2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10 2- m/z 43, 1.0 45 0.48 58 0.42 5 2, 3 2 1 ppm = 4.91 mg/m 3, 20 1 mg/m 3 = 0.204 ppm
2-2 2. 10 492 t 492 t 0 6 1 3. 1 7 2 100 mg/l 30 mg/l BOD 95 OH = 9.71810-12 cm 3 / sec 25 8 OH 510 5 110 6 /cm 3 12 = 305 25 ph7 30 25 ph8 9 2 10 3 61 ppb ppm ppm B/A B/A B/A B/A 0/30 0/30 0.7 0.2 B/A
2-3 4 LC 50 mg/l EC 50 mg/l : *11 Crassius auratus 12 190 96-h * OECD 1,250 mg/kg 2, 13, 14 5. 1 LD 50 3,100 mg/kg 13 1,250-3,930 mg/kg 2, 13, 14 LC 50 LD 50 5,214 mg/kg 13 2 218 mg 13 3 4 1 ICR 62.51252505001,0002,000 mg/kg/day 5 / 5 500 mg/kg/day 1,000 mg/kg/day 2,000 mg/kg/day 1/4 14, 15, 16, 17 2 2005001,000 ppm 8 / 200 ppm 500 ppm 500 ppm 1,000 ppm 2, 14, 15
2-4 5 in vitro in vivo * S9 w CHO S9 D61.M/ 2.91-5.66 18 2.91 CHO S9 1,333 mg/kg 19 / 3,200-32,000 ppm 4,200-42,000 ppm 500-5,000 ppm 20 3,200 ppm 4,200 ppm 500-5,000 ppm * w 6 7 1 1,225 mg/kg/day 7-14 8 21 6. 1 2 15 22 25 1 2 L 1-4 2-2-ME 22
2-5 23, 24, 25 3 EPA 1999 EU 1999 NTP 1999 IARC 1999 ACGIH 2000 2001 24, 25 4 ACGIH 2000 5 ppm 2001 7. 2, 19 2-2-ME 2-ME MAA 17 2-ME 2-ME MAA 2-ME 36 19 2-ME 2-ME 5 24 2-10 19 2-ME 250 mg/kg 2-ME 2-MAA 2-MAA 20 2-MAA 77 19 8. OECD * 11 4 * OECD OECD
2-6 9. 1 2-2-ME 1 in vitro in vivo 2-ME 2 1 1 2 in vivo 3 2-4 5
2-7 CAS 9811 2-110805 9917 2-111762 200026 109864 20016 628966 200168 2-111159 14 5
2-8 1 2002. 2 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 2001. 3 IPCS, International Chemical Safety Cards 1989. 4 KowWin ver 1.66, Syracuse Research Corporation 2001. 5 NIST Library of 54K Compounds 1998. 6 10, 1999. 7, 2002. 8 AOPWIN ver1.86, Syracuse Research Corporation 2001. 9 Hydrowin ver1.67, Syracuse Research Corporation 2001. 10, 2001. 11 OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. OECD Series on Testing and Assessment No. 33 2001. 12 AQUIRE US EPA, ECOTOX Database System. 13US NIOSH, Registry of Toxic Effects of Chemical Substances RTECS2001. 14ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices 1991. 15,, 1994. 16,,, 21, 29-35 1979. 17K. Nagano et al., Experimental Studies on Toxicity of Ethylene Glycol Alkyl Ethers in Japan. Environmental Health Perspectives, 57, 75-84 1984. 18F. K. Zimmermann et al., Acetone, Methyl Ethyl Ketone, Ethyl Acetate, Acetonitrile and other Polar Aprotic Solvents are Strong Inducers of Aneuploidy in Saccharomyces Cervisiae. Mutation Research, 149, 339-351 1985. 19IPCS, Environmental Health Criteria EHC, 115 1990. 20C. Osgood et al., Aneuploidy in Drosophila, II. Further Validation of the FIX and ZESTE Genetic Test Systems Employing Female Drosophila Melanogaster. Mutation Research, 259, 147-163 1991. 21NTIS, Screening of Priority Chemicals for Reproductive Hazards, PB 86-197605 1984. 22H. M. Bolt et al., Maternal Exposure to Ethylene Glycol Monomethyl Ether Acetate and Hypospadia in Offspring : a Case Report, Br. J. Ind. Med., 47, 352-353 1990. 23JETOC,,, 4 1999. 24ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 2000. 25,, 43, 96-101 2001.
2-9 1 2
2-10 mg/l 1,000 100 190 24-h 10 LC 50 1 1 AQUIRE US EPA, ECOTOX Database System.
2-11 5d/w 5w 8d mg/kg/day 10,000 1,000 2,000 1,000-2,000 500-2,000 1,225 : 100 10