her2 kit mono atlas
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1 HER2
2 St. Gallen 1 HER2 1 2) HER2 HER2 3) 20 2 HER2 Contents 1. St. Gallen HER HER2/neu 3 3. HER
3 1. St. Gallen HER2 St. Gallen HER2 FISH FISH 2 3 HER ) 1 e pt* 2cm a Grade**1 b ER / PgR *** c HER2/neu d 35 pt 2cm Grade2-3 b ER PgR c HER2/neu d ER / PgR c HER2/neu d 1-3 ER PgR c HER2/neu d 4 * ** *** ER PgR a pt1a pt1b pt<1cm b 2 c d HER2/neu FISH e 1-3 2
4 2 a a a HER2 b * c b * c HER2 d,e e d,e e d,e * a b c d 1cm e 2. HER2/neu HER2 2 human epidermal growth factor receptor type 2 17q21 c-erbb-2 neu HER2/neu 15 30% HER2 mrna HER2 3 90% HER2 HER2 95% 5% IgG HER2 HER
5 3. HER2 HER2 ASCO ) HER2 6) HER2 HER2 EIA FISH in situ hybridization CISH chromogenic in situ hybridization 7) SISH silver-enhanced in situ hybridization FISH 8 HER2 ELISA EIA HER2 POLYMONO HER2 POLY HER2 MONO SV μm 4
6 5. HER2 MONO Code: HER2 MONO 21600AMZ mL 1 4mL 2 8mL 2 3V/V% 4mL 1 4mL 2 8mL 2 HER2/neu SV2-61 2mL 1 2mL 2 8mL 1 2mL 1 2mL 2 8mL 1 IgG Fab' 4mL 1 4mL 2 8mL 2 3,3-4HCl 0.5mL 1 0.5mL 2 4mL 1 0.5mL 1 0.5mL 2 4mL 1 0.6V/V% 0.5mL 1 0.5mL 2 4mL 1 PBS 191g 1 191g 2 * * PBS PBS Code: HER2 MONOCode: SK-BR-3 HER2/neu 3+ HeLa HER2/neu A 48A 72A 5
7 6 HER2/neuSV Fab' PBS 3 HER2MONO PBS PBS PBS PBS mL
8 HER2 SK-BR-3 3+ HeLa HER2 3 3 HE HER2 HER2 10% % 7
9 1 SK-BR-3 HeLa 2 a b 3 HE
10 7. HER HER2 MONO A % 10% 10% 10%
11
12 3+ fishnet pattern A 23 HER2 MONO
13 8. a b 27 c 28 d 29 e f HER2 26 HE
14 9. 31 FISH 3+ 1+/0 2+ FISH FISH 6 9) 10% 10% 3+ HER2 ASCO/CAP % 3+30% 8) 32 10) FISH HER2/CEP F I S H IHC /0 FISH 31 HER2 HER2 IHC HER2 IHC 3+ >30% HER2 IHC 2+ HER2 HER2 IHC 0 1+ HER2 HER2 HER2/CEP 2 HER ASCO 13
15 10. FISH HER2 MONO FISH 5 11) 3+ 95% FISH 0 1+ FISH HER2 3+ HER2 0/1+ 2+ FISH 83.3% FISH 2+ Kitano SV2-61 HER2 MONO FISH FISH FISH FISH ) HER2 88% 11G 100% 16G 86% 13) 80% 100% 14) ) HER ) 5 HER2MONO FISHHER FISH FISH 0.98 FISH HER2 c-erbb-2 Shimizu /21 38% 5/19 26% 8/21 38% 7/31 22% * % 0/13 0% 0/23 0% * % 0/8 0% 1/8 12.5% * 11. HER2 14
16 1) Goldhirsch, A, Wood, WC, Gelber, RD, Gelber RD, Coates AS, Thürlimann B, Senn HJ; 10th St. Gallen conference. Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer Ann. Oncol. 2007, 18: ) St. Gallen ) Smith I, Procter M, Gelber RD, Gelber RD, Guillaume S, Feyereislova A, Dowsett M, Goldhirsch A, Untch M, Mariani G, Baselga J, Kaufmann M, Cameron D, Bell R, Bergh J, Coleman R, Wardley A, Harbeck N, Lopez RI, Mallmann P, Gelmon K, Wilcken N, Wist E, Sánchez Rovira P, Piccart-Gebhart MJ; HERA study team. 2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial. Lancet 2007,369(9555): ) Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL,Hunt KK, Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer.j Clin Oncol.2005,23: ) 2000 Recommendation: c-erbb-2 overexpression should be evaluated on every primary breast cancer either at the time of diagnosis or at the time of recurrence. Measures of c-erbb-2 amplification may also be of value. 6) HER ) Kumamoto H, Sasano H, Taniguchi T, Suzuki T, Moriya T, Ichinohasam R. Chromogenic in situ hybridization analysis of HER-2/neu status in breast carcinoma: application in screening of patients for trastuzumab (Herceptin) therapy. Pathol Int 2001, 51 : ) Wolff AC, Hammond ME, Schwartz JN, Hagerty KL, Allred DC, Cote RJ, Dowsett M, Fitzgibbons PL, Hanna WM, Langer A, McShane LM, Paik S, Pegram MD, Perez EA, Press MF, Rhodes A, Sturgeon C, Taube SE, Tubbs R, Vance GH, van de Vijver M, Wheeler TM, Hayes DF; American Society of Clinical Oncology; College of American Pathologists. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol. 2007, 25: ) Yaziji H, Goldstein LC, Barry TS, Werling R, Hwang H, Ellis GK, Gralow JR, Livingstone RB, Gown AM. HER-2 testing in breast cancer using parallel tissue-based methods. JAMA 2004, 291: ) Antonio C. Wolff, M. Elizabeth H. Hammond, Jared N. Schwartz, Karen L. Hagerty, D. Craig Allred, Richard J. Cote, Mitchell Dowsett, Patrick L. Fitzgibbons, Wedad M. Hanna, Amy Langer, Lisa M. McShane, Soonmyung Paik, Mark D. Pegram, Edith A. Perez, Michael F. Press, Anthony Rhodes, Catharine Sturgeon, Sheila E. Taube, Raymond Tubbs, Gail H. Vance, Marc van de Vijver, Thomas M. Wheeler, Daniel F. Hayes. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer. Arch Pathol Lab Med Vol 131, January 2007, ) HER p286 12) Kitano Y, Umemura S, Ohbayashi H, Takenaga M, Osamura RY Assessment of a new anti-her2 monoclonal antibody, SV2-61gamma: a best concordance with HER2 FISH. Appl Immunohistochem Mol Morphol : ) Usami S, Moriya T, Amari M, Suzuki A, Ishida T, Sasano H, Ohuchi N. Relaiability of prognostic factors in breast carcinoma determined by core needle biopsy. Jpn J Clin Oncol 2007, 37: ) Rakha EA, Ellis IO. An overview of assessment of prognostic and predictive factors in breast cancer needle core biopsy specimens. J Clin Pathol 2007, 60: ) Chivukula M, Bhargava R, Bryfsky A, Surti U, Dabbs DJ. Clinical importance of HER2 immunohistologic heterogeneous expression in core-needle biopsies vs resection specimens for equivocal (immunohistochemical score 2+) cases. Mod Pathol 2008, 21: ) Gong Y, Booser DJ, Sneige N. Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma. Cancer 2005, 103: ) Shimizu C, Fukutomi T, Tsuda H, Akashi-Tanaka S, Watanabe T, Nanasawa T, Sugihara K. c-erbb-2 protein overexpression and p53 immunoreaction in primary and recurrent breast cancer tissues. J Surg Oncol. 2000, 73: ) HER2/neu : TEL. 03 ( 3248 ) 2208 FAX. 03 ( 3248 ) TEL. 06 ( 6357 ) 2128 FAX. 06 ( 6357 ) 2330 TEL. 03 ( 3248 ) 2208 FAX. 03 ( 3248 ) KN
「適正なHER2検査のために」
乳癌における HER2 病理組織標本作製および 病理診断のガイドライン ( 案 ) 1. はじめに p. 2 2. 標本の準備 p. 2 3. Immunohistochemistry (IHC) 法 p. 2 4. In situ hybridization (ISH) 法 (FISH 法 DISH 法 ) p. 4 5. 病理診断と HER2 分子標的治療適応のフローチャート p. 6 6. 参考文献
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学位論文内容の要旨 HER2 protein overexpression and gene amplification in upper urinary tract urothelial carcinoma-an analysis of 171 patients 上部尿路上皮癌における HER2 タンパク過剰発現 および遺伝子増幅について 171 症例を用いた解析 Yuka Sasaki 佐々木由佳
背景従来, 乳癌の受容体検査は原発巣組織で行われていたが, 原発巣と転移巣の受容体発現に差のある症例が相当数あり, 治療効果は転移巣の受容体発現と関連していることが近年報告されている (1-3). それをふまえて,2010 年の米国臨床腫瘍学会と米国病理医協会 (ASCO/CAP) の指針では転移巣
乳癌穿刺吸引細胞診標本を用いた HER2 およびホルモン受容体の検討 研究実施計画書 独立行政法人国立病院機構四国がんセンター 臨床検査科 乳腺 / 内分泌外科 病理科実施計画書作成日 2010 年 12 月 27 日 Ver.1.0 1 背景従来, 乳癌の受容体検査は原発巣組織で行われていたが, 原発巣と転移巣の受容体発現に差のある症例が相当数あり, 治療効果は転移巣の受容体発現と関連していることが近年報告されている
免疫染色と in situ hybridization 法で決める最近の乳癌治療 Recent Trends of Breast Cancer Therapy Decided by the Results of Immunohistochemistry and in situ Hybridizati
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Polysomy 17 in Breast Cancer 2009 年 10 月 15 日 たちてん web conference 前回提示した症例 58 歳閉経後女性 右 MMK(T4bN1M0 Stage IIIB) に対して H11.8 月 Bt+Mn+Ax 試行 His ; IDC, t= 58mm, n= 9/22, HG3, ER/PR/HER2 = -/+/0 Adj ; ECx6 TAM
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再発腫瘍の個別化医療 京都大学医学研究科標的治療腫瘍学講座 新倉直樹 乳癌の治療におけるバイオマーカー 原発腫瘍 Months/years 再発腫瘍 Months/years Progression ER PgR HER2 Ki67? ER PgR HER2 腫瘍の性格や治療選択が原発腫瘍もしくは再発腫瘍内で同じでいいのか? Abbreviations: ER, oestrogen receptor;
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Title Author(s) 日本における受精卵診断をめぐる論争 (1990 年代 ) - 争いの経過 - 利光, 恵子 Citation 医療 生命と倫理 社会. 7 P.67-P.85 Issue Date 2008-03-20 Text Version publisher URL https://doi.org/10.18910/12560 DOI 10.18910/12560 rights
目次 0. 概要 3 1. 背景と意義 5 2. 目的 5 3. 検討方法 6 4. 検討期間 9 5. 倫理的事項 9 6. 結果の公表 研究資金 参考文献 研究組織 11 2
乳癌の免疫染色 (ER, PgR, HER2) に関する 精度管理システム確立のための検討 実施計画 日本病理学会医療業務委員会 精度管理委員会 乳癌ワーキンググループ ( 平成 22 年 3 月 30 日作成第 1 版 ) ( 平成 23 年 4 月 18 日作成第 2 版 )( 案 ) 1 目次 0. 概要 3 1. 背景と意義 5 2. 目的 5 3. 検討方法 6 4. 検討期間 9 5.
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