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1 5 AFEEPVI EEPVI ablation 5 3 mapping EnSite system St.Jude medical 5 3 ablation AF 5 3 roof line blockline AF 2 CFAE ablation EPS 237 ms 376 ms Mapping 5 activation map 3 post pacing interval PPI 2 PPI activation map focal ablation linear ablation AF AF EEPVI AF FCLAF AF AF AF AF FCL FCL AF AF AF AF V1 R QRS T FFT 4 FCL FCL FCL FCL ms ms 149 ms FCL AF vs vs ms p vs ms p vs ms p FCL AF AF FCL 7 6 AM

2 J Arrhythmia Vol 28 Suppl 2012 CT 64 CT CT CT 1 30 cm/sec 30 cm/sec CT 2 Chicken wing type Non chicken wing type 2 P Chicken wing type P CT Chicken wing type Non chicken wing type AF CA CA 70 AF LVEF LAEF LAESV E/ e and asvt 17 SVT LAEF L 50 LAEF 22 N CA 50 LAEF CA L L vs N vs 6 27p vs 5 23p vs p 0.05 L CA LAEF LAESV E/e L vs N LAEF vs p 0.05 LAESV ml vs p 0.01 E/e sep vs p 0.05 CA LAEF LAESV L L vs N LAESV ml vs p 0.05 LAEF E/e CA LAEF

3 K Cysteinnyl cathepsin K K atrial fibrillation AF K AF 146 AF PAF 63 AF PsAF 112 non AF K IL CRP I PINP ICTP K AF non AF ng/ml vs ng/ml P 0.01 IL CRP ICTP AF P 0.05 AF K IL PAF PsAF P 0.05 Spearman s correlation test K ILP 0.01 ICTP P 0.05 P ng/ml vs ng/ml P 0.01 K CHADS2 BNP D 1 CHADS2 D CHADS2 BNP BNP D CHADS2 D BNP CHADS CHADS /1/2 6/12/41 D g/ml D 0.5 g/ml CHADS BNP 100 pg/ml 7 3 D BNP 100 pg/ml 11 D 1 CHADS BNP D BNP 8 4 D CHADS2 2 D CHADS2 0 1 BNP D 7 6 AM

4 J Arrhythmia Vol 28 Suppl 2012 ST AF ST STEMIAF STEMI STEMI CREDO Kyoto AMI registry AF AF AF P P P AF CHADS2 score 2 45 STEMI AF AF AF STEMI multi channel blocker mg/day mg/day mm RR ms vs ms p 0.05 QT ms vs ms p 0.05 QTc ms vs ms p 0.71 KL 6 2 7TSH mg/day 100 mg/day

5 atrial fibrillation Af sleep disordered breathing SDB SDB Af SDB Af Af 117 STARDUST II Philips Respironics type3 apnea hypopnea index AHIAHI 5 / SDB Af36 Body mass index BMI 26.4 kg/m 2 BMI 26.4 kg/m blanking period mm vs 40.0 mm p vs 38 p AHI 20.1 vs 17.8 p vs 31 p vs 20 p 0.03 SDB Af CTI CA AFL Af CTI CA Af AFL Af AFL AFL Af AFL CTI CA AFL Af 60 AFL 47 AFL Af AFL AFL Af 42 70AFL 8 17 AFL 2 1 Af 39 AFL Af AFL p 0.05AFL 1 Af AFL Af Af Af AFL Af CTI CA AFL Af Af Af CA 7 6 AM

6 J Arrhythmia Vol 28 Suppl D CT merge CT 3D AF CT merge AF CAR TO3 J&J 2 CT merge L&S 4 Landmark point 4 Surface point 4 6 registration merge ACL Landmark point 1 2 CT merge 8 12 Merge L&S ACL ACL p Merge 5 CT L&S mm mm mm ACL mm mm mm ACL p merge ACL CT AF AF AF AT AT AF AT AF 74 AF/AT 21 AF PAFn 7 AF CAFn 9 AT CATn 5 AF PAF 43 CAF 11 CAT 80 3 LAD LVDd LVEF PAF LVDd mm mm p CAT LVEF p CAT 5 4 LVEF 50 1 CAT AT / AT AF/AT PAF 71.4 CAF 22.2 CAT 80 AF AT

7 mean SD 1 Cox / C reactive protein CRP 0.5 mg/dl p 0.10 Cox CRP HR CI 2.39 to p HR CI 1.09 to 5.60 p 0.03 CRP p AM

8 J Arrhythmia Vol 28 Suppl 2012 Adaptive Servo Ventilation AF RF RF Adaptive servo ventilaton ASV AF RF Full Polysomnography RF2 BNP CRP 21 3 ASV AF Apnea hypoxia index AHI ASV RF2 BNP BNP RF2 CRP ASV 3 AF ASV 19 vs 40 p 0.05 AF 2 35 vs 59 p ASV AF AF RF BNP ASV RF BNP mm 3D anatomical mapping Roof line Mitral isthmus blocking line / / / /

9 ATP ATP dormant conduction 60 ATP CARTO ipv ATP dormant conduction /dormant conduction ipv ipv ATP 9 ipv dormant con duction 60 2 ipv ATP 2 ipv dormant con duction /dormant conduction 4 ipv 30 / dormant conduction 91 ipv 60 /dormant conduction ATP 30 f AF AF f AF FFT custom made software QRS f FFT CFAE AF AF II V1 Dominant frequency DF DF 6.2 vs. 6.8Hz p vs. 7.1Hz p vs. 6.3Hz p V1 II V1 DF DF AF f DF DF AF 7 6 AM

10 J Arrhythmia Vol 28 Suppl CT LARV LACV LABPF 3 PeAF RFCA RFCA PeAF 6 CT CT CT R R phase phase 1 LAVmax LAVminLAEF SR 10 PAF 8 AF SR AF LAEF LACV LAVmax ml/m 2 vs ml/m 2 P LAVmin ml/m 2 vs ml/m 2 P LAEF vs P LACV ml/m 2 vs ml/m 2 P LARV SR PAF LABPF LAV max ml/m 2 vs ml/m 2 P LAVmin ml/m 2 vs ml/m 2 P LABPF vs P PeAF RFCA LARV LACV LABPF PMI PMI SND Control296SND Kaplan Meier Log rank PMI SND 70 vs. Control 13 p SND 49 6mm vs. Control 44 6mm p / SND Control SND Log rank test p 0.02 SND 90 vs. Control 66 SND 1.5 vs. Control 1.3 SND 40 vs. 8 p PMI

11 1 PV LA entrance block LA PV PV LA AF AF AF AF 26 2 PVLA PV LA PV LA LA PV entrance block HFS ganglionated plexi GP 30 HFS HFS n 15 HFS n 15 HFS PVI HFS GP HFS PVI GP HFS 80 vs. 40 p vs. 33 p 0.73 HFS PVI GP vs p HFS GP 3 vs HFS PVI GP GP GP 7 6 PM

12 J Arrhythmia Vol 28 Suppl Class2b CFAE ACT ACT MRI ACT ACT ACT ACT ACT ,4ACT ACT 350 ACT J vs J P ACT 350 ACT 350

13 PerAF CA LAAFV 7 PerAF 18 1st to 3rd quartile 5 36 CA 6 TEETTE CA TEE LAAFV cm/sec cm/sec p spontaneous echo contrast SEC vs. 7 p CA SEC LAAFV structural heart disease TTE A E/e multiple regression analysis SEC p A p E/è p LAAFV CA LAAFV SEC SEC A E/è CA OS droms test RA LACS CV OS /63 /3 paf 37 psaf 29 CV LA RA CS droms test drom psaf P paf LA RA CV CS drom Carratelli units U.CARR psaf CS drom CS LA RA , CV nu.carr P CS drom BNP r 0.67 P CS drom BNP psaf CS drom AF drom 7 6 PM

14 J Arrhythmia Vol 28 Suppl 2012 AFFIRM STUDY QOL AT EF brain natriuretic peptide BNP AT pre vs. post watts p 0.05 BNP pre vs. post pg/ml p EF pre vs. post p 0.01 AT BNP EF PVI PVI 29 PAF 29 SAF PVI 3 6 E E DCT ELVDd LVEFE E PAF PVI SAF E cm/sec cm/sec E cm/sec cm/sec E/E PAF SAF PAF E E/E DCT PVI PVI r 0.64 r 0.66 r 0.74 SAF E PVI PVI r 0.56 PAF LVEF LVDd SAF LVEF 57 13PVI 66 8 PVI PVI r 0.68 LVDd PVI PAF PVI SAF PVI

15 AFPVI AF PVR PVI PVR PVR PVR AF AF double Lasso technique W 50 CPVI PVR PVR PVI 60 Long OT group n Short OT group n PVR Long OT group 38.7 vs P PVR Short OT group Long OT group PVR 55.6 vs P CPVI PVI PVR PVR Contact Bipolar Mapping non contact ar ray mapping septopulmonary roof line high density bipolar contact mapping grobal high density bipolar contact map mm 20 Spi ral, St. Jude Medical, USA mapping Navx software St. Jude Medical Bachmann s high density bipolar contact mapping 7 6 PM

16 J Arrhythmia Vol 28 Suppl 2012 Slow Pathway CS ostium AVNRT CS ostium PSVT CS ostium ms CS ostium long RP tachycardia 3 2 jump A A V A His sequence 3 CARTO mapping CS ostium focal pattern CARTO mapping 1 3 slow pathway AVNRT slow pathway ablation 2 corynebacterium diph theriae Voltage Map 2 60 RA isthmus CT Voltage Map

17 ATP ATP focal atrial tachycardia ATP mm 10 mm ATP AT 1 26 inces sant type AT ablation 12 Ensite Velocity Navx System geometry AT propagation map unipolar QS pattern AT Irrigation catherter 30W APC AT AT P exit site AT AT abla tion strategy 7 6 PM

18 J Arrhythmia Vol 28 Suppl 2012 persistent atrial fibrilla tion perimitral atrial flutter PMFL mitral isthmus MI block MI MI 47 differential pacing 17 success group 30 unsuc cess group64 vs. 61 years 82 vs vs 746 vs. 44 mm 56 vs. 61BNP 175 vs. 158 pg/ml MI length 47 vs 45 mm MI depth 9.4 vs 9.6 mm MI thickness 3.7 vs 3.8 mm CS 12 vs 23 Agilis 53 vs 10 success group vs. unsuccess group p 0.05 Agilis MI ASD Right Atrial Reentrant Tachycardia linear ablation incision IVCblockline Atrial tachycardia AT AT AT CTI macro reentry 3 D mapping guide AT 3 D mapping guide ASD gap macro re entry tachycardia Right atrial reentrant tachycar dia IVC linear ablation incision IVC Halo Right lateral Right lateral Halo 3 Ensite array geometry Coronary Sinus CS Halo Right Atrial RA lateral pacing CTI dependent reentrant tachycardia gap Right atrial reen trant tachycardia CTI ablation IVC linear ablation Halo RA lateral pacing Halo RA lateral RA lateral Halo pacing RA lateral incision IVC IVC gap linear ablation Halo Right lateral Right lateral Halo

19 , , bpm vs p vs p 0.02 CHADS vs p vs p vs. 3.9 p vs. 4.3 p vs p vs p vs p vs. 4.0 p vs p 0.01 CFE AF CFE complex frac tionated electrograms CA AF CA CFE CA CFE responder PVI CFE ABL CA AF 24 PVI double Lasso PV CFE ABL Ensite NavX CFE CFE responder CFE ABL 12 1 responder non respond er AF f CFE CFE responder 8 non re sponder mm 41 4 mm CFE mv mv f mv mv CFE responder P f 0.1 mv 16/16 4/8 P CFE ABL f f CFE ABL 7 6 PM

20 J Arrhythmia Vol 28 Suppl 2012 SOUNDSTAR CARTO MERGE SOUNDSTAR CARTO MERGE CARTO SOUND CT MRI 3 D MERGE Fast Mapping FAM MERGE CARTO SOUND MERGE SOUNDSTAR Landmark Surface Registration FAM MERGE Lasso Navistar Thermo Cool 3 Landmark Surface Registra tion MERGE Match Statistics Surface Match Av erage Maximum vs vs vs 39 7 mm 9 vs 7 2 Surface Match Average Maximum CARTO SOUND MERGE Aver age vs mm p Maxi mum vs mm p CARTO SOUND MERGE FAM MERGE Surface Match Maximum Non contact mapping NCM NCM LARA NCM Virtual Unipolar LARA PVI NCM LARA PVI LAA PW LARA LAA PW NCM virtual unipolar LARA unipolar Tpre Tpost PW 20 mm LARA LAA 2 10 PW LARA PW Tpre ms Tpost ms p LARA Tpost/Tpre LARA 2 virtual unipolar

21 1 40 ARVC MRI ICD des moglein 2 hetero narrow QRS ablation AT CL 365 ms CARTO RA activation mapping RAA ablation AT2 CL 252 ms mapping AT2 RAA Ablation AT3 CL 430 ms mapping map ping AT4 CL 360 msraa ablation AT4 ICD ARVC narrow QRS tachycardia 25 mm 66 5 PAC trigger AVRT AVRT PAC Non contact mapping system PAC PAC AVRT AM

22 J Arrhythmia Vol 28 Suppl D Speckle Tracking WPW M 2 D Speckle Tracking WPW WPW 2 D Speckle Tracking WPW 2 D Speckle Tracking Philips QLab D Speckle Tracking 2 D Speckle Tracking CARTO 3 SYSTEM AVNRT 40 AVNRT slow pathway 29 A CARTO 3 SYSTEM 11 B B ACL FAM Slow pathway A vs. B 96 vs. 100 p ns B CARTO 10 3 vs mm p 0.01 CARTO 3 SYSTEM CARTO 3

23 fast slow 1 slow pathway 6 VSD 44 Long RP ISP S A A V 320 ms long RP 280 ms ms ISP 2 Left variant jump up long RP jump up Koch slow potential 2 71 jump up CS5 6 wide QRS Left variant Leftward nodal extension 7 7 AM

24 J Arrhythmia Vol 28 Suppl CT 2 CS RV His decremental CS His V scan PR slow slow PR 1 24 PR 380 ms 108/ narrow QRS tachycardia inces sant 1 AH 472 ms HA 110 ms slow slow AVNRT 2 AH PR slow slow AVNRT antegrade slow pathway ablation PR 3 Slow pathway fast pathway slow pathway fast pathway

25 VSD double switch 2001 RVOT LVOT by stander CPR voltage map low voltage zone LVZ 260 msec activation map LVZ IVC RVOT ICD LVZ IVC IVC IVC ICD CHADS2 score 1.5 CHADS2 score Cre mg/ dl mg mg mg mg AM

26 J Arrhythmia Vol 28 Suppl 2012 Brugada Brugada Brugada BS 25 Brugada non BS 25 V2 V5 QRS R nega tive dv/dt RV AcT LV AcT QRS RV pet LV pet BS I Brugada non BS ST T BS RV AcT RV pet both p vs ms 15 7 vs ms both p 0.05 both p 0.05 Brugada AF ICD Brugada IVF IVF AF 15 Bruga da QT short cou pled torsades de pointes PVC PQ QRS QT J 12 ICD AF ICD 15 8 PAFJ 13J 86 AF VF AF AF 43 VF PAF bpm 3 ICD ICD 1 J ICD

27 Mohamed Shalfee PR interval V 2 V 5 r J inter val r Tp interval r Te interval J Te interval V 2 r J interval msec. v.s msec p 0.01 late potential JA Brugada right ventricular outflow tract RVOT substrate Vf Brugada Haissaguerre PVC Nademanee RVOT substrate PVC substrate Brugada 2. 23ICD 4 Vf mg/ mg/ Vf ICD 12 8 / Vf EPS RVOT PVC Vf low voltage LP late potential low voltage QRS onset 200 ms 23 cm 2 EnSite system coved type 1,486 2 Vf 7 7 AM

28 J Arrhythmia Vol 28 Suppl QT torsades de pointes TDP QT QT 15 QT 24 RR QT Y 24 RR QT QT/ RR y QT QT/RR QT VT storm VT VT VT storm 24 3 VT VT VT storm VT PCI N 5 N 3 N 7N 2 N 1N 1 VT storm VT storm 5 1 PCI 1 4 VT storm

29 mg mg 200 mg 200 mg p mg 200 mg Sustained VT ICD ICD VT 12 V mmHg blocker Sustained VT ICD VT unmappable ICD de layed potential DPDP fragmenta tion VT mappable DP VT ICD VT DP 7 7 AM

30 J Arrhythmia Vol 28 Suppl LVDd70 mm AR EF VPC RVOT AR VPC VPC RVOT activation map RVOT QS RVOT VPC QRS VPC VT VT beating QRS 50 msec VT anterior pulmonary sinus posterior pulmonary sinus interleaflet triangle VPC/VT LBBVT LBBVT 160 bpm VT VT 2 VT1 370 msec LBBVT VT2 440 msec VT2 entrainment 2 VT entrainemnt mapping Carto mapping Pace mapping VT1 QRS exit central proximal VT2 perfect pace mapping VT1 exit central proximal pace mapping 2 exit VT 1

31 Ratchet syndrome DDD DDD ICD ICD DDD ICD 3 0 ICD 8 DDD DDD 1 ICD 2 ICD 3 Twiddler syndrome reel syn drome ratchet syndrome reverse remodeling Brain Natriuretic Peptide 1 CRT CRT Brain Natriuretic Peptide BNP CRTD NYHAclass3 / 76/72 mm 11 CRTD BNP BNP 592 pg/ml BNP BNP CRT super responder reverse remodeling BNP 7 7 PM

32 J Arrhythmia Vol 28 Suppl 2012 SPRINT SPRINT ICD SPRINT 23 SPRINT ICD 11 3 CRTD SPRINT Lead Integrity Alert 1/3 ICD ICD Brugada Brugada DC Brugada Brugada shock Brugada Brugada DC Brugada BS 17 BS DC BS DC p 0.49 DC BS BS BS p BS BS DC Brugada DC Brugada Shock remote monitoring system

33 ICD 2 ICD ICD RMS RMS Lead Integrity Alert LIA ICD 2010 RMS RMS 600 RV Sensing Integrity Counter SIC 22 R VT/VF Episode EGM 3 ICD RMS VT NS Episode ICD 2010 RMS 9 ICD RMS SIC 500 VT/ VF Episode EGM RV ICD VT NS Episode 1 RMS LIA RMS 3 1 RMS LIA ON CRT CRT EASYTRAK2 ACUITY Steerable J 1 1 nah nah vs. J nah p N.S nah vs. J nah p nah vs. J nah p 0.02 J 7 7 PM

34 J Arrhythmia Vol 28 Suppl 2012 CRT D LV EF 35 C.I. 1.7 /min/ m2 PA 45/23 mmhg PCWP 24 mmhg NYHA 4 CRT D NYHA NYHA cycle length CRT D mode switch off PVARP 2 1 CRT D ICD SVT 1 SVT VT ICD VT ICD ICD SJM Atlas Current Promote Unify Verify VT / 15 2 VT 1 VT 1 VT 38 VT 26 VT 68 26/38 VT QRS LVDd LVEF ICD VT 68 26/38 VT 65 11/17

35 CRT rate re sponse RR QOL CRT RR CRT Rate histogram CRT up grade 20 2 VVI A 7 respond er NYHA up grade6 86 RR ON 4 A OFF OFF ON 10 CRT A RR CRT RR ICD 1 ICD TELIGEN 100 CCO CCO VF ICD ICD CCO CCO 777 HF 8 Vigilance 2 IPG ICD CRTD CCO CCO ICD CRTD RV Integrated/True Bipolar 1 ICD CRTD 2 CCO 3 Integrated/True Bipolar 4 ICD CRTD CCO RV 5 CCO TELIGEN KHz Vigilance 2 CCO CCO 1 CCO EMI 7 7 PM

36 J Arrhythmia Vol 28 Suppl ME DDD RV Loose pin CLS Closed Loop stimulation CLS 40 / DDD / CLS DDD BIOTRONIK 50 ppm LF/HF HFDDD CLS DDD R DDD CLS 123 bpm 120 ppm DDD CLS LF/ HF DDD R DDD CLS

37 CT CT 11 N 16 R Cardiac Contraction Map Maine Inc., Kobe Japan 8,000 max contraction max contradiction phase delay algorism RRduration of contraction SD R QRS N vs. R vs ms p max contraction vs ns the max contraction phase vs ns duration of contraction vs SD ns Wide QRS CT merge CARTO 1 cryoablation patch ms 7 7 PM

38 J Arrhythmia Vol 28 Suppl 2012 CARTO SOUND CARTO SOUND 3 D ILVT ILVT 3 CARTO SOUND CT CT SOUND STAR CT MERGE CARTO SOUND 3 ILVT CARTO SOUND ICD ICD QOL ICD ICD 50 Borg 17 CPX CPX VO2AT n 19 n 31 CPX BNP CPX VO2 AT vs bpm p p CI OR ICD CPX ICD

39 ICD DFT ICD DFT ICD ICD 14 20J 1 LEVF LVEF45 8 A LVEF45 6 B CK CK MB I T ANP BNP dp/dtdp/dt index DFT 5 20 B DFT dp/dt mmhg P DFT A DFT ANP BNP ICD 5 DFT 1 SD rat 85 RBC n 1455 Alb n 14 2 LF HF LF/HF norepinephrine NE 2 SD rat 30 RBC n 14 5 Alb n 14 2 Tyrode Na channel Optical Mapping System OMP Action potential duration dispersion APDd 1 RBC LF/HF NE 5 Alb Alb OMP burst pacing RBC 5 Alb APDd RBC APDd 7 7 PM

40 J Arrhythmia Vol 28 Suppl , egfr 60 ml/ min/1.73 m 2 2 4,242 egfr 10 ml/min/1.73 m , ST 10 8, ST 149,568 ST ST Agalsidase alfa 1a Agalsidase beta alfa 1b Agalsidase alfa 2a Agalsidase beta alfa 2b LVmass QRS LVmass 1a Agalsidase alfa RV5 SV1 0.28mV p a 2a 1b 2b QRS Agalsidase beta alfa Agalsidase alfa LVmass RV5 SV1 QRS

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