft Word - 「黄砂とその健康影響について」小冊子180323版
...1...1...1...2...4...4...4...6...7...7...7...7...8...8...9...9...10... 11... 11... 11... 11...12...12...13...16...18...20 1 1-1 1-2 1 1 km 24.5 m/s 10 50 m 1 1-3 μm 1-4 1-5 2 8 http://www.jma-net.go.jp/sat/himawari/obsimg/image_dust.html
会報35号表紙.pdf
35 No. (2017 1 ) RNA 2017 2017 TV 365 365 chunky 26 RNA 2017 Congratulations26 30-1 - RNA 2017-2 - - 3 - - 4 - - 5 - - 6 - 2016 8 31 9 2 RNA 2016 1 RNA RNA RNA RNA RNA 1-7 - RNA RNA 3 3 7 31 RNA ncrna
Perspective-Taking Perspective-Taking.... Vol. No.
Nurses Thinking Process in Understanding Patients Unconscious Denial Tomoko Hayashi Key Words putting oneself in the patient s place, perspective-taking, misunderstand patient s perspective, modifying
加藤茂孝先生
Shigetaka KATOW 2009 4 24 WHO 5 9 1 5 16 1 TV 6 12 6 11 WHO 6 4 5 12 E-mail : modern_media@eiken.co.jp 2009. 4. 28. http:idsc.nih.go.jpidwrkanjaweeklygraph01flu.html 0101-0051 - RIKEN Center of Research
Kyoto Sangyo University Slywotzky and Morrison 1997 Slywotzky ,2001, ,550 6, ,87
1 2008 2 Slywotzky and Morrison 1997 Slywotzky 20021999 20041999,2001,2006 1999 3 3 1997 2007 10 2,550 6,674 2.6 1 2007 2,878 2 12007 2 15 658 39 20 3 13 2 OTC 8 2,294 6 6,108 3 6,911 4 10 15,900 5 9 17
2.2 Gompertz-Makeham Gompertz Makeham Gompertz Gavrilov and Gavrilova Gavrilov and Gavrilova (1991) Mori and Nakazawa (2003) S 2.3 40 80 DNA mev-1 II
(1) 2011 6 20 (nminato@med.gunma-u.ac.jp) 1 aged population senior citizen elderly people 65 65 65 65 65-74 75 1. 2. 3. 13 2001 12 28 *1 65 2 2.1 (1) (2) (3) (4) *1 http://www8.cao.go.jp/kourei/measure/taikou/index-t.html
161 J 1 J 1997 FC 1998 J J J J J2 J1 J2 J1 J2 J1 J J1 J1 J J 2011 FIFA 2012 J 40 56
J1 J1 リーグチーム組織に関する考察 松原悟 Abstract J League began in 1993 by 10 teams. J League increased them by 40 teams in 2012. The numerical increase of such a team is a result of the activity of Football Association
FIG 7 5) 7 FIG ) 7) 8) 9) 10) 11) 12) 3 18 Gymnastik 13) 1793 J. Ch. F. Guts Muths Gymnastik fuer die Juegend 1816 F. L. Jahn Turnkunst Rhythm
1 Bull. of Nippon Sport Sci. Univ. 41 (1) 13 24 2011 Philosophical study on the rules of rhythmic gymnastics scoring Mainly on the conformity of motion characteristics and competitiveness with the scoring
ABSTRACT The "After War Phenomena" of the Japanese Literature after the War: Has It Really Come to an End? When we consider past theses concerning criticism and arguments about the theme of "Japanese Literature
肺癌第50巻第4号
1 Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; 2 Department of Thoracic Surgery, Aichi Cancer Center, Japan;
Kyushu Communication Studies 第２号
Kyushu Communication Studies. 2004. 2:1-11 2004 How College Students Use and Perceive Pictographs in Cell Phone E-mail Messages IGARASHI Noriko (Niigata University of Health and Welfare) ITOI Emi (Bunkyo
本文.indd
35 1 2013 4 Reprinted From THE RESEARCH BULLETIN OF THE FACULTY OF EDUCATION AND WELFARE SCIENCE, OITA UNIVERSITY Vol. 35, No. 1April 2013 OITA, JAPAN Res. Bull. Fac. Educ.Welf. Sci., Oita Univ. 17 7 3
:... a
Title 発達障害と睡眠困難 に関する研究の動向と課題 ( fulltext ) Author(s) 柴田, 真緒 ; 髙橋, 智 Citation 東京学芸大学紀要. 総合教育科学系, 69(2): 107-121 Issue Date 2018-02-28 URL http://hdl.handle.net/2309/148914 Publisher 東京学芸大学学術情報委員会 Rights
Perrett et al.,,,, Fig.,, E I, 76
Attempting to Express Strong-impression Face Images from Features of Spatial Frequency: A Consideration of Billiken Statues and Bijin-ga Sakura Torii abstract It is difficult to express the psychological
A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi
A Study on Throw Simulation for Baseball Pitching Machine with Rollers and Its Optimization Shinobu SAKAI*5, Yuichiro KITAGAWA, Ryo KANAI and Juhachi ODA Department of Human and Mechanical Systems Engineering,
Hohenegger & Schär, a cm b Kitoh et. al., Gigerenzer et. al. Susan et. al.
Study on characteristics of inhabitants acceptance of weather information with a probability Motohiro HONMA *, Kyoko ARAI **, Kento MATSUMOTO *** and Yasushi SUZUKI *** Abstract In this study, we performed
00.\...ec5
Yamagata Journal of Health Science, Vol. 6, 23 Kyoko SUGAWARA, Junko GOTO, Mutuko WATARAI Asako HIRATUKA, Reiko ICHIKAWA Recently in Japan, there has been a gradual decrease in the practice of community
Repatriation and International Development Assistance: Is the Relief-Development Continuum Becoming in the Chronic Political Emergencies? KOIZUMI Koichi In the 1990's the main focus of the global refugee
鹿大広報149号
No.149 Feb/1999 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Learned From Japanese Life and Experiences in Kagoshima When I first came to Japan I was really surprised by almost everything, the weather,
EVALUATION OF MAGNETIC RESONANCE IMAGING (MRI) IN DIAGNOSIS OF ACOUSTIC NEUROMA-COMPARATIVE STUDY WITH PLAIN X-RAY AND CTS- KIMIHISA NOMURA, M.D., MAK
EVALUATION OF MAGNETIC RESONANCE IMAGING (MRI) IN DIAGNOSIS OF ACOUSTIC NEUROMA-COMPARATIVE STUDY WITH PLAIN X-RAY AND CTS- KIMIHISA NOMURA, M.D., MAKOTO SAKAI, M.D., ATSUSHI SHINKAWA, M.D. and HIROSATO
) 5 Lawton QOL 4 4 QOL Lawton 4) Philadelphia Geriatric Center Affect Rating ScaleARS ARS QOL 5) HDS R
Vol. 12 No. 2 2002 389 397 Λ1 Λ2 16 10 30 1 2 Lawton Philadelphia Geriatric Center Affect Rating ScaleARS Lawton ARS + ARS 6 2 ARS 2 12:00 15:0017:00 11:30 16:00 1 2 ARS 1 2 ARS QOL QOL QOL 1) QOL QOL
drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:
(43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND
(43) Vol.33, No.6(1977) T-239 MUTUAL DIFFUSION AND CHANGE OF THE FINE STRUCTURE OF WET SPUN ANTI-PILLING ACRYLIC FIBER DURING COAGULATION, DRAWING AND DRYING PROCESSES* By Hiroshi Aotani, Katsumi Yamazaki
CA HP,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,,.,,,,,.,,,,,,.,,,,,.,,,,,.,,,,,,.,,,,,,.,,
Ritsumeikan Alumni Program CA HP,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,.,,,,,,.,,,,,.,,,,,,.,,,,,.,,,,,.,,,,,,.,,,,,,.,,,,,.,,,,,. ,,, :,, :,,,
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, Sc
A Nutritional Study of Anemia in Pregnancy Hematologic Characteristics in Pregnancy (Part 1) Keizo Shiraki, Fumiko Hisaoka Department of Nutrition, School of Medicine, Tokushima University, Tokushima Fetal
Medical Journal of Aizawa Hospital Medical Journal of Aizawa Hospital Vol. 8 (2010) Key words Neuropsychopharmacology Neuroscientist Curr Opin Neurol Clin Rehabil J Neurol Neurosurg Psychiatry
Core Ethics Vol. QOL N N N N N N N K N N
Core Ethics Vol. N N N N N Core Ethics Vol. QOL N N N N N N N K N N N N O O N N N - N N N O N O N N N N N N N CD N N N Core Ethics Vol. N N N N N N N N N N N N N PSW N K N N N N N N N N N N O N O N O O
ABSTRACT The Social Function of Boys' Secondary Schools in Modern Japan: From the Perspectives of Repeating and Withdrawal TERASAKI, Satomi (Graduate School, Ochanomizu University) 1-4-29-13-212, Miyamaedaira,
) ,
Vol. 2, 1 17, 2013 1986 A study about the development of the basic policy in the field of reform of China s sports system 1986 HaoWen Wu Abstract: This study focuses on the development of the basic policy
St. Andrew's University NII-Electronic Library Service
,, No. F. P. soul F. P. V. D. C. B. C. J. Saleebey, D. 2006 Introduction: Power in the People, Saleebey, D. Ed., The Strengths Perspective in Social Work Practice, 4 th ed, Pearson. 82 84. Rapp, C.
総研大文化科学研究第 11 号 (2015)
栄 元 総研大文化科学研究第 11 号 (2015) 45 ..... 46 総研大文化科学研究第 11 号 (2015) 栄 租借地都市大連における 満洲日日新聞 の役割に関する一考察 総研大文化科学研究第 11 号 (2015) 47 48 総研大文化科学研究第 11 号 (2015) 栄 租借地都市大連における 満洲日日新聞 の役割に関する一考察 総研大文化科学研究第 11 号 (2015)
Generation of neural cells from embryonic stem cells Database Center for Life Science Online Service Takuya Yohei Okada Takahito Hideyuki Shimazaki Yo
Generation of neural cells from embryonic stem cells Takuya Yohei Okada Takahito Hideyuki Shimazaki Yoshizaki* Okano McLean Hospital/Harvard University Udall Parkinson's Disease Research Center of Excellence
Social ecology is based on looking rather than on analysis It is based on perception This I submit distinguishes it what is normally meant by a science. It is not only that it can not be reductionist.
Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad
Key words: Female with bladder irritability, Subjective symptoms, Pyuria, Bacteriuria Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution
b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates
THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS TECHNICAL REPORT OF IEICE.
THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS TECHNICAL REPORT OF IEICE. E-mail: {ytamura,takai,tkato,tm}@vision.kuee.kyoto-u.ac.jp Abstract Current Wave Pattern Analysis for Anomaly
評論・社会科学 ８５号（よこ）（Ｐ）／３．佐分
well-being well-being well-being well-being QOL well-being satisfaction appraisal 69 well-being 2025 520 http : //www.mhlw.go.jp/ 2000 2004 2005 well-being 1 Walker 1996 ; Picot 1997 2003 2004 Zarit 1980
Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,
吉田 今めかし 小考 30
29 総合研究大学院大学文化科学研究科日本文学研究専攻吉田小百合 吉田 今めかし 小考 30 31 吉田 今めかし 小考 32 娍 娍 33 娍 娍 娍 吉田 今めかし 小考 34 娍 35 吉田 今めかし 小考 36 37 吉田 今めかし 小考 38 娍 39 吉田 今めかし 小考 40 41 吉田 今めかし 小考 42 娍 娍 娍 43 吉田 今めかし 小考 The Term imamekashi