1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16 2 80 g/l 20 2 1 ppm = 4.49 mg/m 3, 20 1 mg/m 3 = 0.223ppm 3
2 2. 10 8,118 t 0 t 8,118 t 5 1 3. 1 6 4 100 mg/l 30 mg/l BOD 3543 NO 2 5366 NH 3 TOC 86 GC 96 OH = 7.1210-13 cm 3 / sec 25 7 OH 510 5 110 6 /cm 3 24 2 8 3 55 ppb ppm ppm B/A B/A B/A B/A 0/21 0/21 10 0.10.3 B/A
3 4. LC 50 mg/l EC 50 mg/l : Daphnia magna 10 445 24-h: Lepomis macrochirus 10 Poecilia reticulata 10 Pimephales promelas 10 720 96-h 775 96-h 820 96-h * OECD 5. 2, 11, 12, 13, 14, 15, 16 1 LD 50 172-300 mg/kg 105-300 mg/kg 172-300 mg/kg LC 50 386-452 ppm 4h LD 50 > 2,000 mg/kg 2,134-2,290 mg/kg LD 50 40 mg/kg LD 50 138 mg/kg 17 56.5-685 ppm 250-3,030 mg/m 3 4 160 ppm 710 mg/m 3 24 48 4 LC 50 386 ppm 1,710 mg/m 3 13 2 0.5 ml 24 14 3 14 4 1
4 0.55.050 ppm 2 0.5 ppm 2, 14 2 7.0121.560.6 ppm 0.0310.0950.268 mg/l 6 / 5 / 2 7.01 ppm 21.5 ppm 60.6 ppm 2, 14 14 14.525.8111 ppm 64114493 mg/m 3 6 / 5 / 4 25.8 ppm 111 ppm 2, 18/18 9/18 18 2.926.9222.4 ppm 12.930.699.0 mg/m 3 6 / 5 / 13 22.4 ppm NOAEL 6.92 ppm 2, 14, 18 5 * in vitro TA97TA98TA100 TA1535TA1537S9 mix +/- 12 TA98TA1535TA1537 TA1538S9 mix +/- 100-10,000 µg/plate 14 L5178YS9 mix +/- 5µL/mL 14 DNA S9 mix +/- 2,500 µl/ml 14 in vivo SD 62448 * 6 1964 2 3 14, 15 7 1 30 50 80 mg/kg/day 6-19 14 11, 14
5 2 2.947.1923.5 ppm 13.031.8104 mg/m 3 6 / 22 14, 19 2.926.9222.4 ppm 12.930.699.0 mg/m 3 6 / 5 / 74 53 14, 20 6. 1 2, 14, 15 18 ml 2, 14 2 21, 22, 23 3 EPA 1999 D EU 2000 NTP 2000 IARC 2000 ACGIH 2000 2000 22, 23 4 ACGIH 2000 2 ppm 8.8 mg/m 3 2000
6 7. 1 21 96 42 5 14, 15 50 mg/kg 79 12, 14, 15, 16 5.75 mg/kg 80 6 9 14 8. OECD * 9 2 * OECD OECD 9. 1 in vitro in vivo OH
7 2 1 2 3 4 13 10
8 1 2001. 2 Hazardous Substances Data Bank HSDB, U.S. National Library of Medicine 2001. 3 IPCS, International Chemical Safety Cards 1995. 4 NIST Library of 54K Compounds. 5 10, 1999. 6,,, 1992. 7 AOPWIN ver1.86 Syracuse Research Corporation. 8 2000. 9 OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures, OECD Series on Testing and Assessment No.33 2001. 10 AQUIRE US EPA, ECOTOX Database System. 11 Registry of Toxic Effects of Chemical Substances RTECS, US NIOSH 1998. 12 Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry 1999. 13 Ladd W. Smith, Inhalation Toxicity of adiponitrile in Rats, Toxicology and Applied Pharmacology, 65, 257-263 1982. 14 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 15 OECD/UNEP/WHO/ILO, Screening Information Data Set SIDS, 5 1, 1998. 16,,,, 1994. 17 O. L. Dashiell, The Effects of Fasting on the Acute Oral Toxicity of Nine Chemicals in the Rat, Journal of Applied Toxicology, 4 6, 320-325 1984. 18 R. D. Short, 13-Week Iinhalation Toxicity Study and Fertility Assessment in Rats exposed to Atmospheres Containing Adiponitrile, Journal of Toxicology and Environmental Health, 30, 199-207 1990. 19 EPA/OTS 0516561 Doc#: 86-870000753, Monsanto Co., Female Fertility Study of Sprague-Dawley Rats exposed by the Inhalation Route to Adiponitrile with Attachments Final report1983. 20 EPA/OTS 0515374 Doc#: 86-870000936, Monsanto Co., Male Fertility Study of Sprague-Dawley Rats exposed by Inhalation to Adiponitrile Final report with Cover Letter dated 072787 1987. 21 JETOC,,, 4 1999. 22 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 2000. 23,, 42, 130-154 2000.
9 1 2
10 mg/l 1,000 720 96-h 775 96-h 820 96-h 445 24-h 100 LC 50 EC 50 10 1AQUIRE US EPA, ECOTOX Database System.
11 4 h 6 h/d 5 d/w 2 w 6 h/d 5 d/w 4 w 6 h/d 5 d/w 13 w 6 h/d 1,000 ppm 386 LC 50 100 10 160 60.6 56.5 21.5 25.8 2.94-23.5 22.4 22d 14.5 2.92-22.4 74d 7.01 111 6.92 NOAEL 1 2 ACGIH