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1 GE Healthcare RA RA X MRI

2 1. RA OMERACT Outcome Measures in Rheumatoid Arthritis Clinical Trial [1] : P Fat Femur Fat P Fat : Femur Rad Lun Cap Rad : Lun Cap R A 2

3 2. RA 1 RA RA RA RA [2] RA 1. RA RA RA ACR 68 DAS 44 DAS28 28 PIP /P / / / / MTP [3] 4. PIP RA RA 3

4 5. RA ACR RA X 2009 ACR/EULAR RA RA [4-6] [2] RA OA 6. RA GE LOGIQ : CRP 0.4 mg/dl, RF < 5 U/L, CCP 79 U/mL X PIP P RA ACR ACR/EULAR RA 2 PIP 3 PIP P 3 P 5 NSAID 2 5 CRP 2.3 mg/dl RA MTX 2 2 RA RA * MP 4 MP MP 3 P 2 PIP 3 PIP

5 7. RA RA DAS [7] RA RA [8-10] DAS28 GE Venue Venue 40 Musculoskeletal 8. RA GE LOGIQ7 RA 65 7 RA 2 MTX 8 mg/week DAS28 Steinbrocker Stage III/ Class II RF / CCP 2 DAS28 PIP 7 : CRP 0.3 mg/dl, RF < 5 U/L VAS 93 mm DAS28- CRP 7.02 PIP PIP RA 8 RA DAS28 RA

6 8. 2 * MP Deltoid H 5 PIP 2 P Scapula Deltoid H Femur MP Deltoid Scapula H Femur Tibia : Tibia 9. MRI MRI 2 ADL / / / 2. MRI MRI MRI MRI 6

7 10. RA 2 3 X RA X 1. Wakefield RJ, Balint PV, Szkudlarek M, Filippucci E, Backhaus M, D'Agostino MA, Sanchez EN, Iagnocco A, Schmidt WA, Bruyn GA, Kane D, O'Connor PJ, Manger B, Joshua F, Koski J, Grassi W, Lassere MN, Swen N, Kainberger F, Klauser A, Ostergaard M, Brown AK, Machold KP, Conaghan PG; OMERACT 7 Special Interest Group. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol Dec;32(12): Wakefield RJ, Gibbon WW, Conaghan PG, O'Connor P, McGonagle D, Pease C, Green MJ, Veale DJ, Isaacs JD, Emery P. The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis Rheum Dec;43(12): Monthly Book Orthopaedics 2010 May;23(6): Kane D, Balint PV, Sturrock RD. Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol May;30(5): Wakefield RJ, Green MJ, Marzo-Ortega H, Conaghan PG, Gibbon WW, McGonagle D, Proudman S, Emery P. Should oligoarthritis be reclassified? Ultrasound reveals a high prevalence of subclinical disease. Ann Rheum Dis Apr;63(4): Naredo E, Bonilla G, Gamero F, Uson J, Carmona L, Laffon A. Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis Mar;64(3): Thompson PW, Hart LE, Goldsmith CH, Spector TD, Bell MJ, Ramsden MF. Comparison of four articular indices for use in clinical trials in rheumatoid arthritis: patient, order and observer variation. J Rheumatol 1991;18: Backhaus M, Ohrndorf S, Kellner H, Strunk J, Backhaus TM, Hartung W, Sattler H, Albrecht K, Kaufmann J, Becker K, Sörensen H, Meier L, Burmester GR, Schmidt WA. Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project. Arthritis Rheum Sep 15;61(9): Naredo E, Rodríguez M, Campos C, Rodríguez-Heredia JM, Medina JA, Giner E, Martínez O, Toyos FJ, Ruíz T, Ros I, Pujol M, Miquel X, García L, Aznar JJ, Chamizo E, Páez M, Morales P, Rueda A, Tuneu R, Corominas H, de Agustín JJ, Moragues C, Mínguez D, Willisch A, González- Cruz I, Aragón A, Iglesias G, Armas C, Pablo Valdazo J, Vargas C, Calvo-Alén J, Juan-Mas A, Salvador G, Puigdollers A, Galíndez E, Garrido N, Salaberri J, Raya E, Salles M, Díaz C, Cuadra JL, Garrido J; Ultrasound Group of The Spanish Society of Rheumatology. Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis Rheum Apr 15;59(4): Dougados M, Jousse-Joulin S, Mistretta F, D'Agostino MA, Backhaus M, Bentin J, Chales G, Chary-Valckenaere I, Conaghan PG, Etchepare F, Gaudin P, Grassi W, van der Heijde D, Sellam J, Naredo E, Szkudlarek M, Wakefield R, Saraux A. Evaluation of several ultrasonography scoring systems of synovitis and comparison to clinical examination: Results from a prospective multi-center study of rheumatoid arthritis.ann Rheum Dis Sep 9. [Epub ahead of print] 7

8 使用者の経験に基づく記載であり GE ヘルスケア ジャパン株式会社が 仕様値として保証するものではありません GE WEB LOGIQ BZZ Venue ABBZX Venue 40 Musculoskeletal Musculoskeletal GEヘルスケア ジャパン株式会社 Rev.1.0 0J AK-C1(KM) Printed in Japan CI D42A1-2 JB36892JA

cra28-1.7

cra28-1.7 臨床リウマチ,28: 7~15,2016 7 総説 関節エコー画像診断の進歩 Key words: rheumatoid arthritis, musculoskeletal ultrasonography, guidelines for musculoskeletal ultrasonography, classification criteria for rheumatoid arthritis,

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期待されている 1) この生物学的製剤の登場により RAの治療は 疼痛や腫脹の緩和による ADLの維持から 寛解 治癒へと標的が大きく変化してきている 2) 治療方針も変化し 早い段階から強い治療を受けることにより 寛解が実現できるという報告が多くなされている 当院ではリウマチ患者の約 25% に生

期待されている 1) この生物学的製剤の登場により RAの治療は 疼痛や腫脹の緩和による ADLの維持から 寛解 治癒へと標的が大きく変化してきている 2) 治療方針も変化し 早い段階から強い治療を受けることにより 寛解が実現できるという報告が多くなされている 当院ではリウマチ患者の約 25% に生 論文 関節エコーを臨床へ生かすために リウマチ診療における関節エコー検査 For Applying Joint Ultrasonography to Clinical Medicine Joint Ultrasonography Examinations in Rheumatoid Arthritis Treatment 谷村一秀 1) Kazuhide Tanimura 北野明美 2) Akemi

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さ すなわち小関節に好発する多関節炎 自己抗体陽性 炎症反応上昇 そして持続性病態を良く反映したものとなった ( 図 1) 4)5) しかしながらその有用性の検証では MTX 必要性予測の精度が検証コホートにより必ずしも高くないことが示され (ROC 解析の AUC; ) 臨床評価に

さ すなわち小関節に好発する多関節炎 自己抗体陽性 炎症反応上昇 そして持続性病態を良く反映したものとなった ( 図 1) 4)5) しかしながらその有用性の検証では MTX 必要性予測の精度が検証コホートにより必ずしも高くないことが示され (ROC 解析の AUC; ) 臨床評価に 論文 筋骨格超音波による関節リウマチ診断の精度の向上 Musculoskeletal Ultrasound Improves the Accuracy of Diagnosis of Rheumatoid Arthritis 池田 啓 Kei Ikeda 中込大樹 Daiki Nakagomi 中島 裕史 Hiroshi Nakajima 千葉大学医学部附属病院アレルギー 膠原病内科 2010 年

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