Koshimizu Toshimasa (JAPIC ) DI 1970 50 DI DI 1963 38 DI 1973 48 DI 10
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5 10 1) Body mass index, 6 4-17,2000. 2). 6 18-28,2000. 3) Executive summary of the clinical guidelines on the identification, evaluation,and treatment of overweight and obesity in adults. Arch Intern Med 158:1855,1998. 4) Guidance for the clinical evaluation of weight-control drugs, FDAdocuments,No169,1997. 5) Connolly HM et al:valvular heart disease associated with fenfluramine phentermine. New Engl J Med 337:581-588,1997. 6). 25:343-347,1995. 7) Hagiwara M,et al:delayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol -A case report Jpn Circ J 64:218-221,2000. 8) Bray,GA,et al: Sibutramine produces dose-related weight loss. Obes Res 7: 189 198,1999. 9) Smith IG: Randomized placebo controlled trial of long-term treatment with sibutramine in mild to moderate obesity. J Fam Pract 50:505-512,2001. 10) Luque CA,et al:sibutramine:a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann Pharmacother 33:968-978, 1999. 11) Zhang Y, et al: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432,1994. 12) Heymsfield SB.et al: Recombinant leptin for weight loss in obese and lean adults: a randomized,controlled,dose-escalation trial. JAMA 282:1568-1575,1999. 13) Madsbad S,et al:improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting Glucagons-like Peptide 1 analog liraglutide(nn2211). Diabetes Care 27:1335-1342,2004. 14) Lambert PD, et al: Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat,without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA.98:4652-4657,2001. 15) Simiand J,et al: SR 141716,a CB1 cannabinoid receptor antagonist, selectively
reduces sweet food intake in marmoset. Behav Pharmacol 9:179-181, 1998. 16) Trillou CR.et al:anti-obesity effect of SR141716,a CB1 receptor antagonist,in dietinduced obese mice. Am J Physiol Regul Integr Comp Physiol 284: R345-353,2003. 17) Finer N,et al.:one year treatment of obesity: a randomised, double-blind, placebocontrolled, multicentre study of orlistat(xenicalr), a gastrointestinal lipase inhibitor. Int J Obes Relat Metab Disord 24:306-313,2000. 18) Hill JO,et al. Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting. Am J Clin Nutr 69:1108-1116, 1999. 19). (NIDDM) BAYg5421(Acarbose) Placebo. 149:591-618, 1989. 20) -gulucosidase AO-128. 160: 943-971, 1992.
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