1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow 4.91 6 4.84 6 2 100 m/z 149, 1.0 91 0.72 104 0.17 8 Koc = 68 350 5 1.2 mg / l 3 1 ppm = 12.99 mg/m 3, 20 1 mg/m 3 = 0.077 ppm CH 2 CH 3 7
2 2. 5 2,054 t 400 t 1,654 9 1 3. 1 10 2 100 mg / l 30 mg / l BOD 81% 8 50 90% 28 20% 11 OH OH 1.5 7 100 11 2 = 663 9.73 mg / l 7 12 3 ppb ppb ppm B/A B/A B/A B/A 60 0 / 27 0.1 2 / 27 13 16 10 B/A
3 4. LC 50 mg / l EC 50 mg / l OECD : Selenastrum 0.13 96-h :very toxic capricornutum 7 Daphnia magna 11 0.97 48-h :very toxic Mysidopsis bahia 11 0.74 96-h Cymatogaster 0.51 96-h aggregata 13 Cyprinodon 3 96-h variegatus 13 toxic Lepomis 1.7 96-h macrochirus 11 OECD OECD 5. 7, 14, 15 1 LD 50 4,170-6,160 mg/kg 2,330-13,500 mg/kg 13,750 mg/kg LC 50 LD 50 6,700 mg/kg >10,000 mg/kg LD 50 3,160 mg/kg 4,000 mg/kg 4-8 15, 16 2 16 3
4 15 4 1 1,600 ppm 13 14 2,500 ppm 5,000 ppm 14 6,250 ppm 25,000 ppm 50,000 ppm 1,500 mg/kg/day 4 2,000 mg/kg/day 2 480 mg/kg/day 4 25,000 ppm 13 3 381 mg/kg/day 960 mg/kg/day 2 2,100 mg/m 3 6 / 5 / 4 789 mg/m 3 6 / 5 / 13 7, 14, 15 5 In vitro DNA L5178Y BALB 3T3 14, 15, 17 6 1 B6C3F 1 6,000 12,000 ppm 103 F344 6,000 12,000 ppm 28 103 12,000 ppm LGL
5 15, 18, 19, 20 7 1 5,000 12,500 20,000 ppm 6-15 10 20,000 ppm 0-20 20 0-11 11-20 10 0-20 0-11 11-20 500 1,000 mg/kg/day 14 500 mg/kg/day 1,000 mg/kg/day 750 1,000 mg/kg/day 7-9 13-15 3 7-9 13-15 25,000 50,000 ppm 2 16, 21, 22, 23 6. 1 2 3 EPA 1996 C EU 1996 1996 NTP 1994 IARC 1996 1996 3 ACGIH 1996 1996 1996 1996
6 4 ACGIH 1996 1996 15 7. 14 C 2 20 200 2,000 mg/kg 24 75-84% 4 92% 14 C 200 mg/kg 75% 20% 2,000 mg/kg 72% 22 % 20 mg/kg 4 55% 34% 14 C 26% 13% 1.1% 0.9% 15% 2% 1.8% 0.3% 6 8. OECD 1 5 5 2 very toxic very toxic 9. 1 In vitro 1.5 OH
7 100 very toxic very toxic toxic 2 1 2 3 4 In vitro 5 toxic very toxic
8 1 1997. 2,, 1985. 3 Richardson, M.L. et.al., The Dictionary of Substances and their Effects, Royal Society of Chemistry 1992-1995. 4,, 1996. 5 Handbook of Environmental Data on Organic Chemicals, 2nd. Ed., Van Nostrand Reinhold Co. 1983. 6 C Log P,. 7 Hazardous Substances Data Bank HSDS, U.S.National Library Medicine 1996. 8 NIST Library of 54K Compounds. 9 5,. 10,,, 1992. 11 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 12, 1996. 13 AQUIRE/NUMERICA. 14 IARC, Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 29, 193-201 1982. 15 Journal of the American College of Toxicology, 11 1, 1-23 1992. 16,,,, 1991. 17 NTP, Technical Report Series, 213 1982 18 Makoto Ema, Journal of Applied Toxicology, 12 3, 179-183 1992. 19 A. H. Piersma, Teratology, 51 6, 28A 1995. 20 Makoto Ema, Toxicology, 79, 11-19 1993. 21 JETOC,,, 3 1997. 22 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 1996. 23, 38, 172-181 1996. 1 2 3
9 mg/l 100 10 1 0.97 48-h 0.74 96-h 0.51 96-h 3 96-h 1.7 96-h 0.1 0.13 96-h LC 50 EC 50 0.01 1 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 1995. 2 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 3 AQUIRE/NUMERICA.
10 6,000 12,000 ppm 1-3 F344 28 103 ppm 0 6,000 12,000 7/49 7/49 18/50 1 IARC, Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 29, 193-201 1982. 2 Journal of the American College of Toxicology, 11 1, 1-23 1992. 3 NTP Technical Report Series, 213 1982.
11 mg/kg/day 4 4 weeks 3 14 days 3 days 10,000 1,000 100 2,000 1,500 480 960 1,000 1,000 750 500 381
12 mg/m 3 6 h/d 5 d/w 4 w 6 h/d 5 d/w 13 w 10,000 1,000 2,100 789 100