Title ラット食道の蠕動運動を制御する神経回路に関する研究 ( 本文 (Fulltext) ) Author(s) 嶋, 剛士 Report No.(Doctoral Degree) 博士 ( 獣医学 ) 甲第 450 号 Issue Date Type 博士論文 Vers
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1 Title ラット食道の蠕動運動を制御する神経回路に関する研究 ( 本文 (Fulltext) ) Author(s) 嶋, 剛士 Report No.(Doctoral Degree) 博士 ( 獣医学 ) 甲第 450 号 Issue Date Type 博士論文 Version ETD URL この資料の著作権は 各資料の著者 学協会 出版社等に帰属します
2
3 in vivo
4 SD standard deviation L-NAME N G -nitro-l-arginine methyl ester TRPV1 transient receptor potential cation channel, subfamily V, member 1 NO nitric oxide 3
5 Furness, 2006; Hansen, 2003; Leonard et al., 2006; Olsson and Holmgren, 2011 Furness, 2006; Hansen, 2003; Leonard et al., 2006; Olsson and Holmgren, 2011 Furness, 2006; Hansen, 2003; Leonard et al., 2006; Olsson and Holmgren, 2011 Ciccocioppo et al., 1994; Onori et al., 2003; Shiina et al., 2005; Smith and Robertson, 1998; Suzuki et al., 1994; Waterman and Costa, Andrew, 1956; Clouse and Diamant, 2006; Cunningham and Sawchenko, 1990; Goyal and Chaudhury, 2008; Jean, 2001; Lu and Bieger, 1998; Neuhuber et al., 2006 Shiina et al.,
6 Neuhuber et al., 2006; Wörl and Neuhuber, 2005 Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2006; Shiina et al., 2012 transient receptor potential cation channel, subfamily V, member 1 TRPV1 Holzer, 1988; Holzer, 1991; Holzer, 2004; Geppetti and Trevisani, 2004; Tominaga and Tominaga, 2005 Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2012; Shiina et al., 2006 in vivo in vivo in vitro 5
7 6
8 14 17 Wistar g Sprague-Dawley g SLC 22 ± LABO MR Stock MF α- α- 10% 2-Hydroxypropyl- -cyclodextrin 0.9% NaCl NaCl mm, KCl 4.7 mm, CaCl2 2.5 mm, MgSO4 1.2 mm, NaHCO3 25 mm, KH2PO4 1.2 mm, 11.7 mm D- N G -nitro-l-arginine methyl ester L-NAME N-acetyl-1-tryptophan 3,5-bis (trifuluorometyl) benzyl ester L-732,138 Sigma-Aldrich (St Louis ) 7
9 in vivo α- α- 50 mg/kg α- 40 mg/kg 5 7 mg/kg/h α mg/kg/h 40 mg/kg 7 14 mg/kg 1.2 g/kg In vivo Homeothermic Blanket Systems (Harvard Holliston ) C 1 mm 2.4 mm 1.5 mm 5 mm 8
10 AD Instruments Bella Vista NEW Power Lab System AD Instruments (mmhg) 200 mg/kg 9
11 Rodent Ventilator Model 683 Harvard Bioscience, Boston, Capsaicin Tsuda et al., 2000; Yamashita et al., % 10% Tween80 50mg/kg % in vitro 1.0 cm 10
12 35 10 ml 95% O2 5% CO2 T ORIENTEC AC STRAIN AMPLIFIER AS1202 NEC Power Lab AD Instruments 1.0 g 30 Model SEN µ 1 80 V 100 µ 80 V 1 20 Hz 5 5 D- L NAME L-732,
13 standard deviation SD Dunnet s P
14 In vivo (mmhg) 13
15 35 95% O2 5% CO2 10 ml Power Lab 14
16 in vivo Neuhuber et al., 2006; Wörl and Neuhuber, 2005 Furness, 2006; Clouse and Diamant, 2006 Andrew, 1956; Clouse and Diamant, 2006; Cunningham and Sawchenko, 1990; Goyal and Chaudhury, 2008; Jean, 2001; Lu and Bieger, 1998; Neuhuber et al., 2006 Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2006; Shiina et al., 2012 NO Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2006; Shiina et al., 2012 NO 15
17 Izumi et al., 2003; Shiina et al., 2006 co-innervation Neuhuber et al., 2006; Wörl and Neuhuber, 2005 Holzer, 1988; Holzer, 2004; Geppetti and Trevisani, 2004; Sasamura and Kuraishi, 1999; Szallasi and Blumberg, 1999; Szolcsanyi and Bartho, 2001; Tominaga and Tominaga, 2005 in vivo in vivo Lu and Bieger, 1998 Sengupta, 2001 Lu and Bieger, 1998; Sang and Goyal, 2001 Satchell,
18 (Bogeski et al., 2005; Shimizu et al., 2006) in vivo 17
19 in vitro NO NO 18
20 0 mmhg 4 mmhg - n = 4 n = 4 8 mmhg - 8 mmhg 8 mmhg 19
21 2 mmhg 4 mmhg 4 mmhg 8 mmhg 4 mmhg 8 mmhg 20
22 in vivo mmhg ml mmhg 0 1 mmhg 4 mmhg 21
23 In vivo 4 mmhg 22
24 8 mmhg mmhg ml mmhg 23
25 2 4 8 mmhg in vivo mmhg ml mmhg c 24
26 2 4 8 mmhg in vivo a b µl c mmhg SD (n = 6) P <
27 8 mmhg a b c d mmhg in vivo a mmhg b SD (n = 6) P <
28 in vivo in vivo Clouse and Diamant, 2006 Lu and Bieger, 1998 Clouse and Diamant, 2006; Bieger and Neuhuber 2006; Lu and Bieger, 1998 NMDA GABA Broussard et al., 1996; Broussard et al.,
29 Hashimo and Bieger, 1989; Wang and Bieger, 1991 NMDA GABA in vivo 4 mmhg 6 mmhg Satchell, 1984; Yu et al., 2005 Loomis et al., mmhg in vivo 28
30 in vivo 29
31 in vivo TRPV1 ; Izumi et al., 2003; Shiina et al., 2006 In vivo 30
32 in vivo 4 mmhg 2 mmhg 31
33 3 2 mmhg 32
34 8 mmhg mmhg ml mmhg 33
35 2 4 8 mmhg in vivo a µl mmhg SD n = 6 n = 5 P <
36 0 8 mmhg SD n = 3 n = 3 35
37 a 8 mmhg mmhg in vivo b mmhg SD n = 6 n = 5 P <
38 in vivo mmhg mmhg 4 mmhg 2 mmhg 37
39 in vivo Spencer et al., 2008; Yu et al., 2005 Intraganglionic laminar endings IGLE Berthoud et al., 1997a; Phillips and Powley, 2000; Sengupta, 2000; Zagorodnyuk and Brookes, 2000 Berthoud et al., 1997b; Patterson et al.,
40 Andrew, 1956; Clouse and Diamant, 2006; Cunningham and Sawchenko, 1990; Goyal and Chaudhury, 2008; Jean, 2001; Lu and Bieger, 1998; Neuhuber et al., 2006 Spencer et al., 2008; Yu et al., 2005 Banik and Brennan, 2009; Rong et al., 2004 NO NO Page et al., 2009 NO Shiina et al., 2013; Shiina et al., 2006 NO n-nos 2 Masliukov et al.,
41 n-nos NO NO Berthoud et al., 1997b; Shiina et al., 2006 in vivo in vivo 40
42 41
43 in vivo in vivo Banik and Brennan, 2009; Rong et al., 2004 NO 42
44 NO ; Boudaka et al., 2007; Izumi et al., 2003; Shiina et al., 2013; Shiina et al., 2012; Shiina et al., 2006 NO in vitro 43
45 In vitro 30 µm NO L-NAME 200 µm NK1 L-732,138 2 µm 4.27 ± 0.87 g (n = 5) 4.24 ± 44
46 0.96 g (n = 3) d- d- d- b c d 45
47 100 µ 80 V 30 µm SD n = 3 n = 3 P <
48 NO NK1 100 µ 80 V 30 µm NO L-NAME 200 µm NK1 L-732,138 2 µm 30 µm 47
49 a 100 µ 80 V 100% SD n = 4 n = 4 48
50 µ 80 V 100% SD n = 4 n = 4 49
51 100 µ 80 V 5 1~50 Hz 50
52 D- a D µm 100 µ 80 V D µm 100% SD n = 4 n = 4 51
53 a 100 µ 80 V c d, SD n = 5 n = 3 52
54 d- 53
55 d- Jonsson et al., 2009 d- Ca 2+ Nogueira and Hogan, 2010 c Aizawa et al., 2011; De Groat et al., 1982; Yu et al., 2009 in vitro 54
56 55
57 in vitro Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2012; Shiina et al., 2006 NO NO NO Neuhuber et al., 2006; Wörl and Neuhuber 2005 in vivo Neuhuber et al., 2006; Wörl and Neuhuber 2005 Furness, 2006; Hansen, 2003; 56
58 Leonard et al., 2006; Olsson and Holmgren, 2011 Furness, 2006; Hansen, 2003; Leonard et al., 2006; Olsson and Holmgren, 2011 Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2012; Shiina et al., 2006 in vivo Boudaka et al., 2007; Boudaka et al., 2009; Izumi et al., 2003; Shiina et al., 2012; Shiina et al., 2006 in vivo in vitro in vivo in vivo in vitro 57
59 in vivo > 30 mmhg Spencer et al., 2008; Yu et al., mmhg 58
60 59
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様式 C-19 科学研究費補助金研究成果報告書 平成 23 年 5 月 9 日現在 機関番号 :13701 研究種目 : 若手研究 (B) 研究期間 :2008 ~ 2010 課題番号 :20780206 研究課題名 ( 和文 ) 胃食道逆流症モデル動物における食道運動の解析研究課題名 ( 英文 ) Studies on the esophageal motility in the gastroesophageal
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Title 舟橋聖一 白い魔魚 論 : ビルドゥングスロマン / 中間小説 / 風土小説 Author(s) 林, 正子 Citation [ 岐阜大学国語国文学 ] no.[34] p.[1]-[23] Issue Date Jan-08 Rights Version URL http://repository.lib.gifu-u.ac.j この資料の著作権は 各資料の著者 学協会 出版社等に帰属します
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