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Transcription:

23 2 21 31 2008 context bias executive function cognitive neuroscience Learning Disorders; LD Attention-Deficit/Hyperactivity Disorder; ADHD 6.3 409-3898 1110 2008 2 15 2008 2 25 17 4 1 1,2 3,4

22 1 feeling cognitive neuroscience 5 ADHD Barkley executive function ADHD 3,4 1 emotion motivation ADHD ADHD ADHD 6 7 5

23 non-verbal working memory setshort-term memory reset working memory temporal integration 2 8 ADHD 5 6 verbal working memory 9 1 2 setshortterm memory reset set inattention distractibility impersistence reset perseveration

24 10 11 ADHD 12,13 egocentric context 14 mental self context-dependent reasoning 1 3 3 30 60 4 5 6 15 5 16 context-independent reasoning 3 Cognitive bias task 1994 Goldberg lateralization cognitive bias task CBT cognitive novelty and cognitive routinization theory 15 4 2 4 egocentric context

25 context-dependent reasoning 8 CBT SPECT activation study 6 17 CBT CBT representation 7 18 innateness 5 CBT Aihara M, et al, 2003 16 5 6 15 6 CBT (SPECT activation study) Shimoyama H, et al, 2004 17

26 7 Aoyagi K, et al, 2005 18 LLF; left-sided lesions/epileptic foci, RLF; right-sided lesions/epileptic foci 1 event-related potential; ERP 19,20 sympathetic skin response; SSR 21,22 ERP SSR ERP SSR 12 1 Neuropack8 3 0.3 Hz 1 C 2 A 3 B 4 selfpaced key- pushing paradigm; S 10 1 ERP SSR somatosensory event-related potential; SERP Cz SSR Cz C3 C4 C3 C4 2 cm readiness potential; RP movement related cortical potential; MRCP B S SERP SSR 8 C A B habituation S A B S 9 A B S C4 A B RP S MRCP ERP A B SERP P250 23 S

27 8 SERP MRCP SSR Aihara M, et al, 2003 21 SERP; somatosensory event-related potential, MRCP; movement related cortical potential, SSR; sympathetic skin response MRCP P+300 A B S P250 P+300 SSR coupling SSR top down bottom up SSR 21 SSR SSR frontal lobe epilepsy; FLE FLE FLE benign partial epilepsy centrotemporal spikes; BECT SERP 0.3 Hz 32

28 10 250 msec P250 24 8 SERP P250 jitter control SERP P250 trigger SERP P250 11 A BECT 10 SERP 11 B Trigger SERP control SERP FLE FLE / AD/HD 2 1 2 WCST 2 SSR 12 25,26 1 SSR 2 9 RP MRCP RP; readiness potential, MRCP; movement related cortical potential 10

29 11 SERP SERP trigge-serp A SERP trigge-serp B SERP; somatosensory event-related potential 12 SSR SSR 13 27 / 28,29

30 13 SSR 2005 22 SSR a SSR b executive function context bias 2,5,20,28 1 1995 2 Fuster JM ed: The prefrontal cortex. 3 rd ed, Lippincott-Raven, Philadelphia: 209 252, 1997. 3 Barkley RA: Genetics of childhood disorders: XVII. ADHD, Part 1: The executive functions and ADHD. J Am Aca Child Adol Psychi, 39: 1064 1068, 2000. 4 Barkley RA ADHD 24: 357 376, 2003. 5 Adolphs R: Cognitive neuroscience of human social behaviour. Nat Rev Neurosci, 4: 165 178, 2003. 6 37: 10 14, 2005. 7. 253 271 2000 8 Block RA, Zakay D: Models of psychological time revisited. In: Helfrich H ed. Time and Mind. Hogrefe & Huber Publishers, Seattle: 171 195, 1996. 9 1 9 1997. 10 Plutchik R: Emotions: a general psychoevolutionary theory. In: Scherer K, Ekman P eds, Approaches to Emotion. Erlbaum, Hillsdale, NJ: 197 220, 1984. 11 56: 39 44, 2005. 12 Fuster JM ed: The Prefrontal Cortex, 3 rd ed. Lippincott-Raven, Philadelphia: 209 252, 1997. 13 Goldberg E: The executive brain, frontal lobes and the civilized mind. Oxford University Press, Oxford, 2001. 14 Strange BA: Anterior prefrontal cortex mediates rule learning in humans. Cereb Cortex, 11: 1040 1046, 2001. 15 Goldberg E, Podell K: Cognitive bias, functional cortical geometry, and the frontal lobes: laterality, sex, and handedness. J Cognit Neurosci, 6: 276 296, 1994. 16 Aihara M, Aoyagi K, Goldberg E, Nakazawa S: Age shifts frontal cortical control in a cognitive bias task from right to left: part I. neuropsychological study. Brain Dev, 25: 555 559, 2003. 17 Shimoyama H, Aihara M, Fukuyama H, Hashikawa K, Goldberg E, et al: Context-dependent reasoning in a cognitive bias task; part II.

31 SPECT activation study. Brain Dev, 26: 37 42, 2004. 18 Aoyagi K, Aihara M, Goldberg E, Nakazawa S: Lateralization of the frontal lobe functions elicited by a cognitive bias task is a fundamental process. Lesion study. Brain Dev, 27: 419 423, 2005. 19. 16: 1 9, 2004. 20 47: 335 345, 2006. 21 Aihara M, Sata Y, Osada M, Ozaki Y, Nakazawa S: The effects of higher cortical functions on SSR. In: Hashimoto I, Kakigi R, eds, Recent advances in human neurophysiology, Elsevier, Amsterdam: 1089 1094, 1998. 22 Wilson 47: 425 429, 2005. 23 I., 30: 30 37, 1998. 24 29: 276 284, 2001 25. 36: 372 377, 2004. 26 /. 36: 49 54, 2004. 27 45: 441 446, 2003. 28 48: 189 195, 2007. 29 Tanaka SC, Doya K, Okada G, Ueda K, Okamoto Y, et al: Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nature Neurosci, 7: 887 893, 2004.