1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0 )30 (0.58) 8) 55% 9) 10) 1 ppm = 1.25 mg/m 3 (, 20) 1 mg/m 3 = 0.801 ppm 10) 11)
2 2. 5 287,232 t( 287,181 t 51 t) 12) 1) 3. 1) 13) 2 100 mg l 30 mg l BOD 91% OH = 19, 14) = 6.0 14) 2) 15) 3) ppb ppm ppm B/A B/A B/A B/A () ( ) ( ) ( ) ( ) 0/100 50 ( 100500 ) B/A
3 4) 16) 2943 ppm 17) 1961 0.0050.16 ppm 16) 1966 18) 0.050.12 ppm 1969 0.0020.136 ppm 16) 1979 15 ppb 19) 4. LC 50 ( mg l ) EC 50 ( mg l ) OECD ) : Scnedesmus. sp. 20) 0.3() very toxic ( ) Cypridopsis sp. shrimp 11) 1.05(96-h) ( ) Daphnia magna 21) 2.0 (48-h) toxic ( ) Oncorhynchus Mykiss 22) ( ) Lepomis Macrochirus 20) ( ) Morne saxatilis 20) (Striped bass) 73.5 (96-h) 100 (96-h) 6.7 (96-h) harmful harmful Chilomonas 4.5 (48-h) paramecium Corbicula sp. 21) ( ) Notonecta sp. ( ) 21) E.coli 20) ( ) ( ) 21) 126 (96-h) 835 (96-h) 1 () OECD OECD
4 5. 20, 22, 23) 1) LD 50 800 mg/kg 660 mg/kg 260 mg/kg LC 50 801 ppm (30 min) 471 ppm (4 h) 405 ppm (4 h) LD 50 270 mg/kg 100 ppm 21, 23) 2) 0.1-20% 21, 23) 3) 21, 22, 23) 4) (1) 125 mg/kg 4 150 mg/kg 13 100 mg/kg 13 (2) 10-40 ppm 6 / 5 / 13 20 40 ppm 40 ppm 40 ppm 6 / 5 / 13 1 ppm 6 / 5 / 13 10 ppm 20 ppm 40 ppm 0.3 ppm
5 3 ppm 22 / 7 / 26 1 ppm 6 / 5 / 8 1 ppm 22 / 7 / 26 6 1 3 ppm 6 6 ppm 6 / 5 / 1 6 6 21, 22, 23, 24) 5) In vitro CHO (SCE) Hela DNA (UDS) BALB/c 3T3 C3H/10T1/2 Cl 8 0.1-2.5 µg/ml 24 In vivo 16-40 mg/kg ICR/Ha Q 50 mg/kg 21, 22, 23, 24, 25, 26, 27, 28, 29) 6) EPA (1996 ) EU (1996 ) NTP (1994 ) IARC (1996 ) B1 3 2A ACGIH (1996 ) A2 (1996 ) 2 (1) Wistar ( 1.21581 mg/kg 1.821109 mg/kg)2 1050300 mg/kg 2
6 Wistar 2 N- -N - -N- (MNNG)100 mg/l 8 0.5 % 32 (2) 6 B6C3F1 2.05.614.3 ppm 6 / 5 / 24 14.3 ppm 2/120 9 SD 14.2 ppm 6 / 5 / 588 (382 ) 10/100 14.3 ppm 10 ppm (374 ) 12/100 14.1 ppm 9.5 ppm (378 ) 5/100 1/100 8 SD 14.7 ppm 10.6 ppm 6 / 5 / 25/99 3/99 F344 (7 )2.05.6 14.3 ppm 6 / 5 / 24 5.6 ppm 1/119 1/116 14.3 ppm 51/117 52/115 2 ppm (3) / 2 [a] (DMBA) 22) 7) (1) 6-15 185 mg/kg (2) 3040 50 mg/kg 7-14 (3) 8910 11 37 % 0.5 ml
7 21, 22, 23, 24, 27, 28, 29) 6. 1) 0.06 mg/m 3 0.12 mg/m 3 0.5 mg/m 3 2) 0.39-0.60 mg/m 3 8 / 8 40% 12650 mg 10 3) 2 ppm 5 20 (1971 5 ppm; 1970 1 ppm) 15 1.8-3.9 ppm ( 9.1 ppm) 6 1-3 20 0.15-4.3 ppm 85 29 0.08-0.32 ppm 15 1.2 ppm 2 / 10 6 SCE
8 4) ACGIH (1996 ) 0.3 ppm (0.37 mg/m 3 ) (1996 ) 0.5 ppm (0.61 mg/m 3 ) *: 21, 22) 7. 8. (OECD ) 1) 3 2 2 harmful very toxic 9. 1) OH 19 6.0 OECD harmful very toxic
9 2) (1) (2) (3) (4) (5) (6) (7) very toxic toxic (8)
10 1) () (1996). 2),,,, (1991). 3),, (1995). 4), 5, (1985). 5) Handbook of Environmental Data on Organic Chemicals, 2nd Ed., Van Nostrand Reinhold Co. (1983). 6) Richardson, M. L. et. al., The Dictionary of Substances and their Effects, Royal Society of Chemistry (1993). 7) C Log P, (). 8) NIST Library of 54K Compounds. 9) The Merck Index, 11th Ed., Merck & Co. Inc. (1989). 10),, (1989). 11),, (1984). 12) 5. 13), (1996). 14) Hazardous Substances Data Bank (HSDB), U.S.National Library Medicine (1995). 15), (1995). 16) Kitchens, J.F., et. al., Investigation of Selected Potential Environmental Protection Agency, Office of Toxic Substances, pp. 59-81, 85-110, 126-132, 147-166, 172, 183-204 (1976). 17) Altshuller, A. P., et. al., Analysis of aliphatic aldehydes in source effluents and in the atmosphere, Anal. Chim. Acta., 25, 101-117 (1961). 18) Patterson, R.M., et. al., US Environmental Protection Agency, Assessment of Formaldehyde as a Potential Air Pollution Problem, Vol.8, Bedford, MA, GCA Corporation, pp.9-14, 18-20 (1976). 19) US Environmental Protection Agency, Springfield, VA, Human Exposure to Formaldehyde. Draft Report (Contract No.68-01- 5791). for Office of Pesticides and Toxic Substances, Versar Inc., pp.70-72, 103, 107 (1980). 20) IUCLID (International Uniform Chemical Information Data Base), EU. 21) ICPS, Environmental Health Criteria, 89 (1989). 22) IRPTC ( International Register of Potentially Toxic Chemicals ) Data Base, UN. 23) ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices (1991). 24) IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans 29 (1982). 25) JETOC,,, 3 (1997). 26) IARC, Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, List of IARC Evaluations (1995). 27) ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices (1996). 28), 38, 172-181 (1996). 29) ECETOC, Technical Report 65, Formaldehyde and Human Cancer Risk (1995).
11 1) 2) 3)
(mg/l) 1,000 100 10 0.1 LC50 EC50 1)IUCLID (International Uniform Chemical Information Data Base), EU. 2)ICPS, Environmental Health Criteria 89 (1989). 3)IRPTC (International Register of Potentially Toxic Chemicals) Date Base, UN.
(B6C3F) 24 (ppm) 1) (6 / 0 (ppm) 0 2.0 5.6 14.3 0 2.0 5.6 14.3 2) 5/) 2.0 5.6 0/120 0/120 0/120 2/120 0/120 0/120 0/120 0/120 14.3 (SD) (SD) 588 (ppm) (6 / 14.3 5/) 10.0 14.1 12/100 5/100 10/100 0/100 0/100 9.5 0/100 1/100 0/100 0/100 0/100 14.2 10.2 (ppm) (6 / 14.7 5/) 10.6 25/99 0/50 3/99 0/50 1) 2) 1) 2) (F344) 24 (6 / 5/) (ppm) 0 2.0 5.6 14.3 (ppm) 0 2.0 5.6 14.3 0 2.0 5.6 14.3 0/118 0/118 1/119 51/117 0/114 0/118 1/116 52/115 1/118 4/118 6/119 4/117 0/114 4/118 0/116 1/115 1) 2) 1) IARC Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans, 29(1982) 2) IPCS, Environmental Health Criteria 89(1989)
mg/kg 4w 2 10d 1,000 100 125 185 10
ppm 6h/d5d/w13w 6h/d5d/w13w 6h/d5d/w24m 6h/d5d/w588d 100 40 40 20-40 14.3 14.2 10 10-40 1 1-10 0.3-0.5 0.1