1,4-1 1,4- p- 1, 4-1, 4- CAS 123-91-1 C 4 H 8 O 2 88.11 2 1) 2) 11.80 3) 1- / (logp ow ) 101.1 760 mmhg 3) 1.033720 4) 37 mmhg25 5) 1 ppm = 3.60 mg/m 3 at 25, 6) -0.27 7) 8) 9) 3 7) 7) 10) 11) OH NO NO 12) 2.6 BOD 0% 14 100 mg/l 30 13) 6) n- / BCF 0.3-0.7 42 1 mg/l 13) 0.2-0.6 42 10 mg/l 13) 112
14) 4 12 4,500t 113
1 EUSES 2.1 2,400 km 2 800 1 2.1 85.3 8.4 6.0 0.2 114
115 2 2.2 2.2 µg/m 3 µg/g µg/l µg/l µg/l µg/kg µg/kg 0.029 0.01 0.05 0.21 0.4 0.24 0.22 0.16 0.4 0.16 0.18 10 8 10 11 8 8 0.076 0.01 0.05 6.0 0.4 3.2 0.75 0.55 0.4 0.42 0.44 10 8 10 11 8 8 0.0068 0.08 0.4 0.08 0.08 0.08 0.08 0.08 8 2 1 8 0.5 1 0.45 88 5.7 40 4.4 4.4 2.1 2.5 26 21 0.0068 0.01 0.05 0.08 0.4 0.08 0.08 0.08 0.4 0.08 0.08 8-10 2-8 1-10 8-11 0.5-8 1-8 9/12 0/45 0/15 9/16 3/65 11/17 11/17 13/17 0/11 14/18 11/19 0/16 0/17 1/17 0/17 0/19 1/19 1997 1999 1998 1999 1998 1999 1998 1999 1998 2 3 4 2 4 6 7 2 4 6 7 2 6 7 2 6 7 1 2 21.8 µg/l 1990 5 3 820 µg/l 2002 8)
3 2.3 15 m 3 2 L 2,000 g 50 kg 2.3 0.029 µg/m 3 0.0087 µg/kg/day 0.05 µg/l 0.002 µg/kg/day 0.21 µg/l 0.0084 µg/kg/day 0.01 µg/g 1997 0.4 µg/kg/day 0.45 µg/m 3 0.14 µg/kg/day 0.05 µg/l 0.002 µg/kg/day 88 µg/l 3.5 µg/kg/day 0.01 µg/g 1997 0.4 µg/kg/day 2.4 0.14 µg/kg/day 0.45 µg/m 3 0.40 µg/kg/day 0.4 µg/kg/day 14 820 µg/l 33 µg/kg/day 0.14 µg/kg/day 0.54 µg/kg/day 116
2.4 µg/kg/day µg/kg/day 0.0087 0.14 0.002 0.002 0.0084 3.5 0.4 0.4 0.402 0.402 0.0087+0.402 0.14+0.402 1 2 4 PEC 2.5 PEC 88 µg/l 4.4 µg/l 2.5 0.21 µg/l 88 µg/l 0.16 µg/l 4.4 µg/l 117
1 1) 3.1 LD 50 4,200 mg/kg LD 50 5,300 mg/kg LD 50 3,150 mg/kg LD 50 2,000 mg/kg LC 50 46,000 mg/m 3 (2hr) LC 50 37,000 mg/m 3 (2hr) LCLo 44,000 mg/m 3 (7hr) 2) TCLo 1,720 mg/m 3 1) Sherman 60 1 0 0.01 0.1 1 0 9.6 94 1,015 mg/kg/day 0191481,599 mg/kg 716 0.1 1 NOAEL 9.6 mg/kg/day 3) F344/DuCrj 50 1 0 0.02 0.1 0.5 0 16 81 398 mg/kg/day 021103514 mg/kg/day 104 0.02 0.1 0.5 45) LOAEL 16 mg/kg/day() Wistar 288 1 0400 mg/m 3 2 7 / 5 / 400 mg/m 3 ALP NOAEL 400 mg/m 3 83 mg/m 3 6) 00.54.720.5 mg/m 3 30 4.7 mg/m 3 GOT GPT 20.5 mg/m 3 7) 118
Sprague-Dawley 1720 1 02585171,033 mg/kg/day 6 15 1,033 mg/kg/day 8) NOAEL 517 mg/kg/day Sprague Dawley 2035 Swiss Webster 3040 1 6 14 3.5% 1,1,1-300 ppm 7 / 9) 120 mg/m 3 10) Osborne-Mendel 35 1 00.51.0 % 110 11) 0.5 74 25 24 23 GOTGPT -GPT -GPT 80g/ 27 12 14.5 15 0.0248 mg/m 3 3.7 mg/m 3 12) 1 10 165 90 mg/m 3 13) 2 Fischer 344/DuCrj 50 1 00.020.10. 5 01681 398 mg/kg/day 021103514 mg/kg/day 104 0.5 4) 0.5 Crj:BDF 1 50 1 0.05 0.2 0.8 0 66 250 770 mg/kg/day 0773201,070 mg/kg/day 104 0.8 0.05 0.05 0.2 0.8 45) B6C3F 1 50 1 00.51 0720830 mg/kg/day 0380860 mg/kg/day 90 0.5 0.5 1 11) Osborne-Mendel 35 1 00.51 0240530 mg/kg/day 119
0350640 mg/kg/day 110 0.5 0.5 11) 19,000 19701984 1.64 1.50 19831991 10 mg/m 3 1415) IARC 2B 16) 3 NOAEL NOAEL 9.6 mg/kg/day NOAEL 400 mg/m 3 83 mg/m 3 4 3.2 MOE 0.40 µg/kg/day 0.40 µg/kg/day 9.6 mg/kg/day 2,400 33 µg/kg/day 29 0.029 µg/m 3 0.45 µg/m 3 18,000 83 mg/m 3 1 2() 0.40 µg/kg/day 33 µg/kg/day 9.6 mg/kg/day MOEMargin of Exposure 2,400 120
MOE 29 0.029 µg/m 3 0.45 µg/m 3 83 mg/m 3 MOE 18,000 121
1 4.1 4.1 [µg/l] [] a b c No. 580,000 Selenastrum capricornutum NOEC BMS 3 1,000,000 Selenastrum capricornutum NOEC GRO 3 >1,000,000 Selenastrum capricornutum EC 50 BMS 3 >1,000,000 Selenastrum capricornutum EC 50 GRO 3 1,000,000 Daphnia magna NOEC REP 21 >1,000,000 Daphnia magna EC 50 IMM 2 4,700,000 Daphnia magna LC 50 MOR 1 5718 8,450,000 Daphnia magna EC 50 1 707 >100,000 Oryzias latipes LC 50 MOR 4 1,870,000 Oryzias latipes NOEC GRO 28 17126 6,700,000 Menidia beryllina LC 50 MOR 4 863 9,850,000 Pimephales promelas LC 50 MOR 4 3217 10,800,000 Pimephales promelas LC 50 MOR 4 3217 PNEC PNEC EC 50 Median Effective Concentration: LC 50 Median Lethal Concentration): NOECNo Observed Effect Concentration: BMSBiomass : GROGrowth IMMImmobilization): MORMortality): REPReproduction): 2 PNEC PNEC Selenastrum capricornutum 72 EC 50 1,000,000 µg/l Daphnia magna 48 EC 50 1,000,000 µg/l Pimephales promelas 96 LC 50 9,850,000 µg/l 3 100 9,850,000µg/L PNEC 98,500 µg/l Selenastrum capricornutum 72 122
NOEC 580,000 µg/l Daphnia magna 21 NOEC 1,000,000 µg/l Oryzias latipes 28 NOEC 1,870,000µg/L 3 10 580,000 µg/l PNEC 58,000 µg/l PNEC 10 58,000µg/L 3 4.2 [95 ] PNEC PEC/ PEC PNEC 0.21µg/L () 88µg/L () 58,000 0.002 0.16µg/L () 4.4µg/L () µg/l 0.00008 1 2 0.21µg/L 0.16 µg/l PEC 88µg/L 4.4µg/L PEC PNEC 0.002 0.00008 123
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