(Pantothenic acid, C 9 H 17 NO 5, MW: 219.24 CH 3 OH HOCH 2 C CHCONHCH 2 CH 2 COOH CH 3 (Calcium pantothenate, C 18 H 32 CaN 2 O 10, MW: 476.54) CH 3 CH 3 OH HOOC 2 HC 2 HCHNOCHC C OCH 2 Ca OCH 2 C CHCONHCH 2 CH 2 COOH OH CH 3 CH3 CoA (Coenzyme A, C 21 H 36 N 7 O 16 P 3 S, MW: 767.54 OH OH CH 3 OH O HO P O OCH 3 H H O P O OH P OCH 2 O H O H OH N N C CH 3 C HCO NHCH 2 CH 2 CO NHCH 2 CH 2 SH N N NH 2 198
ε 199
200
1. K. Shibata, C. J. Gross and L. M. Henderson, Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine. J. Nutr., 113, 2207-2215 (1983). 2. D.K. Fenstermacher and R.C. Rose, Am. J. Physiol., 250, G155-60 (1986) 3. Y. Abiko, Metabolism of sulfur compounds. Metabolic pathways (D. M. Greenberg ed.), Vol. 7, p.1, Academic Press, 1975 4. Y. Abiko et al., Biochim. Biophys. Acta, 268, 364, (1972). 5. A.G. Tahiliani and C.J. Beinlich, Pantothenic acid in health and disease. Vitam Horm., 46, 165-228 (1991). 6. 1999 7. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B 6, Folate, Vitamin B 12, Pantothenic acid, Biotin, and Choline, Institute of Medicine, National Academy of Sciences, 1998. 8. L. Johnson, L. Vaughan and H. M. Fox, Pantothenic acid content of human milk. Am. J. Clin. Nutr., 34, 2205-2209 (1981). 9. 10 - - 10, 11-20 (1996). 10. W. O. Song, G. M. Chan, B. W. Wyse, and R. G. Hansen, Effect of pantothenic acid status on the content of the vitamin in human milk. Am. J. Clin. Nutr., 40, 317-324 (1984) 11. J. B. Tarr, T. Tamura, E. L. Stokstad, Availability of vitamin B6 and pantothenate in an average American diet in man. Am. J. Clin. Nutr., 34, 1328-1337 (1981). 12. (I) 46, 261-265 (1972). 13. 33596 (1957). 14. V. Schmidt, The excretion of Pantothenic acid in the urine in young 201
and old individuals. J. Gerontol., 6, 132-134 (1951). 15. J. K. Pace, L. B. Stier, D. D. Taylor and P. S. Goodman, Metabolic patterns in preadolescent children. 5. Intake and urinary excretion of pantothenic acid and of folic acid. J. Nutr., 74, 345-251 (1961). 16. B. R. Eissenstat, B. W. Wyse, and R. G. Hansen, Pantothenic acid status of adolescents. Am. J. Clin. Nutr., 44, 931-937 (1986). 17. N. Kimura, T. Fukuwatari, F. Hayakawa, R. Sasaki, and K. Shibata, Vitamin intakes in Japanese college women students. J. Nutr. Sci. Vitaminol., 49, 149-155 (2003) 18. M. Hatano, Microbiological assay of Pantothenic acid in blood and urine. J. Vitaminol., 8, 134-142 (1962) 19. 202 27. E. Kerry, S. Crispin, H. M. Fox, and C. Kies, Nutritional status of preschool children. I. Dietary and biochemical findings. Am. J. Clin. Nutr., 21, 1274-1279 (1968) 28. C. M. Lewis and J. C. King, Effect of oral contraceptive agents on thiamin, riboflavin, and pantothenic acid status in young women. Am. J. Clin. Nutr., 33, 832-838 (1980) 29. 19, 433-432 (1967) 30. N. L. Bull and D. H. Buss, Biotin, pantothenic acid and vitamin E in the British household food supply. Hum. Nutr.: Appl. Nutr., 36, 190-196 (1982) 31. W. O. Song, B. W. Wyse, and R. G. Hansen, Pantothenic acid status of pregnant and lactating women. J. Am. Diet. Assoc., 85, 192-198 (1985) 40, 27-31 (1969) 20. C. W. Denko, W. E. Grundy, J. W. Porter, Blood levels in normal adults on a restricted dietary intake of B-complex vitamins and tryptophan. Arch. Biochem., 13, 481-484 (1947) 21. J. Fitzpatrick, S. L. Tompsett, The excretion of riboflavin, biotin, Pantothenic acid, and nicotinic acid derivatives by normals. J. Clin. Path., 3, 69-71 (1950) 22. V. Schmidt, The excretion of Pantothenic acid in the urine in young and old individuals. J. Gerontol., 6, 132-134 (1951). 23. H. M. Fox and H. Linkswiler, Pantothenic acid excretion on three levels of intake. J. Nutr., 75, 451-454 (1961). 24. V. Srinivasan, N. Christensen, B. W. Wyse, and R. G. Hansen, Pantothenic acid nutritional status in the elderly institutionalized and noninstitutinalized. Am. J. Clin. Nutr., 34, 1736-1742 (1981) 25. J. H. Walsh, B. W. R. G. Hansen, Pantothenic acid content of a nursing home diet 1,2. Ann. Nutr. Metab., 25, 178-181 (1981). 26. W. O. Song, B. W. Wyse, and R. G. Hansen, Pantothenic acid status of pregnant and lactating women. J. Am. Diet. Assoc., 85, 192-198 (1985)
Body weight gain (g) 200 150 100 50 0 0 5 10 15 20 25 30 Day Food intake (g) 20 15 10 5 0 0 5 10 15 20 25 30 Day 0 % PaA control (0.0016 % PaA) 1 % PaA 3 % PaA 203
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