Taro10-睡眠障害報道資料.PDF

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13 Froberg JE : Twenty-four-hour patterns in human performance, subjective and physiological variables and differences between morning and evening active subjects. Biol Psychol 5: , 1977 Bolbery Daan process-s process-c Two-process process-c process-c process-c process-s process-s process-c process-s process- C process-s process-c process-c process- C 8

Biol Psychol 5:119-134, 1977 Bolbery Daan process-s process-c Two-process process-c

14 process-s GABA Two-process Daan S : Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol: 246:R ,

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19 Epworth sleepiness ScaleESS Johns MW:A new method for measuring daytime sleepiness:the Epworth sleepiness scale.sleep 14: ,

20 Doi Y,Minowa M:Gender differences in excessive daytime sleepiness among Japanese workers.soc Sci Med :56: Roehrs T, Shore E, Papineau K,Rosenthal L,Roth T.A two week sleep extension in sleepy normals.sleep :19: Roth B.Narcolepsy and hypersomnia :review and classification of 642 personally observed cases.schweiz Arch Neurol Neurochir Psychiatr :119: Bonnet MH.:Effect of sleep disruption on sleep,performance and mood.sleep, 8:11-19,1985 Young T,Palta M,Dempsey J,et al:the occurrence of sleep-disordered breathing among middleaged adults. N Engl J Med 328: ,1993 Hamilton,G.S.et al.:obstructive sleep apnoea and cardiovascular disease.intern. Med.J.,34(7): ,2004 Phillips,B.:sleep-disordered breathing and cardiovascular disease.sleep Med.Rev., 9(2): ,2005 Gottlieb, D.J.,et al:relation of sleepiness to respiratory disturbance index; The Sleep Heart Health Study, Am J Respir Crit Care Med, 159: , Sullivan CE,Issa FG,Berthon-Jones M et al.reversal of obstructive sleep apnoea by continuos positive airway pressure applied through the nares.lancet.18;1 8225:862-5, Lowe AA,Sjoholm TT.Ryan CF et al:treatment,airway and compliance effects of a titratable oral appliance.sleep.15;23 Suppl 4:S Prinsell JR:Maxillomandibular advancement surgery in a sitespecific treatment approach for obstructive sleep apnea in 50 consecutive patients.chest.1166: ,

schweiz Arch Neurol Neurochir Psychiatr :119:31-41 1976 Bonnet MH.:Effect of sleep disruption on sleep,performance and mood.

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25 Stoohs(1994) 90 SAS SAS 2 Stoohs(1995) 350 MESAM-4 ODI5 73 ODI Findley(1995) Haraldsson (1995) 62 SAS Steer Clear 13 SAS UPPP UPPP Wu(1996) 253 SAS Teran-Santos (1999) Shiomi OSAS Case-control study OSAS 6.3 PSG OSAS OSAS AHI Mc Nicholas OSAS ERS (2002) Sassani (2004) OSAS OSAS CL: MEDLINE- PubMed Howard (2005) 2,342 PSG161 ESS OSAS 24 EDS 59.6 SDB 15.8 Hartenbaum (2006) OSAS ACCP, ACOEM, NSF. Chest 130: 902-5,

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31 1) Michael G.Lenne, Thomas J.Triggs, Jennifer R.Redman.Interactive Effects of Sleep Deprivation, Time of Day, and Driving Experience on a Driving, SLEEP, vol.21,no.1, ) Findley, L.J.,et al. Vigilance and Automobile Accidents in Patients with Sleep Apnea or Narcolepsy, Chest, 108: , ) Matthew R.Risser MS, J. Catesby Ware PhD, Frederick G. Freeman PhD. Driving Simulation with EEG Monitoring in Normal and Obstructive Sleep Apnea Patients, SLEEP, Vol.23,No3,2000 4) P M Turkington, M Saralaya, M W Elliott. Time Course of Changes in driving Simulator Performance with and without Treatment in Patients with Sleep Apnoea Hypopnoea Syndrome, Thorax, 59: 56-59, ) Pierre Philip, MD, PhD, et al. Fatigue, Sleepiness, and Performance in Simulated Versus Real Driving Conditions, SLEEP, vol.28,no.12,

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38 (1) Van Den Berg, J., Landstrom, Ulf. Symptoms of sleepiness while driving and their relationship to prior sleep, work and individual characteristics. Transportation Research Part F 9, :2006 (2) Flatly, D., Reyner, L.A., Horne, J.A. Sleep-related crashes on sections of different road types in the UK( ) Road Safety Research Report No.52: 2004,London: Department of Transport. (3)..., pp :1996 (4) Pack, A.I., Pack, A.M., Rodgman, E., Cucchiara, A., Dinges, DF.,Schwab, C.W. Characteristic of crashes attributed to the driver having fallen asleep. Accident Analysis Prevention, 27, :

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84 (2) SAS 78

85 REM OSAS 7.3 OSAS 7.3 (PolysomnographyPSG) (Sleep Apnea SyndromeSAS) (Multiple sleep latency test MSLT) 79

86 NREM NREM Rapid EyeMovement; REM REM CPAP (apnea hypopnea index;ahi) 80

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