HPLC カラム 総合カタログ 2015

HPLC カラム 総合カタログ 201

HPLC ZIC -HILIC ZIC -chilic ZIC -philic Chromolith HighResolution RP-8e RP-8 RP-selectB Si Chromolith NH 2 CN DIL NEW Phenyl PAH PAH PEEK PEEK PEEK PEEK PEEK (µm) 3., 3 - - (Å 100, 200 100 - - - (mm) 0.07, 0.1, 0.3, 1, 2.1, 4.6, 7., 10, 21.2 0.3, 1, 2.1, 4.6 2.1, 4.6 4.6 0.0, 0.1, 0.2, 2, 3, 4.6, 10, 2 (mm) 20, 30, 0, 100, 10, 20 0, 100, 10, 20 0, 100, 10 2, 0, 100 2, 0, 100, 10, 300, ZIC-HILIC ph10 HPLC HPLC 4 6 6 ZIC-HILIC Chromolith Hibar 600 bar HR 400 bar RT HPLC HPLC 4-4 mm 2

STAR Purospher STAR Purospher Superspher LiChrospher LiChrosolb NEW ChiraDex 2, 3, 3, 4, 10, 10, 10 120 120 90 100, 60 100, 60 100, 60, 300 60 60-2, 2.1, 3, 4, 4.6 2, 3, 4, 4.6, 10 3, 4 2, 3, 4 4, 4.6 3, 4, 4.6, 10 4 4 4 30, 0, 100, 12, 10, 20 30,, 7, 100, 12, 10, 20 12, 20 10, 2, 7, 12, 20 100, 12, 10, 20 2, 7, 100, 12, 10, 20 12, 20 12, 20 20 4 µm 30 - ph 1.-10. 8 9 10 11 12 13 1 1 17 LichroCART 20 bar / 4-4 mm 10 HPLC 10 4-4 mm 18 3

ZIC -HILIC ph DS ZIC-HILIC ZIC-pHILIC ZIC-cHILIC CH 3 CH 2 N CH2 CH2 CH2 S3 P CH 3 スルフォベタイン基 CH 2 CH 2 N CH 3 CH 3 CH 3 ホスホリルコリン基 CH2 CH2 CH2 S3 H 2 CH3 H 2 CH3 CH2 N H 2 CH2 CH2 CH2 S3 CH3 H 2 Analyte H 2 CH2 N CH3 Hydrophilic Partitioning H 2 Analyte H 2 CH3 CH2 CH2 CH2 S3 CH2 N CH3 Analyte Week Electrostatic Interactions H 2 H 2 H 2 CH3 CH2 N CH3 CH2 CH2 CH2 S3 H 2 H 2 H 2 CH3 CH2 N CH3 Analyte H 2 CH2 CH2 CH2 S3 Week Electrostatic Interactions ph ph2-8 ph2-10 ph2-8 H 2 H 2 ZIC-HILIC ZIC-HILIC mm µm ZIC-HILIC, PEEK HPLC Column 20-2.1 3. 100 1 1.0439.0001 82,700 0-2.1 3. 100 1 1.0440.0001 11,200 100-2.1 3. 100 1 1.0441.0001 131,00 10-2.1 3. 100 1 1.0442.0001 147,700 20-2.1 3. 100 1 1.0443.0001 169,900 10-4.6 3. 100 1 1.0444.0001 147,700 0-2.1 3. 200 1 1.044.0001 11,200 100-2.1 3. 200 1 1.0447.0001 131,00 10-2.1 3. 200 1 1.0448.0001 147,700 0-4.6 3. 200 1 1.0446.0001 11,200 10-4.6 3. 200 1 1.0449.0001 147,700 0-2.1 200 1 1.040.0001 104,700 100-2.1 200 1 1.042.0001 119,00 10-2.1 200 1 1.044.0001 134,300 20-2.1 200 1 1.047.0001 14,400 0-4.6 200 1 1.041.0001 104,700 100-4.6 200 1 1.043.0001 119,00 10-4.6 200 1 1.04.0001 134,300 20-4.6 200 1 1.048.0001 14,400 10-7. 200 1 1.046.0001 268,00 ZIC-HILIC, Microbore-HPLC Column ZIC-HILIC, Nano-HPLC Column ZIC-HILIC, Capillary-HPLC Column 30-1 3. 200 1 1.0478.0001 98,000 10-1 3. 100 1 1.0487.0001 146,200 10-1 3. 200 1 1.0480.0001 146,200 10-1 200 1 1.0482.0001 132,900 100-0.1 3. 200 1 1.0466.0001 142,000 10-0.07 200 1 1.046.0001 14,000 30-0.3 3. 200 1 1.0489.0001 98,000 10-0.3 3. 200 1 1.0479.0001 146,200 10-0.3 200 1 1.0481.0001 132,900 4

>>ZIC-HILIC mm µm ZIC-pHILIC ZIC-HILIC, Steel HPLC Column 0-10 200 1 1.049.0001 20,600 10-10 200 1 1.0493.0001 376,600 20-10 200 1 1.0494.0001 476,400 0-21.2 200 1 1.0496.0001 10-21.2 200 1 1.0497.0001 20-21.2 200 1 1.0671.0001 ZIC-HILIC Guard Column -0.3 200 1.0492.0001 94,800-1 200 1.0490.0001 94,800 14-1 200 1.0434.0001,300 20-2.1 200 1 1.043.0001 19,700 20-2.1 200 3 1.0436.0001 63,700 ZIC-cHILIC ZIC-HILIC mm µm ZIC-cHILIC, PEEK HPLC Column ZIC-cHILIC Capillary HPLC column ZIC-cHILIC Guard Column 1, 3 ZIC-cHILIC Capillary Guard Column 0-2.1 3 100 1 1.066.0001 94,00 100-2.1 3 100 1 1.067.0001 107,800 10-2.1 3 100 1 1.068.0001 121,100 0-4.6 3 100 1 1.069.0001 94,00 100-4.6 3 100 1 1.0660.0001 107,800 10-4.6 3 100 1 1.0661.0001 121,100 20-4.6 3 100 1 1.0662.0001 139,300 10-0.3 3 100 1 1.0669.0001 119,900 10-1 3 100 1 1.0670.0001 119,900 20-2.1 100 1 1.0664.0001,400-0.3 100 1 1.066.0001 60,400-1 100 3 1.0666.0001 60,400 ZIC-pHILIC ph10 mm µm ZIC-pHILIC, PEEK HPLC Column 0-2.1 1 1.049.0001 120,400 100-2.1 1 1.0462.0001 137,400 10-2.1 1 1.0460.0001 14,400 0-4.6 1 1.0463.0001 120,400 100-4.6 1 1.0464.0001 137,400 10-4.6 1 1.0461.0001 14,400 ZIC-pHILIC, Guard Column 20-2.1 1 1.0437.0001 22,700 ZIC-pHILIC, Guard Column 1, 3 20-2.1 1.0438.0001 9,00 ZIC-HILIC ZIC-pHILIC www.merckmillipore.jp/zic-hilic

Chromolith HPLC - RP-8e Si NH 2 CN DIL Phenyl 2 mm; 1. µm 3, 4.6, 10, 2 mm; 2 µm 1.1 µm 130 Å 10 Å - - 1 ml/g >80% 2.9 ml/g 300 m 2 /g 20 m 2 /g 18% 11% - 11% 18% ph 2-7. NEW 2 4.6 mm:200 bar 10 mm:10 bar 2 mm:100 bar 2 µm 1. µm 13 nm Chromolith High Resolution mm 1, 3 3 µm! 1! 2-4.6 1 1.2020.0001 38,200 0-4.6 1 1.2021.0001 7,300 100-4.6 1 1.2022.0001 86,400-4.6 1 1.2024.0001 37,100 3-4.6 3 1.202.0001 27,600 Chromolith 6 mm 2-2 1 1.2014.0001 46,200 2-3 1 1.2003.0001 42,000 2-4.6 1 1.1463.0001 38,200 0-2 1 1.2007.0001 68,800 0-3 1 1.2002.0001 63,000 100-2 1 1.2006.0001 99,300 100-3 1 1.2001.0001 89,000 100-4.6 1 1.02129.0001 86,400 0-4.6 1 1.140.0001 7,300 1, 3 3 3 RP-8e! -2 1 1.2008.0001 43,900-3 1 1.2004.0001 40,00-4.6 1 1.1470.0001 37,100 10-4.6 1 1.1471.0001 40,800-2 1 1.2009.0001 34,00-3 1 1.200.0001 31,100-4.6 1 1.141.0001 27,600 10-4.6 1 1.142.0001 31,00 100-4.6 3 1.1466.0001 21,000 RP-8e 100-4.6 1 1.1468.0001 86,400 RP-8e 1, 3-4.6 1 1.2012.0001 37,100 RP-8e 3-4.6 3 1.2013.0001 27,600

>>Chromolith mm Si Si 100-4.6 1 1.146.0001 81,600 Si 1, 3-4.6 1 1.2010.0001 33,600 Si 3-4.6 3 1.2011.0001 24,200 NH 2 NH 2 0-4.6 1 1.2027.0001 7,300 2-4.6 1 1.2026.0001 38,200 100-4.6 1 1.2028.0001 86,400 NH 2 1, 3-4.6 1 1.2029.0001 37,100 NH 2 3-4.6 3 1.2030.0001 27,600 CN 100-4.6 1 1.2048.0001 86,400 CN 0-4.6 1 1.2047.0001 7,300 2-4.6 1 1.2046.0001 38,200 CN 3-4.6 3 1.200.0001 27,600 DIL 100-4.6 1 1.3172.0001 86,400 DIL 0-4.6 1 1.3171.0001 7,300 2-4.6 1 1.3170.0001 38,200 DIL 3-4.6 3 1.317.0001 27,600 NEW Phenyl 100-4.6 1 1.206.0001 86,400 Phenyl 0-4.6 1 1.207.0001 7,300 Phenyl 3-4.6 3 1.209.0001 27,600-4.6mm 1 1.2032.0001 10-4.6mm 1 1.2033.0001 1 1.1467.0001 7,100 10-0.0 1 1.0403.0001 133,00 10-0.1 1 1.0402.0001 133,00 300-0.1 1 1.0424.0001 173,00 10-0.2 1 1.040.0001 133,00 HR 10-0.1 1 1.0404.0001 133,00 10-0.2 1 1.0407.0001 133,00 0-0.1 1 1.0426.0001 46,300 0-0.2 1 1.0409.0001 46,300 RP-8e RP-8e 10-0.1 1 1.0400.0001 133,00 RP-8e 0-0.1 1 1.2031.0001 46,300 100-10 1 1.2016.0001 181,400 100-2 1 1.222.0001 72,700 10-10 1 1.2036.0001 62,100 10-2 1 1.2261.0001 119,100 Si Si 100-10 1 1.201.0001 163,300 Si 100-2 1 1.221.0001 63,100 Si 10-10 1 1.203.0001,100 Si 10-2 1 1.2260.0001 103,800 1 1.2037.0001 1 1.2262.0001 1 1.229.0001 16,300 1 1.226.0001 1,200 1 1.227.0001 18,300 1 1.224.0001 27,100 1 1.22.0001 2,100 7

STAR / ph Purospher STAR STAR HPLC ppm STAR RP- 18e RP-8e ph 1.-10. STAR RP-8e Si NH 2 Phenyl 0. mm 2 mm RP-8e Si NH 2 Phenyl Na, Ca, Mg, Al: 1 ppm, Fe: 3 ppm 2 µm, 3 µm, µm µm 2,3, µm - 120 Å 1.1 ml/g 330 m 2 /g 17% 11.2% - 3.% 12.% ph 1. - 10. 1. - 10. 2-7. 2-7. 1.-10. 20 bar, RT 400 bar, HR: 600 bar NEW HR STAR RT STAR RP-8e RT STAR RP-8e mm µm 30-2.1 2 1 1.064.0001 40,800 0-2.1 2 1 1.0646.0001 49,00 100-2.1 2 1 1.0648.0001 8,300 10-2.1 2 1 1.0649.0001 7,700 30-2.1 3 1 1.060.0001 34,700 0-2.1 3 1 1.061.0001 42,100 100-2.1 3 1 1.063.0001 49,00 10-2.1 3 1 1.064.0001 64,400 20-2.1 3 1 1.06.0001 71,100 100-3 3 1 1.0398.0001 62,200 12-3 3 1 1.0413.0001 64,000 10-3 3 1 1.0414.0001 64,000 20-3 3 1 1.0427.0001 71,100 12-4 3 1 1.0431.0001 64,000 20-4 3 1 1.0468.0001 71,100 100-4.6 3 1 1.0469.0001 64,000 10-4.6 3 1 1.0470.0001 64,000 20-4.6 3 1 1.0471.0001 71,100 0-2 1 1.093.0001 40,800 12-2 1 1.096.0001 3,300 10-2 1 1.097.0001 1,800 20-2 1 1.098.0001 9,200 0-3 1 1.0607.0001 42,100 100-3 1 1.0612.0001 49,00 12-3 1 1.061.0001 3,300 10-3 1 1.0617.0001 3,300 20-3 1 1.0620.0001 9,200 0-4 1 1.0621.0001 42,100 12-4 1 1.0036.0001 3,300 20-4 1 1.0037.0001 9,200 100-4.6 1 1.0622.0001 3,300 10-4.6 1 1.14.0001 3,300 20-4.6 1 1.146.0001 9,200 12-4 1 1.0033.0001 3,300 10-4.6 1 1.143.0001 3,300 20-4 1 1.003.0001 9,200 20-4.6 1 1.144.0001 9,200 8

>>Purospher STAR> NEW Phenyl RT STAR Phenyl mm µm 10-4.6 1 1.1919.0001 3,300 20-4.6 1 1.1918.0001 9,200 0-2.1 2 1 1.1013.0001 49,00 100-2.1 2 1 1.1014.0001 8,300 0-2.1 3 1 1.0672.0001 42,100 100-2.1 3 1 1.0673.0001 49,400 mm µm 7-4 3 1 1.1460.0001 4,300 100-2 1 1.0623.0001 48,900 12-2 1 1.02.0001 48,900 10-2 1 1.0624.0001 48,900 20-2 1 1.026.0001 4,800 100-3 1 1.062.0001 48,900 STAR 12-3 1 1.023.0001 48,900 10-3 1 1.0626.0001 48,900 20-3 1 1.024.0001 4,800 12-4 1 1.021.0001 48,900 20-4 1 1.022.0001 4,800 100-4.6 1 1.0627.0001 48,900 10-4.6 1 1.038.0001 48,900 20-4.6 1 1.039.0001 4,800 30-4 3 3 1.022.0001 66,600 STAR 3-2 3 3 1.0241.0001 80,800-4 3 3 1.0231.0001 80,800 30-4 3 1 1.0239.0001 3,00 STAR 1, 1-2 3 1 1.0240.0001 42,600-4 3 1 1.0242.0001 42,600 STAR 2-4.6 mm 4-4 10 1.020.0001 31,100 RP-8e 12-2 1 1.0274.0001 48,900 12-3 1 1.0038.0001 48,900 STAR RP-8e 20-3 1 1.0273.0001 4,800 12-4 1 1.0271.0001 48,900 20-4 1 1.0272.0001 4,800 10-4.6 1 1.0031.0001 48,900 STAR RP-8e 2-4.6 mm 4-4 10 1.0270.0001 31,100 Si 12-4 1 1.0268.0001 46,200 STAR Si 20-4 1 1.0269.0001 1,800 10-4.6 1 1.036.0001 46,200 20-4.6 1 1.037.0001 1,800 STAR Si 2-4.6 mm 4-4 10 1.0249.0001 29,300 NH 2 STAR NH 2 20-4 1 1.024.0001 4,800 10-4.6 1 1.0247.0001 48,900 12-4 1 1.0244.0001 48,900 20-4.6 1 1.0248.0001 4,800 STAR NH 2 2-4.6 mm 4-4 10 1.0267.0001 31,100 NEW Phenyl STAR Phenyl 10-4.6 1 1.1922.0001 48,900 20-4.6 1 1.1921.0001 4,800 STAR 20-10 1 1.027.0001 173,200 8e 18 STAR RP-8e 20-10 1 1.0276.0001 173,200 9

ピューロスフェア 高純度球状シリカゲルカラム ピューロスフェアは 高純度で金属含有量の少ないシリカゲルを用 いて生産された汎用 HPLC 担体です 担体表面は化学修飾と不活化 工程を繰り返して処理されているため 塩基性物質やキレート性物 質の分析でもテーリングが生じにくくなっています また化学的に 安定なため 弱塩基性条件下で長期間分析に用いた場合でも劣化が 少なくなっています Purospher 仕様 担体 高純度球状シリカゲル 粒径 µm 表面修飾基 オクタデシル基 エンドキャップ処理 有 無 90 Å 細孔径 細孔容積 1. ml/g 比表面積 480 m2/g 18.0% 炭素率 17.0% 使用可能 ph カートリッジ式カラム リクロカート 製品名 ph 2-8 別売りのカラムホルダーが必要です 詳しくは 18 ページを参照ください カラムサイズ mm 粒径 µm 包装単位 カタログ番号 12-3 1本 1.0798.0001 48,900 20-3 1本 1.1384.0001 4,800 12-4 1本 1.0168.0001 48,900 20-4 1本 1.0169.0001 4,800 12-3 3 本組 1.0799.0001 102,100 4-4 10 本組 1.0167.0001 31,100 12-4 1本 1.0142.0001 48,900 20-4 1本 1.0144.0001 4,800 4-4 10 本組 1.0141.0001 31,100 20-4 1本 1.1436.0001 4,800 希望販売価格 分析用カラム リクロカート ピューロスフェア リクロカート ピューロスフェア カートリッジ 3 リクロカート ピューロスフェア 内径 2-4.6 mm カラム用ガードカラム リクロカート ピューロスフェア リクロカート ピューロスフェア 内径 2-4.6 mm カラム用ガードカラム リクロカート ピューロスフェア HC 溶離液の接続方法がトラブルの元になっていませんか?? データの再現性を確保 暴露も防げます HPLCポンプ稼動時のみエアバルブが開き ボトルの引圧を防止 フィルターが大気中の粒子ゴミをシャットアウト 密閉により有機溶媒の揮発も防止 溶離液の組成も変化なし アルミホイルをフタに使っている パラフィンフィルムを巻いている キャップに穴を開けて使っている 配管をお好きな方向に設置できます 回転し キャップを締めると固定できます 接続部分は360 この状態では 溶離液の汚染や 有機溶媒の揮発に よる溶離液の変質 暴露の危険があります フェラル 廃液用エアフィルター エアバルブ そんな溶離液の接続にお困りの場合は 溶媒アダプターS40で問題解決 溶離液の汚染防止 フィッティング HPLCボトルアダプターS40 1セット カタログ番号1.03830.0001 プラグ HPLCボトルアダプターS40廃液用 1セット カタログ番号 1.03831.0001 暴露の予防 製品名 包装単位 カタログ番号 廃液貯蔵に HPLCボトルアダプタ- S40 HPLCボトルアダプタ- S40 廃液用 1セット 1セット 10個 10個 10個 10個 1個 1.03830.0001 1.03831.0001 1.03832.0001 1.0383.0001 1.03834.0001 1.03836.0001 1.03833.0001 溶離液の組成も一定に保ちます エアバルブ 3.2 安全な実験環境とデータの再現性を確保できます! 1 L 2. L 4 Lのボトルに対応します 10 3.2 mm A.D. PTFEフェラル mm.d.フィッティング プラグ 廃液用エアフィルター

4 µm Superspher HPLC 4 µm HPLC 100,000 N/m RP-8, RP-8e,,, RP-select B 2 mm 4 mm RP-8e RP-8 RP-select B Si 4 µm - 100 Å 60 Å 1.2 ml/g 0.8 ml/g 400 m 2 /g 700 m 2 /g 21.6% 21.0% 13.0% 12.% 11.% - ph ph 2-7. - 18 mm µm 100 100 3 100 100 3 RP-8e 60 RP-8e RP-8 60 RP-8 RP-select B 60 RP-select B 60 RP-select B 3 Si Si 60 12-2 4 1 1.0198.0001 62,000 20-2 4 1 1.0193.0001 69,900 12-4 4 1 1.168.0001 9,000 20-4 4 1 1.1688.0001 66,900 2-4 4 3 1.16869.0001 4,100 12-2 4 1 1.0200.0001 9,000 12-3 4 1 1.0792.0001 62,000 20-3 4 1 1.1299.0001 69,900 12-4 4 1 1.1601.0001 62,000 20-4 4 1 1.1606.0001 69,900 10-2 4 3 1.0204.0001 21,100 2-4 4 3 1.16039.0001 4,100 7-4 4 3 1.0980.0001 71,100 12-4 4 1 1.1684.0001 62,000 20-4 4 1 1.1687.0001 69,900 20-4 4 1 1.16010.0001 69,900 12-4 4 1 1.1602.0001 62,000 12-2 4 1 1.0197.0001 69,100 20-2 4 1 1.1308.0001 77,800 12-3 4 1 1.0791.0001 69,100 20-3 4 1 1.1288.0001 77,800 12-4 4 1 1.097.0001 69,100 20-4 4 1 1.0973.0001 77,800 10-2 4 3 1.020.0001 21,100 7-4 4 3 1.0974.0001 79,100 12-4 4 1 1.1604.0001 8,00 20-4 4 1 1.16009.0001 66,000 11

HPLC LiChrospher, RP-8, RP-Select B CN NH 2 DIL Si RP-8e RP-8 RP-select B µm, 10 µm 100 Å 60 Å 1.2 ml/g 0.9 ml/g 30 m 2 /g 21.6% 21.0% 13.0% 12.% 11.% ph ph 2-7. Si NH 2 CN DIL µm, 10 µm - - 60Å 100 Å 0.8 ml/g 1.2 ml/g 700 m 2 /g 400 m 2 /g 30 m 2 /g - - 4.6% 6.6% 8.0% ph ph 2-7. mm µm 100 100-4.6 1 1.048.0001 6,700 10-4.6 1 1.049.0001 6,700 20-4.6 1 1.00.0001 63,000 100 12-4 1 1.0477.0001 6,700 20-4 1 1.0377.0001 9,000 100-4.6 1 1.04.0001 6,700 10-4.6 1 1.046.0001 6,700 20-4.6 1 1.047.0001 63,000 RP-8e 100 RP-8e 100-4.6 1 1.081.0001 6,700 10-4.6 1 1.082.0001 6,700 20-4.6 1 1.083.0001 63,000 RP-8 100 RP-8 20-4 1 1.0329.0001 63,000 100-4.6 1 1.078.0001 6,700 10-4.6 1 1.079.0001 6,700 20-4.6 1 1.080.0001 63,000 RP-select B 60 RP-select B 100-4.6 1 1.073.0001 62,400 10-4.6 1 1.074.0001 62,400 20-4.6 1 1.07.0001 69,300 Si Si 100 20-4 1 1.0316.0001 9,900 NH 2 100 NH 2 20-4.6 1 1.1904.0001 69,300 10-4.6 1 1.190.0001 6,700 12

>> HPLC 18 mm µm 100 100 2-4.6 mm 100 100 2-4.6 mm PAH PAH PAH 2-4.6 mm RP-8e 100 RP-8e 100 RP-8e 2-4.6 mm RP-8 100 RP-8 100 RP-8 2-4.6 mm 2-4 3 1.0936.0001 39,900 12-4 1 1.0828.0001 47,800 12-4 3 1.0734.0001 9,200 20-4 1 1.0838.0001 2,900 20-4 3 1.099.0001 99,900 20-4 10 1 1.0848.0001 2,900 4-4 10 1.0962.0001 37,900 100-4.6 1 1.0603.0001 47,800 10-4.6 1 1.0604.0001 47,800 20-4.6 1 1.060.0001 4,100 12-3 1 1.019.0001 47,800 20-3 1 1.014.0001 4,100 2-4 1 1.0931.0001 39,900 7-4 1 1.0987.0001,100 12-4 1 1.0823.0001 46,000 12-4 3 1.0943.0001 9,200 20-4 1 1.0833.0001 2,900 20-4 3 1.0983.0001 99,900 20-4 10 1 1.0843.0001 4,100 4-4 10 1.097.0001 39,300 100-4.6 1 1.0600.0001 47,800 10-4.6 1 1.0601.0001 47,800 20-4.6 1 1.0602.0001 4,100 20-3 1 1.016.0001 8,700 20-4 1 1.0149.0001 91,400 4-4 10 1.0148.0001 40,600 12-4 1 1.0827.0001 47,800 20-4 1 1.0837.0001 2,900 20-4 10 1 1.0847.0001 4,100 100-4.6 1 1.0637.0001 47,800 10-4.6 1 1.0638.0001 47,800 20-4.6 1 1.0639.0001 4,100 4-4 10 1.0961.0001 39,300 2-4 3 1.0930.0001 39,900 7-4 3 1.0986.0001,100 12-4 1 1.0822.0001 47,800 20-4 1 1.0832.0001 2,900 12-4 3 1.0942.0001 9,200 20-4 10 1 1.0842.0001 4,100 20-4 3 1.0982.0001 99,900 100-4.6 1 1.0634.0001 47,800 10-4.6 1 1.063.0001 47,800 20-4.6 1 1.0636.0001 4,100 4-4 10 1.096.0001 37,900 13

>> HPLC mm µm RP-select B 60 RP-select B 60 RP-select B 2-4.6 mm Si Si 60 Si 60 2-4.6 mm NH 2 100 NH 2 100 NH 2 2-4.6 mm CN 100 CN 100 CN 2-4.6 mm DIL 100 DIL 100 DIL 2-4.6 mm 12-3 1 1.018.0001 3,00 20-3 1 1.01.0001 60,400 2-4 3 1.0937.0001 46,600 7-4 3 1.0993.0001 61,00 12-4 1 1.0829.0001 3,00 12-4 3 1.0981.0001 97,200 20-4 1 1.0839.0001 9,000 20-4 3 1.0984.0001 119,400 20-4 10 1 1.0742.0001 60,400 100-4.6 1 1.0640.0001 3,00 10-4.6 1 1.0641.0001 3,00 20-4.6 1 1.0642.0001 60,400 4-4 10 1.0963.0001 39,300 2-4 3 1.0928.0001 39,000 12-4 1 1.0820.0001 4,000 20-4 1 1.0830.0001 1,000 20-4 10 1 1.0840.0001 1,000 4-4 10 1.09.0001 39,300 2-4 3 1.0932.0001 39,900 12-4 1 1.0824.0001 47,800 20-4 1 1.0834.0001 2,900 20-4 10 1 1.0844.0001 4,100 4-4 10 1.098.0001 39,300 12-4 1 1.082.0001 47,800 20-4 1 1.0892.0001 4,100 20-4 10 1 1.084.0001 4,100 4-4 10 1.099.0001 39,300 12-4 1 1.0826.0001 47,800 20-4 1 1.0836.0001 2,900 4-4 10 1.0960.0001 39,300 100 20-10 10 1 1.088.0001 148,700 100 20-10 10 1 1.083.0001 148,700 Si Si 60 20-10 10 1 1.080.0001 140,800 14

LiChrosorb 30 10 µm RP-8 Si 60 3 RP-8 µm, 10 µm 1.0 ml/g 300 m 2 /g 16.2% 9.% Si 60 µm, 10 µm - 0.7 ml/g 00 m 2 /g - mm µm 12-4 1 1.0433.0001 74,100 20-4 1 1.0333.0001 82,400 20-4 10 1 1.0334.0001 82,400 RP-8 12-4 1 1.0432.0001 74,100 RP-8 20-4 1 1.0332.0001 82,400 20-4 10 1 1.0318.0001 82,400 Si 60 Si 60 20-4 1 1.0388.0001 78,200 18 mm µm RP-8 RP-8 Si 60 Si 60 12-4 1 1.1349.0001 4,400 20-4 1 1.13.0001 62,600 20-4 10 1 1.136.0001 62,600 12-4 1 1.134.0001 4,400 20-4 1 1.133.0001 62,600 20-4 10 1 1.134.0001 62,600 12-4 1 1.1343.0001 0,700 20-4 1 1.131.0001 8,00 1

ADS LiChrospher ADS ADS HPLC DIL RP-4 ADS / RP-8 ADS / ADS 18 mm µm ADS 2-2 2 1 1.038.0001 9,100 ADS 3 ADS 1, 1 RP-8 2-2 2 3 1.0386.0001 19,700 2-4 2 3 1.0947.0001 207,600 2-4 2 1 1.0187.0001 100,000 RP-8 ADS 2-2 2 1 1.0382.0001 7,400 RP-8 3 RP-8 ADS 1, 1 RP-4 2-2 2 3 1.0383.0001 10,800 2-4 2 3 1.0209.0001 201,00 2-4 2 1 1.0207.0001 97,000 RP-4 ADS 2-2 2 1 1.0380.0001 7,400 RP-4 ADS 3 RP-4 ADS 1, 1 HPLC 2-2 2 3 1.0381.0001 1,000 2-4 2 3 1.0208.0001 201,00 2-4 2 1 1.0206.0001 97,000 ADS HPLC RP-4 ADS 1, RP-8 ADS 1, ADS 1, 1 2-4 2 1 1.0210.0001 231,400 ADS PEEK 1 1 1.1192.0001 23,700 1 1.1193.0001 1,300 16

ChiraDex - -CD -CD -7 - -CD -CD 7 D- -1,4-2 H 1 CD D- 7 CD CD C2,C3 H H H H H H H H H H H H H H H H H H H H hydrophobic cavity 1.3 nm 0.78 nm hydrophilic shell H Cromakalim Column LiChroCART 20-4 ChiraDex Mobile phase Flow rate Detection Water/Methanol 80/20 (v/v) 0.8 ml/min UV 24 nm NC N H CH 3 CH 3 0 4 8 12 RT [min] Selevtivity with Sertralin Column LiChroCART 20-4 ChiraDex HighResolution Mobile phase Flow rate Detection Injection volume Sample Acetonitril/10 mm Phosphat buffer adjusted with Triethylamin to ph=7.0 30/70 v/v 0.6 ml/min UV 220 nm µl 1 mg/ml Sertralin Resolution = 2.11 = 1.12 0 2. 7. 10 12. 1 17. 20 22. 2 27. 30 32. 3 37. RT [min] H 3 C H N H H Cl Cl 18 mm µm 20-4 1 1.1333.0001 129,800 20-4 1 1.1000.0001 103,00 4-4 10 1.0117.0001 40,400 17

manu-cart HPLC HPLC NT NT 2~4.6 mm, 7~20 mm HPLC 4-4 1 1.1486.0001 26,00 2-4 2~4.6 mm HPLC 2-4HPLC 1/16" 30-2,3,4 2, 3, 4 mm, 30 mm HPLC 1/16" -2,3,4 2, 3, 4 mm, mm HPLC 1/16" 10 mm, 7~20 mm HPLC 10-10 2-2,4 2-4HPLC 1/16" 1 1.0082.0001 33,600 1 1.0227.0001 20,100 1 1.0226.0001 24,200 1 1.1419.0001 3,400 1 1.0017.0001 34,200 4-4 4-4 1/16" 4-4 4-4 1/16" 1 1.16217.0001 29,100 1 1.1487.0001 22,300 2~4.6 mm HPLC 2 1 1.0083.0001 1,000 4 mm 4 1 1.127.0001 9,000 4 mm 2 1 1.128.0001 16,000 10-4.6mm NT 4-4mm NT 18

HPLC µm 100 4 10 g 1.19618.0010 122,000 100 4 10 g 1.19613.0010 122,000 60 RP-8 4 10 g 1.19612.0010 122,000 60 RP-select B 4 10 g 1.19643.0010 1,600 100 10 g 1.19637.0010 104,600 10 10 g 1.19633.0010 104,600 100 10 g 1.16177.0010 104,400 10 10 g 1.1610.0010 104,400 100 RP-8e 10 g 1.19636.0010 104,600 10 10 g 1.19632.0010 104,600 100 RP-8 10 g 1.16129.0010 104,400 10 10 g 1.16139.0010 104,400 60 RP-select B 10 g 1.19641.0010 132,900 10 10 g 1.19642.0010 119,000 Si 60 10 g 1.19640.0010 38,900 100 NH 2 10 g 1.16178.0010 104,400 100 CN 10 g 1.19638.0010 104,600 100 DIL 10 g 1.1612.0010 104,400 RP-8 10 g 1.09333.0010 64,600 10 10 g 1.09334.0010 6,000 10 g 1.09332.0010 64,600 10 10 g 1.09318.0010 9,00 10 100 g 1.09318.0100 Si 100 10 10 g 1.09309.0010 13,000 19

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